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International Journal of Neuroscience Volume 112, 2002 - Issue 5
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Research Article

EFFECTS OF EXCITOTOXIC MEDIAN RAPHE LESIONS ON SCOPOLAMINE-INDUCED WORKING MEMORY DEFICITS IN INHIBITORY AVOIDANCE

EMINE BABAR Department of Physiology Division of Neurophysiology Medical Faculty Çukurova University Balcalí-Adana, Turkey
,
ENVER MELIK Department of Physiology Division of Neurophysiology Medical Faculty Çukurova University Balcalí-Adana, Turkey
,
TUNCAY ÖZGÜNEN Department of Physiology Division of Neurophysiology Medical Faculty Çukurova University Balcalí-Adana, Turkey
,
MEHMET KAYA Department of Histology Medical Faculty Çukurova University Balcalí-Adana, Turkey
&
SAIT POLAT Department of Histology Medical Faculty Çukurova University Balcalí-Adana, Turkey
Pages 525-535 | Published online: 07 Jul 2009

  • Azmita, E. C., & Segal, M. (1978). An autoradiographic analysis of the ascending projection of the dorsal and median raphe nucleus in the rat. Journal of Comparative Neurology. 179, 641-668.
  • Awh, F., & Jonides, J. (2001). Overlapping mechanisms of attention and spatial working memory. Trends in Cognitive Science. 5, 119-126.
  • Babar, E., Melik, E., Özgünen, T., & Polat. S. (2002). Effects of excitotoxic median raphe lesion on working memory deficits produced by the dorsal hippocampal muscarinic receptor blockade in the Inhibitory Avoidance in rats. Brain Research Bulletin. 57(5), 683-688.
  • Babar, E., Özgünen, T., Melik, E., Polat, S., & Akman, H. (2001) Effects of ketamine on different types of anxiety/fear and related memory in rats with lesions of the median raphe nucleus. European Journal of Pharmacology. 431, 315-320.
  • Bartus, R. T., & Dean, R. L. (1988). Effects of cholinergic and adrenergic drugs on memory in aged monkeys. In E. Giacohini & R. Becker (Eds.). Current research in Atzheimer's disease. New York: Taylor & Francis.
  • Baddeley, A. C., & Lieberman, K. (1980). Spatial working memory. In R. S. Nickerson (Ed.). Attention and performance (vol. 8. pp. 521-539). Hillsdale. NJ: Erlbaum.
  • Bchzadi, G., Kulen, P., Parvopassu, F., & Wiklund, L. (1990). Afferents to the median raphe nucleus of the rat: Retrograde cholera toxin and wheat germ conjugated horseradish peroxidase tracing and selective D-('H) aspartate labelling of possible excitatory amino acid inputs. Neuroscience, 37, 77-100.
  • Carlt, M., Luschi, R., & Samanin, R. (1998). (S)-WAY 100135, a5-HTIA receptor antagonisl, prevents the impairment ol spatial learning caused by intrahippocampal scopulamine. European Journal of Pharmacology. 283, 133-139.
  • Chan-Palay, V., Huchli, M., Jentsch, B., Leonard, B., & Zetzche, T. (1992). Raphe serotonin neurons in the human brain stern in normal controls and patients with senile dementia of the Alzheimer type and Parkinson's disease: Relationship to monoamine oxidase enzyme localisation. Dementia. 3, 253-269.
  • Consolo, S., Bertorelli, R., Russi, G., Zambelli, M., & Ladinsky, H. (1994). Serotonergic facilitation of acetyleholine release in vivo from rat dorsal hippocampus via serotonin 5HT3 receptors. Journal of Neurochemistry. 64, 2254-2261.
  • Dringenberg, H. C., & Zalan, R. M. (1999). Serotonin-dependent maintenance of spatial performance and EEG activation after cholinergic blockade: Effects of serotomergic receptor antagonists. Brain Research, 837, 242-253.
  • Dunnett, S. B., Wareham, A. T., & Torres, E. M. (1990). Cholinergic blockade in prefrontal cortex and hippocampus disrupts short-term memory in rats. Neuroreport. 1, 61-64.
  • Erb, C., Klein, J., Koppen, A., Loffelholze, K., Jeltsch, H., & Cassel, J. C. (1997). Modulation of hippocampal acetyicholine release after fibria fornix lesions and septal transplantation in rats. Neuroscience Letter, 231, 5-8.
  • Gold, P. E., & McGauah, J. L. (1975). A single trace, two process view of memory storage processes. In D. Deutsch & J. A. Deutsch (Eds.). Short-term memory (pp. 355378), New York: Academic Press.
  • Hodpes, H., Sowinski, P., Sinden, J. D., Netto, C. A., & Fletcher. A. (1995). The selective 5 HT3 receptor antagonist. WAY100289. enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergie projection system. Psychopharmacology (Berl).117, 318-332.
  • Hong, Y., & Krnjevi, K. (1989). Serotonin bluckes the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Canadian Journal of Physiology and Plaharmacology. 67, 47-53.
  • Izquierdo, L. Izquierdo, L. A., Barros, D. M., MeIIo e Sonza, T., de Sonza, M. M., Quevedo, J., Rodrigues, C., Sant' Anna. M. K., Madruga, M., & Medina, J. H. (1998). Differential involvement of cortical receptor mechanisms in working. short- and long term memory. Behavioural Pharmacology, 9, 421-427.
  • Izquierdo, I., Medina, J. H., Vianna, M. R. M., Izquierdo, L. A., & Barros, D. M. (1999). Separate mechanisms for short- and long-term memory. Behavioural Brain Research. 103, 1-11.
  • Koning, F. R. J., & Klippol, R. A. (1963). The rat brain. In Stercotasic atlas. Baltimore: Williams andl Wilkins.
  • Mann, D. M. A., & Yates, P. O. (1983). Neurotransmitter deficits in Alzheimer's disease and in other demanding disorders. Human Neurobiology. 5, 147-158.
  • Melik, E. M., Babar-Melik, K., Özgünen, T., & Binokay, S. (2000). Median raphe nucleus mediates forming long-term but not short-term contextual fear conditioning in rats. Behavioural Brain Research. 112, 145-150.
  • Milner, T. A., & Veznedaroglu, E. (1993). Serolonin-containing terminals synapse on septohippocampal neurons in the rats. Journal of Neuroscience Research. 36, 260271.
  • Muir, J., Dunnett, S. B., Robbins, T. W., & Everitt, B. J. (1992). Attentional functions of the forebrain cholinergic systems: Effects of intraventricular hemicholinium. physostigmine. basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Experimental Bram Research. 89, 611-622.
  • Nilsson, O. G. Strecker, R. E. Daszuta, A., & Bjorlund, A. (1988). Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat Brain Reseach 453, 235-246.
  • Normile, H. J., & Altman, H. J. (1992). Effects of combined acetylcholinesterase inhibition and serolonergic receptor blockade on age-associated memory impairments in rats. Neurobiology of Aging, 13, 735-740.
  • Ohno, M., & Watanabe, S. (1906). Blockade of 5-HTIA receptors compensate loss of hippocampal cholinergic neurotransmission involved in working memory of rats. Brain Research. 736, 180-188.
  • Reynolds, G. P., Mason, S. L., Meldrum, A., De Keczer, S., Parnes, H., Eglen, R. M., & Wong E. H. P. (1995). 5-Hydroxytryptamine (5-HT) receptors in postmortem human brain tissue: Distribution, pharmacology and effects of neurodegenerative disease. British Journal of Pharmacology. 114, 993-998.
  • Richter-Levin, G., & Segal, M. (1989). Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission. Brain Research. 477, 414-407.
  • Richter-Levin, G., & Segal, M. (1991). The effects of serotonin depiction and raphe grafts on hippocampal electrophysiology and behavior. Journal of Neuroscience. 11, 15851596.
  • Riekkinen, M., Riekkinen, P., Sirvio, J., & Rickkinen, P., Jr. (1992). Effects ol combined methysergic and mecamylamine/icopolamine treatment on spatial navigation. Brain Research. 585, 322-326.
  • Roberts, C., Belenguer, A., Middlemiss, D. N., & Roultledge. C. (1998). Differential effects of 5-HTIB/ID receptor antagonists in dorsal and median raphe innervated brain regions. European Journal of Pharmacology, 346, 175-180.
  • Robinson, T. E., Casteneda, E., & Whisshow, I. Q. (1983). Effects of specific serotonergic lesions on cholinergic neurons in the hippocampus, contex and striatum. Life Science, 32, 345-353.
  • RONSON, M., & Iversen, L. L. (1986). Non-cholinergic neurotransmitter abnormalities in Alzheimer's disease, British Medical Bullctin, 42, 70-74.
  • Rudy, J. W. (1996). Scopolamine administered before alnd after training impairs both contextual and auditory-cue fear conditioning. Neurobiology of Learning ang Memory. 65, 73-81.
  • Ruotsalainen, S., Miettinen, R., McDonald, E., Riekkinen, M., & Sirvio, J. (1998). The role of the dorsal raphe-serotonergic system and cholinergic receptors in the modula-tion of working memory. Neuroscience Biobeharioural Review. 22, 21-31.
  • Sakurai, Y., & Wenk, G L. (1990). The interaction of acetylcholinergic and serotonercic neuronal systems on performance in a continuous non-matching to sample ask, Brain Research. 519, 118-121.
  • Smythe, J. W., Bhatnagar, S., Murphy, D., Timothy, C., & Costall, B. (1998). The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the blackwhite box test. Brain Research Bulletin. 45, 89-93.
  • Steekler, T., & Sahgal, A. (1995). The role of serolonergic-cholinergic interactions in the mediation of cognitive behaviour. Behavioural Brain Research. 67, 165-199.
  • Taber, E., Brodal, A., & Walberg, F. (1960) The raphe nuclei of te brain stem of the cat. Journal of Comparative Neurology. 114, 161-168.
  • Yamamoto, T., & Hirano, A. (1985). Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons. Annual Neurology. 17, 573-577.

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