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Review Article

Monoclonal antibody therapy for neuromyelitis optica spectrum disorder: current and future

, , &
Pages 735-744 | Received 24 May 2016, Accepted 26 Sep 2016, Published online: 14 Oct 2016

References

  • Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004;364(9451):2106–12. doi:10.1016/S0140-6736(04)17551-X. PubMed PMID: 15589308.
  • Matiello M, Jacob A, Wingerchuk DM, et al. Neuromyelitis optica. Curr Opin Neurol 2007;20(3):255–60. doi:10.1097/WCO.0b013e32814f1c6b. PubMed PMID: 17495617.
  • Argyriou AA, Makris N. Neuromyelitis optica: a distinct demyelinating disease of the central nervous system. Acta Neurol Scand 2008;118(4):209–17. doi:10.1111/j.1600-0404.2008.01002.x. PubMed PMID: 18336627.
  • Kim SH, Huh SY, Lee SJ, et al. A 5-year follow-up of rituximab treatment in patients with neuromyelitis optica spectrum disorder. JAMA Neurol 2013;70(9):1110–17. doi:10.1001/jamaneurol.2013.3071. PubMed PMID: 23897062.
  • Cree BA, Lamb S, Morgan K, et al. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 2005;64(7):1270–2. doi:10.1212/01.WNL.0000159399.81861.D5. PubMed PMID: 15824362.
  • Ringelstein M, Harmel J, Distelmaier F, et al. Neuromyelitis optica and pregnancy during therapeutic B cell depletion: infant exposure to anti-AQP4 antibody and prevention of rebound relapses with low-dose rituximab postpartum. Mult Scler 2013;19(11):1544–7. doi:10.1177/1352458513498125. PubMed PMID: 23886825.
  • Mahmood NA, Silver K, Onel K, et al. Efficacy and safety of rituximab in pediatric neuromyelitis optica. J Child Neurol 2011;26(2):244–7. doi:10.1177/0883073810381445. PubMed PMID: 21183724.
  • Pittock SJ, Lennon VA, McKeon A, et al. Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study. Lancet Neurol 2013;12(6):554–62. doi:10.1016/S1474-4422(13)70076-0. PubMed PMID: 23623397.
  • Wang HH, Dai YQ, Qiu W, et al. Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse. J Clin Neurosci 2011;18(10):1313–7. doi:10.1016/j.jocn.2011.01.031. PubMed PMID: 21795048.
  • Li Y, Wang H, Long Y, et al. Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis. J Neuroimmunol 2011;234(1–2):155–60. doi:10.1016/j.jneuroim.2011.03.009. PubMed PMID: 21489641.
  • Linhares UC, Schiavoni PB, Barros PO, et al. The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients. J Clin Immunol 2013;33(1):179–89. doi:10.1007/s10875-012-9780-2. PubMed PMID: 22948743.
  • Wong CK, Lit LC, Tam LS, et al. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 2008;127(3):385–93. doi:10.1016/j.clim.2008.01.019. PubMed PMID: 18373953.
  • Kaplin AI, Deshpande DM, Scott E, et al. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. J Clin Invest 2005;115(10):2731–41. doi:10.1172/JCI25141. PubMed PMID: 16184194.
  • Araki M, Matsuoka T, Miyamoto K, et al. Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study. Neurology 2014;82(15):1302–6. doi:10.1212/WNL.0000000000000317. PubMed PMID: 24634453.
  • Tradtrantip L, Zhang H, Saadoun S, et al. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol 2012;71(3):314–22. doi:10.1002/ana.22657. PubMed PMID: 22271321.
  • Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189(11):1747–56. PubMed PMID: 10359578.
  • Okada K, Matsushita T, Kira J, et al. B-cell activating factor of the TNF family is upregulated in neuromyelitis optica. Neurology 2010;74(2):177–8. doi:10.1212/WNL.0b013e3181c919ee. PubMed PMID: 20065253.
  • Wang H, Wang K, Zhong X, et al. Cerebrospinal fluid BAFF and APRIL levels in neuromyelitis optica and multiple sclerosis patients during relapse. J Clin Immunol 2012;32(5):1007–11. doi:10.1007/s10875-012-9709-9. PubMed PMID: 22644841.
  • Quan C, ZhangBao J, Lu J, et al. The immune balance between memory and regulatory B cells in NMO and the changes of the balance after methylprednisolone or rituximab therapy. J Neuroimmunol 2015;282:45–53. doi:10.1016/j.jneuroim.2015.03.016. PubMed PMID: 25903728.
  • Ishizu T, Osoegawa M, Mei FJ, et al. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 2005;128(Pt 5):988–1002. doi:10.1093/brain/awh453. PubMed PMID: 15743872.
  • Herges K, de Jong BA, Kolkowitz I, et al. Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein. Mult Scler 2012;18(4):398–408. doi:10.1177/1352458512440060. PubMed PMID: 22343184.
  • Saadoun S, Waters P, MacDonald C, et al. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol 2012;71(3):323–33. doi:10.1002/ana.22686. PubMed PMID: 22374891.
  • Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6(9):805–15. doi:10.1016/S1474-4422(07)70216-8. PubMed PMID: 17706564.
  • Uzawa A, Mori M, Ito M, et al. Markedly increased CSF interleukin-6 levels in neuromyelitis optica, but not in multiple sclerosis. J Neurol 2009;256(12):2082–4. doi:10.1007/s00415-009-5274-4. PubMed PMID: 19655191.
  • Barros PO, Cassano T, Hygino J, et al. Prediction of disease severity in neuromyelitis optica by the levels of interleukin (IL)-6 produced during remission phase. Clin Exp Immunol 2016;183(3):480–9. doi:10.1111/cei.12733. PubMed PMID: 26472479.
  • Ishizu T, Osoegawa M, Mei FJ, et al. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 2005;128(Pt 5):988–1002. doi:10.1093/brain/awh453. PubMed PMID: 15743872.
  • Chihara N, Aranami T, Sato W, et al. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 2011;108(9):3701–6. doi:10.1073/pnas.1017385108. PubMed PMID: 21321193.
  • Spolski R, Leonard WJ. IL-21 and T follicular helper cells. Int Immunol 2010;22(1):7–12. doi:10.1093/intimm/dxp112. PubMed PMID: 19933709.
  • Stromnes IM, Cerretti LM, Liggitt D, et al. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 2008;14(3):337–42. doi:10.1038/nm1715. PubMed PMID: 18278054.
  • Kroenke MA, Carlson TJ, Andjelkovic AV, et al. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 2008;205(7):1535–41. doi:10.1084/jem.20080159. PubMed PMID: 18573909.
  • Rothhammer V, Heink S, Petermann F, et al. Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE. J Exp Med. 2011;208(12):2465–76. doi:10.1084/jem.20110434. PubMed PMID: 22025301.
  • Liu SM, King C. IL-21-producing Th cells in immunity and autoimmunity. J Immunol 2013;191(7):3501–6. doi:10.4049/jimmunol.1301454. PubMed PMID: 24058193.
  • Uzawa A, Mori M, Arai K, et al. Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6. Mult Scler 2010;16(12):1443–52. doi:10.1177/1352458510379247. PubMed PMID: 20739337.
  • Takahashi T, Fujihara K, Nakashima I, et al. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 2007;130(Pt 5):1235–43. doi:10.1093/brain/awm062. PubMed PMID: 17449477.
  • Cardarelli PM, Quinn M, Buckman D, et al. Binding to CD20 by anti-B1 antibody or F(ab′)(2) is sufficient for induction of apoptosis in B-cell lines. Cancer Immunol Immunother 2002;51(1):15–24. doi:10.1007/s00262-001-0247-1. PubMed PMID: 11845256.
  • Edwards JC, Cambridge G. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol 2006;6(5):394–403. doi:10.1038/nri1838. PubMed PMID: 16622478.
  • Ribrag V, Koscielny S, Bosq J, et al. Rituximab and dose-dense chemotherapy for adults with Burkitt's lymphoma: a randomised, controlled, open-label, phase 3 trial. Lancet 2016; 387(10036):2402–11. doi:10.1016/S0140-6736(15)01317-3. PubMed PMID: 27080498.
  • Shankar AG, Kirkwood AA, Depani S, et al. Relapsed or poorly responsive nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents – a report from the United Kingdom's Children's Cancer and Leukaemia Study Group. Br J Haematol 2016;173(3):421–31. doi:10.1111/bjh.13979. PubMed PMID: 26996288.
  • De Keyser F, Hoffman I, Durez P, et al. Longterm followup of rituximab therapy in patients with rheumatoid arthritis: results from the Belgian MabThera in Rheumatoid Arthritis registry. J Rheumatol 2014;41(9):1761–5. doi:10.3899/jrheum.131279. PubMed PMID: 25128506.
  • Carubbi F, Alunno A, Cipriani P, et al. Rituximab in primary Sjögren's syndrome: a ten-year journey. Lupus 2014;23(13):1337–49. doi:10.1177/0961203314546023. PubMed PMID: 25096066.
  • He D, Yu Y, Yan W, et al. Individualized rituximab treatment for relapsing neuromyelitis optica: a pediatric case report. Pediatr Neurol 2014;51(2):255–8. doi:10.1016/j.pediatrneurol.2014.01.039. PubMed PMID: 25079575.
  • Yang CS, Yang L, Li T, et al. Responsiveness to reduced dosage of rituximab in Chinese patients with neuromyelitis optica. Neurology 2013;81(8):710–3. doi:10.1212/WNL.0b013e3182a1aac7. PubMed PMID: 23884041.
  • Beres SJ, Graves J, Waubant E. Rituximab use in pediatric central demyelinating disease. Pediatr Neurol 2014;51(1):114–8. doi:10.1016/j.pediatrneurol.2014.02.007. PubMed PMID: 24768216.
  • Capobianco M, Malucchi S, di SA, et al. Variable responses to rituximab treatment in neuromyelitis optica (Devic's disease). Neurol Sci 2007;28(4):209–11. doi:10.1007/s10072-007-0823-z. PubMed PMID: 17690854.
  • Lindsey JW, Meulmester KM, Brod SA, et al. Variable results after rituximab in neuromyelitis optica. J Neurol Sci 2012;317(1–2):103–5. doi:10.1016/j.jns.2012.02.017. PubMed PMID: 22405926.
  • Kim SH, Kim HJ. Lack of response to rituximab therapy in patients with neuromyelitis optica: true non-responders or insufficient treatment. J Neurol Sci 2012;319(1–2):171; author reply 172. doi:10.1016/j.jns.2012.05.005. PubMed PMID: 22633442.
  • Pellkofer HL, Krumbholz M, Berthele A, et al. Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 2011;76(15):1310–5. doi:10.1212/WNL.0b013e3182152881. PubMed PMID: 21482945.
  • Etemadifar M, Nasr Z, Khalili B, et al. Epidemiology of neuromyelitis optica in the world: a systematic review and meta-analysis. Mult Scler Int 2015;2015:174720. doi:10.1155/2015/174720. PubMed PMID: 25973275.
  • Jacob A, McKeon A, Nakashima I, et al. Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders. J Neurol Neurosurg Psychiatry 2013;84(8):922–30. doi:10.1136/jnnp-2012-302310. PubMed PMID: 23142960.
  • Thongpooswan S, Chapagain B, Bandagi S. A rare case of neuromyelitis optica spectrum disorder in patient with Sjogren's syndrome. Case Rep Rheumatol 2014;2014:158165. doi:10.1155/2014/158165. PubMed PMID: 25506022.
  • Kovacs KT, Kalluri SR, Boza-Serrano A, et al. Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: a preliminary study. Mult Scler 2016; 22(9):1192–201. doi:10.1177/1352458515613165. PubMed PMID: 26514978.
  • Saison J, Costedoat-Chalumeau N, Maucort-Boulch D, et al. Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. Lupus 2015;24(1):74–81. doi:10.1177/0961203314547795. PubMed PMID: 25117654.
  • Li H, Dai Y, Wu AM, et al. Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders. J Neuroimmunol 2015;281:38–43. doi:10.1016/j.jneuroim.2015.02.014. PubMed PMID: 25867466.
  • Sudulagunta SR, Sodalagunta MB, Khorram H, et al. Autoimmune thyroiditis associated with neuromyelitis optica (NMO). Ger Med Sci 2015;13:Doc22. doi:10.3205/000226. PubMed PMID: 26633965.
  • Nasir S, Kerr DA, Birnbaum J. Nineteen episodes of recurrent myelitis in a woman with neuromyelitis optica and systemic lupus erythematosus. Arch Neurol 2009;66(9):1160–3. doi:10.1001/archneurol.2009.194. PubMed PMID: 19752308.
  • Birnbaum J, Kerr D. Optic neuritis and recurrent myelitis in a woman with systemic lupus erythematosus. Nat Clin Pract Rheumatol 2008;4(7):381–6. doi:10.1038/ncprheum0818. PubMed PMID: 18493269.
  • Nosadini M, Alper G, Riney CJ, et al. Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. Neurol Neuroimmunol Neuroinflamm 2016;3(1):e188. doi:10.1212/NXI.0000000000000188. PubMed PMID: 26819962.
  • Jacob A, Weinshenker BG, Violich I, et al. Treatment of neuromyelitis optica with rituximab: retrospective analysis of 25 patients. Arch Neurol 2008;65(11):1443–8. doi:10.1001/archneur.65.11.noc80069. PubMed PMID: 18779415.
  • Fernández-Megía MJ, Casanova-Estruch B, Pérez-Miralles F, et al. Clinical evaluation of rituximab treatment for neuromyelitis optica. Neurologia 2015;30(8):461–4. doi:10.1016/j.nrl.2014.09.001. PubMed PMID: 25444411.
  • Kim SH, Kim W, Li XF, et al. Repeated treatment with rituximab based on the assessment of peripheral circulating memory B cells in patients with relapsing neuromyelitis optica over 2 years. Arch Neurol 2011;68(11):1412–20. doi:10.1001/archneurol.2011.154. PubMed PMID: 21747007.
  • Rommer PS, Dörner T, Freivogel K, et al. Safety and clinical outcomes of rituximab treatment in patients with multiple sclerosis and neuromyelitis optica: experience from a National Online Registry (GRAID). J Neuroimmune Pharmacol 2016;11(1):1–8. doi:10.1007/s11481-015-9646-5. PubMed PMID: 26589235.
  • Felli V, Di SA, Anselmi M, et al. Progressive multifocal leukoencephalopathy following treatment with Rituximab in an HIV-negative patient with non-Hodgkin lymphoma. A case report and literature review. Neuroradiol J 2014;27(6):657–64. PubMed PMID: 25489887.
  • Henegar CE, Eudy AM, Kharat V, et al. Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus: a systematic literature review. Lupus 2016;25(6):617–26. doi:10.1177/0961203315622819. PubMed PMID: 26743322.
  • Kim SH, Hyun JW, Jeong IH, et al. Anti-JC virus antibodies in rituximab-treated patients with neuromyelitis optica spectrum disorder. J Neurol 2015;262(3):696–700. doi:10.1007/s00415-014-7629-8. PubMed PMID: 25559683.
  • Kim SH, Jeong IH, Hyun JW, et al. Treatment outcomes with Rituximab in 100 patients with neuromyelitis optica: influence of FCGR3A polymorphisms on the therapeutic response to Rituximab. JAMA Neurol 2015;72(9):989–95. doi:10.1001/jamaneurol.2015.1276. PubMed PMID: 26167726.
  • Cornec D, Tempescul A, Querellou S, et al. Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy. Ann Hematol 2012;91(5):715–21. doi:10.1007/s00277-011-1369-y. PubMed PMID: 22083514.
  • Fujimoto K, Ida H, Hirota Y, et al. Intracellular dynamics and fate of a humanized anti-interleukin-6 receptor monoclonal antibody, Tocilizumab. Mol Pharmacol 2015;88(4):660–75. doi:10.1124/mol.115.099184. PubMed PMID: 26180046.
  • Saraux A, Rouanet S, Flipo RM, et al. Glucocorticoid-sparing in patients suffering from rheumatoid arthritis and treated with tocilizumab: the SPARE-1 study. Clin Exp Rheumatol 2016;34(2):303–10. PubMed PMID: 26941130.
  • Hirabayashi Y, Munakata Y, Miyata M, et al. Clinical and structural remission rates increased annually and radiographic progression was continuously inhibited during a 3-year administration of tocilizumab in patients with rheumatoid arthritis: a multi-center, prospective cohort study by the Michinoku Tocilizumab Study Group. Mod Rheumatol 2016:1–8. doi:10.3109/14397595.2016.1160991. PubMed PMID: 26934116.
  • Araki M, Aranami T, Matsuoka T, et al. Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. Mod Rheumatol 2013;23(4):827–31. doi:10.1007/s10165-012-0715-9. PubMed PMID: 22782533.
  • Ringelstein M, Ayzenberg I, Harmel J, et al. Long-term therapy with interleukin 6 receptor blockade in highly active neuromyelitis optica spectrum disorder. JAMA Neurol 2015;72(7):756–63. doi:10.1001/jamaneurol.2015.0533. PubMed PMID: 25985228.
  • Kieseier BC, Stüve O, Dehmel T, et al. Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: implication for cellular immune responses. JAMA Neurol 2013;70(3):390–3. doi:10.1001/jamaneurol.2013.668. PubMed PMID: 23599943.
  • Ayzenberg I, Kleiter I, Schröder A, et al. Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy. JAMA Neurol 2013;70(3):394–7. doi:10.1001/jamaneurol.2013.1246. PubMed PMID: 23358868.
  • Harmel J, Ringelstein M, Ingwersen J, et al. Interferon-β-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab. BMC Neurol 2014;14:247. doi:10.1186/s12883-014-0247-3. PubMed PMID: 25516429.
  • Komai T, Shoda H, Yamaguchi K, et al. Neuromyelitis optica spectrum disorder complicated with Sjogren syndrome successfully treated with tocilizumab: A case report. Mod Rheumatol 2016; 26(2):294–6. doi:10.3109/14397595.2013.861333. PubMed PMID: 24313919.
  • Loschi M, Porcher R, Barraco F, et al. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no-treatment study. Am J Hematol 2016;91(4):366–70. doi:10.1002/ajh.24278. PubMed PMID: 26689746.
  • Nakayama H, Usuki K, Echizen H, et al. Eculizumab dosing intervals longer than 17 days may be associated with greater risk of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria. Biol Pharm Bull 2016;39(2):285–8. doi:10.1248/bpb.b15-00703. PubMed PMID: 26830487.
  • Mallett A, Hughes P, Szer J, et al. Atypical haemolytic uraemic syndrome treated with the complement inhibitor eculizumab: the experience of the Australian compassionate access cohort. Intern Med J 2015;45(10):1054–65. doi:10.1111/imj.12864. PubMed PMID: 26247170.
  • Goncalves MV, Melo LH, Benedet CM, et al. Eculizumab, neuromyelitis optica, and tuberculosis: we live an era of challenging combinations. CNS Neurosci Ther 2015;21(11):914–5. doi:10.1111/cns.12465. PubMed PMID: 26404521.
  • Azzopardi L, Cox AL, McCarthy CL, et al. Alemtuzumab use in neuromyelitis optica spectrum disorders: a brief case series. J Neurol 2016;263(1):25–9. doi:10.1007/s00415-015-7925-y. PubMed PMID: 26477020.
  • Gelfand JM, Cotter J, Klingman J, et al. Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO. Neurol Neuroimmunol Neuroinflamm 2014;1(3):e34. doi:10.1212/NXI.0000000000000034. PubMed PMID: 25340086.
  • Uygunoğlu, Pasha M, Saip S, et al. Recurrent longitudinal extensive transverse myelitis in a neuro-Behçet syndrome treated with infliximab. J Spinal Cord Med 2015;38(1):111–4. doi:10.1179/2045772314Y.0000000209. PubMed PMID: 24673549.
  • Yamamura T, Miyake S. B-cell-directed therapy: which B cells should be targeted and how. Immunotherapy 2012;4(5):455–7. doi:10.2217/imt.12.35. PubMed PMID: 22642324.
  • Coiffier B, Thieblemont C, de Guibert S, et al. A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. Br J Haematol 2016. doi:10.1111/bjh.13992. PubMed PMID: 27010483.
  • Kantarjian HM, Lioure B, Kim SK, et al. A phase II study of Coltuximab Ravtansine (SAR3419) monotherapy in patients with relapsed or refractory acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk 2016;16(3):139–45. doi:10.1016/j.clml.2015.12.004. PubMed PMID: 26775883.
  • Hua F, Comer GM, Stockert L, et al. Anti-IL21 receptor monoclonal antibody (ATR-107): safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol 2014;54(1):14–22. doi:10.1002/jcph.158. PubMed PMID: 23913720.
  • Vaknin-Dembinsky A, Brill L, Kassis I, et al. T-cell responses to distinct AQP4 peptides in patients with neuromyelitis optica (NMO). Mult Scler Relat Disord 2016;6:28–36. doi:10.1016/j.msard.2015.12.004. PubMed PMID: 27063619.
  • Saadoun S, Waters P, Leite MI, et al. Neuromyelitis optica IgG causes placental inflammation and fetal death. J Immunol 2013;191(6):2999–3005. doi:10.4049/jimmunol.1301483. PubMed PMID: 23935196.
  • Tradtrantip L, Ratelade J, Zhang H, et al. Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody. Ann Neurol 2013;73(1):77–85. doi:10.1002/ana.23741. PubMed PMID: 23055279.

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