279
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia

&
Pages 384-396 | Received 09 Jan 2020, Accepted 20 Jul 2020, Published online: 11 Sep 2020

References

  • Toledo JB, Arnold SE, Raible K, et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain. 2013;136(Pt 9):2697–2706.
  • Murphy MP, Corriveau RA, Wilcock DM. Vascular contributions to cognitive impairment and dementia (VCID). Biochim Biophys Acta. 2016;1862(5):857–859.
  • Lu DL, Liu G, et al. Neuroprotective and anti-dementia role of Tongqiao Huoxue decoction in rats with vascular dementia. Int J Clin Exp Med. 2016;9:3197–3202.
  • Marshall RS. Effects of altered cerebral hemodynamics on cognitive function. J Alzheimers Dis. 2012;32(3):633–642.
  • Peters R. Blood pressure, smoking and alcohol use, association with vascular dementia. Exp Gerontol. 2012;47:865–872.
  • Sheng M, Lu H, Liu P, et al. Sildenafil improves vascular and metabolic function in patients with Alzheimer's disease. J Alzheimers Dis. 2017;60(4):1351–1364.
  • Jiwa NS, Garrard P, Hainsworth AH. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. J Neurochem. 2010;115(4):814–828.
  • Gooch J, Wilcock DM. Animal models of vascular cognitive impairment and dementia (VCID). Cell Mol Neurobiol. 2016;36(2):233–239.
  • Halene TB, Siegel SJ. PDE inhibitors in psychiatry – future options for dementia, depression and schizophrenia? Drug Discov Today. 2007;12(19–20):870–878.
  • Wu Y, Li Z, Huang YY, et al. Novel phosphodiesterase inhibitors for cognitive improvement in Alzheimer's disease. J Med Chem. 2018;61(13):5467–54688.
  • Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006;58(3):488–520.
  • Prickaerts J, Heckman PR, Blokland A. Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease. Expert Opin Investig Drugs. 2017;26(9):1033–1048.
  • Harrison SA, Reifsnyder DH, Gallis BY, et al. Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Mol Pharmacol. 1986;29(5):506–514.
  • Tanaka T, Ishikawa T, Hagiwara M, et al. Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle. Pharmacology. 1988;36(5):313–320.
  • Padma-Nathan H, McMurray JG, Pullman WE, for the IC351 On-Demand Dosing Study Group, et al. On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunction. Int J Impot Res. 2001;13(1):2–9.
  • Martinez A, Gil C. cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opin Ther Pat. 2014;24(12):1311–1321.
  • Ölmestig JN, Marlet IR, Hainsworth AH, et al. Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: a systematic review of preclinical studies. Cell Signal. 2017;38:39–48.
  • Titus DJ, Oliva AA, Wilson NM, et al. Phosphodiesterase inhibitors as therapeutics for traumatic brain injury. Curr Pharm Des. 2015;21(3):332–342.
  • Mao F, Wang H, Ni W, et al. Design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (ache) and phosphodiesterase 5 (PDE5) for the treatment of Alzheimer's disease. ACS Chem Neurosci. 2018;9(2):328–345.
  • Pauls MM, Clarke N, Trippier S, et al. Perfusion by arterial spin labelling following single dose tadalafil in small vessel disease (PASTIS): study protocol for a randomised controlled trial. Trials. 2017;18(1):229.
  • Schwartz BG, Jackson G, Stecher VJ, et al. Phosphodiesterase type 5 inhibitors improve endothelial function and may benefit cardiovascular conditions. Am J Med. 2013;126(3):192–199.
  • Bhatia P, Singh N. Ameliorative effect of phosphodiesterase-5 inhibitor in rat model of vascular dementia. Curr Neurovasc Res. 2019;16(1):27–39.
  • Sharma B, Singh N. Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology (Berl). 2011;215(4):677–687.
  • Gulati P, Singh N. Neuroprotective effect of tadalafil, a PDE-5 inhibitor, and its modulation by l-NAME in mouse model of ischemia–reperfusion injury. J Surg Res. 2014;186(1):475–483.
  • Mangat GS, Jaggi AS, Singh N. Ameliorative effect of a selective endothelin ETA receptor antagonist in rat model of l-Methionine-induced vascular dementia. Korean J Physiol Pharmacol. 2014;18(3):201–209.
  • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11(1):47–60.
  • Parle M, Singh N. Reversal of memory deficits by atorvastatin and simvastatin in rats. Yakugaku Zasshi. 2007;127(7):1125–1137.
  • Pieper GM, Langenstroer P, Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res. 1997;34(1):145–156.
  • Sharma B, Singh N. Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes. Curr Neurovasc Res. 2010;7(3):180–189.
  • Teixeira CE, Priviero FB, Webb RC. Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta. J Pharmacol Exp Ther. 2006;316(2):654–661.
  • Koladiya RU, Jaggi AS, Singh N, et al. Ameliorative role of atorvastatin and pitavastatin in l-Methionine induced vascular dementia in rats. BMC Pharmacol. 2008; 8:14.
  • Allam A, Ammar H, Radwan A. Serum homocysteine level and eye involvement in Egyptian patients with Behçet’s disease. Egypt Rheumatol. 2014;36(1):29–34.
  • Sastry K, Moudgal R, Mohan J, et al. Spectrophotometric determination of serum nitrite and nitrate by copper–cadmium alloy. Anal Biochem. 2002;306(1):79–82.
  • Ellman GL, Courtney KD, Andres VD, et al. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95.
  • Voss G, Sachsse K. Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by a modified acetylthiocholine/DTNB procedure. Toxicol Appl Pharmacol. 1970;16(3):764–772.
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358.
  • Beutler RG, Duron O, Kelly B. Improved methods for determination of blood reduced glutathion estimation. J Lab Clin Med. 1963;61:882–888.
  • Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Meth Enzymol. 1990;186:729–742.
  • Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265–275.
  • Banchroft AS, Turner DR. Theory and practice of histological techniques, 4th ed. Toronto, ON: Churchill Livingstone; 1996.
  • Lash JM, Haase EI, Shoukas AA. Systemic responses to carotid occlusion in the anesthetized rat. J Appl Physiol. 1992; 72(4):1247–1254.
  • Camarasa J, Rodrigo T, Pubill D, et al. Memantine is a useful drug to prevent the spatial and non-spatial memory deficits induced by methamphetamine in rats. Pharmacol Res. 2010;62(5):450–456.
  • Clarke R, Smith AD, Jobst KA, et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998; 55(11):1449–1455.
  • Smith AD, Refsum H, Bottiglieri T, et al. Homocysteine and dementia: an international consensus statement. J Alzheimers Dis. 2018;62(2):561–570.
  • Liu HH, Shih TS, Huang HR, et al. Plasma homocysteine is associated with increased oxidative stress and antioxidant enzyme activity in welders. Sci World J. 2013; 2013:1–8.
  • Bhatia P, Gupta S, Sharma S. Homocysteine excess and vascular endothelium dysfunction: delineating the pathobiological mechanisms. Int J Pharmacol. 2014;10(4):200–212.
  • Bonetti F, Brombo G, Zuliani G. The relationship between hyperhomocysteinemia and neurodegeneration. Neurodegener Dis Manag. 2016;6(2):133–145.
  • Škovierová H, Vidomanová E, Mahmood S, et al. The molecular and cellular effect of homocysteine metabolism imbalance on human health. IJMS. 2016;17(10):1733.
  • Bhatia P, Singh N. Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol. 2015;29(6):522–528.
  • Scherer EB, Loureiro SO, Vuaden FC, et al. Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues. Mol Neurobiol. 2014;50(2):589–596.
  • Xiao Y, Guan ZZ, Wu CX, et al. Correlations between cholinesterase activity and cognitive scores in post-ischemic rats and patients with vascular dementia. Cell Mol Neurobiol. 2012;32(3):399–407.
  • Saxena A, Fedorko JM, Vinayaka CR, et al. Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases. Eur J Biochem. 2003;270(22):4447–4458.
  • Tomimoto H, Ohtani R, Shibata M, et al. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dement Geriatr Cogn Disord. 2005;19(5–6):282–288.
  • Wang J, Zhang HY, Tang XC. Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment. Acta Pharmacol Sin. 2009;30(7):879–888.
  • Weekman EM, Sudduth TL, Price BR, et al. Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events. J Neuroinflammation. 2019;16(1):284.
  • Guzeloglu M, Yalcinkaya F, Atmaca S, et al. The beneficial effects of tadalafil on renal ischemia-reperfusion injury in rats. Urol Int. 2011;86(2):197–203.
  • Rashid M, Kotwani A, Fahim M. Long-acting phosphodiesterase-5 inhibitor, tadalafil, and superoxide dismutasemimetic, tempol, protect against acute hypoxia-induced pulmonary hypertension in rats. Hum Exp Toxicol. 2012;31(6):626–636.
  • Zhang R, Wang Y, Zhang L, et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke. 2002;33(11):2675–2680.
  • Nunes AKdS, Rapôso C, Luna RLdA, et al. Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model. Cytokine. 2012;60(2):540–551.
  • Guazzi M, Samaja M. The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development. Curr Med Chem. 2007;14(20):2181–2191.
  • Singh N, Parle M. Sildenafil improves acquisition and retention of memory in mice. Indian J Physiol Pharmacol. 2003; 47:318–324.
  • Pelliccione F, D'Angeli A, D'Andrea S, et al. Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk. Asian J Androl. 2014;16(2):290–294.
  • Jin F, Gong QH, Xu YS, et al. Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling. Int J Neuropsychopharmacol. 2014;17(6):871–881.
  • Pezet S, Cunningham J, Patel J, et al. BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn. Mol Cell Neurosci. 2002;21(1):51–62.
  • Koladiya RU, Jaggi AS, Singh N, et al. Beneficial effects of donepezil on vascular endothelial dysfunction-associated dementia induced by l-Methionine in rats. J Health Sci. 2009;55(2):215–225.
  • Kumar A, Kumar A, Jaggi AS, et al. Efficacy of Cilostazol a selective phosphodiesterase-3 inhibitor in rat model of streptozotocin diabetes induced vascular dementia. Pharmacol Biochem Behav. 2015;135:20–30.
  • Black S, Román GC, Geldmacher DS, et al. Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. Stroke. 2003;34(10):2323–2330.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.