Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19

References

• Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733.
   PubMed Web of Science ®Google Scholar
• Zhou P, Yang X-L, Wang X-G, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–273.
   PubMed Web of Science ®Google Scholar
• Asghari A, Naseri M, Safari H, et al. The novel insight of SARS-CoV-2 molecular biology and pathogenesis and therapeutic options. DNA Cell Biol. 2020;39(10):1741–1753.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). November 2019. 2020.
   Google Scholar
• Poyiadji N, Shahin G, Noujaim D, et al. COVID-19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology. 2020;296(2):E119–E120.
   PubMed Web of Science ®Google Scholar
• Das G, Mukherjee N, Ghosh S. Neurological Insights of COVID-19 pandemic. ACS Chem Neurosci. 2020;11(9):1206–1209.
   PubMed Web of Science ®Google Scholar
• Wu C, Zheng M. Single-cell RNA expression profiling shows that ACE2, the putative receptor of Wuhan 2019-nCoV, has significant expression in the nasal, mouth, lung and colon tissues, and tends to be co-expressed with HLA-DRB1 in the four tissues. 2020. DOI:10.21203/rs.3.rs-16992/v1. PPR:PPR123290.
   Google Scholar
• Ellul M, Solomon T. Acute encephalitis - diagnosis and management. Clin Med (Lond)). 2018;18(2):155–159.
   PubMed Web of Science ®Google Scholar
• Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med. 2005;202(3):415–424.
   PubMed Web of Science ®Google Scholar
• Mizuguchi M, Yamanouchi H, Ichiyama T, et al. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand. 2007;115(4 Suppl):45–56.
   PubMed Web of Science ®Google Scholar
• Tauber SC, Eiffert H, Brück W, et al. Septic encephalopathy and septic encephalitis. Expert Rev anti Infect Ther. 2017;15(2):121–132.
   PubMed Web of Science ®Google Scholar
• Dobbs MR. Toxic encephalopathy. Semin Neurol. 2011;31(2):184–93.
   PubMed Web of Science ®Google Scholar
• Lee N, Wong CK, Chan PK, et al. Acute encephalopathy associated with influenza A infection in adults. Emerg Infect Dis. 2010;16(1):139–142.
   PubMed Web of Science ®Google Scholar
• Mao L, Wang M, Chen S, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. MedR. 2020;xiv. DOI:10.1101/2020.02.22.20026500
   Google Scholar
• Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–422.
   PubMed Web of Science ®Google Scholar
• Elkind MS. Why now? Moving from stroke risk factors to stroke triggers. Curr Opin Neurol. 2007;20(1):51–57.
   PubMed Web of Science ®Google Scholar
• Warren-Gash C, Blackburn R, Whitaker H, et al. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018;51(3):1701794.
   PubMed Web of Science ®Google Scholar
• Muhammad S, Haasbach E, Kotchourko M, et al. Influenza virus infection aggravates stroke outcome. Stroke. 2011;42(3):783–791.
   PubMed Web of Science ®Google Scholar
• Li Y, Li H, Fan R, et al. Coronavirus infections in the central nervous system and respiratory tract show distinct features in hospitalized children. Intervirology. 2016;59(3):163–169.
   PubMed Web of Science ®Google Scholar
• Fan W, Su Z, Bin Y, et al. Holmes EC, Zhang Y-Z, A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265–269.
   PubMed Web of Science ®Google Scholar
• Tsai L-K, Hsieh S-T, Chao C-C, et al. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol. 2004;61(11):1669–1673.
   PubMedGoogle Scholar
• Hosking MP, Lane TE. The pathogenesis of murine coronavirus infection of the central nervous system. Crit Rev Immunol. 2010;30(2):119–130.
   PubMed Web of Science ®Google Scholar
• Arbour N, Day R, Newcombe J, et al. Neuroinvasion by human respiratory coronaviruses. J Virol. 2000;74(19):8913–8921.
   PubMed Web of Science ®Google Scholar
• Cheyette SR, Cummings JL. Encephalitis lethargica: lessons for contemporary neuropsychiatry. J Neuropsychiatry Clin Neurosci. 1995;7(2):125–34. DOI:10.1176/jnp.7.2.125
   Google Scholar
• Fazzini E, Fleming J, Fahn S. Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease. Mov Disord. 1992;7(2):153–158.
   PubMed Web of Science ®Google Scholar
• Desforges M, Le Coupanec A, Dubeau P, et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. 2019;12(1):14.
   PubMed Web of Science ®Google Scholar
• To K, Lo AW. Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2) ). J Pathol. 2004;203(3):740–743.
   PubMed Web of Science ®Google Scholar
• Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme–related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87(5):e1–e9.
   PubMed Web of Science ®Google Scholar
• Mattern T, Scholz W, Feller A, et al. Expression of CD26 (dipeptidyl peptidase IV) on resting and activated human T-lymphocytes. Scand J Immunol. 1991;33(6):737–748.
   PubMed Web of Science ®Google Scholar
• Boonacker E, Van Noorden CJ. The multifunctional or moonlighting protein CD26/DPPIV. Eur J Cell Biol. 2003;82(2):53–73.
   PubMed Web of Science ®Google Scholar
• Chan PK, To KF, Lo AW, et al. Persistent infection of SARS coronavirus in colonic cells in vitro. J Med Virol. 2004;74(1):1–7.
   PubMed Web of Science ®Google Scholar
• Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol. 2003;200(3):282–289.
   PubMed Web of Science ®Google Scholar
• Bernstein H-G, Dobrowolny H, Keilhoff G, et al. Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques. Neurochem Int. 2018;114:55–57.
   PubMed Web of Science ®Google Scholar
• Ding Y, He L, Zhang Q, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 2004;203(2):622–630.
   PubMed Web of Science ®Google Scholar
• Xu J, Zhong S, Liu J, et al. Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis. 2005;41(8):1089–1096.
   PubMed Web of Science ®Google Scholar
• Netland J, Meyerholz DK, Moore S, et al. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol. 2008;82(15):7264–7275.
   PubMed Web of Science ®Google Scholar
• Khan S, Ali A, Siddique R, et al. Novel coronavirus is putting the whole world on alert. J Hosp Infect. 2020;104(3):252–253.
   PubMed Web of Science ®Google Scholar
• Li Y-C, Bai W-Z, Hirano N, et al. Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res. 2012;163(2):628–635.
   PubMed Web of Science ®Google Scholar
• Mengeling W, Wl M, Ad B, et al. Characteristics of a coronavirus (strain 67N) of pigs. Am J Vet Res. 1972;33(2):297–308.
   PubMed Web of Science ®Google Scholar
• Andries K, Pensaert M. Immunofluorescence studies on the pathogenesis of hemagglutinating encephalomyelitis virus infection in pigs after oronasal inoculation. Am J Vet Res. 1980;41(9):1372–1378.
   PubMed Web of Science ®Google Scholar
• Matsuda K, Park C, Sunden Y, et al. The vagus nerve is one route of transneural invasion for intranasally inoculated influenza a virus in mice. Vet Pathol. 2004;41(2):101–107.
   PubMed Web of Science ®Google Scholar
• Dubé M, Le Coupanec A, Wong AH, et al. Axonal transport enables neuron-to-neuron propagation of human coronavirus OC43. J Virol. 2018;92(17):e00404.
   PubMed Web of Science ®Google Scholar
• Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin-converting enzyme cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275(43):33238–33243.
   PubMed Web of Science ®Google Scholar
• Rice GI, Thomas DA, Grant PJ, et al. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383(Pt 1):45–51.
   PubMed Web of Science ®Google Scholar
• Walls AC, Park Y-J, Tortorici MA, et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181(2):281–292.e6.
   PubMed Web of Science ®Google Scholar
• Yan R, Zhang Y, Li Y, et al. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444–1448.
   PubMed Web of Science ®Google Scholar
• Shang J, Ye G, Shi K, et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020;581(7807):221–224.
   PubMed Web of Science ®Google Scholar
• Miller AJ, Arnold AC. The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications. Clin Auton Res. 2019;29(2):231–243.
   PubMed Web of Science ®Google Scholar
• Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 2004;25(6):291–294.
   PubMed Web of Science ®Google Scholar
• Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260–1263.
   PubMed Web of Science ®Google Scholar
• Baig AM, Khaleeq A, Ali U, et al. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020;11(7):995–998.
   PubMed Web of Science ®Google Scholar
• Kochar IS, Ramachandran S, Kochar G. Care of pediatric and adolescent endocrine disorders during COVID-19 pandemic: personal practice. Apollo Medicine. 2020;17(5):11.
   Google Scholar
• Millet JK, Whittaker GR. Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis. Virus Res. 2015;202:120–134.
   PubMed Web of Science ®Google Scholar
• Zhou D, Qi R, Zhang W. Accessible surface glycopeptide motifs on spike glycoprotein of 2019-nCoV: implications on vaccination and antibody therapeutics. 2020:2020020381. DOI:10.20944/preprints202002.0381.v1
   Google Scholar
• Chlamydas S, Papavassiliou AG, Piperi C. Epigenetic mechanisms regulating COVID-19 infection. Epigenetics. 2020:1–8. DOI:10.1080/15592294.2020.1796896
   PubMed Web of Science ®Google Scholar
• Aghagoli G, Gallo Marin B, Katchur NJ, et al. Neurological involvement in COVID-19 and potential mechanisms: a review. Neurocritical Care. 2020:1–10. DOI:10.1007/s12028-020-01049-4
   Web of Science ®Google Scholar
• Gemmati D, Bramanti B, Serino ML, et al. COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in females be protective against SARS-CoV-2 compared to the single X-chromosome in males? Int J Mol Sci. 2020;21(10):3474. DOI:10.3390/ijms21103474
   PubMed Web of Science ®Google Scholar
• Bergman A, Atzmon G, Ye K, et al. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput Biol. 2007;3(8):e170.
   PubMed Web of Science ®Google Scholar
• Finch CE, Kulminski AM. The ApoE locus and COVID-19: are we going where we have been? J Gerontol A Biol Sci Med Sci. 2020;glaa200. DOI:10.1093/gerona/glaa200
   Google Scholar
• Fuior EV, Gafencu AV. Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond. Int J Mol Sci. 2019;20(23):5939.
   PubMed Web of Science ®Google Scholar
• Moriguchi T, Harii N, Goto J, et al. A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020;94:55–58.
   PubMed Web of Science ®Google Scholar
• Lau K-K, Yu W-C, Chu C-M, et al. Possible central nervous system infection by SARS coronavirus. Emerg Infect Dis. 2004;10(2):342–344.
   PubMed Web of Science ®Google Scholar
• Duong L, Xu P, Liu A. Meningoencephalitis without respiratory failure in a young female patient with covid-19 infection in downtown Los Angeles, early April 2020. Brain Behav Immun. 2020;87:33.
   PubMed Web of Science ®Google Scholar
• Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun. 2020;88:945–946.
   PubMed Web of Science ®Google Scholar
• Tseng C-TK, Huang C, Newman P, et al. Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol. 2007;81(3):1162–1173.
   PubMed Web of Science ®Google Scholar
• Gholipoor P, Saboory E, Ghazavi A, et al. Prenatal stress potentiates febrile seizure and leads to long-lasting increase in cortisol blood levels in children under 2years old. Epilepsy Behav. 2017;72:22–27.
   PubMed Web of Science ®Google Scholar
• Bohmwald K, Galvez N, Ríos M, et al. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386.
   PubMed Web of Science ®Google Scholar
• Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034.
   PubMed Web of Science ®Google Scholar
• Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev. 2018;98(1):477–504.
   PubMed Web of Science ®Google Scholar
• Jasti M, Nalleballe K, Dandu V, et al. A review of pathophysiology and neuropsychiatric manifestations of COVID-19. J Neurol. 2020:1–6. DOI:10.1007/s00415-020-09950-w
   Web of Science ®Google Scholar
• Reinhold A, Rittner H. Barrier function in the peripheral and central nervous system-a review. Pflugers Arch. 2017;469(1):123–134.
   PubMed Web of Science ®Google Scholar