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Review Article

Cerebral small vessel disease and post-stroke cognitive impairment

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Pages 824-830 | Received 09 Aug 2016, Accepted 12 Nov 2016, Published online: 28 Nov 2016

References

  • Gottesman RF, Hillis AE. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurol 2010;9:895–905.
  • Jacquin A, Binquet C, Rouaud O, et al. Post-stroke cognitive impairment: high prevalence and determining factors in a cohort of mild stroke. J Alzheimers Dis 2014;40:1029–38.
  • Mellon L, Brewer L, Hall P, et al. Cognitive impairment six months after ischaemic stroke: a profile from the ASPIRE-S study. BMC Neurol 2015;15:31.
  • Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol 2009;8:1006–18.
  • Savva GM, Stephan BC. Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke 2010;41:e41–6.
  • Qu Y, Zhuo L, Li N, et al. Prevalence of post-stroke cognitive impairment in china: a community-based, cross-sectional study. PLoS One 2015;10:e0122864.
  • Bejot Y, Giroud M. Mean age at stroke onset: an instructive tool from epidemiological studies. Eur J Neurol 2009;16:e3.
  • Charidimou A, Pantoni L, Love S. The concept of sporadic cerebral small vessel disease: a road map on key definitions and current concepts. Int J Stroke 2016;11:6–18.
  • Norrving B. Evolving concept of small vessel disease through advanced brain imaging. J Stroke 2015;17:94–100.
  • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689–701.
  • Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–38.
  • Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol 2013;12:483–97.
  • Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:2672–713.
  • Ihara M, Yamamoto Y. Emerging evidence for pathogenesis of sporadic cerebral small vessel disease. Stroke 2016;47:554–60.
  • Ostergaard L, Engedal TS, Moreton F, et al. Cerebral small vessel disease: capillary pathways to stroke and cognitive decline. J Cereb Blood Flow Metab 2016;36:302–25.
  • De Silva TM, Faraci FM. Microvascular dysfunction and cognitive impairment. Cell Mol Neurobiol 2016;36:241–58.
  • Kim BJ, Lee SH. Prognostic impact of cerebral small vessel disease on stroke outcome. J Stroke 2015;17:101–10.
  • Pinter D, Enzinger C, Fazekas F. Cerebral small vessel disease, cognitive reserve and cognitive dysfunction. J Neurol 2015;262:2411–9.
  • Varghese V, Chandra SR, Christopher R, et al. Factors determining cognitive dysfunction in cerebral small vessel disease. Indian J Psychol Med 2016;38:56–61.
  • Dichgans M, Wardlaw J, Smith E, et al. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the joint programme for neurodegenerative disease research. Alzheimers Dement 2016. doi:10.1016/j.jalz.2016.06.004
  • Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol 2015;11:157–65.
  • de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001;70:9–14.
  • Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. Br Med J 2010;341:c3666.
  • Bolandzadeh N, Davis JC, Tam R, et al. The association between cognitive function and white matter lesion location in older adults: a systematic review. BMC Neurol 2012;12:126.
  • Dufouil C, Godin O, Chalmers J, et al. Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history. Stroke 2009;40:2219–21.
  • Sachdev PS, Brodaty H, Valenzuela MJ, et al. The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients. Neurology 2004;62:912–9.
  • Kliper E, Ben AE, Tarrasch R, et al. Cognitive state following stroke: the predominant role of preexisting white matter lesions. PLoS One 2014;9:e105461.
  • Kang HJ, Firbank M, Ogbole GI, et al. White matter hyperintensities and functional outcomes at 2 weeks and 1 year after stroke. Cerebrovasc Dis 2013;35:138–45.
  • Burton EJ, Kenny RA, O'Brien J, et al. White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients. Stroke 2004;35:1270–5.
  • Jokinen H, Kalska H, Mantyla R, et al. White matter hyperintensities as a predictor of neuropsychological deficits post-stroke. J Neurol Neurosurg Psychiatry 2005;76:1229–33.
  • Firbank MJ, Burton EJ, Barber R, et al. Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors. Neurobiol Aging 2007;28:1664–9.
  • Ihle-Hansen H, Thommessen B, Fagerland MW, et al. Impact of white matter lesions on cognition in stroke patients free from pre-stroke cognitive impairment: a one-year follow-up study. Dement Geriatr Cogn Dis Extra 2012;2:38–47.
  • Lambert C, Benjamin P, Zeestraten E, et al. Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. Brain 2016;139:1136–51.
  • Fan Y, Lan L, Zheng L, et al. Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior. Metab Brain Dis 2015;30:1479–86.
  • Lan LF, Zheng L, Yang X, et al. Peroxisome proliferator-activated receptor-gamma agonist pioglitazone ameliorates white matter lesion and cognitive impairment in hypertensive rats. CNS Neurosci Ther 2015;21:410–6.
  • Chen A, Akinyemi RO, Hase Y, et al. Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. Brain 2016;139:242–58.
  • Vermeer SE, Longstreth WJ, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurol 2007;6:611–9.
  • Makin SD, Turpin S, Dennis MS, et al. Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes. J Neurol Neurosurg Psychiatry 2013;84:893–900.
  • Bejot Y, Aboa-Eboule C, Durier J, et al. Prevalence of early dementia after first-ever stroke: a 24-year population-based study. Stroke 2011;42:607–12.
  • Chen CF, Lan SH, Khor GT, et al. Cognitive dysfunction after acute lacunar infarct. Kaohsiung J Med Sci 2005;21:267–71.
  • Rasquin SM, van Oostenbrugge RJ, Verhey FR, et al. Vascular mild cognitive impairment is highly prevalent after lacunar stroke but does not increase over time: a 2-year follow-up study. Dement Geriatr Cogn Disord 2007;24:396–401.
  • Grau-Olivares M, Arboix A. Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia? Expert Rev Neurother 2009;9:1201–17.
  • Edwards JD, Jacova C, Sepehry AA, et al. A quantitative systematic review of domain-specific cognitive impairment in lacunar stroke. Neurology 2013;80:315–22.
  • Blanco-Rojas L, Arboix A, Canovas D, et al. Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study. BMC Neurol 2013;13:203.
  • Yates PA, Villemagne VL, Ellis KA, et al. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front Neurol 2014;4:205.
  • Qiu C, Cotch MF, Sigurdsson S, et al. Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik study. Neurology 2010;75:2221–8.
  • Poels MM, Ikram MA, van der Lugt A, et al. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 2012;78:326–33.
  • Cordonnier C, Al-Shahi SR, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007;130:1988–2003.
  • Gregoire SM, Smith K, Jager HR, et al. Cerebral microbleeds and long-term cognitive outcome: longitudinal cohort study of stroke clinic patients. Cerebrovasc Dis 2012;33:430–5.
  • Brundel M, Kwa VI, Bouvy WH, et al. Cerebral microbleeds are not associated with long-term cognitive outcome in patients with transient ischemic attack or minor stroke. Cerebrovasc Dis 2014;37:195–202.
  • Werring DJ, Frazer DW, Coward LJ, et al. Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. Brain 2004;127:2265–75.
  • Gregoire SM, Scheffler G, Jager HR, et al. Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient ischemic attack. Stroke 2013;44:1267–72.
  • Wang Z, Wong A, Liu W, et al. Cerebral microbleeds and cognitive function in ischemic stroke or transient ischemic attack patients. Dement Geriatr Cogn Disord 2015;40:130–6.
  • Patel B, Lawrence AJ, Chung AW, et al. Cerebral microbleeds and cognition in patients with symptomatic small vessel disease. Stroke 2013;44:356–61.
  • Tang WK, Chen YK, Lu JY, et al. Absence of cerebral microbleeds predicts reversion of vascular ‘cognitive impairment no dementia’ in stroke. Int J Stroke 2011;6:498–505.
  • Jokinen H, Lipsanen J, Schmidt R, et al. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology 2012;78:1785–92.
  • Yang J, Wong A, Wang Z, et al. Risk factors for incident dementia after stroke and transient ischemic attack. Alzheimers Dement 2015;11:16–23.
  • Stebbins GT, Nyenhuis DL, Wang C, et al. Gray matter atrophy in patients with ischemic stroke with cognitive impairment. Stroke 2008;39:785–93.
  • Akinyemi RO, Firbank M, Ogbole GI, et al. Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors. BMC Res Notes 2015;8:625.
  • Kebets V, Gregoire SM, Charidimou A, et al. Prevalence and cognitive impact of medial temporal atrophy in a hospital stroke service: retrospective cohort study. Int J Stroke 2015;10:861–7.
  • Kliper E, Bashat DB, Bornstein NM, et al. Cognitive decline after stroke: relation to inflammatory biomarkers and hippocampal volume. Stroke 2013;44:1433–5.
  • Brundel M, de Bresser J, van Dillen JJ, et al. Cerebral microinfarcts: a systematic review of neuropathological studies. J Cereb Blood Flow Metab 2012;32:425–36.
  • Allan LM, Rowan EN, Firbank MJ, et al. Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. Brain 2011;134:3716–27.
  • Benjamin P, Viessmann O, MacKinnon AD, et al. 7 Tesla MRI in cerebral small vessel disease. Int J Stroke 2015;10:659–64.
  • Potter GM, Doubal FN, Jackson CA, et al. Enlarged perivascular spaces and cerebral small vessel disease. Int J Stroke 2015;10:376–81.
  • Huijts M, Duits A, Staals J, et al. Basal ganglia enlarged perivascular spaces are linked to cognitive function in patients with cerebral small vessel disease. Curr Neurovasc Res 2014;11:136–41.
  • Ramirez J, Berezuk C, McNeely AA, et al. Imaging the perivascular space as a potential biomarker of neurovascular and neurodegenerative diseases. Cell Mol Neurobiol 2016;36:289–99.
  • Hurford R, Charidimou A, Fox Z, et al. MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA. J Neurol Neurosurg Psychiatry 2014;85:522–5.
  • Arba F, Quinn TJ, Hankey GJ, et al. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. Int J Stroke 2016. doi:10.1177/1747493016666091

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