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ORIGINAL ARTICLE

The effects of α-methyldopa on myometrial noradrenaline release and myometrial contractility in rat

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Pages 986-994 | Received 19 Jan 2007, Published online: 03 Aug 2009

References

  • Frishman WH, Schlocker SJ, Awad K, Tejani N. Pathophysiology and medical management of systemic hypertension in pregnancy. Cardiol Rev. 2005; 13: 274–84
  • Magee LA. Drugs in pregnancy. Antihypertensives. Best Pract Res Clin Obstet Gynaecol. 2001; 15: 827–45
  • Sibai BM. Treatment of hypertension in pregnant women. N Engl J Med. 1996; 335: 257–65
  • Borghi C, Esposti DD, Cassani A, Immordino V, Bovicelli L, Ambrosioni E. The treatment of hypertension in pregnancy. J Hypertens Suppl. 2002; 20: S52–6
  • Gunenc O, Cicek N, Gorkemli H, Celik C, Acar A, Akyurek C. The effect of methyldopa treatment on uterine, umbilical and fetal middle cerebral artery blood flows in preeclamptic patients. Arch Gynecol Obstet. 2002; 266: 141–4
  • Finch L, Haeusler G. Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat. Br J Pharmacol. 1973; 47: 217–28
  • Henning M, Rubenson A. Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline. J Pharm Pharmacol. 1971; 23: 407–11
  • Day MD, Roach AG, Whiting RL. The mechanism of the antihypertensive action of α-methyldopa in hypertensive rats. Eur J Pharmacol. 1973; 21: 271–80
  • Goldberg MR, Tung CS, Feldman RD, Smith HE, Oates JA, Robertson D. Differential competition by l-alpha-methyldopa metabolites for adrenergic receptors in rat forebrain. J Pharmacol Exp Ther. 1982; 220: 552–60
  • Adham N, Schenk EA. Autonomic innervation of the rat vagina, cervix, and uterus and its cyclic variation. Am J Obstet Gynecol. 1969; 104: 508–16
  • Bell C. Autonomic nervous control of reproduction: circulatory and other factors. Pharmacol Rev. 1972; 24: 657–736
  • Papka RE, Cotton JP, Traurig HH. Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive and noradrenergic nerves in the reproductive tract of the female rat. Cell Tissue Res. 1985; 242: 475–90
  • Thorbert G, Alm P, Björklund AB, Owman C, Sjöberg NO. Adrenergic innervation of the human uterus. Disappearance of the transmitter and transmitter-forming enzymes during pregnancy. Am J Obstet Gynecol. 1979; 135: 223–6
  • Zupkó I, Csonka D, Falkay G. A rat model for functional characterization of pregnancy-induced denervation and postpartum reinnervation in the myometrium and cervix: a superfusion study. Reproduction. 2005; 130: 743–9
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72: 248–54
  • Rosenthal HE. A graphic method for the determination and presentation of binding parameters in a complex system. Anal Biochem. 1967; 20: 525–32
  • Oates JA, Gillespie L, Udenfriend S, Sjoerdsma A. Decarboxylase inhibition and blood pressure reduction by alpha-methyl-3,4-dihydroxy-dl-phenylalanine. Science. 1960; 131: 1890–1
  • Nakamura K, Okada T, Ishii H, Nakamura K. Differential effects of alpha-methyldopa, clonidine and hydralazine on norepinephrine and epinephrine synthesizing enzymes in the brainstem nuclei of spontaneously hypertensive rats. Jpn J Pharmacol. 1980; 30: 1–10
  • van Zwieten PA, Timmermans PB, van BP. Role of α adrenoceptors in hypertension and in antihypertensive drug treatment. Am J Med. 1984; 77: 17–25
  • Schloos J, Wellstein A, Palm D. Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations. Naunyn Schmiedebergs Arch Pharmacol. 1987; 336: 48–59
  • Bell C, Malcolm SJ. Observations on the loss of catecholamine fluorescence from intrauterine adrenergic nerves during pregnancy in the guinea-pig. J Reprod Fertil. 1978; 53: 51–8
  • Alm P, Björklund A, Owman C, Thorbert G. Tyrosine hydroxylase and DOPA decarboxylase activities in the guinea-pig uterus: further evidence for functional adrenergic denervation in association with pregnancy. Neuroscience. 1979; 4: 145–54
  • Ihalainen JA, Tanila H. In vivo regulation of dopamine and noradrenaline release by α2A-adrenoceptors in the mouse nucleus accumbens. J Neurochem. 2004; 91: 49–56
  • Falkay G, Melis K, Kovács L. Correlation between β- and α-adrenergic receptor concentrations in human placenta. J Recept Res. 1994; 14: 187–95
  • Johnston H, Majewski H. Prejunctional β-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of α-adrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol. 1986; 87: 553–62
  • Kitamura Y, Nomura Y. β-Adrenoceptor stimulation-induced increase in the number of α2-adrenoceptors of cerebral cortical membranes in rats. Brain Res. 1985; 329: 259–64
  • Nakamura T, Tsujimura R, Nomura J. Interaction between α2- and β-adrenergic receptors in rat cerebral cortical membranes: clonidine-induced reduction in agonist and antagonist affinity for β-adrenergic receptors. Brain Res. 1991; 542: 181–6
  • Nomura Y, Kawai M, Segawa T. The interaction between β- and α2-adrenoceptors in cerebral cortical membranes: isoproterenol-induced increase in [3H]clonidine binding in rats. Brain Res. 1984; 302: 101–9
  • Woodcock EA, Johnston CI. α-Adrenergic receptors modulate β-receptor affinity in rat kidney membranes. Nature. 1980; 286: 159–60
  • Sastre M, Guimon J, Garcia-Sevilla JA. Relationships between β- and α2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide. Brain Res. 2001; 898: 242–55

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