METHYLPHENIDATE (RITALIN): BEHAVIORAL STUDIES IN THE RAT

REFERENCES

• Accardo P., Blondis T. A. What's all the fuss about?. Ritalin? J. Pediatr 2001; 138: 6–9
   PubMed Web of Science ®Google Scholar
• Achat-Mendes C., Anderson K. L., Itzhak Y. Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood. Neuropharmacology 2003; 45: 106–115
   PubMed Web of Science ®Google Scholar
• Adriani W., Chiarotti F., Laviola G. Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice. Behav. Neurosci. 1998; 112: 1152–1156
   PubMed Web of Science ®Google Scholar
• Aizenstein M. L., Segal D. S., Kuczenski R. Repeated amphetamine and fencamfamine: sensitization and reciprocal cross-sensitization. Neuropsycho-pharmacology 1990; 3: 283–290
   PubMed Web of Science ®Google Scholar
• Andersen S. L., Teicher M. H. Sex differences in dopamine receptors and their relevance to ADHD. Neurosci. Biobehav. Rev. 2000; 24: 137–141
   PubMed Web of Science ®Google Scholar
• Andersen S. L., Arvanitogiannis S. A., Pliakas A. M., LeBlance C., Carlezon W. A. Altered responsiveness to cocaine in rats exposed to methylphenidate during development. Nat. Neurosci. 2002; 51: 13–14
   Web of Science ®Google Scholar
• Appenrodt E., Bojanowska E., Janus J., Stempniak B., Guzek J. W. Effects of methylphenidate on oxytocin and vasopressin levels in pinealectomized rats during light-dark cycle. Pharmacol Biochem Behav. 1997; 58: 415–419
   PubMed Web of Science ®Google Scholar
• Augustyniak P. N., Kourrich S., Rezazadeh S. M., Stewart J., Arvanitogiannis A. Differential behavioral and neurochemical effects of cocaine alter early exposure to methylphenidate in an animal model of ADHD. Behav. Brain Res. 2006; 167: 379–382
   PubMed Web of Science ®Google Scholar
• Archer T. Neurotoxin-induced cognitive and motor activity modification: a catecholamine connection. Attention deficit disorder: clinical and basic research., T. Sagvolden, T. Archer. Hillsdale Lawrence Erlbaum Pub. 1989; 287–322
   Google Scholar
• Barret S. P., Darredeau C., Bordy L. E., Pihl R. O. Characteristics of methylphenidate misuse in an university student sample. Can. J. Psychiatry 2005; 50: 457–461
   PubMed Web of Science ®Google Scholar
• Berridge K. C., Robinson T. E. The mind of an addicted brain: neural sensitization of wanting versus liking. Current Direct Psychological Sci. 1995; 4: 71–76
   Web of Science ®Google Scholar
• Bolanos C. A., Glatt S. J., Jackson D. Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis. Dev. Brain Res. 1998; 111: 25–33
   PubMedGoogle Scholar
• Bowman B. P., Kuhn C. M. Age-related differences in the chronic and acute response to cocaine in the rat. Dev. Psychobiol. 1996; 29: 597–611
   PubMed Web of Science ®Google Scholar
• Brandon C. L., Marinelli M., Baker L. K., White F. J. Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats. Neuropsychopharmacol. 2001; 25: 651–661
   PubMed Web of Science ®Google Scholar
• Browne R. G., Segal D. S. Metabolic and experimental factors in the behavioral response to repeated amphetamine. Pharmacol Biochem Behav. 1977; 5: 545–552
   Web of Science ®Google Scholar
• Butcher S. P., Liptrot J., Aburthnott G. W. Characterization of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis. Neurosci. Lett. 1991; 122: 245–248
   PubMed Web of Science ®Google Scholar
• Byrnes J. J., Pritchard G. A., Koff J. M., Miller L. G. Prenatal cocaine exposure: Decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring. Neuropharmacol. 1993; 32: 721–723
   PubMed Web of Science ®Google Scholar
• Cadoni C., Marcello S., Di Chiara G. Psychostimulant sensitization: Differential changes in accumbal shell and core dopamine. Eur. J. Pharmacol. 2000; 388: 69–76
   PubMed Web of Science ®Google Scholar
• Camp D. M., Robinson T. E. Susceptibility to sensitization: I. Sex differences in the enduring effects of chronic D-amphetamine treatment on locomotion, stereotyped behavior and brain monoamines. Behav. Brain Res. 1988; 30: 55–68
   PubMed Web of Science ®Google Scholar
• Chalman T. D., Lipsky J. J. Methylphenidate: Its pharmacology and uses. Mayo Cli. Proc. 2000; 75: 711–721
   PubMed Web of Science ®Google Scholar
• Cirulli F., Laviola G. Paradoxical effects of D-amphetamine in infant and adolescent mice: role of gender and environmental risk factors. Neurosci. Biobehav. Rev. 2000; 24: 73–84
   PubMed Web of Science ®Google Scholar
• Clarke P. B., Fibiger H. C. Apparent absence of nicotine-induced conditioned place preference in rats. Psychopharmacology (Berl) 1987; 92: 84–88
   PubMed Web of Science ®Google Scholar
• Clure C., Brandy K. T., Saladin M. E., Johnson D., Waid R. Attention deficit/hyperactivity disorder and substance use: symptom pattern and drug choice. Am. J. Drug Alcohol Abuse 1999; 25: 441–448
   PubMed Web of Science ®Google Scholar
• Collins R. J., Weeks J. R., Cooper M. M., Good P. I., Russell R. R. Prediction of abuse liability of drugs using IV self-administration by rats. Psychopharmacology (Berl) 1984; 82: 6–13
   PubMed Web of Science ®Google Scholar
• Cone E. J. Pharmacokinetics and pharmacodynamics of cocaine. J. Anal. Toxicol. 1995; 19: 459–478
   PubMed Web of Science ®Google Scholar
• Crawford C. A., McDougall S. A., Meier T. L., Collins R. L., Watson J. B. Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum. Psychopharmacology (Berl) 1998; 136: 34–43
   PubMed Web of Science ®Google Scholar
• Crutchley A., Temlett J. A. Methylphenidate (Ritalin) use and abuse. S. Afr. Med. J. 1999; 89: 1076–1079
   PubMed Web of Science ®Google Scholar
• Dell’Anna M. E., Luthman J., Landqvist E., Olson L. Development of monoamine systems after neonatal anoxia in rats. Brain Res. Bull. 1993; 32: 159–170
   PubMed Web of Science ®Google Scholar
• Deutsch H. M., Schweri M. M. Can stimulant binding and dopamine transport be differentiated? Studies with GBR 12783 derivatives. Life Sci. 1994; 55: 115–120
   Web of Science ®Google Scholar
• Diaz-Granados J. L., Greene P. L., Ansel A. Selective activity enhancement and persistence in weanling rats after hippocampal x-irradiation in infancy: possible relevance for ADHD. Behav. Neural Biol. 1994; 61: 251–259
   PubMedGoogle Scholar
• Ding Y. S., Fowler J. S., Volkow N. D., Gatley S. J., Logan J. Pharmacokinetics and in vivo specificity of 011 C0dl-threo-methylphenidate for the presynaptic dopaminergic neuron. Synapse 1994; 18: 152–160
   PubMed Web of Science ®Google Scholar
• Druhan J. P., Jakob A., Stewart J. The development of behavioral sensitization to apomorphine in blocked by MK-801. Eur. J. of Pharmacol. 1993; 243: 73–77
   PubMed Web of Science ®Google Scholar
• Eckermann K., Beasley A., Yang P., Gaytan O., Swann A., et al. Methylphenidate sensitization is modulated by Valproate. Life Sci. 2001; 69: 47–57
   PubMed Web of Science ®Google Scholar
• Eichlseder W. Ten years of experience with 1.000 hyperactive children in a private practice. Pediatr. 1985; 76: 176–184
   PubMed Web of Science ®Google Scholar
• Feldpausch D. L., Needham L. M., Stone M.P., Althaus J. S., Yamamoto B. K., et al. The role of D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations. J. Pharmacol. Exp. Ther. 1998; 286: 497–508
   PubMed Web of Science ®Google Scholar
• Fregly M. J., Black B. A. Effect of Methylphenidate on Spontaneous Activity, Food, Intake, and Cold Tolerance of Propylthiouracil-Treated Rats. Canad. J. Physiol. Pharmacol. 1964; 42: 415–419
   PubMed Web of Science ®Google Scholar
• Fujiwara Y., Kazahaya Y., Nakashima M., Sato M., Otsuki S. Behavioral sensitization to methamphetamine in the rat: an ontogenic study. Psychopharmacol. 1987; 91: 316–319
   PubMed Web of Science ®Google Scholar
• Fukui R., Svenningsson P., Matsuishi T., Higashi H., Nairn A. C., et al. Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice. J. Neurochem. 2003; 87: 1391–1401
   PubMed Web of Science ®Google Scholar
• Gardner E. L. Brain reward mechanisms. Williams and Wilkins Substance Abuse: A Comprehensive Textbook, J.H. Lowinson, R.B. Millman, J.G. Langrod, Baltimore 1997; 51–58
   Google Scholar
• Garland E. J. Intranasal abuse of prescribed methylphenidate. J. Am. Acad. Child Adolesc. Psychaitry 1998; 37: 573–574
   PubMed Web of Science ®Google Scholar
• Gatley S. J., Volkow N. D., Gifford A. N., Fowler J. S., Dewery S. L., et al. Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans. Psychopharmacology 1999; 146: 93–100
   PubMed Web of Science ®Google Scholar
• Gatley S. J., Meehan S. M., Chen R., Pan D. F., Schechter M. D., et al. Place preference and microdialysis studies with two derivatives of methylphenidate. Life Sci. 1996; 58: PL345–PL352
   PubMed Web of Science ®Google Scholar
• Gaytan O., Al-Rahim S., Swann A., Dafny N. Sensitization to locomotor effects of methylphenidate in the rat. Life Sci. 1997a; 61: PL101–PL107
   PubMed Web of Science ®Google Scholar
• Gaytan O., Ghelani D, Martin S., Swann A., Dafny N. Dose response characteristics of methylphenidate on different indices of rats’ locomotor activity at the beginning of the dark cycle. Brain Res. 1996; 727: 13–21
   PubMed Web of Science ®Google Scholar
• Gaytan O., Ghelani D., Martin S., Swann A., Dafny N. Methylphenidate: diurnal effects on locomotor and stereotypic behavior in the rat. Brain Res. 1997b; 777: 1–12
   PubMed Web of Science ®Google Scholar
• Gaytan O., Lewis C., Swann A., Dafny N. Diurnal differences in amphetamine sensitization. Eur. J. Pharmacol. 1999; 374: 1–9
   PubMed Web of Science ®Google Scholar
• Gaytan O., Nason R., Alagugurusamy R., Swann A., Dafny N. MK-801 blocks the development of sensitization to the locomotor effects of methylphenidate. Brain Res Bull. 2000a; 51: 485–492
   PubMed Web of Science ®Google Scholar
• Gaytan O., Sripada S., Swann A., Dafny N. Blockade of sensitization to methylphenidate by MK-801: partial dissociation from motor effects. Neuropharmacology 2001; 40: 298–309
   PubMed Web of Science ®Google Scholar
• Gaytan O., Swann A., Dafny N. Diurnal differences in rat's motor resonse to amphetamine. Eur. J. Pharmacol. 1998a; 345: 119–128
   PubMed Web of Science ®Google Scholar
• Gaytan O., Swann A., Dafny N. Time-dependent differences in the rat's motor response to amphetamine. Pharmacol. Biochem. Behav. 1998b; 59: 459–467
   PubMed Web of Science ®Google Scholar
• Gaytan O., Swann A. C., Dafny N. Disruption of sensitization to methylphenidate by a single administration of MK-801. Life Sci. 2002; 70: 2271–2285
   PubMed Web of Science ®Google Scholar
• Gaytan O., Yang P., Swann A., Dafny N. Diurnal differences in sensitization to methylphenidate. Brain Res. 2000b; 864: 24–39
   PubMed Web of Science ®Google Scholar
• Gerasimov M. R., Franceschi M., Volkow N. D., Gifford A., Gatley S. J. Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study. J. Pharmacol. Exp. Ther. 2000; 295: 51–57
   PubMed Web of Science ®Google Scholar
• Glick S. D., Hinds P. A. Sex differences in sensitization to cocaine-induced rotation. Eur. J. Pharmacol. 1984; 99: 119–121
   PubMed Web of Science ®Google Scholar
• Goldman L. S., Genel M., Bezman R. J., Slanetz P. J. Diagnosis and treatment of attention deficit hyperactivity disorder in children and adolescents. JAMA 1998; 279: 1100–1107
   PubMed Web of Science ®Google Scholar
• Goudie A. J., Emmett-Oglesby M. W. Psychoactive drugs: tolerance and sensitization. Humana Press, Clifton New Jersey 1989
   Google Scholar
• Grund T., Lehmann K., Bock N., Rothenberger A., Teuchert-Noodt G. Influence of methylphenidate on brain development—an update of recent animal experiments. Behav. Brain Funct. 2006; 10: 2–12
   Google Scholar
• Hoffman B. B., Lefkowitz R. J. Catecholamines and sympathomimetic drugs, and adrenergic receptor antagonists. Goodman and Gilman the Pharmacological Basis of Therapeutics 9th, J. G. Hardman, L. E. Limbird, R. W. Ruddon, A. D. Gilman. Pergamon, New York 1996; 199–250
   Google Scholar
• Honma S., Honma K. Locomotor rhythms induced by methylphenidate in suprachiasmatic nuclei-lesioned rats. Neurosci Lett. 1992; 137: 24–28
   PubMed Web of Science ®Google Scholar
• Horger B. A., Giles M. K., Schenk S. Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine. Psychopharmacological 1992; 107: 271–276
   PubMed Web of Science ®Google Scholar
• Hovens J. G., Cantwell D. P., Kiriakos R. Psychiatric comorbidity in hospitalized adolescent substance abusers. J. Am. Acad. Child Adolesc. Psychiatry 1994; 33: 476–483
   PubMed Web of Science ®Google Scholar
• Hurd Y. L., Ungerstedt U. In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen. Eur. J. Pharmacol. 1989; 166: 251–260
   PubMed Web of Science ®Google Scholar
• Huttenlocher P. R. Synaptic density in human frontal cortex-developmental changes and effects of aging. Brain Res. 1979; 163: 195–205
   PubMed Web of Science ®Google Scholar
• Insel T. R., Charney D. S. Research on major depression strategies and priorities. JAMA 2003; 289: 3167–3168
   PubMed Web of Science ®Google Scholar
• Isaac W., Kallman W. M. Stimulants and lesions of the substantia nigra and red nucleus. Physiol Behav. 1975; 5: 471–474
   Google Scholar
• Izenwasser S., Coy A. E., Ladenheim B., Loeloff R. J., Cadet J. L., et al. Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine. Eur. J. Pharmacol. 1999; 373: 187–193
   PubMed Web of Science ®Google Scholar
• Jaffe S. L. Intranasal abuse of prescribed methylphenidate by an alcohol and drug abusing adolescent with ADHD. J. Am. Acad. Child Adolesc. Psychiatry 1991; 30: 773–775
   PubMed Web of Science ®Google Scholar
• Jerziorski M., White F., Wolf M. MK-801 prevents the development of behavioral sensitization during repeated morphine administration. Synapse 1994; 16: 137–147
   PubMed Web of Science ®Google Scholar
• Kalivas P. W., Churchill L., Klitenick M. A. The circuitry mediating the translation of motivational stimuli into adaptive motor responses. Limbic Motor Circuits and Neuropsychiatry, P. W. Kalivas, C. D. Barnes. CRC Press, Boca Raton 1993; 237–287
   Google Scholar
• Kalivas P. W., Duffy P., DuMars L. A., Skinner C. Behavioral and neurochemical effects of acute and daily cocaine administration in rats. J. Pharmacol. Exp. Ther. 1998; 245: 485–492
   Google Scholar
• Kalivas P. W., Pierce R. C., Cornish J., Sorg B. A. A role for sensitization in craving and relapse in cocaine addiction. J. Psychopharmacol. 1998; 12: 49–53
   PubMed Web of Science ®Google Scholar
• Kalivas P. W., Stewart J. Dopamine transmission in the initiation and expression of drug-and stress-induced sensitization of motor activity. Brain Res. Rev. 1991; 16: 223–244
   PubMed Web of Science ®Google Scholar
• Kallman W. M., Isaac W. The effects of age and illumination on the dose-response curves for three stimulants. Psychopharmacologia 1975; 40: 313–318
   PubMed Web of Science ®Google Scholar
• Kankaanpaa A., Meririnne E., Seppala T. 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat. Psychopharmacology (Berl). 2000; 159: 341–350
   Web of Science ®Google Scholar
• Karler R., Calder L. D., Chaudhry I. A., Turkanis S. A. Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801. Life Sci. 1989; 45: 599–606
   PubMed Web of Science ®Google Scholar
• Kollins S. H., MacDonald E. K., Rush C. R. Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review. Pharmacol. Biochem. Behav. 2001; 68: 611–627
   PubMed Web of Science ®Google Scholar
• Komater V. A., Browman K. E., Curzon P., Hancock A. A., Decker M. W., et al. H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization. Psychopharmacology (Berl). 2003; 1674: 363–372
   Web of Science ®Google Scholar
• Kuczenski R., Segal D. S. Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. J. Neurochem. 1997; 685: 2032–2037
   Google Scholar
• Kuczenski R., Segal S. D. Sensitization of amphetamine-induced stereotyped behaviors during the acute response. J. Pharmacol. Exp. Therap. 1999; 288: 699–709
   PubMed Web of Science ®Google Scholar
• Kuczenski R., Segal D. S. Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine. J. Pharmacol. Exp. Ther. 2001; 296: 876–883
   PubMed Web of Science ®Google Scholar
• Kuczenski R., Segal D. S. Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. J. Neurosci. 2002; 22: 7264–7271
   PubMed Web of Science ®Google Scholar
• Lambert N. M., Hartsongh C. S. Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. J. Learn. Disabil. 1998; 31: 533–544
   PubMed Web of Science ®Google Scholar
• Landrup P., Wallace L. J. Sensitization elicited by directly and indirectly acting dopaminergic agonists: Comparison using neural network analysis. Psychopharmacologia 1999; 141: 169–174
   Web of Science ®Google Scholar
• Laviola G., Wood R. D., Kuhn C., Francis R., Spear L. P. Cocaine sensitization in periadolescent and adult rats. J. Pharmacol. Exp. Ther. 1995; 275: 345–357
   PubMed Web of Science ®Google Scholar
• LeMoal M., Simon H. Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol. Rev. 1991; 71: 155–234
   PubMed Web of Science ®Google Scholar
• Lett B. T. Repeated exposures intensity rather than diminish the rewarding effects of amphetamine, morphine, and cocaine. Psychopharmacol. (Berl.) 1989; 98: 357–362
   PubMed Web of Science ®Google Scholar
• Li Y., Wolf M. E. Ibotenic acid lesions of the prefrontal cortex do not prevent the expression of behavioral sensitization to amphetamine. Behav. Brain Res. 1999; 84: 285–289
   Web of Science ®Google Scholar
• Lucas A. R., Weiss M. Methylphenidate hallucinosis. JAMA 1971; 217: 1079–1081
   PubMed Web of Science ®Google Scholar
• Mao L., Wang J. Q. Differentially altered mGluR1 and mGluR5 mRNA expression in rat caudate nucleus and nucleus accumbens in the development and expression of behavioral sensitization to repeated amphetamine administration. Synapse 2001; 41: 230–240
   PubMed Web of Science ®Google Scholar
• Martin-Iverson M. T., Ortmann R., Fibiger C. H. Place preference conditioning with methylphenidate and nomifensine. Brain Res. 1985; 332: 59–67
   PubMed Web of Science ®Google Scholar
• Massello W., Carpenter D. A. A fatality due to the intranasal abuse of methylphenidate (Ritalin). J. Forensic Sci. 1999; 44: 220–221
   PubMed Web of Science ®Google Scholar
• McCormick T. C., McNeel T. W. Acute psychosis and Ritalin abuse. Tex. State J. Med. 1963; 59: 99–100
   Google Scholar
• McClung C. A., Nestler E. J. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci. 2003; 6: 1208–1215
   PubMed Web of Science ®Google Scholar
• McNamara C. G., Davidson E. S., Schenk S. A comparison of the motor-activating effects of acute and chronic exposure to amphetamine and methylphenidate. Pharmacol. Biochem. Behav 1993; 45: 729–732
   PubMed Web of Science ®Google Scholar
• Melnick S. M., Dow-Edwards D. L. Differential behavioral responses to chronic amphetamine in adult male and female rats exposed to postnatal cocaine treatment. Pharmacol. Biochem. Behav. 2001; 69: 219–224
   PubMed Web of Science ®Google Scholar
• Methylphenidate Review. Eight Factor Analysis 1995, Washington DC, Drug and Chemical Evaluation Section, Office of Diversion Control, Drug Enforcement Administration
   Google Scholar
• Meririnne E., Kankaanpaa A., Seppala T. Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1- and D2-receptor antagonists. J. Pharmacol. Exp. Ther. 2001; 298: 539–550
   PubMed Web of Science ®Google Scholar
• Meyers C. A., Weitzner M. A., Valentine A. D., Levin V. A. Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J. Clin. Oncol. 1998; 16: 2522–2527
   PubMed Web of Science ®Google Scholar
• Mithani S., Martin-Iverson M. T., Phillips A. G., Fibiger H. C. The effects of haloperidol on amphetamine- and methylphenidate-induced conditioned place preferences and locomotor activity. Psychopharmacology (Berl). 1986; 90: 247–252
   PubMed Web of Science ®Google Scholar
• Mogenson G. J., Brudzynski S. M., Wu M., Yang C. R., Yim C. Y. From motivation to action: a review of dopaminergic regulation of limbic-nucleus accumbens-pedunculopontine nucleus circuitries involved in limbic-motor integration. Limbic Motor Circuits and Neuropsychiatry, P. W. Kalivas, C.D. Barnes. CRC Press, Boca Raton 1980; 193–236
   Google Scholar
• Morton W. A., Stockton G.G. Methylphenidate abuse and psychiatric side effects, Primary Care Companion. J. Clin. Psychiatry 2000; 2: 159–164
   Google Scholar
• Muray J. B. Psychophysiological effects of methylphenidate (Ritalin). Psycho. l Rep. 1987; 61: 315–336
   PubMed Web of Science ®Google Scholar
• Niculescu M., Ehrlich M. E., Unterwald E. M. Age-specific behavioral responses to psychostimulants in mice. Pharmacol. Biochem. Behav. 2005; 82: 280–288
   PubMed Web of Science ®Google Scholar
• NIDA. Meeting Summary “Cross-sensitization between drugs: a behavioral and neural basis for ‘gateway’”. 2000, at http://www.nida.nih.gov/MeetSum/NS2000/Gatewayabs.html)
   Google Scholar
• NIDA Notes. 2003; 18(3)
   Google Scholar
• Nielsen J. A., Duda N. J., Mokler D. J., Moore K. E. Self-administration of central stimulants by rats: a comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612. Pharmacol. Biochem. Behav 1984; 20: 227–232
   PubMed Web of Science ®Google Scholar
• Nolan E. E., Gadow K. D., Sprafkin J. Stimulant medication withdrawal during long-term therapy in children with comorbid attention-defiict hyperactivity disorder and chronic multiple Tic disorder. Pediatric 1999; 103: 730–737
   PubMed Web of Science ®Google Scholar
• Pan D., Gatley S. J., Dewey S. L., Chen R., Alexoff D. A., et al. Binding of brominic-substituted analogs of methylphenidate to monoamine transporters. Eur. J. Pharmacol. 1994; 264: 177–182
   PubMed Web of Science ®Google Scholar
• Parran T. V., Jasinski D. R. Intravenous methylphenidate abuse: prototype for prescription drug abuse. Arch. Intern. Med. 1991; 151: 781–783
   PubMed Web of Science ®Google Scholar
• Patrick K. S., Markowitz J. S. Pharmacology of methylphenidate, amphetamine enantiomers, and pemoline in attention deficit/hyperactivity disorder. Human Psychopharmacol. 1997; 12: 527–546
   Web of Science ®Google Scholar
• Pudiak C. M., Bozarth M. A. L-NAME and MK-801 attenuate sensitization to the locomotor-stimulating effects of cocaine. Life Sci. 1993; 53: 1517–1524
   PubMed Web of Science ®Google Scholar
• Puumala T., Ruotsalainan S., Jakala P., Kaivisto E., Riekkinen P., Sirvio J. Behavioral and pharmacological studies on the validation of new animal model for attention deficit hyperactivity disorder. Neurobiol. Learn. Mem. 1996; 66: 198–211
   PubMed Web of Science ®Google Scholar
• Rakie P. Development of the primate cerebral cortex. Child and Adolescent Psychiatry., M. Lewis. Williams and Wilkins, Baltimore 1986
   Google Scholar
• Randall S., Hannigan J. H. In utero alcohol and postnatal methylphenidate: locomotion and dopamine receptors. Neurotoxicol. Teratol. 1999; 21: 587–593
   PubMed Web of Science ®Google Scholar
• Ritz M. C., Lamb R. J., Goldberg S.R., Kuhar M. J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 1987; 237: 1219–1223
   PubMed Web of Science ®Google Scholar
• Robbins T. W., Jones G. H., Sahakian B. J. Control stimulants, transmitters and attention disorder: a perspective from animal studies. Attention deficit disorders: Clinical basic research., T. Sagvolden, T. Archer. Lawrence Erlbaum, Hillsdale 1989; 199–222
   Google Scholar
• Robbins M. S., Kumar S., Walker-Barnes C., Feaster D. J., Briones E., et al. Ethnic differences in comorbidity among substance-abusing adolescents referred to outpatient therapy. J. Amer. Acad. Child Adolesc. Psychiatry 2002; 41: 394–401
   PubMed Web of Science ®Google Scholar
• Robinson T. E. Persistent sensitizing effects of drugs on brain dopamine systems and behavior: implications for addiction and relapse. Biological Basis of Substance Abuse, S. G. Korenman, J. D. Barchas. University Press, Oxford 1993; 373–402
   Google Scholar
• Robinson T. E., Becker J. B. Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. 1986; 396: 157–198
   PubMed Web of Science ®Google Scholar
• Robinson T. E., Berridge K. C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Rev. 1993; 18: 247–291
   PubMed Web of Science ®Google Scholar
• Roffman J. L., Raskin L. A. Stereotyped behavior: effects of d-amphetamine and methylphenidate in the young rat. Pharmacol. Biochem. Behav. 1997; 58: 1095–1102
   PubMed Web of Science ®Google Scholar
• Russell V. A. The nucleus accumbens motor-limbic interface of the spontaneously hypertensive rat (SHR) as studied in vitro by the superfusion slice technique. Neurosci. Biobehav. Rev. 2000; 24: 133–136
   PubMed Web of Science ®Google Scholar
• Sadile A.G., Pellicano M. P., Sagvolden T., Sergeant A. J. NMDA and non-NMDA sensitive study. Behav. Brain Res. 1996; 78: 163–174
   PubMed Web of Science ®Google Scholar
• Safer D. J., Zito E. M. Fine, Increase methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics 1996; 98: 1084–1088
   PubMed Web of Science ®Google Scholar
• Sagvolden T., Sergeant J. A. Attention deficit/hyperactivity disorder-from brain dysfunction to behaviour. Behav. Brain Res. 1998; 94: 1–10
   PubMed Web of Science ®Google Scholar
• Sagvolden T. Behavioral validation of spontaneous hypertensive rat (SHR) as an animal model of attention deficit/hyperactivity disorder (AD/HD). Neurosci. Biobehav. Rev. 2000; 24: 31–39
   PubMed Web of Science ®Google Scholar
• Scheel-Kruger J. Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur. J. Pharmacol. 1971; 14: 47–59
   PubMed Web of Science ®Google Scholar
• Schenk S., Davidson E. S. Stimulant pre-exposure sensitizes rats and humans to the rewarding effects of cocaine. NIDA Res. Monogr. 1998; 169: 56–82
   PubMedGoogle Scholar
• Segal D. S., Geyer M. A., Schuckit M. A. Stimulant-induced psychosis: an evaluation of animal models. Essays Neurochem. Neuropharmacol. 1981; 5: 95–129
   PubMedGoogle Scholar
• Segal D. S., Kuczenski R. Repeated binge exposure to amphetamine and methamphetamine: Behavioral and neurochemical characterization. J. Pharmacol. Exp. Ther. 1987; 282: 561–573
   Google Scholar
• Segal D. S., Kuczenski R. Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile. J. Pharmacol. Exp. Ther 1999; 291: 19–30
   PubMed Web of Science ®Google Scholar
• Shuster L., Hudson J., Anton M., Righi D. Sensitization of mice to methylphenidate. Psychopharmacology (Berl). 1982; 77: 31–36
   PubMed Web of Science ®Google Scholar
• Silbergeld E. K., Goldberg A. M. Lead-induced behavioral dysfunction: an animal model of hyperactivity. Exp. Neurol. 1974; 42: 146–157
   PubMed Web of Science ®Google Scholar
• Solanto M. V. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav. Brain Res. 1998; 94: 127–152
   PubMed Web of Science ®Google Scholar
• Solanto M. V. Clinical psychopharmacology of AD/HD: implications for animal models. Neurosci. Biobehav. Rev. 2000; 24: 27–30
   PubMed Web of Science ®Google Scholar
• Spear L. P., Brake S. C. Periadolescence: Age-dependent behavior and psychopharmacological responsivity in rats. Dev. Psychobiol. 1983; 16: 83–109
   PubMed Web of Science ®Google Scholar
• Spensley J., Rockwell D. A. Psychosis during methylphenidate abuse. N. Engl. J. Med. 1972; 286: 880–881
   PubMed Web of Science ®Google Scholar
• Sripada S., Gaytan O., Al-rahim S., Swann A., Dafny N. Dose-related effects of MK-801 on acute and chronic methylphenidate administration. Brain Res. 1998; 814: 78–85
   PubMed Web of Science ®Google Scholar
• Stewart J., Badiani A. Tolerance and sensitization in the behavioral effects of drugs. Behav. Pharmacol. 1993; 4: 289–312
   PubMed Web of Science ®Google Scholar
• Swanson J. M., Sergeant J. A., Taylor E., Sonuga-Barke E. J., Jensen P. S., et al. Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet 1998; 351: 429–433
   PubMed Web of Science ®Google Scholar
• Swanson J. M., Gupta S., Guinta D., Flynn D., Agler D., et al. Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children. Clin. Pharmacol. Ther. 1999; 66: 295–305
   PubMed Web of Science ®Google Scholar
• Taylor E. Clinical foundations of hyperactivity research. Behav. Brain Res. 1998; 94: 11–24
   PubMed Web of Science ®Google Scholar
• Teo S. K., Stirling D. I., Thomas S. D., Khetani V. D. Neurobehavioral effects of racemic threo-methylphenidate and its D and L enantiomers in rats. Pharmacol. Biochem. Behav. 2003; 74: 747–754
   PubMed Web of Science ®Google Scholar
• Volkow N. D., Ding Y. S., Fowler J. S., Want G. J., Logan J., et al. Is methylphenidate like?. cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch. Gen. Psychiatry 2001; 52: 456–463
   Google Scholar
• Volkow N. D., Want G. J., Fowler J. S., Hitzemann R., Angristm B., et al. Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implication in addiction. Am. J. Psychiatr. 1996; 156: 16–26
   Google Scholar
• Wang G. J., Volkow N. D., Hitzemann R. J., Wong C., Angrist B., et al. Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers. Eur. Addict Res. 1997; 41: 49–54
   Web of Science ®Google Scholar
• West R. Theories of addiction. Addiction 2001; 96: 3–13
   PubMed Web of Science ®Google Scholar
• White P. J., Kalivas P. W. Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 1998; 51: 141–153
   PubMed Web of Science ®Google Scholar
• Wiley R. F. Abuse of methylphenidate (Ritalin). New Engl. J. Med. 1971; 285: 464
   Web of Science ®Google Scholar
• Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatry 1986; 10: 677–690
   PubMed Web of Science ®Google Scholar
• Wilson L. M. Some developmental aspects of open-field behavior in the spontaneously hypertensive rat (SHR) and two normotensive strains. 1976, Paper presented to the Int Soc Devl Psychobiol meeting, Toronto, Canada
   Google Scholar
• Wolf M. E. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog. Neurobiol. 1998; 54: 88–102
   Web of Science ®Google Scholar
• Wolf M. E., Dahlin S. L., Hu X. T., Xue C. J., White K. Effects of lesions of prefrontal cortex, amygdale, or fornix on behavioral sensitization to amphetamine: comparison with N-methyl-D-aspartate antagonists. Neuroscience 1995; 69: 417–439
   PubMed Web of Science ®Google Scholar
• Wood W. G., Schreiber H. L., Villescas R., Carlson R. H. Effects of prior experience and ‘functional disturbance’ on acute and chronic tolerance to methylphenidate. Psychopharmacology (Berl). 1997; 51: 165–168
   Web of Science ®Google Scholar
• Wultz B., Sagvolden T., Moser E. I., Moser M. B. The spontaneous hypertensive rat as an animal model of attention-deficit hyperactivity disorder: effects of methylphenidate on exploratory behavior. Behav Neurol Biol 1990; 53: 88–102
   PubMedGoogle Scholar
• Yang P., Beasley A., Eckermann K., Swann A., Dafny N. Valproate prevents the induction of sensitization to methylphenidate (ritalin) in rats. Brain Res. 2000a; 887: 276–284
   PubMed Web of Science ®Google Scholar
• Yang P., Beasley A., Swann A., Dafny N. Valproate modulates the expression of methylphenidate (ritalin) sensitization. Brain Res. 2000b; 874: 216–220
   PubMed Web of Science ®Google Scholar
• Yang P., Singhal N., Modi G., Swann A., Dafny N. Effects of lithium chloride on induction and expression of methylphenidate sensitization. Eur J Pharmacol 2001; 426: 65–72
   PubMed Web of Science ®Google Scholar
• Yang P., Swann A., Dafny N. NMDA receptor antagonist disrupts acute and chronic effects of methylphenidate. Physiol Behav 2000c; 71: 133–145
   PubMed Web of Science ®Google Scholar
• Zahnister N. R., Larson G. A., Gerhardt G. A. In vivo dopamine clearance rate in rat striatum regulation by extracellular dopamine concentration and dopamine transporter inhibitors. J. Pharmacol. Exp. Ther. 1999; 289: 266–277
   PubMed Web of Science ®Google Scholar