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Acta Oto-Laryngologica Volume 122, 2002 - Issue 2
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Research Article

Induction of Mucous Cell Metaplasia in the Middle Ear of Rats Using a Three-step Method: An Improved Model for Otitis Media with Mucoid Effusion

Yasuhiro Tsuboi Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Youngki Kim Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
G. Scott Giebink Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Chap Le Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Michael M. Paparella Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Nengqian Chen Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Patricia A. Schachern Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Steven K. Juhn Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
&
Jizhen Lin Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
 show all
Pages 153-160 | Published online: 08 Jul 2009

  • Kawano H, Schachern PA, Haruta A, Kim Y, Paparella MM, Lin J. Induction of mucous cell metaplasia by TNF-a in rat middle ear: the pathologic basis for mucin hyperproduction in MOM? Ann Otol Rhinol Laryngol 2002; in press.
  • Hellstrom SOM, Hermansson A, Johansson U, Prellner K. Experimentally induced mucoid effusion in rat middle ear--a complete model for otitis media research? In: Lim DJ, Bluestone CD, Klein JO, Nelson JD, eds. Recent advances in otitis media. Philadelphia, PA: B.C. Decker, 1987: 462-4.
  • Goldie P, Hellstrom S, Johanson U. Vascular events in experimental otitis media model a comparative study. ORL J Otorhinolaryngol Relat Spec 1990; 52: 104-12.
  • Caye-Thomasen P, Hermansson A, Tos M, Prellner K. Changes in mucosal goblet cell density in acute otitis media caused by non-typeable Haemophilus influenzae. Acta Otolaryngol (Stockh) 1998; 118: 211-5.
  • Jewett BS, Prazma JP, Hunter SE, et al. Systemic reactivation of otitis media with effusion in a rat model Otolaryngol Head Neck Surg 1999; 121: 7-12.
  • Giebink GS, Meier JD, Quartey MK, Liebeier CL, Le CT. Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model J Infect Dis 1996; 173: 119-27.
  • Lin J, Vambutas A, Haruta A, Paparella MM, Giebink GS, Kim Y. Pneumococcus activation of the S-lipoxygenase pathway and production of glycoproteins in the middle ear of rats. J Infect Dis 1999; 179: 1145-51.
  • Carrie S, Hutton DA, Birchall JP, Green GG, Pearson JP. Otitis media with effusion: components which contribute to the viscous properties. Acta Otolaryngol (Stockh) 1992; 112: 504-11.
  • Caye-Thomasen P, Tos M. Polyp and fibrous adhesion formation in acute otitis media caused by non-typeable or type b Haemophilus influenzae or moraxella catarrhalis. Acta Otolaryngol 2000; 120: 810-4.
  • Larsen PL, Tos M. Polyp formation by experimental tubal occlusion in the rat. Acta Otolaryngol (Stockh) 1991; 111: 926-33.
  • Caye-Thomasen P, Hermansson A, Tos M, Prellner K. Polyp pathogenesis-a histopathological study in experimental otitis media. Acta Otolaryngol (Stockh) 1995; 115: 76-82.

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