Phenotypic markers as risk factors in schizophrenia: neurocognitive functions

References

• Chapman LJ, Edell WS, Chapman JP. Physical anhedonia, perceptual aberration, and psychosis proneness. Schizophrenia Bulletin 1980; 6: 639–653
   PubMed Web of Science ®Google Scholar
• Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM‐III‐R criteria. Schizophrenia Bulletin 1991; 17: 555–564
   PubMed Web of Science ®Google Scholar
• Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Deisman LJ, Tsuang MT. Diagnostic accuracy and linkage analysis: How useful are schizophrenia spectrum phenotypes?. American Journal of Psychiatry 1995; 152: 1286–1290
   PubMed Web of Science ®Google Scholar
• Holzman PS, Proctor LR, Levy DL, Yasillo MJ, Meltzer HY, Hurt SW. Eye tracking dysfunctions in schizophrenic patients and their relatives. Archives of General Psychiatry 1974; 31: 143–151
   PubMed Web of Science ®Google Scholar
• Holzman PS, Kringlen E, Matthysse S, et al. A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Archives of General Psychiatry 1988; 45: 641–647
   PubMed Web of Science ®Google Scholar
• Clementz BA, Sweeney JA, Hirt M, Haas G. Pursuit gain and saccadic intrusions in first‐degree relatives of probands with schizophrenia. Journal of Abnormal Psychology 1990; 99: 327–335
   PubMed Web of Science ®Google Scholar
• Clementz BA, Grove WM, Iacono WG, Sweeney JA. Smooth‐pursuit eye‐movement dysfunction and liability for schizophrenia: implications for genetic modeling. Journal of Abnormal Psychology 1992; 101: 117–129
   PubMed Web of Science ®Google Scholar
• Park S, Holzman PS, Goldman‐Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry 1995; 52: 821–828
   PubMed Web of Science ®Google Scholar
• Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyions MJ, Tsuang MT. Neuropsychological functioning among the nonpsychotic relatives of schizophrenia patients: a diagnostic efficiency analysis. Journal of Abnormal Psychology 1995; 104: 286–304
   PubMed Web of Science ®Google Scholar
• Laurent A, Moreaud O, Bosson J ‐L, et al. Neuropsychological functioning among non‐psychotic syblings and parents of schizophrenic patients. Psychiatry Research 1999; 87: 147–167
   PubMed Web of Science ®Google Scholar
• Clementz BA, McDowell JE, Zisook S. Saccadic system functioning among schizophrenia patients and their first‐degree biological relatives. Journal of Abnormal Psychology 1994; 103: 277–287
   PubMed Web of Science ®Google Scholar
• Ross RG, Harris JG, Olincy A, Radant A, Adler LE, Freedman R. Familial transmission of two independent saccadic abnormalities in schizophrenia. Schizophrenia Research 1998; 30: 59–70
   PubMed Web of Science ®Google Scholar
• Clementz BA, Geyer MA, Braff DL. Poor P50 suppression among schizophrenia patients and their first‐degree biological relatives. American Journal of Psychiatry 1998; 155: 1691–1694
   PubMed Web of Science ®Google Scholar
• Freedman R, Coon H, Myles‐Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proceedings of the National Academy of Sciences of the USA 1997; 94: 587–592
   PubMed Web of Science ®Google Scholar
• Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses. Archives of General Psychiatry 1984; 41: 607–612
   PubMed Web of Science ®Google Scholar
• Waldo M, Myles‐Worsley M, Madison A, Byerley W, Freedman R. Sensory gating deficits in parents of schizophrenics. American Journal of Medical Genetics 1995; 60: 506–511
   PubMed Web of Science ®Google Scholar
• Kidogami Y, Yoneda H, Asaba H, Sakai T. P300 in first degree relatives of schizophrenics. Schizophrenia Research 1991; 6: 9–13
   PubMed Web of Science ®Google Scholar
• Kimble M, Lyons M, O'Donnell B, Nestor P, Niznikiewicz M, Toomey R. The effect of family status and schizotypy on electrophysiologic measures of attention and semantic processing. Biological Psychiatry 2000; 47: 402–412
   PubMed Web of Science ®Google Scholar
• Blackwood DH, St Clair DM, Muir WJ, Duffy JC. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Archives of General Psychiatry 1991; 48: 899–909
   PubMed Web of Science ®Google Scholar
• Frangou S, Sharma T, Alarcon G, et al. The Maudsley Family Study, II: Endogenous event‐related potentials in familial schizophrenia. Schizophrenia Research 1997; 23: 45–53
   PubMed Web of Science ®Google Scholar
• Roxborough H, Muir WJ, Blackwood DH, Walker MT, Blackburn IM. Neuropsychological and P300 abnormalities in schizophrenics and their relatives. Psychological Medicine 1993; 23: 305–314
   PubMed Web of Science ®Google Scholar
• Parasuraman R. The attentive brain: issues and prospects. The attentive brain, R Parasuman. Bradford, Cambridge 1998; 3–15
   Google Scholar
• Zubin J. Problem of attention in schizophrenia. Experimental approaches to psychopathology, ML Keitsman, S Sutton, J Zubin. Academic Press, New York 1975; 136–166
   Google Scholar
• Kraepelin E. Dementia praecox and paraphrenia. Robert E. Krieger, New York 1919
   Google Scholar
• Cornblatt BA, Lenzenweger MF, Erlenmeyer‐Kimling L. The Continuous Performance Test, Identical Pairs Version: II. Contrasting attentional profiles of schizophrenic and depressed patients. Psychiatry Research 1989; 29: 65–85
   PubMed Web of Science ®Google Scholar
• Nuechterlein K. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology 1983; 92: 4–28
   PubMed Web of Science ®Google Scholar
• Van den Bosch RJ, Rombouts RP, van Asma MJO. What determines continuous performance task performance?. Schizophrenia Bulletin 1996; 22: 643–651
   PubMed Web of Science ®Google Scholar
• Chen WJ, Liu SK, Chang CJ, Lien Y ‐J, Chang Y ‐H, Hwu H ‐G. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. American Journal of Psychiatry 1998; 155: 1214–1220
   PubMed Web of Science ®Google Scholar
• Rutschmann J, Cornblatt B, Erlenmeyer‐Kimling L. Sustained attention in children at risk for schizophrenia: findings with two visual continuous performance tests in a new sample. Journal of Abnormal Child Psychology 1986; 14: 365–385
   PubMed Web of Science ®Google Scholar
• Chen YH, Lam LCW, Chen RYL, Nguyen DGG, Chan CKY, Wilkins AJ. Neuropsychological correlates of sustained attention in schizophrenia. Schizophrenia Research 1997; 24: 299–310
   PubMed Web of Science ®Google Scholar
• Mirsky AF, Lochhead SJ, Jones BP, Kugelmann S, Walsh D, Kendler KS. On familial factors in the attentional deficit in schizophrenia: a review and report of two new subject samples. Journal of Psychiatric Research 1992; 26: 383–403
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Erlenmeyer‐Kimling L. Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology 1985; 94: 470–486
   PubMed Web of Science ®Google Scholar
• Erlenmeyer‐Kimling L, Cornblatt BA. A summary of attentional findings in the New York High‐Risk project. Journal of Psychiatry Research 1992; 26: 405–426
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Lenzenweger MF, Dworkin RH, Erlenmeyer‐Kimling L. Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. British Journal of Psychiatry 1992; 161: 59–64
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophrenia Bulletin 1994; 20: 31–46
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Winters L, Erlenmeyer‐Kimling L. Attentional markers of schizophrenia: evidence from the New York High‐Risk study. Schizophrenia: scientific progress, SC Schulz, CA Tammiga. Oxford University Press, New York 1989; 83–92
   Google Scholar
• Cornblatt BA, Obuchowski M, Andreasen A, Smith C. High‐risk research in schizophrenia: new strategies, new designs. Origins and development of schizophrenia: advances in experimental psychopathology, MF Lenzenweger, RH Dworkin. American Psychological Association, Washington, DC 1998; 349–383
   Google Scholar
• Orzack MH, Kornetsky C. Attention dysfunction in chronic schizophrenia. Archives of General Psychiatry 1966; 14: 323–326
   PubMed Web of Science ®Google Scholar
• Orzack MH, Kornetsky C. Environmental and familial predictors of attention behavior in chronic schizophrenics. Journal of Psychiatric Research 1971; 9: 21–35
   PubMed Web of Science ®Google Scholar
• Wohlberg GW, Kornetsky C. Sustained attention in remitted schizophrenics. Archives of General Pychiatry 1973; 28: 533–537
   PubMed Web of Science ®Google Scholar
• Asarnow RF, MacCrimmon DJ. Residual performance deficit in clinical remitted schizophrenics: a marker of schizophrenia?. Journal of Abnormal Psychology 1978; 87: 597–608
   PubMed Web of Science ®Google Scholar
• Nuechterlein K, Dawson ME, Ventura J, Fogelson D, Gitlin M, Mintx J. Testing vulnerability indicators across clinical state. Search for the causes of schizophrenia, vol. 2, H Hafner, WF Gattax. Springer, Heidelberg 1991; 177–191
   Google Scholar
• Steinhauer SR, Zubin J, Condray R, Shaw DB, Peters JL, VanKammen DP. Electrophysiological and behavioral signs of attentional disturbance in schizophrenics and their siblings. Advances in neuropsychiatry and psychopharmacology: vol. 1. Schizophrenia research, CA Tamminga, SC Schulz. Raven Press, New York 1991; 169–178
   Google Scholar
• Harvey PD, Keefe RSE, Moskowitz J, Putnam KM, Mohs RC, Davis KL. Attentional markers of vulnerability to schizophrenia: Performance of medicated and unmedicated patients and normals. Psychiatry Research 1990; 33: 179–188
   PubMed Web of Science ®Google Scholar
• Nestor PG, Faux SF, McCarley RW, Sands SF, Horvath TB, Peterson A. Neuroleptics improve sustained attention in schizophrenia: a study using signal detection theory. Neuropsychopharmacology 1991; 4: 45–149
   Web of Science ®Google Scholar
• Laurent A, Saoud M, Bougerol T, et al. Attentional deficits in patients with schizophrenia and in their non‐psychotic first‐degree relatives. Psychiatry Research 1999; 89: 147–159
   PubMed Web of Science ®Google Scholar
• Lenzenweger MF, Cornblatt BA, Putnick ME. Schizotypy and sustained attention. Journal of Abnormal Psychology 1991; 100: 84–89
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Erlenmeyer‐Kimling L. Gobal attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology 1954; 94: 470–486
   Web of Science ®Google Scholar
• Freedman LR, Rock D, Roberts SA, Cornblatt BA, Erlenmeyer‐Kimling L. The New York High‐Risk Project: attention, anhedonia and social outcome. Schizophrenia Research 1998; 30: 1–9
   PubMed Web of Science ®Google Scholar
• Erlenmeyer‐Kimling L, Cornblatt BA, Rock D, Roberts S, Bell M, West A. The New York High‐Risk project: anhedonia, attentional deviance, and psychopathology. Schizophrenia Bulletin 1993; 19: 141–153
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Obuchowski M, Roberts S, Pollack S, Erlenmeyer‐Kimling L. Cognitive and behavioral precursors of schizophrenia. Development and Psychopathology 1999; 11: 487–508
   PubMed Web of Science ®Google Scholar
• McGhie A, Chapman J. Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology 1961; 34: 103–117
   PubMed Web of Science ®Google Scholar
• Shakow D. Adaptation in schizophrenia: the theory of segmental set. Wiley, New York 1979
   Google Scholar
• Nuechterlein K, Edell WS, Norris M, Dawson ME. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophrenia Bulletin 1986; 12: 408–426
   PubMed Web of Science ®Google Scholar
• Cannon TD, Zorilla LE, Shtasek D, et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Archives of General Psychiatry 1994; 51: 651–661
   PubMed Web of Science ®Google Scholar
• Nestor PG, Faux SF, McCarley RW, Shenton ME, Sands SF. Measurement of visual sustained attention in schizophrenia using signal detection analysis and a newly developed computerized CPT task. Schizophrenia Research 1990; 3: 329–332
   PubMed Web of Science ®Google Scholar
• Finkelstein JR, Cannon TD, Gur RE, Moberg P. Attentional dysfunctions in neuroleptic‐naïve and neuroleptic‐withdrawn schizophrenic patients and their siblings. Journal of Abnormal Psychology 1997; 106: 203–212
   PubMed Web of Science ®Google Scholar
• Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia?. American Journal of Psychiatry 1996; 153: 321–330
   PubMed Web of Science ®Google Scholar
• Keefe RSE, Silva SG, Perkins DO, Lieberman JA. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta‐analysis. Schizophrenia Bulletin 1999; 25: 201–222
   PubMed Web of Science ®Google Scholar
• Medalia A, Aluma M, Tryon W, Merriam AE. Effectiveness of attention training in schizophrenia. Schizophrenia Bulletin 1998; 24: 147–152
   PubMed Web of Science ®Google Scholar
• Wilkins AJ, Shallice T, McCarthy R. Frontal lesions and sustained attention. Neuropsychologia 1987; 25: 359–365
   PubMed Web of Science ®Google Scholar
• Cabeza R, Nyberg L. Imaging cognition II. An empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience 2000; 12: 1–47
   PubMed Web of Science ®Google Scholar
• Morecraft RJ, Guela C, Mesulam MM. Architecture of connectivity within a cingulo‐fronto‐parietal neurocognitive network for directed attention. Archives of Neurology 1993; 50: 279–284
   PubMed Web of Science ®Google Scholar
• Posner MI, Dehane S. Attentional networks. Trends in Neurosciences 1994; 17: 75–79
   PubMed Web of Science ®Google Scholar
• LaBerge D. Attentional processing. Harvard University Press, Cambridge 1995
   Google Scholar
• Siegel BJ, Nuechterlein KH, Abel L, Wu JC, Buchsbaum MS. Glucose metabolic correlates of continuous performance test performance in adults with a history of infantile autism, schizophrenics, and controls. Schizophrenia Research 1995; 17: 85–94
   PubMed Web of Science ®Google Scholar
• Carter CS, Todd SB, Barch DM, Botvinick MM, Noll D, Cohen JD. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 1998; 280: 747–749
   PubMed Web of Science ®Google Scholar
• Cohen RM, Semple WE, Gross M, King AC, Nordahl TE. Metabolic brain pattern of sustained auditory discrimination. Experimental Brain Research 1992; 92: 165–172
   PubMed Web of Science ®Google Scholar
• Hager H, Volz HP, Gaser C, Mentzel H ‐J, Kaiser WA, Sauer H. Challenging the anterior attentional system with a continuous performance task: a functional magnetic resonance imaging approach. European Archives of Psychiatry Clinical Neuroscience 1998; 248: 161–170
   PubMed Web of Science ®Google Scholar
• Keilp JG, Herrera J, Stritzke P, Cornblatt BA. The continuous performance test, identical pairs version (CPT‐IP): III. Brain functioning during performance of numbers and shapes subtasks. Psychiatry Research 1997; 74: 35–45
   PubMed Web of Science ®Google Scholar
• Buchsbaum MS, Nuechterlein KH, Haier RJ, et al. Glucose metabolic rate in normals and schizophrenics during continuous performance test assessed by positron emission tomography. British Journal of Psychiatry 1990; 156: 216–227
   PubMed Web of Science ®Google Scholar
• Schroeder JN, Buchsbaum MS, Siegal BV, et al. Patterns of cortical activity in schizophrenia. Psychological Medicine 1994; 24: 947–955
   PubMed Web of Science ®Google Scholar
• Volpz HP, Gaser C, Hager F, et al. Decreased frontal activation in schizophrenics during stimulation with the continuous performance test – a functional magnetic resonance imaging study. European Psychiatry 1999; 14: 17–24
   PubMed Web of Science ®Google Scholar
• Frith CD, Friston KJ, Herold S, et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British Journal of Psychiatry 1995; 67: 343–349
   Web of Science ®Google Scholar
• Fletcher PC, McKenna PJ, Friston KJ, Frith CD, Dolan RJ. Abnormal cingulate modulation of fronto‐temporal connectivity in schizophrenia. Neuroimage 1999; 9: 337–342
   PubMed Web of Science ®Google Scholar
• Benes FM. Is there a neuroanatomic basis for schizophrenia?. Neuroscientist 1995; 1: 112–120
   Google Scholar
• Andreasen NC, Arndt S, Swayse V, et al. Thalamic abnormalities in schizophrenia visualised through magnetic resonance imaging. Science 1994; 226: 294–298
   Web of Science ®Google Scholar
• Chakos MH, Lieberman JA, Bilder RM, et al. Increase in caudate nuclei volumes of first episode schizophrenic patients taking antipsychotic drugs. American Journal of Psychiatry 1994; 151: 1430–1436
   PubMed Web of Science ®Google Scholar
• Turetsky B, Cowell P, Gur RC, Grossman RI, Shtasel DL, Gur RE. Frontal and temporal lobe brain volumes in schizophrenia. Relationship to symptoms and clinical subtype. Archives of General Psychiatry 1995; 52: 1061–1070
   PubMed Web of Science ®Google Scholar
• Snodgrass JG, Corwin J. Pragmatics of measuring recognition memory: applications to dementia and amnesia. Journal of Experimental Psychology: General 1988; 117: 34–50
   PubMed Web of Science ®Google Scholar