A practical approach to the understanding and diagnosis of lymphoma: an assessment of the WHO classification based on immunoarchitecture and immuno-ontogenic principles

References

• Swerdlow S H, Campo E, Harris N L, et al. Pathology and Genetics. Tumours of Haematopoeitic and Lymphoid Tissues. World Health Organisation Classification of Tumours. International Agency for Research on Cancer, Lyon 2008
   Google Scholar
• Marafioti T, Hummel M, Foss H D, et al. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 2000; 95: 1443–1450
   PubMed Web of Science ®Google Scholar
• Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 1997; 337: 453–458
   PubMed Web of Science ®Google Scholar
• Hall P A. Differentiation, stem cells and tumour histogenesis. Recent Advances in Histopathology, P P Anthony, R NM MacSween. Churchill Livingstone, Edinburgh 1992; 15: 1–16
   Google Scholar
• Graham C F. Tumour cell differentiation and control. Oxford Textbook of Pathology, JO'D Mc Gee, P G Isaacson, N A Wright. Oxford University Press, Oxford 1992; 1: 597–607
   Google Scholar
• Wynford-Thomas D. Telomeres, tumour-suppressors and lifespan checkpoints: implications for tumour pathology. Progress in Pathology, N Kirkham, N R Lemoine. Churchill Livingstone, Edinburgh 1998; 4: 79–97
   Google Scholar
• Kadin M E. Hodgkin disease: cell of origin, immunobiology and pathogenesis. Neoplastic Hematopathology, D M Knowles. Williams and Wilkins, Philadelphia 2001; 667–690
   Google Scholar
• Müller G, Hopken U E, Stein H, et al. Systemic immunoregulatory and pathogenetic functions of homeostatic chemokine receptors. J Leukoc Biol 2002; 72: 1–8
   PubMed Web of Science ®Google Scholar
• Falini B, Fizzotti M, Pucciarini A, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells and activated T cells. Blood 2000; 95: 2084–2092
   PubMed Web of Science ®Google Scholar
• Calame C, Lin K-I, Tunyaplin C. Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 2003; 21: 205–230
   PubMed Web of Science ®Google Scholar
• Rappaport H, Winter W J, Hicks E B. Follicular lymphoma. A re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer 1956; 9: 792–821
   PubMed Web of Science ®Google Scholar
• Brill N E, Baehr G, Rosenthal N. Generalized giant follicle hyperplasia of lymph nodes and spleen. A hitherto undescribed type. J Am Med Assoc 1925; 84: 668–671
   Google Scholar
• Symmers D. Follicular lymphadenopathy with splenomegaly: a newly recognized disease of the lymphatic system. Arch Pathol 1927; 3: 816–820
   Google Scholar
• Anagnostopoulos I, Hansmann M L, Franssila K, et al. European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals two types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood 2000; 96: 1889–1899
   PubMed Web of Science ®Google Scholar
• Kadin M E, Glatstein E, Dorfman R F. Clinicopathologic studies of 117 untreated patients subjected to laparotomy for the staging of Hodgkin disease. Cancer 1971; 27: 1277–1294
   PubMed Web of Science ®Google Scholar
• Van Parys G, de Wolf-Peeters C, van den Oord J J, et al. Lymph node architecture in Hodgkin disease: evidence for the role of the composite nodule in nodular sclerosing Hodgkin disease. Hematol Oncol 1987; 5: 147–154
   PubMed Web of Science ®Google Scholar
• Cabone A, Gloghini A, Gaidano G, et al. Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin disease. Blood 1998; 92: 2220–2228
   PubMed Web of Science ®Google Scholar
• Falini B, Bigema B, Pasqualucci L, et al. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin disease. Blood 1996; 87: 465–471
   PubMed Web of Science ®Google Scholar
• Carbone A, Gloghini A, Aldinucci D, et al. Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin disease. Br J Haematol 2002; 117: 366–372
   PubMed Web of Science ®Google Scholar
• Poppema S. The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin disease. Am J Pathol 1989; 135: 351–357
   PubMed Web of Science ®Google Scholar
• Frizzera G, Moran E M, Rappaport H. Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 1974; 1: 1070–1073
   PubMed Web of Science ®Google Scholar
• Attygalle A, Al-Jehani R, Diss T C, et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 2002; 99: 627–633
   PubMed Web of Science ®Google Scholar
• Attygalle A, Diss T C, Munson P, et al. CD10 expression in extranodal dissemination of angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2004; 28: 54–61
   PubMed Web of Science ®Google Scholar
• De Leval L, Savilo E, Longtine J, et al. Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype. Am J Surg Pathol 2001; 25: 395–400
   PubMed Web of Science ®Google Scholar
• Jones D, Jorgensen J L, Shahsafaei A, et al. Characteristic proliferations of reticular and dendritic cells in angioimmunoblastic lymphoma. Am J Surg Pathol 1998; 22: 956–964
   PubMed Web of Science ®Google Scholar
• Lee S-S, Rudiger T, Odenwald T, et al. Angioimmunoblastic T-cell lymphoma is derived from mature T-helper cells with varying expression and loss of detectable CD4. Int J Cancer 2003; 103: 12–20
   PubMed Web of Science ®Google Scholar
• Grogg K, Attygalle A, Macon W R, et al. Angioimmunoblastic T-cell lymphoma: a neoplasm of germinal-center T-helper cells. Blood 2005; 106: 1501–1502
   PubMed Web of Science ®Google Scholar
• Dupuis J, Boye K, Martin N, et al. Expression of CXCL13 by neoplastic cells of angioimmunoblastic T-cell lymphoma (AITL). A new diagnostic marker providing evidence that AITL derives from follicular helper T-cells. Am J Surg Pathol 2006; 30: 490–494
   PubMed Web of Science ®Google Scholar
• Krenacs L, Schaerii P, Kis G, et al. Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells. Blood 2006; 108: 1110–1111
   PubMed Web of Science ®Google Scholar
• De Leval L, Rickman D S, Thielen C, et al. The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 2007; 109: 4952–4963
   PubMed Web of Science ®Google Scholar
• Ottensmeier C H, Thompsett A R, Zhu D, et al. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood 1998; 91: 4292–4299
   PubMed Web of Science ®Google Scholar
• Bräuninger A, Wacker H-H, Rajewsky K, et al. Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin lymphoma. Cancer Res 2003; 63: 1644–1651
   PubMed Web of Science ®Google Scholar
• Chapman C J, Wright D, Stevenson F K. Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis. Leuk Lymphoma 1998; 30: 257–267
   PubMed Web of Science ®Google Scholar
• Brauninger A, Spieker T, Willenbrock K, et al. Survival and clonal expansion of mutating ‘forbidden’ (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T-cell lymphoma. J Exp Med 2001; 194: 927–940
   PubMed Web of Science ®Google Scholar
• Knecht H, Berger C, Rothenberger S, et al. The role of Epstein-Barr virus in neoplastic transformation. Oncology 2001; 60: 289–302
   PubMed Web of Science ®Google Scholar
• Ambinder R F. Epstein-Barr virus-associated lymphoproliferations in the AIDS setting. Eur J Cancer 2001; 37: 1209–1216
   PubMed Web of Science ®Google Scholar
• Dalla-Favera R, Migliazza A, Chang C C, et al. Molecular pathogenesis of B cell malignancy: the role of BCL-6. Curr Top Microbiol Immunol 1999; 246: 257–263
   PubMed Web of Science ®Google Scholar
• Wang F, Gregory C, Sample C, et al. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol 1990; 64: 2309–2318
   PubMed Web of Science ®Google Scholar
• Strickler J G, Fedeli F, Horwitz C A, et al. Infectious mononucleosis in lymphoid tissue. Histopathology, in situ hybridization, and differential diagnosis. Arch Pathol Lab Med 1993; 117: 269–278
   PubMed Web of Science ®Google Scholar
• Ye B H, Cattoretti G, Shen Q, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 1997; 16: 161–170
   PubMed Web of Science ®Google Scholar
• Lam N, Sugden B. CD40 and its viral mimic, LMP1: similar means to different ends. Cell Signal 2003; 15: 9–16
   PubMed Web of Science ®Google Scholar
• Uchida J, Yasui T, Takaoka-Shichijo Y, et al. Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 1999; 286: 300–303
   PubMed Web of Science ®Google Scholar
• Yasui T, Muraoka M, Takaoka-Shichijo Y, et al. Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 2002; 14: 319–329
   PubMed Web of Science ®Google Scholar
• Qin J, Konno H, Ohshima D, et al. Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs. J Immunol 2007; 179: 6799–6807
   PubMed Web of Science ®Google Scholar
• Kersten M J, van Gorp J, Pals S T, et al. Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin lymphomas: correlation with histology and CD4-cell number. Leuk Lymphoma 1998; 30: 515–524
   PubMed Web of Science ®Google Scholar
• Gabarre J, Raphael M, Lepage E, et al. Human immunodeficiency virus-related lymphoma: relation between clinical features and histologic subtypes. Am J Med 2001; 111: 704–711
   PubMed Web of Science ®Google Scholar
• Carbone A, Gaidano G, Gloghini A, et al. Differential expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immune deficiency syndrome-related non-Hodgkin lymphomas. Blood 1998; 91: 747–755
   PubMed Web of Science ®Google Scholar
• Carbone A, Gaidano G, Gloghini A, et al. BCL-6 protein expression in AIDS-related non-Hodgkin lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression. Am J Pathol 1997; 150: 155–165
   PubMed Web of Science ®Google Scholar
• Anagnostopoulos I, Hummel M, Kreschel C, et al. Morphology, immunophenotype and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Blood 1995; 85: 744–750
   PubMed Web of Science ®Google Scholar
• Niedobitek G, Herbst H, Young L S, et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 1992; 79: 2520–2526
   PubMed Web of Science ®Google Scholar
• Kurth J, Hansmann M L, Rajewsky K, et al. Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc Natl Acad Sci USA 2003; 100: 4730–4735
   PubMed Web of Science ®Google Scholar
• Zhou Y, Attygalle A D, Chuang S S, et al. Angioimmunoblastic T-cell lymphoma: histological progression associates with EBV and HHV6B viral load. Br J Haematol 2007; 138: 44–53
   PubMed Web of Science ®Google Scholar
• Willenbrock K, Bräuninger A, Hansmann M L. Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases. Br J Haematol 2007; 138: 733–739
   PubMed Web of Science ®Google Scholar
• Polack A, Hortnagel K, Pajic B, et al. C-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc Natl Acad Sci USA 1996; 93: 10411–10416
   PubMed Web of Science ®Google Scholar
• Jochner N, Eick D, Zimber-Strobl U, et al. Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin µ gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells. EMBO J 1996; 15: 375–382
   PubMed Web of Science ®Google Scholar
• Isaacson P G. Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol 1992; 76: 14–23
   PubMedGoogle Scholar
• Isaacson P G, Norton A J. Extranodal Lymphomas. Churchill Livingstone, Edinburgh 1994
   Google Scholar
• Isaacson P G. Malignant lymphomas with a follicular growth pattern. Histopathology 1996; 28: 487–495
   PubMed Web of Science ®Google Scholar
• Lalani E-N, Stamp G WH. Role of the stroma in neoplastic growth and progression. Progress in Pathology, N Kirkham, N R Lemoine. Churchill Livingstone, New York 1997; 3: 102–124
   Google Scholar
• Addis B J, Hyjek E, Isaacson P G. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 1988; 13: 1–17
   PubMed Web of Science ®Google Scholar
• Schmid U, Eckert F, Griesser H, et al. Cutaneous follicular lymphoid hyperplasia with monotypic plasma cells. A clinicopathologic study of 18 patients. Am J Surg Pathol 1995; 19: 12–20
   PubMed Web of Science ®Google Scholar
• Lukes R J. Criteria for involvement of lymph node, bone marrow, spleen, and liver in Hodgkin disease. Cancer Res 1971; 31: 1755–1767
   PubMed Web of Science ®Google Scholar
• Kadin M E, Glatstein E, Dorfman R F. Clinicopathologic studies of 117 untreated patients subjected to laparotomy for the staging of Hodgkin disease. Cancer 1971; 27: 1277–1294
   PubMed Web of Science ®Google Scholar
• Van Parys G, de Wolf-Peeters C, van den Oord J J, et al. Lymph node architecture in Hodgkin disease: evidence for the role of the composite nodule in nodular sclerosing Hodgkin disease. Hematol Oncol 1987; 5: 147–154
   PubMed Web of Science ®Google Scholar
• Ashton-Key M, Thorpe P A, Allen J P, et al. Follicular Hodgkin disease. Am J Surg Pathol 1995; 19: 1294–1299
   PubMed Web of Science ®Google Scholar
• Schwarting R, Gerdes J, Durkop H, et al. A new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood 1989; 74: 1678–1689
   PubMed Web of Science ®Google Scholar
• Carbone A, Gloghini A, Aldinucci D, et al. Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin disease. Br J Haematol 2002; 117: 366–372
   PubMed Web of Science ®Google Scholar
• Carbone A, Gloghini A, Gaidano G, et al. Expression status of bcl-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin disease. Blood 1998; 92: 2220–2228
   PubMed Web of Science ®Google Scholar
• Carbone A, Gloghini A, Larocca L M, et al. Human immunodeficiency virus-associated Hodgkin disease derives from post-germinal center B-cells. Blood 1999; 93: 2319–2326
   PubMed Web of Science ®Google Scholar
• Hopken U E, Foss H-D, Meyer D, et al. Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte- predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood 2002; 99: 1109–1116
   PubMed Web of Science ®Google Scholar
• Alkan S, Ross C W, Hanson C A, et al. Epstein-Barr virus and bcl-2 protein overexpression are not detected in the neoplastic cells of nodular lymphocyte predominance Hodgkin disease. Mod Pathol 1995; 8: 544–547
   PubMed Web of Science ®Google Scholar
• Kim S H, Shin Y K, Lee I-S, et al. Viral latent membrane protein 1 (LMP-1)-induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin and Reed-Sternberg phenotype. Blood 2000; 95: 294–300
   PubMed Web of Science ®Google Scholar
• Kim S H, Choi E Y, Shin Y K, et al. Generation of cells with Hodgkin and Reed-Sternberg phenotype through downregulation of CD99 (Mic2). Blood 1998; 92: 4287–4295
   PubMed Web of Science ®Google Scholar
• Tindle B H, Parker J W, Lukes R J. ‘Reed-Sternberg cells’ in infectious mononucleosis?. Am J Clin Pathol 1972; 58: 607–617
   PubMed Web of Science ®Google Scholar
• Childs C C, Parham D M, Berard C W. Infectious mononucleosis. The spectrum of morphologic changes simulating lymphoma in lymph nodes and tonsils. Am J Surg Pathol 1987; 11: 122–132
   PubMed Web of Science ®Google Scholar
• Mao Z, Quintanilla-Martinez L, Raffeld M, et al. IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol 2007; 31: 1605–1614
   PubMed Web of Science ®Google Scholar
• Tzankov A, Fong D. Hodgkin disease variant of Richter's syndrome clonally related to chronic lymphocytic leukemia arises in ZAP-70 negative mutated CLL. Med Hypotheses 2006; 66: 577–579
   PubMed Web of Science ®Google Scholar
• Ma Y, Visser L, Blokzijl T, et al. The CD4 + CD26- T-cell population in classical Hodgkin lymphoma displays a distinctive regulatory T-cell profile. Lab Invest 2008; 88: 482–490
   PubMed Web of Science ®Google Scholar
• Lukes R L, Tindle B H. Immunoblastic lymphadenopathy: a hyperimmune entity resembling Hodgkin disease. N Engl J Med 1975; 292: 1–8
   PubMed Web of Science ®Google Scholar
• Hertel C B, Zhou X G, Hamilton-Dutoit S J, et al. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene 2000; 21: 4908–4920
   Web of Science ®Google Scholar
• Theil J, Laumen H, Marafioti T, et al. Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells. Blood 2001; 97: 3191–3196
   PubMed Web of Science ®Google Scholar
• Su W, Spencer, Wotherspoon A C. Relative distribution of tumour cells and reactive cells in follicular lymphoma. J Pathol 2001; 193: 498–504
   PubMed Web of Science ®Google Scholar
• Adam P, Katzenberger T, Eifert M, et al. Presence of preserved reactive germinal centers in follicular lymphoma is a strong histopathologic indicator of limited disease stage. Am J Surg Pathol 2005; 29: 1661–1664
   PubMed Web of Science ®Google Scholar
• Freedman A S, Saporito L, Rhynhart K, et al. Adhesion of follicular lymphoma cells to lymphoid geminal centers—a potential mechanism of tumor cell homing following autologous transplantation. Leuk Lymphoma 1994; 13: 47–52
   PubMed Web of Science ®Google Scholar
• Fan Z, Natkunam Y, Bair E, et al. Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 2003; 27: 1346–1356
   PubMed Web of Science ®Google Scholar
• Kojima M, Nakamura S, Itoh H, et al. Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: a clinicopathological and immunohistochemical study of 10 cases. APMIS 2001; 109: 699–706
   PubMed Web of Science ®Google Scholar
• Ree H J, Kadin M E, Kikuchi M, et al. Angioimmunoblastic lymphoma (AILD-type T-cell lymphoma) with hyperplastic germinal centers. Am J Surg Pathol 1998; 22: 643–655
   PubMed Web of Science ®Google Scholar
• Ree H J, Kadin M E, Kikuchi M, et al. Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma. Hum Pathol 1999; 30: 403–411
   PubMed Web of Science ®Google Scholar
• Tan L HC, Chiu L L, Koay E SC. Diagnostic impact of molecular lineage analysis on paraffin-embedded tissue in hematolymphoid neoplasia reclassified by current WHO criteria. Mol Diagn Ther 2007; 11: 29–53
   PubMed Web of Science ®Google Scholar
• Du M, Diss T C, Xu C, et al. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 1996; 10: 1990–1997
   PubMed Web of Science ®Google Scholar
• Aarts W M, Willemze R, Bende R J, et al. VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching. Blood 1998; 92: 3857–3864
   PubMed Web of Science ®Google Scholar
• Tan S Y. Cell Populations in Normal and Neoplastic Lymphoid Tissues. University of Oxford, Nuffield Department of Clinical Laboratory Sciences, Oxford 2007; 175–200
   Google Scholar
• Lynch R G. Components of immune function studied with lymphoid tumors. Int Rev Immunol 1986; 1: 335–348
   PubMedGoogle Scholar
• Janz M, Dörken B, Mathas S. Reprogramming of B lymphoid cells in human lymphoma pathogenesis. Cell Cycle 2006; 5: 1057–1061
   PubMed Web of Science ®Google Scholar
• Müller-Hermelink H K, Zettl A, Pfeifer W, et al. Pathology of lymphoma progression. Histopathology 2001; 38: 285–306
   PubMed Web of Science ®Google Scholar
• Johansson B, Mertens F, Mitelman F. Secondary chromosomal abnormalities in acute leukemias. Leukemia 1994; 8: 953–962
   PubMed Web of Science ®Google Scholar
• Kwon M S, Go J H, Choi J S, et al. Critical Evaluation of bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine. Am J Surg Pathol 2003; 27: 790–798
   PubMed Web of Science ®Google Scholar
• Omonishi K, Yoshino T, Sakuma I, et al. Bcl-6 protein is identified in high-grade but not low-grade mucosa-associated lymphoid tissue lymphomas of the stomach. Mod Pathol 1998; 11: 181–185
   PubMed Web of Science ®Google Scholar
• Uherova P, Ross C W, Finn W G, et al. Peripheral T-cell lymphoma mimicking marginal zone lymphoma. Mod Pathol 2002; 15: 420–425
   PubMed Web of Science ®Google Scholar
• Rudiger T, Ichinohasama I, Ott M M, et al. Peripheral T-cell lymphoma with distinct perifollicular growth pattern. A distinct subtype of T-cell lymphoma?. Am J Surg Pathol 2000; 24: 117–122
   PubMed Web of Science ®Google Scholar
• Lai R, Lefresne S V, Franko B, et al. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome. Mod Pathol 2006; 19: 1498–1505
   PubMed Web of Science ®Google Scholar
• Nakamura N, Abe M. Histogenesis of CD5-positive and CD5-negative B-cell neoplasms on the aspect of somatic mutation of immunoglobulin heavy chain gene variable region. Fukushima J Med Sci 2003; 49: 55–67
   PubMedGoogle Scholar
• Bahler D W, Aguilera N S, Chen C C, et al. Histological and immunoglobulin VH gene analysis of interfollicular small lymphocytic lymphoma provides evidence for two types. Am J Pathol 2000; 157: 1063–1070
   PubMed Web of Science ®Google Scholar
• Farinha P, Gascoyne R. Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma. J Clin Oncol 2005; 23: 6370–6378
   PubMed Web of Science ®Google Scholar
• González D, van der Burg M, García-Sanz R, et al. Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma. Blood 2007; 110: 3112–3121
   PubMed Web of Science ®Google Scholar
• Alizadeh A A, Eisen M B, Davis R E, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511
   PubMed Web of Science ®Google Scholar
• Berglund M, Thunberg U, Amini R M, et al. Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. Mod Pathol 2005; 18: 1113–1120
   PubMed Web of Science ®Google Scholar
• Chang C C, McClintock S, Cleveland R P, et al. Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol 2004; 28: 464–470
   PubMed Web of Science ®Google Scholar
• Huang J Z, Sanger W G, Greiner T C, et al. The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. Blood 2002; 99: 2285–2290
   PubMed Web of Science ®Google Scholar
• Fang J-M, Finn W G, Hussong J W, et al. CD10 antigen expression correlates with the t(14;18)(q32;q21) major breakpoint region in diffuse large B-cell lymphoma. Mod Pathol 1999; 12: 295–300
   PubMed Web of Science ®Google Scholar
• Davies A J, Rosenwald A, Wright G, et al. Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms. Br J Haematol 2007; 136: 286–293
   PubMed Web of Science ®Google Scholar
• Eshoa C, Perkins S, Kampalath B, et al. Decreased CD10 expression in Grade III and in interfollicular infiltrates of follicular lymphomas. Am J Clin Pathol 2001; 115: 882–867
   Web of Science ®Google Scholar
• Dierlamm J, Penas E MM, Bentink S, et al. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma. Haematologica 2008; 93: 688–696
   PubMed Web of Science ®Google Scholar
• Brown P J, Ashe S L, Leich E, et al. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. Blood 2008; 111: 2816–2824
   PubMed Web of Science ®Google Scholar
• Sagaert X, de Paepe P, Libbrecht L, et al. Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation into diffuse large B-cell lymphoma. J Clin Oncol 2006; 24: 2490–2497
   PubMed Web of Science ®Google Scholar
• Calvo K R, Traverse-Glehen A, Pittaluga S, et al. Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma. Implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. Adv Anat Pathol 2004; 11: 227–238
   PubMed Web of Science ®Google Scholar
• Leithäuser F, Bäuerle M, Huynh M Q, et al. Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma. Blood 2001; 98: 2762–2770
   PubMed Web of Science ®Google Scholar
• Willemze R, Jaffe E S, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768–3785
   PubMed Web of Science ®Google Scholar
• Shen D-F, Doukhan L, Kalams S, et al. High-resolution analysis of T-cell receptor β-chain repertoires using DNA heteroduplex tracking: generally stable, clonal CD8+ expansions in all healthy young adults. J Immunol Methods 1998; 215: 113–121
   PubMed Web of Science ®Google Scholar
• Manfras B J, Rudert W A, Trucco M, et al. Analysis of the α/β T-cell receptor repertoires by competitive and quantitative family-specific PCR with exogenous standards and high resolution fluorescence based CDR3 size imaging. J Immunol Methods 1997; 210: 235–249
   PubMed Web of Science ®Google Scholar
• Cochet M, Pannetier C, Regnault A, et al. Molecular detection and in vivo anaysis of the specific T-cell response to a protein antigen. Eur J Immunol 1992; 22: 2639–2647
   PubMed Web of Science ®Google Scholar
• Dunon D, Courtois D, Vainio O, et al. Ontogeny of the immune system γ/δ and α/β T cells migrate from thymus to the periphery in alternating waves. J Exp Med 1997; 186: 977–988
   PubMed Web of Science ®Google Scholar
• Deusch K, Luling F, Reich K, et al. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur J Immunol 1991; 21: 1053–1059
   PubMed Web of Science ®Google Scholar
• Falini B, Flenghi L, Pileri S, et al. Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues. J Immunol 1989; 143: 2480–2488
   PubMed Web of Science ®Google Scholar
• Asnafi V, Beldjord K, Boulanger E, et al. Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 2003; 101: 2693–2703
   PubMed Web of Science ®Google Scholar
• Langerak A W, van den Beemd R, Wolvers-Tettero I LM, et al. Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations. Blood 2001; 98: 165–173
   PubMed Web of Science ®Google Scholar
• Przybylski G K, Wu H, Macon W R, et al. Hepatosplenic and subcutaneous panniculitis-like γ/δ T cell lymphomas are derived from different Vδ subsets of γ/δ T lymphocytes. J Mol Diagn 2000; 2: 11–19
   PubMed Web of Science ®Google Scholar
• De Wolf-Peeters C, Achten R. γδ T-cell lymphomas: a homogeneous entity?. Histopathology 2000; 36: 294–305
   PubMed Web of Science ®Google Scholar
• Pagels H R. Perfect Symmetry. Bantam Books, Toronto 1986
   Google Scholar
• Müschen M, Küppers R, Spieker T, et al. Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells harbouring unmutated immunoglobulin variable region genes. Lab Invest 2001; 81: 289–295
   PubMed Web of Science ®Google Scholar