Tumour-associated macrophages secrete IL-6 and MCP-1 in head and neck squamous cell carcinoma tissue

References

• Mantovani A, Allavena P, Sica A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur J Cancer 2004; 40: 1660–7
   PubMed Web of Science ®Google Scholar
• Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 2000; 6: 3282–9
   PubMed Web of Science ®Google Scholar
• Nakayama Y, Nagashima N, Minagawa N, Inoue Y, Katsuki T, Onitsuka K, et al. Relationships between tumor-associated macrophages and clinicopathological factors in patients with colorectal cancer. Anticancer Res 2002; 22: 4291–6
   PubMedGoogle Scholar
• Marcus B, Arenberg D, Lee J, Kleer C, Chepeha DB, Schmalbach CE, et al. Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma. Cancer 2004; 101: 2779–87
   PubMed Web of Science ®Google Scholar
• Andreesen R, Hennemann B, Krause SW. Adoptive immunotherapy of cancer using monocyte-derived macrophages: rationale, current status, and perspectives. J Leukoc Biol 1998; 64: 419–26
   PubMed Web of Science ®Google Scholar
• Whiteside TL. Immunobiology of head and neck cancer. Cancer Metastasis Rev 2005; 24: 95–105
   PubMed Web of Science ®Google Scholar
• Heimdal JH, Aarstad HJ, Olsnes C, Olofsson J. Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD14-dependent pathway. Scand J Immunol 2001; 53: 162–70
   PubMed Web of Science ®Google Scholar
• Kross KW, Heimdal JH, Olsnes C, Olofsson J, Aarstad HJ. Head and neck squamous cell carcinoma spheroid- and monocyte spheroid-stimulated IL-6 and monocyte chemotactic protein-1 secretion are related to TNM stage, inflammatory state and tumor macrophage density. Acta Otolaryngol (Stockh) 2005; 125: 1097–104
   PubMed Web of Science ®Google Scholar
• Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003; 149: 1–38
   PubMed Web of Science ®Google Scholar
• Ohno S, Suzuki N, Ohno Y, Inagawa H, Soma G, Inoue M. Tumor-associated macrophages: foe or accomplice of tumors?. Anticancer Res 2003; 23: 4395–409
   PubMedGoogle Scholar
• Thiele DL, Lipsky PE. Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells. J Immunol 1985; 134: 786–93
   PubMedGoogle Scholar
• Sawada T, Hashimoto S, Tohma S, Nishioka Y, Nagai T, Sato T, et al. Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614. Immunopharmacology 2000; 49: 285–94
   PubMedGoogle Scholar
• Thiele DL, Lipsky PE. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol 1986; 136: 1038–48
   PubMed Web of Science ®Google Scholar
• Heimdal J, Aarstad HJ, Olofsson J. Monocytes secrete interleukin-6 when co-cultured in vitro with benign or malignant autologous fragment spheroids from squamous cell carcinoma patients. Scand J Immunol 2000; 51: 271–8
   PubMedGoogle Scholar
• Boyum A. Isolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium. Scand J Immunol 1983; 17: 429–36
   PubMed Web of Science ®Google Scholar
• Heimdal JH, Aarstad HJ, Aakvaag A, Olofsson J. In vitro T-lymphocyte function in head and neck cancer patients. Eur Arch Otorhinolaryngol 1997; 254: 318–22
   PubMed Web of Science ®Google Scholar
• Thiele DL, Kurosaka M, Lipsky PE. Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester. J Immunol 1983; 131: 2282–90
   PubMedGoogle Scholar
• Pechhold K, Kabelitz D. Human peripheral blood gamma delta T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester. Eur J Immunol 1993; 23: 562–5
   PubMedGoogle Scholar
• Chen Z, Malhotra PS, Thomas GR, Ondrey FG, Duffey DC, Smith CW, et al. Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 1999; 5: 1369–79
   PubMed Web of Science ®Google Scholar
• Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749–59
   PubMed Web of Science ®Google Scholar
• Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41: 2502–12
   PubMed Web of Science ®Google Scholar
• Kleine-Lowinski K, Gillitzer R, Kuhne-Heid R, Rosl F. Monocyte-chemo-attractant-protein-1 (MCP-1)-gene expression in cervical intra-epithelial neoplasias and cervical carcinomas. Int J Cancer 1999; 82: 6–11
   PubMedGoogle Scholar
• Liss C, Fekete MJ, Hasina R, Lam CD, Lingen MW. Paracrine angiogenic loop between head-and-neck squamous-cell carcinomas and macrophages. Int J Cancer 2001; 93: 781–5
   PubMed Web of Science ®Google Scholar
• Li C, Shintani S, Terakado N, Nakashiro K, Hamakawa H. Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma. Oncol Rep 2002; 9: 1219–23
   PubMed Web of Science ®Google Scholar
• Leek RD, Harris AL. Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia 2002; 7: 177–89
   PubMed Web of Science ®Google Scholar
• Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71–8
   PubMed Web of Science ®Google Scholar
• Valkovic T, Fuckar D, Stifter S, Matusan K, Hasan M, Dobrila F, et al. Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. J Cancer Res Clin Oncol 2005; 131: 453–8
   PubMedGoogle Scholar
• Varney ML, Johansson SL, Singh RK. Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A. Melanoma Res 2005; 15: 417–25
   PubMed Web of Science ®Google Scholar
• Dysvik B, Vasstrand EN, Lovlie R, Elgindi OA, Kross KW, Aarstad HJ, et al. Gene expression profiles of head and neck carcinomas from Sudanese and Norwegian patients reveal common biological pathways regardless of race and lifestyle. Clin Cancer Res 2006; 12: 1109–20
   PubMedGoogle Scholar