Synchronous multiple ipsilateral breast cancers: implications for patient management

References

• Cheatle G L. Benign and malignant changes in duct epithelium of breast. Br J Surg 1921; 8: 285–306
   Google Scholar
• Cheatle G L, Cutler M. Tumours of the Breast: Their Pathology, Symptoms, Diagnosis and Treatment. JB Lippincott, Philadelphia 1931; 161
   Google Scholar
• Qualheim R E, Gall E A. Breast carcinoma with multiple sites of origin. Cancer 1957; 10: 460–8
   PubMed Web of Science ®Google Scholar
• Morgenstern L, Kaufman P A, Friedman N B. The case against tylectomy for carcinoma of the breast. The factor of multicentricity. Am J Surg 1975; 130: 251–8
   PubMed Web of Science ®Google Scholar
• Fisher E R, Gregorio R, Redmond C, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4). I. Observations concerning the multicentricity of mammary cancer. Cancer 1975; 35: 247–54
   PubMed Web of Science ®Google Scholar
• Lagios M D. Multicentricity of breast carcinoma demonstrated by routine correlated serial subgross and radiographic examination. Cancer 1977; 40: 1726–34
   PubMed Web of Science ®Google Scholar
• Schwartz G F, Patchefsky A S, Feig S A, et al. Clinically occult breast cancer. Multicentricity and implications for treatment. Ann Surg 1980; 191: 8–12
   PubMed Web of Science ®Google Scholar
• Westman-Naeser S, Bengtsson E, Eriksson O, et al. Multifocal breast carcinoma. Am J Surg 1981; 142: 255–7
   PubMed Web of Science ®Google Scholar
• Egan R L. Multicentric breast carcinomas: clinical-radiographic-pathologic whole organ studies and 10-year survival. Cancer 1982; 49: 1123–30
   PubMed Web of Science ®Google Scholar
• Holland R, Veling S H, Mravunac M, Hendriks J H. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 1985; 56: 979–90
   PubMed Web of Science ®Google Scholar
• Fisher E R, Sass R, Fisher B, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6). II. Relation of local breast recurrence to multicentricity. Cancer 1986; 57: 1717–24
   PubMed Web of Science ®Google Scholar
• Tavassolli F A. Pathology of the Breast. 2nd ed. Appleton and Lange, Hong Kong 1999; 56–58
   Google Scholar
• ‘Sardanelli F, Giuseppetti G M, Panizza P, et al. Sensitivity of MRI versus mammography for detecting foci of multifocal, multicentric breast cancer in fatty and dense breasts using the whole-breast pathologic examination as a gold standard. Am J Roentgenol 2004; 183: 1149–57
   PubMed Web of Science ®Google Scholar
• Dawson P J, Baekey P A, Clark R A. Mechanisms of multifocal breast cancer: an immunocytochemical study. Hum Pathol 1995; 26: 965–9
   PubMed Web of Science ®Google Scholar
• Middleton L P, Vlastos G, Mirza N Q, et al. Multicentric mammary carcinoma: evidence of monoclonal proliferation. Cancer 2002; 94: 1910–6
   PubMed Web of Science ®Google Scholar
• Noguchi S, Aihara T, Koyama H, et al. Discrimination between multicentric and multifocal carcinomas of the breast through clonal analysis. Cancer 1994; 74: 872–7
   PubMed Web of Science ®Google Scholar
• Tsuda H, Hirohashi S. Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q. Cancer Res 1995; 55: 3395–8
   PubMed Web of Science ®Google Scholar
• Teixeira M R, Pandis N, Bardi G, et al. Discrimination between multicentric and multifocal breast carcinoma by cytogenetic investigation of macroscopically distinct ipsilateral lesions. Genes Chromosomes Cancer 1997; 18: 170–4
   PubMed Web of Science ®Google Scholar
• Teixeira M R, Pandis N, Bardi G, et al. Cytogenetic analysis of multifocal breast carcinomas: dectection of karyotypically unrelated clones as well as clonal similarities between tumour foci. Br J Cancer 1997; 56: 855–9
   Google Scholar
• Teixeira M R, Ribeiro F R, Torres L, et al. Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis. Br J Cancer 2004; 91: 775–82
   PubMed Web of Science ®Google Scholar
• Wa C V, DeVries S, Chen Y Y, et al. Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors. Mod Pathol 2005; 18: 591–7
   PubMed Web of Science ®Google Scholar
• Dawson P J. What is new in our understanding of multifocal breast cancer?. Pathol Res Pract 1993; 189: 111–6
   PubMed Web of Science ®Google Scholar
• Katz A, Strom E A, Buchholz T A, et al. The influence of pathologic tumor characteristics on locoregional recurrence rates following mastectomy. Int J Radiat Oncol Biol Phys 2001; 50: 735–42
   PubMed Web of Science ®Google Scholar
• Derebek E, Balci P, Alanyali H, et al. Detection of bilateral multifocal breast cancer using Tc-99m sestamibi imaging. The role of delayed imaging. Clin Nucl Med 1999; 24: 590–3
   PubMed Web of Science ®Google Scholar
• Cwikla J B, Buscombe J R, Holloway B, et al. Can scintimammography with (99m) Tc-MIBI identify multifocal and multicentric primary breast cancer?. Nucl Med Commun 2001; 22: 1287–93
   PubMed Web of Science ®Google Scholar
• Moon W K, Noh D Y, Im J G. Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients. Radiology 2002; 224: 569–76
   PubMed Web of Science ®Google Scholar
• Fischer U, Zachariae O, Baum F, et al. The influence of preoperative MRI of the breasts on recurrence rate in patients with breast cancer. Eur Radiol 2004; 14: 1725–31
   PubMed Web of Science ®Google Scholar
• Wilkinson L S, Given-Wilson R, Hall T, et al. Increasing the diagnosis of multifocal primary breast cancer by the use of bilateral whole-breast ultrasound. Clin Radiol 2005; 60: 573–8
   PubMed Web of Science ®Google Scholar
• Piwkowski P, Zielińska D, Kołodziejczyk A, et al. Clinical importance of (99m) Tc-MIBI mammoscintigraphy in multifocal breast lesions. Nucl Med Rev Cent East Eur 2006; 9: 144–6
   PubMedGoogle Scholar
• Spanu A, Cottu P, Manca A, et al. Scintimammography with dedicated breast camera in unifocal and multifocal/multicentric primary breast cancer detection: a comparative study with SPECT. Int J Oncol 2007; 31: 369–77
   PubMed Web of Science ®Google Scholar
• Braun M, Pölcher M, Schrading S, et al. Influence of preoperative MRI on the surgical management of patients with operable breast cancer. Breast Cancer Res Treat 2008; 111: 179–87
   PubMed Web of Science ®Google Scholar
• Spanu A, Chessa F, Battista Meloni G, et al. Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study. Q J Nucl Med Mol Imaging 2008, Apr 25: (Epub ahead of print)
   Web of Science ®Google Scholar
• Houssami N, Ciatto S, Macaskill P, et al. Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer. J Clin Oncol 2008; 26: 3248–58
   PubMed Web of Science ®Google Scholar
• Drew P J, Chatterjee S, Turnbull L W, et al. Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer. Ann Surg Oncol 1999; 6: 599–603
   PubMed Web of Science ®Google Scholar
• Van Goethem M, Schelfout K, Dijckmans L, et al. MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue: comparison with mammography and ultrasound. Eur Radiol 2004; 14: 809–16
   PubMed Web of Science ®Google Scholar
• Hlawatsch A, Teifke A, Schmidt M, et al. Preoperative assessment of breast cancer: sonography versus MR imaging. AJR 2002; 179: 1493–501
   PubMed Web of Science ®Google Scholar
• Lagios M D, Westdahl P R, Rose M R. The concept and implications of multicentricity in breast carcinoma. Pathol Annu 1981; 16: 83–102
   PubMedGoogle Scholar
• Rezo A, Rodins K, Davis A J, et al. Assessment of tumour size and its relationship to nodal involvement in multifocal and multicentric breast cancer. J Clin Oncol 2007; 25: 10602
   Web of Science ®Google Scholar
• Sarnelli R, Squartini F. Multicentricity in breast cancer: a submacroscopic study. Pathol Annu 1986; 21: 143–58
   PubMedGoogle Scholar
• Sikand K, Lee A H, Pinder S E, et al. Sections of the nipple and quadrants in mastectomy specimens for carcinoma are of limited value. J Clin Pathol 2005; 58: 543–5
   PubMed Web of Science ®Google Scholar
• Coombs N J, Boyages J. Multifocal and multicentric breast cancer: does each focus matter?. J Clin Oncol 2005; 23: 7497–502
   PubMed Web of Science ®Google Scholar
• Overton K, Shadbolt B, Fadia M, et al. Detection of breast cancer in surgical specimens by trainees: what trainee characteristics matter?. Pathol Int 2008; 58: A8
   Google Scholar
• Royal College of Pathologists of Australasia (RCPA). Trainee Handbook, 24 September. RCPA, Sydney 2007, 2007; 51. http://www.rcpa.edu.au/public/default.cfm (accessed 8 July 2008)
   Google Scholar
• Faverly D R, Burgers L, Bult P, Holland R. Three dimensional imaging of mammary ductal carcinoma in situ: clinical implications. Semin Diagn Pathol 1994; 11: 193–8
   PubMed Web of Science ®Google Scholar
• Gump F E, Shikora S, Habif D V, et al. The extent and distribution of cancer in breasts with palpable primary tumors. Ann Surg 1986; 204: 384–90
   PubMed Web of Science ®Google Scholar
• Chua B, Ung O, Taylor R, Boyages J. Frequency and predictors of axillary lymph node metastases in invasive breast cancer. ANZ J Surg 2001; 71: 723–8
   PubMed Web of Science ®Google Scholar
• Andea A A, Wallis T, Newman L A, et al. Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma. Cancer 2002; 94: 1383–90
   PubMed Web of Science ®Google Scholar
• Greene F L, Page D L, Fleming I D. AJCC Cancer Staging Handbook/American Joint Committee on Cancer. 6th ed. Springer-Verlag, New York 2002; 261
   Google Scholar
• Andea A A, Bouwman D, Wallis T, Visscher D W. Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma. Cancer 2004; 100: 20–27
   PubMed Web of Science ®Google Scholar
• Fish E B, Chapman J A, Link M A. Assessment of tumor size for multifocal primary breast cancer. Ann Surg Oncol 1998; 5: 442–6
   PubMed Web of Science ®Google Scholar
• Tresserra F, Rodriguez I, García-Yuste M, et al. Tumor size and lymph node status in multifocal breast cancer. Breast J 2007; 13: 68–71
   PubMed Web of Science ®Google Scholar
• O'Daly B J, Sweeney K J, Ridgway P F, et al. The accuracy of combined versus largest diameter in staging multifocal breast cancer. J Am Coll Surg 2007; 204: 282–5
   PubMed Web of Science ®Google Scholar
• Fisher B, Bauer M, Margolese R, et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 1985; 312: 665–73
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. N Engl J Med 1995; 333: 1444–55
   PubMed Web of Science ®Google Scholar
• Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: 1233–41
   PubMed Web of Science ®Google Scholar
• Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347: 1227–32
   PubMed Web of Science ®Google Scholar
• Fisher B, Wickerham D L, Deutsch M, et al. Breast tumor recurrence following lumpectomy with and without breast irradiation: an overview of recent NSABP findings. Semin Surg Oncol 1992; 8: 153–60
   PubMedGoogle Scholar
• Schwartz G F, Veronesi U, Clough K B, et al. Consensus Conference Committee. Proceedings of the Consensus Conference on Breast Conservation, April 28 to May 1, 2005, Milan, Italy. Cancer 2006; 107: 242–50
   PubMed Web of Science ®Google Scholar
• Kurniawan E D, Wong M H, Windle I, et al. Predictors of surgical margin status in breast-conserving surgery within a breast screening program. Ann Surg Oncol 2008; 15: 2542–9
   PubMed Web of Science ®Google Scholar
• Solin L J, Orel S G, Hwang W T, et al. Relationship of breast magnetic resonance imaging to outcome after breast-conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ. J Clin Oncol 2008; 26: 386–91
   PubMed Web of Science ®Google Scholar
• Fowble B, Yeh I T, Schultz D J, et al. The role of mastectomy in patients with stage I-II breast cancer presenting with gross multifocal or multicentric disease or diffuse microcalcifications. Int J Radiat Oncol Biol Phys 1993; 27: 567–73
   PubMed Web of Science ®Google Scholar
• Vlastos G, Rubio I T, Mirza N Q, et al. Impact of multicentricity on clinical outcome in patients with T1-2, N0-1, M0 breast cancer. Ann Surg Oncol 2000; 7: 581–7
   PubMed Web of Science ®Google Scholar
• Rakowsky E, Klein B, Kahan E, et al. Prognostic factors in node-positive operable breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat 1992; 21: 121–31
   PubMed Web of Science ®Google Scholar
• Pedersen L, Gunnarsdottir K A, Rasmussen B B, et al. The prognostic influence of multifocality in breast cancer patients. Breast 2004; 13: 188–93
   PubMed Web of Science ®Google Scholar
• Haley M M, Garces Y I, Kee A Y, et al. Breast conservation therapy (BCT) in multifocal vs. unifocal early stage breast cancer patients: the Mayo experience. Int J Radiat Oncol Biol Phys 2007; 69(Suppl)S208–9
   Web of Science ®Google Scholar
• Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 1997; 349: 1864–7
   PubMed Web of Science ®Google Scholar
• Houssami N, French J, Brennan M, et al. Breast cancer—new and emerging technologies for diagnosis and management. Aust Fam Physician 2005; 34: 657–61
   PubMedGoogle Scholar
• Kumar R, Jana S, Heiba S I, et al. Retrospective analysis of sentinel node localization in multifocal, multicentric, palpable, or nonpalpable breast cancer. J Nucl Med 2003; 44: 7–10
   PubMed Web of Science ®Google Scholar
• Goyal A, Newcombe R G, Mansel R E, et al. Sentinel lymph node biopsy in patients with multifocal breast cancer. Eur J Surg Oncol 2004; 30: 475–9
   PubMed Web of Science ®Google Scholar
• Goyal A, Mansel R E. Multifocality and sentinel node biopsy in breast cancer. Eur J Surg Oncol 2004; 30: 3–4
   PubMed Web of Science ®Google Scholar
• Ferrari A, Dionigi P, Rovera F, et al. Multifocality and multicentricity are not contraindications for sentinel lymph node biopsy in breast cancer surgery. World J Surg Oncol 2006; 4: 79
   PubMedGoogle Scholar
• Behm E C, Buckingham J M. Sentinel node biopsy in larger or multifocal breast cancers: to do or not to do. ANZ J Surg 2008; 78: 151–7
   PubMed Web of Science ®Google Scholar
• Knauer M, Konstantiniuk P, Haid A, et al. Multicentric breast cancer: a new indication for sentinel node biopsy—a multi-institutional validation study. J Clin Oncol 2006; 24: 3374–80
   PubMed Web of Science ®Google Scholar
• Australian Cancer Network Working Party. The Pathology Reporting of Breast Cancer. A Guide for Pathologists, Surgeons, Radiologists and Oncologists: Recommendations of the Australian Cancer Network Working Party. 2nd ed. IntraMed Educational Group, North Sydney 2001
   Google Scholar