Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients

References

• Kassebaum NJ, Bernabé E, Dahiya M, et al. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045–1053. doi: 10.1177/0022034514552491.
   PubMed Web of Science ®Google Scholar
• Kassebaum NJ, Smith AGC, Bernabé E, et al. Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990–2015: a systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res. 2017;96(4):380–387. doi: 10.1177/0022034517693566.
   PubMed Web of Science ®Google Scholar
• Baima G, Romandini M, Citterio F, et al. Periodontitis and accelerated biological aging: a geroscience approach. J Dent Res. 2022;101(2):125–132. doi: 10.1177/00220345211037977.
   PubMed Web of Science ®Google Scholar
• Ioannidou E. The sex and gender intersection in chronic periodontitis. Front Public Health. 2017;5:189. doi: 10.3389/fpubh.2017.00189.
   PubMed Web of Science ®Google Scholar
• Luis Muñoz-Carrillo J, Elizabeth Hernández-Reyes V, Eduardo García-Huerta O, et al. Pathogenesis of periodontal disease. In: ; Mohammed Ahmed Yussif, N., editor. Periodontal Disease - Diagnostic and adjunctive non-surgical considerations.; IntechOpen; 2020 ISBN 978-1-78984-460-3. doi: 10.5772/intechopen.86548.
   Google Scholar
• Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409–419. doi: 10.1111/j.2041-1014.2012.00663.x.
   PubMed Web of Science ®Google Scholar
• Hajishengallis G. The inflammophilic character of the periodontitis-associated microbiota. Mol Oral Microbiol. 2014;29(6):248–257. doi: 10.1111/omi.12065.
   PubMed Web of Science ®Google Scholar
• Celik D, Kantarci A. Vascular changes and hypoxia in periodontal disease as a link to systemic complications. Pathogens. 2021;10(10):1280. doi: 10.3390/pathogens10101280.
   PubMed Web of Science ®Google Scholar
• da Silva MK, de Carvalho ACG, Alves EHP, et al. Genetic factors and the risk of periodontitis development: findings from a systematic review composed of 13 studies of meta-analysis with 71,531 participants. Int J Dent. 2017;2017:1914073–1914079. doi: 10.1155/2017/1914073.
   PubMedGoogle Scholar
• Moens S, Goveia J, Stapor PC, et al. The multifaceted activity of VEGF in angiogenesis – implications for therapy responses. Cytokine Growth Factor Rev. 2014;25(4):473–482. doi: 10.1016/j.cytogfr.2014.07.009.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci. 2005;109(3):227–241. doi: 10.1042/CS20040370.
   PubMed Web of Science ®Google Scholar
• Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem. 1991;266(18):11947–11954.
   PubMed Web of Science ®Google Scholar
• Andrikopoulos P, Fraser SP, Patterson L, et al. Angiogenic functions of voltage-gated Na + channels in human endothelial cells. J Biol Chem. 2011;286(19):16846–16860. doi: 10.1074/jbc.M110.187559.
   PubMed Web of Science ®Google Scholar
• Lucarini G, Tirabassi G, Zizzi A, et al. Uncoupling of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (INOS) in gingival tissue of type 2 diabetic patients. Inflammation. 2016;39(2):632–642. doi: 10.1007/s10753-015-0288-9.
   PubMed Web of Science ®Google Scholar
• Johnson RB, Serio FG, Dai X. Vascular endothelial growth factors and progression of periodontal diseases. J Periodontol. 1999;70(8):848–852. doi: 10.1902/jop.1999.70.8.848.
   PubMed Web of Science ®Google Scholar
• Tayman MA, Kurgan Ş, Önder C, et al. Disintegrin‐like and metalloproteinase with thrombospondin‐1 (ADAMTS‐1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor‐A, hypoxia‐inducible factor‐1α, and clinical parameters in patients with advanced periodontitis. J Periodontol. 2019;90(10):1182–1189. doi: 10.1002/JPER.18-0195.
   PubMedGoogle Scholar
• Padma R, Sreedhara A, Indeevar P, et al. Vascular endothelial growth factor levels in gingival crevicular fluid before and after periodontal therapy. J Clin Diagn Res. 2014;8:75–79.
   Google Scholar
• Tian Y, Li J, Hao L, et al. Association of cytokines, high sensitive C-reactive protein, VEGF and Beta-Defensin-1 gene polymorphisms and their protein expressions with chronic periodontitis in the Chinese population. Int J Biol Markers. 2013;28(1):100–107. doi: 10.5301/jbm.5000010.
   PubMed Web of Science ®Google Scholar
• Lin ZJ, Luo RH, Xie LL, et al. Effects of basic periodontal treatment on endothelin, vascular endothelial growth factor-A and tumor necrosis factor-α levels in gingival crevicular fluid and serum. Shanghai Kou Qiang Yi Xue. 2019;28(5):504–508.
   PubMedGoogle Scholar
• Afacan B, Keleş Yücel ZP, Paşali Ç, et al. Effect of non‐surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor‐1 alpha, vascular endothelial growth factor and tumor necrosis factor‐alpha levels in generalized aggressive periodontitis patients. J Periodontol. 2020;91(11):1495–1502. doi: 10.1002/JPER.19-0521.
   PubMed Web of Science ®Google Scholar
• Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J. 2021;71(6):462–476. doi: 10.1111/idj.12630.
   PubMed Web of Science ®Google Scholar
• Taskan MM, Karatas O, Balci Yuce H, et al. Hypoxia and collagen crosslinking in the healthy and affected sites of periodontitis patients. Acta Odontol Scand. 2019;77(8):600–607. doi: 10.1080/00016357.2019.1624819.
   PubMed Web of Science ®Google Scholar
• ClinVar aggregates information about genomic variation and its relationship to human health. https://www.ncbi.nlm.nih.gov/clinvar/.
   Google Scholar
• Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89(Suppl 1):S173–S182.
   PubMed Web of Science ®Google Scholar
• Web tool for SNP analysis. SNPStats. Available at: https://www.snpstats.net/start.htm. (Accessed: 2 April 2023).
   Google Scholar
• Hood JD, Meininger CJ, Ziche M, et al. VEGF upregulates EcNOS message, protein, and NO production in human endothelial cells. Am J Physiol. 1998;274(3):H1054–H1058. doi: 10.1152/ajpheart.1998.274.3.H1054.
   PubMedGoogle Scholar
• Virtej A, Løes S, Iden O, et al. Vascular endothelial growth factors signalling in normal human dental pulp: a study of gene and protein expression. Eur J Oral Sci. 2013;121(2):92–100. doi: 10.1111/eos.12019.
   PubMed Web of Science ®Google Scholar
• Sakai VT, Zhang Z, Dong Z, et al. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010;89(8):791–796. doi: 10.1177/0022034510368647.
   PubMed Web of Science ®Google Scholar
• Matsushita K, Motani R, Sakuta T, et al. The role of vascular endothelial growth factor in human dental pulp cells: induction of chemotaxis, proliferation, and differentiation and activation of the AP-1-Dependent signaling pathway. J Dent Res. 2000;79(8):1596–1603. doi: 10.1177/00220345000790081201.
   PubMed Web of Science ®Google Scholar
• Balci Yuce H, Karatas Ö, Tulu F, et al. Effect of diabetes on collagen metabolism and hypoxia in human gingival tissue: a stereological, histopathological, and immunohistochemical study. Biotech Histochem. 2019;94(1):65–73. doi: 10.1080/10520295.2018.1508745.
   PubMed Web of Science ®Google Scholar
• Karatas O, Balci Yuce H, Tulu F, et al. Evaluation of apoptosis and hypoxia-related factors in gingival tissues of smoker and Non-Smoker periodontitis patients. J Periodontal Res. 2020;55(3):392–399. doi: 10.1111/jre.12723.
   PubMed Web of Science ®Google Scholar
• Ramya M, Kumar S. Expression of VEGF in periodontal tissues of type II diabetes mellitus patients with chronic periodontitis -an immunohistochemical study. J Clin Diagn Res. 2014;8: ZC01–03.
   PubMedGoogle Scholar
• Zhang J, Liu X, Yu W, et al. Effects of human vascular endothelial growth factor on reparative dentin formation. Mol Med Rep. 2016;13(1):705–712. doi: 10.3892/mmr.2015.4608.
   PubMed Web of Science ®Google Scholar
• Nagaraja S, Mathew S, Abraham A, et al. Evaluation of vascular endothelial growth factor - A release from platelet-rich fibrin, platelet-rich fibrin matrix, and dental pulp at different time intervals. J Conserv Dent. 2020;23(4):359–363. doi: 10.4103/JCD.JCD_465_19.
   PubMedGoogle Scholar
• Gomez-Sosa JF, Caviedes-Bucheli J, Barrera L. Gene expression of vascular endothelial growth factor a and its receptors in dental pulp of immature and mature teeth. Eur Endod J. 2021;6(3):259–263. doi: 10.14744/eej.2021.86580.
   PubMed Web of Science ®Google Scholar
• Artese L, Rubini C, Ferrero G, et al. Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps. J Endod. 2002;28(1):20–23. doi: 10.1097/00004770-200201000-00005.
   PubMed Web of Science ®Google Scholar
• Zeng HH, Dong W, Xie YP, et al. Cyclooxygenase-2 overexpression and vascular endothelial growth factor expression in pharyngeal tissue of patients with OSAHS correlates with angiogenesis. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011;27(2):210–213.
   PubMedGoogle Scholar
• Safak AS, Bulut F, Cumbul A. Histopathological role of vitamin D deficiency in recurrent/chronic tonsillitis pathogenesis: vascular epithelial growth factor‐mediated angiogenesis in tonsil. Clin Exp Dent Res. 2022;8(3):699–706. doi: 10.1002/cre2.539.
   PubMed Web of Science ®Google Scholar
• Dimitrakopoulos FI, Koliou GA, Kotoula V, et al. Genetic variation in the vascular endothelial growth factor (VEGFA) gene at Rs13207351 is associated with overall survival of patients with head and neck cancer. Cancers. 2021;13(5):1163. doi: 10.3390/cancers13051163.
   PubMed Web of Science ®Google Scholar
• Chen M, Cai E, Huang J, et al. Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2012;21(7):1126–1134. doi: 10.1158/1055-9965.EPI-12-0020.
   PubMed Web of Science ®Google Scholar
• Formento JL, Etienne-Grimaldi MC, Francoual M, et al. Influence of the VEGF-A 936C > T germinal polymorphism on tumoral VEGF expression in head and neck cancer. Pharmacogenomics. 2009;10(8):1277–1283. doi: 10.2217/pgs.09.54.
   PubMed Web of Science ®Google Scholar
• Xu B, Li JM, Tong N, et al. VEGFA +936C > T polymorphism and cancer risk: a meta-analysis. Cancer Genet Cytogenet. 2010;198(1):7–14. doi: 10.1016/j.cancergencyto.2009.11.007.
   PubMedGoogle Scholar
• Leng WD, He MN, Chen QL, et al. Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer: a meta-analysis involving 2,444 individuals. Mol Biol Rep. 2013;40(10):5987–5992. doi: 10.1007/s11033-013-2708-y.
   PubMed Web of Science ®Google Scholar
• Guleria K, Kaur S, Mahajan D, et al. Impact of VEGFA promoter polymorphisms on esophageal cancer risk in North-West Indians: a case-control study. Genes Genomics. 2022;44(8):923–936. doi: 10.1007/s13258-022-01269-2.
   PubMedGoogle Scholar
• Qasim I, Bhat IA, Masoodi KZ, et al. Role of +405C > G and +936C > T polymorphisms of the vascular endothelial growth factor gene and risk of esophageal cancer in the Kashmiri population. Asian Pac J Cancer Prev. 2015;16(1):97–101. doi: 10.7314/apjcp.2015.16.1.97.
   PubMedGoogle Scholar
• Eng L, Azad AK, Qiu X, et al. Discovery and validation of vascular endothelial growth factor (VEGF) pathway polymorphisms in esophageal adenocarcinoma outcome. Carcinogenesis. 2015;36(9):956–962. doi: 10.1093/carcin/bgv073.
   PubMed Web of Science ®Google Scholar
• Yang PW, Hsieh MS, Huang YC, et al. Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma. PLoS One. 2014;9(6):e100326. doi: 10.1371/journal.pone.0100326.
   PubMed Web of Science ®Google Scholar
• Wang T, Hu K, Ren J, et al. Polymorphism of VEGF-2578C/a associated with the risk and aggressiveness of nasopharyngeal carcinoma in a chinese population. Mol Biol Rep. 2010;37(1):59–65. doi: 10.1007/s11033-009-9526-2.
   PubMed Web of Science ®Google Scholar
• Supic G, Jovic N, Zeljic K, et al. Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. Oral Oncol. 2012;48(11):1171–1177. doi: 10.1016/j.oraloncology.2012.05.023.
   PubMed Web of Science ®Google Scholar
• Psoma E, Koliou GA, Dimitrakopoulos FI, et al. Genetic variations of VEGFA gene are associated with infiltration of adjacent tissues and the clinical outcome of patients with nasopharyngeal carcinoma. Anticancer Res. 2020;40(2):677–688. doi: 10.21873/anticanres.13997.
   PubMed Web of Science ®Google Scholar