149
Views
24
CrossRef citations to date
0
Altmetric
Original

Central Nervous System Complications of Diabetes in Streptozotocin-Induced Diabetic Rats: A Histopathological and Immunohistochemical Examination

, , , &
Pages 1155-1169 | Received 01 Sep 2006, Published online: 13 Aug 2009

REFERENCES

  • Abdel-Wahab M. H., Abd-Allah A. R. Possible protective effect of melatonin and/or desferrioxamine against streptozotocin-induced hyperglycaemia in mice. Pharmacology Research 2000; 41: 533–537
  • Baydas G., Canatan H., Turkoglu A. Comparative analysis of the protective effects of melatonin and vitamin E on streptozotocin-induced diabetes mellitus. Journal of Pineal Research 2002; 32: 225–230
  • Baydas G., Nedzvetskii V. S., Tuzcu M., Yasar A., Kirichenko S. V. Increase of glial fibrillary acidic protein and S-100B in hippocampus and cortex of diabetic rats: effects of vitamin E. European Journal of Pharmacology 2003a; 462: 67–71
  • Baydas G., Ozer M., Yasar A., Koz S. T., Tuzcu M. Melatonin prevents oxidative stres and inhibits reactive gliosis induced by hyperhomocysteinemia in rats. Biochemistry 2006; 71: S91–S95
  • Baydas G., Reiter R. J., Yasar A., Tuzcu M., Akdemir I., Nedzvetskii V. S. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radical Biology and Medicine 2003b; 35: 797–804
  • Baydas G., Sonkaya E., Tuzcu M., Yasar A., Donder E. Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats. Acta Pharmacologica Sinica 2005; 26: 417–422
  • Biessels G. J., Kappelle A. C., Bravenboer B., Erkelens D. W., Gispen W. H. Cerebral function in diabetes mellitus. Diabetologia 1994; 37: 643–650
  • Cam M., Yavuz O., Guven A., Ercan F., Bukan N., Ustundag N. Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats. Journal of Pineal Research 2003; 35: 212–220
  • Celik S., Baydas G., Yilmaz O. Influence of vitamin E on the levels of fatty acids and MDA in some tissues of diabetic rats. Cell Biochemistry and Function 2002; 20: 67–71
  • Coleman E., Judd R., Hoe L., Dennis J., Posner P. Effects of diabetes mellitus on astrocyte GFAP and glutamate transporters in the CNS. Glia 2004; 48: 166–178
  • Dai J., Vrensen G. F., Schlingemann R. O. Blood-brain barrier integrity is unaltered in human brain cortex with diabetes mellitus. Brain Research 2002; 954: 311–316
  • Gispen W. H., Biessels G. J. Cognition and synaptic plasticity in diabetes mellitus. Neuroscience 2000; 23: 542–549
  • Hatfield R. H., McKernan R. M. CSF neuron-specific enolase as a quantitative marker of neuronal damage in a rat stroke model. Brain Research 1992; 577: 249–252
  • Jakobsen J., Knudsen G. M., Juhler M. Cation permeability of the blood-brain barrier in streptozotocin-diabetic rats. Diabetologia 1987; 30: 409–413
  • Kamal A., Artola A., Biessels G. J., Gispen W. H., Ramakers G. M. Increased spike broadening and slow afterhyperpolarization in CA1 pyramidal cells of streptozotocin-induced diabetic rats. Neuroscience 2003; 118: 577–583
  • Kamal A., Biessels G. J., Urban I. J., Gispen W. H. Hippocampal synaptic plasticity in streptozotocin-diabetic rats: impairment of long-term potentiation and facilitation of long-term depression. Neuroscience 1999; 90: 737–745
  • Lenk S. E., Bhat D., Blakeney W., Dunn W. A., Jr. Effects of streptozotocin-induced diabetes on rough endoplasmic reticulum and lysosomes of rat liver. American Journal of Physiology 1992; 263: 856–862
  • Liedtke W., Edelmann W., Bieri P. L., Chiu F. C., Cowan N. J., Kucherlapati R., et al. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 1996; 17: 607–615
  • Maritim A. C., Moore B. H., Sanders R. A., Watkins J. B. III. Effects of melatonin on oxidative stres in streptozotosin-induced diabetic rats. International Journal of Toxicology 1999; 18: 161–166
  • Mercuri F., Quagliaro L., Ceriello A. Oxidative stress evaluation in diabetes. Diabetes Technology & Therapeutics 2000; 2: 589–600
  • Persson L., Hardemark H. G., Gustafsson J., Rundstrom G., Mendel-Hartvig I., Esscher T., et al. S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke 1987; 18: 911–918
  • Reiter R. J., Tan D. X., Osuna C., Gitto E. Actions of melatonin in the reduction of oxidative stress: a review. Journal of Biomedical Science 2000; 7: 444–458
  • Saravia F. E., Revsin Y., Gonzalez Deniselle M. C., Gonzalez S. L., Roig P., Lima A., et al. Increased astrocyte reactivity in the hippocampus of murine models of type 1 diabetes: the nonobese diabetic (NOD) and streptozotocin-treated mice. Brain Research 2002; 957: 345–353
  • Sener G., Sehirli A. O., Ayanoglu-Dulger G. Melatonin protects against mercury(II)-induced oxidative tissue damage in rats. Pharmacology and Toxicology 2003; 93: 290–296
  • Sewerynek E., Reiter R. J., Melchiorri D., Ortiz G. G., Lewinski A. Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin. Hepatogastroenterology 1996; 43: 898–905
  • Vural H., Sabuncu T., Arslan S. O., Aksoy N. Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats. Journal of Pineal Research 2001; 31: 193–198
  • West I. C. Radicals and oxidative stress in diabetes. Diabetic Medicine 2000; 17: 171–180
  • Yasuda H., Terada M., Maeda K., Kogawa S., Sanada M., Haneda M., et al. Diabetic neuropathy and nerve regeneration. Progress in Neurobiology 2003; 69: 229–285
  • Yamagishi N., Nakayama K., Wakatsuki T., Hatayama T. Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats. Life Science 2001; 69: 2603–2609
  • Yavuz O., Cam M., Bukan N., Guven A., Silan F. Protective effect of melatonin on beta-cell damage in streptozotocin-induced diabetes in rats. Acta Histochemica 2003; 105: 261–266
  • Yuan J., Young B. J., Martinus R. D. Expression of chaperonin 60 in the hippocampus of the streptozotocin diabetic rat. Neuroreport 2006; 17: 239–242
  • Zhang R.-L., Lu C.-Z., Ren H.-M., Xiao B.-G. Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Experimental Neurology 2003; 184: 746–752

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.