THE ROLE OF PREFRONTAL SYSTEMS IN SEXUAL BEHAVIOR

REFERENCES

• Absher J. R., Vogt B. A., Clark D. G., Flowers D. L., Gorman D. G., Keyes J. W., Wood F. B. Hypersexuality and hemiballism due to subthalamic infarction. Neuropsychiatry, Neuropsychology, & Behavioral Neurology 2000; 13(3)220–229
   PubMedGoogle Scholar
• Agmo A., Villalpando A. Central nervous stimulants facilitate sexual behavior in male rats with medial prefrontal cortex lesions. Brain Research 1995; 696(1–2): 1–2; 187–193
   Web of Science ®Google Scholar
• Aloni R., Katz S. A review of the effect of traumatic brain injury on the human sexual response. Brain Injury 1999; 13(4)269–280
   PubMed Web of Science ®Google Scholar
• Arnow B. A., Desmond J. E., Banner L. L., Glover G. H., Solomon A., Polan M. L., Lue T. F., Atlas S. W. Brain activation and sexual arousal in healthy, heterosexual males. Brain 2002; 125(5)1014–1023
   PubMed Web of Science ®Google Scholar
• Bazanis E., Rogers R. D., Dowson J. H., Taylor P., Meux C., Staley C., Nevinson-Andrews D., Taylor C., Robbins T. W., Sahakian B. J. Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder. Psychological Medicine 2002; 32(8)1395–1405
   PubMed Web of Science ®Google Scholar
• Bechara A. Risky business: Emotion, decision-making, and addiction. Journal of Gambling Studies 2003; 19(1)23–51
   PubMedGoogle Scholar
• Bechara A., Damasio A. R., Damasio H., Anderson S. W. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 1994; 50(1–3): 1–3; 7–15
   Web of Science ®Google Scholar
• Bechara A., Damasio H., Damasio A. R., Lee G. P. Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. Journal of Neuroscience 1999; 19(13)5473–5481
   PubMed Web of Science ®Google Scholar
• Blood A. J., Zatorre R. J. Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proceedings of the National Academy of Science USA 2001; 98(20)11818–11823
   PubMed Web of Science ®Google Scholar
• Breiter H. C., Rosen B. R. Functional magnetic resonance imaging of brain reward circuitry in the human. Annals of the New York Academy of Science 1999; 877: 523–547
   PubMed Web of Science ®Google Scholar
• Brody A. L., Mandelkern M. A., London E. D., Childress A. R., Lee G. S., Bota R. G., Ho M. L., Saxena S., Baxter L. R., Jr, Madsen D., Jarvik M. E. Brain metabolic changes during cigarette craving. Archives of General Psychiatry 2002; 59(12)1162–1172
   PubMed Web of Science ®Google Scholar
• Cavedini P., Riboldi G., Keller R., D’Annucci A., Bellodii L. Frontal lobe dysfunction in pathological gambling patients. Biological Psychiatry 2002; 51(4)334–341
   PubMed Web of Science ®Google Scholar
• Chudasama Y., Bussey T. J., Muir J. L. Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning. European Journal of Neuroscience 2001; 14(6)1009–1020
   PubMed Web of Science ®Google Scholar
• Crowe S. F., Ponsford J. The role of imagery in sexual arousal disturbances in the male traumatically brain injured individual. Brain Injury 1999; 13(5)347–354
   PubMed Web of Science ®Google Scholar
• de Bruin J. P., van Oyen H. G., Van de Poll N. Behavioural changes following lesions of the orbital prefrontal cortex in male rats. Behavioral Brain Research 1983; 10(2–3)209–232
   PubMed Web of Science ®Google Scholar
• Deiber M. P., Honda M., Ibanez V., Sadato N., Hallett M. Mesial motor areas in self-initiated versus externally triggered movements examined with fMRI: Effect of movement type and rate. Journal of Neurophysiology 1999; 81(6)3065–3077
   PubMed Web of Science ®Google Scholar
• Del Parigi A., Chen K., Gautier J. F., Salbe A. D., Pratley R. E., Ravussin E., Reiman E. M., Tataranni P. A. Sex differences in the human brain's response to hunger and satiation. American Journal of Clinical Nutrition 2002; 75(6)1017–1022
   PubMed Web of Science ®Google Scholar
• Dell D. L., Halford J. J. Dementia presenting as postpartum depression. Obstetrics and Gynecology 2002; 99(5 Pt 2)925–928
   PubMed Web of Science ®Google Scholar
• Devinsky O., Morrell M. J., Vogt B. A. Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118(Pt 1)279–306
   PubMed Web of Science ®Google Scholar
• Dressing H., Obergriesser T., Tost H., Kaumeier S., Ruf M., Braus D. F. [Homosexual pedophilia and functional networks—An fMRI case report and literature review]. Fortschritte der Neurologie-Psychiatrie 2001; 69(11)539–544
   PubMed Web of Science ®Google Scholar
• Elliott R., Friston K. J., Dolan R. J. Dissociable neural responses in human reward systems. Journal of Neuroscience 2000; 20(16)6159–6165
   PubMed Web of Science ®Google Scholar
• Elliott R., Newman J. L., Longe O. A., Deakin J. F. Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: A parametric functional magnetic resonance imaging study. Journal of Neuroscience 2003; 23(1)303–307
   PubMed Web of Science ®Google Scholar
• Eslinger P. J. Neurological and neuropsychological bases of empathy. European Neurology 1998; 39(4)193–199
   PubMed Web of Science ®Google Scholar
• Everitt B. J., Cador M., Robbins T. W. Interactions between the amygdala and ventral striatum in stimulus-reward associations: Studies using a second-order schedule of sexual reinforcement. Neuroscience 1999; 30(1)63–75
   Web of Science ®Google Scholar
• Francis S., Rolls E. T., Bowtell R., McGlone F., O’Doherty J., Browning A., Clare S., Smith E. The representation of pleasant touch in the brain and its relationship with taste and olfactory areas. Neuroreport 1999; 10(3)453–459
   PubMed Web of Science ®Google Scholar
• Frohman E. M., Frohman T. C., Moreault A. M. Acquired sexual paraphilia in patients with multiple sclerosis. Archives of Neurology 2002; 59(6)1006–1010
   PubMedGoogle Scholar
• Gehring W. J., Willoughby A. R. The medial frontal cortex and the rapid processing of monetary gains and losses. Science 2002; 295(5563)2279–2282
   PubMed Web of Science ®Google Scholar
• Ghaem O., Mellet E., Crivello F., Tzourio N., Mazoyer B., Berthoz A., Denis M. Mental navigation along memorized routes activates the hippocampus, precuneus, and insula. Neuroreport 1997; 8(3)739–744
   PubMed Web of Science ®Google Scholar
• Giuliano F., Rampin O., Allard J. Neurophysiology and pharmacology of female genital sexual response. Journal of Sex & Marital Therapy 2002; 28(Suppl 1)101–121
   PubMed Web of Science ®Google Scholar
• Goldenberg G., Schuri U., Gromminger O., Arnold U. Basal forebrain amnesia: Does the nucleus accumbens contribute to human?. memory? Journal of Neurology, Neurosurgery, & Psychiatry 1999; 67(2)163–168
   PubMed Web of Science ®Google Scholar
• Goldstein R. Z., Volkow N. D. Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry 2002; 159(10)1642–1652
   PubMed Web of Science ®Google Scholar
• Gondim Fde A., Thomas F. P. Episodic hyperlibidinism in multiple sclerosis. Multiple Sclerosis 2001; 7(1)67–70
   PubMed Web of Science ®Google Scholar
• Huws R., Shubsachs A. P., Taylor P. J. Hypersexuality, fetishism and multiple sclerosis. British Journal of Psychiatry 1991; 158: 280–281
   PubMed Web of Science ®Google Scholar
• Ikemoto S., Panksepp J. The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation with special reference to reward-seeking. Brain Research Brain Research Reviews 1999; 31(1)6–41
   PubMed Web of Science ®Google Scholar
• Inzelberg R., Nisipeanu P., Joel D., Sarkantyus M., Carasso R. L. Acute mania and hemichorea. Clinical Neuropharmacology 2001; 24(5)300–303
   PubMed Web of Science ®Google Scholar
• Janszky J., Szucs A., Halasz P., Borbely C., Hollo A., Barsii P., Mirnics Z. Orgasmic aura originates from the right hemisphere. Neurology 2002; 58(2)302–304
   PubMed Web of Science ®Google Scholar
• Karama S., Lecours A. R., Leroux J. M., Bourgouin P., Beaudoin G., Joubert S., Beauregard M. Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping 2002; 16(1)1–13
   PubMed Web of Science ®Google Scholar
• Kawagoe R., Takikawa Y., Hikosaka O. Expectation of reward modulates cognitive signals in the basal ganglia. Nature Neuroscience 1998; 1(5)411–416
   PubMed Web of Science ®Google Scholar
• Kelley A. E. Functional specificity of ventral striatal compartments in appetitive behaviors. Annals of the NY Academy of Science 1999; 877: 71–90
   PubMed Web of Science ®Google Scholar
• Kilts C. D., Schweitzer J. B., Quinn C. K., Gross R. E., Faber T. L., Muhammad F., Ely T. D., Hoffman J. M., Drexlerm K. P. Neural activity related to drug craving in cocaine addiction. Archives of General Psychiatry 2001; 58: 334–341
   PubMed Web of Science ®Google Scholar
• Knutson B., Westdorp A., Kaiser E., Hommer D. FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 2000; 12: 20–27
   PubMed Web of Science ®Google Scholar
• Koob G. F. The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the NY Academy of Science 1999; 877: 445–460
   PubMed Web of Science ®Google Scholar
• Korpelainen J. T., Kauhanen M. L., Kemola H., Malinen U., Myllyla V. V. Sexual dysfunction in stroke patients. Acta Neurologica Scandanavica 1998; 98(6)400–405
   PubMed Web of Science ®Google Scholar
• Koyama T., Kato K., Tanaka Y. Z., Mikami A. Anterior cingulate activity during pain-avoidance and reward tasks in monkeys. Neuroscience Research 2001; 39(4)421–430
   PubMed Web of Science ®Google Scholar
• Kremsdorf R. B., Holmen M. L., Laws D. R. Orgasmic reconditioning without deviant imagery: A case report with a pedophile. Behavior Research Therapy 1980; 18(3)203–207
   PubMed Web of Science ®Google Scholar
• Levine S. B., Risen C. B., Althof S. E. Essay on the diagnosis and nature of paraphilia. Journal of Sex & Marital Therapy 1990; 16(2)89–102
   PubMed Web of Science ®Google Scholar
• Liu Y. C., Sachs B. D., Salamone J. D. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacology Biochemistry and Behavior 1998; 60(2)585–592
   PubMed Web of Science ®Google Scholar
• Malloy P., Bihrle A., Duffy J. The orbitomedial frontal syndrome. Archives of Clinical Neuropsychology 1993; 8(3)185–201
   PubMed Web of Science ®Google Scholar
• Marshall W. L., Hamilton K., Fernandez Y. Empathy deficits and cognitive distortions in child molesters. Sex Abuse 2001; 13: 123–130
   PubMedGoogle Scholar
• Masterman D. L., Cummings J. L. Frontal-subcortical circuits: The anatomic basis of executive, social and motivated behaviors. Journal of Psychopharmacology 1997; 11(2)107–114
   PubMed Web of Science ®Google Scholar
• McCarthy G., Puce A., Constable R. T., Krystal J. H., Gore J. C., Goldman-Rakic P. Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. Cerebral Cortex 1996; 6(4)600–611
   PubMed Web of Science ®Google Scholar
• McKenna K. E. Some proposals regarding the organization of the central nervous system control of penile erection. Neuroscience Biobehavioral Reviews 2000; 24(5)535–540
   PubMed Web of Science ®Google Scholar
• McKenna K. E. Neural circuitry involved in sexual function. Journal of Spinal Cord Medicine 2001; 24(3)148–154
   PubMedGoogle Scholar
• McKenna K. E. The neurophysiology of female sexual function. World Journal of Urology 2002; 20(2)93–100
   PubMed Web of Science ®Google Scholar
• Mega M. S., Cohenour R. C. Akinetic mutism: Disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychology and Behavioral Neurology 1997; 10(4)254–259
   PubMedGoogle Scholar
• Mendez M. F., Adams N. L., Lewandowski K. S. Neurobehavioral changes associated with caudate lesions. Neurology 1989; 39(3)349–354
   PubMed Web of Science ®Google Scholar
• Mendez M. F., Chow T., Ringman J., Twitchell G., Hinkin C. H. Pedophilia and temporal lobe disturbances. Journal of Neuropsychiatry and Clinical Neurosciences 2000; 12(1)71–76
   PubMed Web of Science ®Google Scholar
• Meston C. M., Frohlich P. F. The neurobiology of sexual function. Archives of General Psychiatry 2000; 57(11)1012–1030
   PubMed Web of Science ®Google Scholar
• Meunier M., Bachevalier J., Mishkin M. Effects of orbital frontal and anterior cingulate lesions on object and spatial memory in rhesus monkeys. Neuropsychologia 1997; 35(7)999–1015
   PubMed Web of Science ®Google Scholar
• Miller B. L., Cummings J. L., McIntyre H., Ebers G., Grode M. Hypersexuality or altered sexual preference following brain injury. Journal of Neurology, Neurosurgery, and Psychiatry 1986; 49(8)867–873
   PubMed Web of Science ®Google Scholar
• Montorsi F., Perani D., Anchisi D., Salonia A., Scifo P., Rigiroli P., Deho F., De Vito M. L., Heaton J., Rigatti P., Fazio F. Brain activation patterns during video sexual stimulation following the administration of apomorphine: Results of a placebo-controlled study. European Urology 2003; 43(4)405–411
   PubMed Web of Science ®Google Scholar
• Nims J. P. Imagery, shaping, and orgasm. Journal of Sex Marital Therapy 1975; 1(3)198–203
   PubMed Web of Science ®Google Scholar
• O’Doherty J., Kringelbach M. L., Rolls E. T., Hornak J., Andrews C. Medial and lateral orbitofrontal cortex differentially activated by reward and punishment during an emotion-related reversal task. NeuroImage 2000; 11(5)S234
   Google Scholar
• O’Doherty J., Kringelbach M. L., Rolls E. T., Hornak J., Andrews C. Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience 2001; 4(1)95–102
   PubMed Web of Science ®Google Scholar
• O’Doherty J., Winston J., Critchley H., Perrett D., Burt D. M., Dolan R. J. Beauty in a smile: The role of medial orbitofrontal cortex in facial attractiveness. Neuropsychologia 2003; 41(2)147–155
   PubMed Web of Science ®Google Scholar
• Ohkura S., Fabre-Nys C., Broad K. D., Kendrick K. M. Sex hormones enhance the impact of male sensory cues on both primary and association cortical components of visual and olfactory processing pathways as well as in limbic and hypothalamic regions in female sheep. Neuroscience 1997; 80(1)285–297
   PubMed Web of Science ®Google Scholar
• Ongur D., Price J. L. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cerebral Cortex 2000; 10(3)206–219
   PubMed Web of Science ®Google Scholar
• Ortega N., Miller N. L., Itabashi H., Cummings J. L. Altered sexual behavior with multiple sclerosis: A case report. Journal of Neuropsychiatry, Neuropsychology, and Behavioral Neurology 1993; 6: 260–264
   Google Scholar
• Rauch S. L., Shin L. M., Dougherty D. D., Alpert N. M., Orr S. P., Lasko M., Macklin M. L., Fischman A. J., Pitman R. K. Neural activation during sexual and competitive arousal in healthy men. Psychiatry Research 1999; 91(1)1–10
   PubMed Web of Science ®Google Scholar
• Redoute J., Stoleru S., Gregoire M. C., Costes N., Cinotti L., Lavenne F., Forest M. G., Pujol J. F. Brain processing of visual sexual stimuli in human males. Human Brain Mapping 2000; 11(3)162–177
   PubMed Web of Science ®Google Scholar
• Rivas F. J., Mir D. Effects of nucleus accumbens lesion on female rat sexual receptivity and proceptivity in a partner preference paradigm. Behavioral Brain Research 1990; 41(3)239–249
   PubMed Web of Science ®Google Scholar
• Rivas F. J., Mir D. Accumbens lesion in female rats increases mount rejection without modifying lordosis. Revista Espanola de Fisiologia 1991; 47(1)1–6
   PubMedGoogle Scholar
• Robertson G. S., Pfaus J. G., Atkinson L. J., Matsumura H., Phillips A. G., Fibiger H. C. Sexual behavior increases c-fos expression in the forebrain of the male rat. Brain Research 1991; 564(2)352–357
   PubMed Web of Science ®Google Scholar
• Rolls E. T. The orbitofrontal cortex. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences 1996; 351: 1433–1443
   PubMed Web of Science ®Google Scholar
• Schultz W., Tremblay L., Hollerman J. R. Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology 1998; 37(4–5): 4–5; 421–429
   Web of Science ®Google Scholar
• Sell L. A., Morris J. S., Bearn J., Frackowiak R. S., Friston K. J., Dolan R. J. Neural responses associated with cue evoked emotional states and heroin in opiate addicts. Drug & Alcohol Dependence 2000; 60(2)207–216
   PubMed Web of Science ®Google Scholar
• Sewards T. V., Sewards M. A. Representations of motivational drives in mesial cortex, medial thalamus, hypothalamus and midbrain. Brain Research Bulletin 2003; 61(1)25–49
   PubMed Web of Science ®Google Scholar
• Simpson G., Blaszczynski A., Hodgkinson A. Sex offending as a psychosocial sequela of traumatic brain injury. Journal of Head Trauma Rehabilitation 1999; 14(6)567–580
   PubMed Web of Science ®Google Scholar
• Small D. M., Zatorre R. J., Dagher A., Evans A. C., Jones-Gotman M. Changes in brain activity related to eating chocolate: From pleasure to aversion. Brain 2001; 124(Pt 9)1720–1733
   PubMed Web of Science ®Google Scholar
• Spinella M. A relationship between smell identification and empathy. International Journal of Neuroscience 2002; 112(6)605–612
   PubMed Web of Science ®Google Scholar
• Spinella M. Hypersexuality and dysexecutive syndrome after a thalamic infarct. International Journal of Neuroscience 2004; 114(12)1581–1590
   PubMed Web of Science ®Google Scholar
• Spinella M., White J. Prefrontal System Dysfunction and Symptoms of Sexual Addiction, in review
   Google Scholar
• Spinella M., White J., Frank M., Schiraldi J. Evidence of orbitofrontal dysfunction in sex offenders. International Journal of Forensic Psychology 2007, in press
   Google Scholar
• Starkstein S. E., Robinson R. G. Mechanism of disinhibition after brain lesions. Journal of Nervours and Mental Disease 1997; 185(2)108–114
   PubMed Web of Science ®Google Scholar
• Starkstein S. E., Berthier M. L., Leiguarda R. Psychic akinesia following bilateral pallidal lesions. International Journal of Psychiatry in Medicine 1989; 19(2)155–164
   PubMed Web of Science ®Google Scholar
• Stein E. A., Pankiewicz J., Harsch H. H., Cho J. K., Fuller S. A., Hoffmann R. G., Hawkins M., Rao S. M., Bandettini P. A., Bloom A. S. Nicotine-induced limbic cortical activation in the human brain: A functional MRI study. American Journal of Psychiatry 1998; 155(8)1009–1015
   PubMed Web of Science ®Google Scholar
• Stoléru S., Grégoire M. C., Gérard D., Decety J., Lafarge E., Cinotti L., Lavenne F., Le Bars D., Vernet-Maury E., Rada H., Collet C., Mazoyer B., Forest M. G., Magnin F., Spira A., Comar D. Neuroanatomical correlates of visually evoked sexual arousal in human males. Archives of Sexual Behavior 1999; 28(1)1–21
   PubMed Web of Science ®Google Scholar
• Stuss D., Levine B. Adult neuropsychology. Lessons from studies of the frontal lobes. Annual Review of Psychology 2002; 53: 401–433
   PubMed Web of Science ®Google Scholar
• Tataranni P. A., Gautier J. F., Chen K., Uecker A., Bandy D., Salbe A. D., Pratley R. E., Lawson M., Reiman E. M., Ravussin E. Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America 1999; 96(8)4569–4574
   PubMed Web of Science ®Google Scholar
• Tekin S., Cummings J. L. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update. Journal of Psychosomatic Research 2002; 53(2)647–654
   PubMed Web of Science ®Google Scholar
• Thut G., Schultz W., Roelcke U., Nienhusmeier M., Missimer J., Maguire R. P., Leenders K. L. Activation of the human brain by monetary reward. Neuroreport 1997; 8(5)1225–1228
   PubMed Web of Science ®Google Scholar
• Tiihonen J., Kuikka J., Kupila J., Partanen K., Vainio P., Airaksinen J., Eronen M., Hallikainen T., Paanila J., Kinnunen I., Huttunen J. Increase in cerebral blood flow of right prefrontal cortex in man during orgasm. Neuroscience Letters 1994; 170(2)241–243
   PubMed Web of Science ®Google Scholar
• Trautner R. J., Cummings J. L., Read S. L., Benson D. F. Idiopathic basal ganglia calcification and organic mood disorder. American Journal of Psychiatry 1988; 145(3)350–353
   PubMed Web of Science ®Google Scholar
• Thut G., Schultz W., Roelcke U., Nienhusmeier M., Missimer J., Maguire R. P., Leenders K. L. Activation of the human brain by monetary reward. Neuroreport 1997; 8(5)1225–1228
   PubMed Web of Science ®Google Scholar
• Tulving E., Markowitsch H. J., Kapur S., Habib R., Houle S. Novelty encoding networks in the human brain: Positron emission tomography data. Neuroreport 1994; 5(18)2525–2528
   PubMed Web of Science ®Google Scholar
• Tzschentke T. M. The medial prefrontal cortex as a part of the brain reward system. Amino Acids 2000; 19(1)211–219
   PubMed Web of Science ®Google Scholar
• Whipple B., Ogden G., Komisaruk B. R. Physiological correlates of imagery-induced orgasm in women. Archives of Sexual Behavior 1992; 21(2)121–133
   PubMed Web of Science ®Google Scholar
• Wright P., Nobrega J., Langevin R. Brain density and symmetry in pedophilic and sexually aggressive offenders. Annals of Sex Research 1990; 3(3)319–328
   Google Scholar
• Yamanouchi K., Arai Y. Possible role of cingulate cortex in regulating sexual behavior in male rats: Effects of lesions and cuts. Endocrinology Japan 1992; 39(3)229–234
   PubMedGoogle Scholar
• Yoo S. S., Freeman D. K., McCarthy J. J., 3rd, Jolesz F. A. Neural substrates of tactile imagery: A functional MRI study. Neuroreport 2003; 14(4)581–585
   PubMed Web of Science ®Google Scholar
• Zald D. H., Lee J. T., Fluegel K. W., Pardo J. V. Aversive gustatory stimulation activates limbic circuits in humans. Brain 1998; 121(6)1143–1154
   PubMed Web of Science ®Google Scholar