Prerequisites for establishing general recommendations for diagnosis and treatment of vitamin B₁₂ deficiency and cost‐utility evaluation of these guidelines

REFERENCES

• Martens JH, Barg H, Warren MJ, Jahn D. Microbial production of vitamin B12. Appl Microbiol Biotechnol 2002; 58: 275–85.
   PubMed Web of Science ®Google Scholar
• Bachli E, Fehr J. Diagnosis of vitamin B12 deficiency: only apparently child's play. Schweiz Med Wochenschr 1999; 129: 861–72.
   PubMedGoogle Scholar
• Carmel R. Subtle and atypical cobalamin defi-ciency states. Am J Hematol 1990; 34: 108–14.
   PubMed Web of Science ®Google Scholar
• Holleland G, Schneede J, Ueland PM, Lund PK, Refsum H, Sandberg S. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnos-tic strategies. Clin Chem 1999; 45: 189–98.
   Google Scholar
• Wertalik LF, Metz EN, LoBuglio AF, Balcerzak SP. Decreased serum B12 levels with oral contra-ceptive use. JAMA 1972; 221: 1371–4.
   PubMed Web of Science ®Google Scholar
• Morris MS, Jacques PF, Selhub J, Rosenberg IH. Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2000; 152: 140 — 8.
   PubMed Web of Science ®Google Scholar
• Ermens AA, Vlasveld LT, van Marion-Kievit JA, Lensen CJ, Lindemans J. The significance of an elevated cobalamin concentration in the blood. Ned Tijdschr Geneeskd 2002; 146: 459–64.
   PubMedGoogle Scholar
• Lindgren A, Lindstedt G, Kilander AF. Advan-tages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery. J Intern Med 1998; 244: 341–9.
   Google Scholar
• Wickramasinghe SN, Saunders J. Correlations between the deoxyuridine-suppressed value and some conventional haematological parameters in patients with folate or vitamin B12 deficiency. Scand J Haematol 1976; 16: 121–7.
   PubMedGoogle Scholar
• Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1720–8.
   PubMed Web of Science ®Google Scholar
• Cohen H, Weinstein WM, Camel R. Hetero-geneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption. Gut 2000; 47: 638–45.
   Google Scholar
• van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I, et al. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998; 68: 328–34.
   PubMed Web of Science ®Google Scholar
• Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, et al. common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 1999; 67: 317–23.
   PubMed Web of Science ®Google Scholar
• Miller JW, Ramos MI, Garrod MG, Flynn MA, Green R. Transcobalamin II 775G>C poly-morphism and indices of vitamin B12 status in healthy older adults. Blood 2002; 100: 718–20.
   Google Scholar
• McCaddon A, Blennow K, Hudson P, Regland B, Hill D. Transcobalamin polymorphism and homo-cysteine. Blood 2001; 98: 3497–9.
   Google Scholar
• Klee GG. Cobalamin and folate evaluation: measure-ment of methylmalonic acid and homocysteine vs vitamin B(12) and folate. Clin Chem 2000; 46: 1277— 83.
   PubMed Web of Science ®Google Scholar
• Elin RJ, Winter WE. Methylmalonic acid: a test whose time has come? Arch Pathol Lab Med 2001; 125: 824–7.
   PubMed Web of Science ®Google Scholar
• Camel R, Karnaze DS. The deoxyuridine sup-pression test identifies subtle cobalamin deficiency in patients without typical megaloblastic anemia. JAMA 1985; 253: 1284–7.
   PubMed Web of Science ®Google Scholar
• Chanarin I, Metz J. Diagnosis of cobalamin deficiency: the old and the new. Br J Haematol 1997; 97: 695–700.
   PubMed Web of Science ®Google Scholar
• Ulleland M, Eilertsen I, Quadros EV, Rothenberg SP, Fedosov SN, Sundrehagen E, et al. Direct assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum. Clin Chem 2002; 48: 526–32.
   PubMed Web of Science ®Google Scholar
• Nexo E, Hvas AM, Bleie O, Refsum H, Fedosov SN, Vollset SE, et al. Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study. Clin Chem 2002; 48: 1768–71.
   Google Scholar
• Hvas AM, Ellegaard J, Nexo E. Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency. Arch Intern Med 2001; 161: 1534–41.
   Google Scholar
• Stabler SP, Allen RH, Barrett RE, Savage DG, Lindenbaum J. Cerebrospinal fluid methylmalonic acid levels in normal subjects and patients with cobalamin deficiency. Neurology 1991; 41: 1627 — 32.
   Google Scholar
• Pametti L, Bottiglieri T, Lowenthal D. Role of homocysteine in age-related vascular and non-vascular diseases. Aging (Milano) 1997; 9: 241–57.
   Google Scholar
• Nyhan WL, Gargus JJ, Boyle K, Selby R, Koch R. Progressive neurologic disability in methylma-lonic acidemia despite transplantation of the liver. Eur J Pediatr 2002; 161: 377–9.
   Google Scholar
• van Asselt DZ, Karlietis MH, Poels PJ, de Jong JG, Wevers RA, Hoefnagels WH. Cerebrospinal fluid methylmalonic acid concentrations in neuro-logical patients with low and normal serum cobalamin concentrations. Acta Neurol Scand 1998; 97: 413–6.
   Google Scholar
• Hall CA, Begley JA, Green-Colligan PD. The availability of therapeutic hydroxocobalamin to cells. Blood 1984; 63: 335–41.
   Google Scholar
• Lane LA, Rojas-Fernandez C. Treatment of vitamin B(12)-deficiency anemia: oral versus parenteral therapy. Ann Pharmacother 2002; 36: 1268–72.
   PubMed Web of Science ®Google Scholar
• Roos D. The vibration perception threshold in gastrectomized patients with low serum B12. A clinical and biothesiometric follow-up after inten-sive B12 therapy. Acta Neurol Scand 1977; 56: 551— 62.
   Google Scholar
• Hemmer B, Glocker FX, Schumacher M, Deuschl G, Lucking CH. Subacute combined degeneration: clinical, electrophysiological, and magnetic reso-nance imaging findings. J Neurol Neurosurg Psychiatry 1998; 65: 822–7.
   Google Scholar
• Baker SJ, Mathan VI. Evidence regarding the minimal daily requrement of dietary vitamin B12. Am J Clin Nutr 1981; 34: 2423–33.
   PubMed Web of Science ®Google Scholar
• Kondo H. Haematological effects of oral cobalamin preparations on patients with megaloblastic anae-mia. Acta Haematol 1998; 99: 200–5.
   PubMed Web of Science ®Google Scholar
• Yamada K, Shrier DA, Tanaka H, Numaguchi Y. A case of subacute combined degeneration: MRI findings. Neuroradiology 1998; 40: 398–400.
   PubMed Web of Science ®Google Scholar
• Stott DJ, Langhorne P, Hendry A, McKay PJ, Holyoake T, Macdonald J, et al. Prevalence and haemopoietic effects of low serum vitamin B12 levels in geriatric medical patients. Br J Nutr 1997; 78: 57–63.
   PubMed Web of Science ®Google Scholar
• Jones SJ, Yu YL, Rudge P, Kriss A, Gilois C, Hirani N, et al. Central and peripheral SEP defects in neurologically symptomatic and asymptomatic subjects with low vitamin B12 levels. J Neurol Sci 1987; 82: 55–65.
   PubMed Web of Science ®Google Scholar
• Munro J, Booth A, Nicholl J. Routine preopera-tive testing: a systematic review of the evidence. Health Technol Assess 1997; 1: 1–62.
   Google Scholar
• Thompson WG, Babitz L, Cassino C, Freedman M, Lipkin M. Jr. Evaluation of current criteria used to measure vitamin B12 levels. Am J Med 1987; 82: 291–4.
   Google Scholar
• Takemura Y, Ishida H, Inoue Y, Beck JR. Common diagnostic test panels for clinical evalua-tion of new primary care outpatients in Japan: a cost-effectiveness evaluation. Clin Chem 1999; 45: 1752— 61.
   PubMed Web of Science ®Google Scholar
• Larsson A, Palmer M, Hulten G, Tryding N. Wide variations among hospitals in use of laboratory tests. Information and education to increase cost-effectiveness. Lakartidningen 2000; 97: 4300, 4303–8, 4310.
   Google Scholar
• Mookhoek EJ, Sterrenburg-vd Nieuwegiessen IM. Screening for somatic disease in elderly psychiatric patients. Gen Hosp Psychiatry 1998; 20: 102–7.
   PubMed Web of Science ®Google Scholar
• Chui CH, Lau FY, Wong R, Soo OY, Lam CK, Lee PW, et al. Vitamin B12 deficiency—need for a new guideline. Nutrition 2001; 17: 917–20.
   PubMed Web of Science ®Google Scholar
• Schroeder SA, Myers LP, McPhee SJ, Showstack JA, Simborg DW, Chapman SA, et al. The failure of physician education as a cost containment strategy. Report of a prospective controlled trial at a university hospital. JAMA 1984; 252: 225— 30.
   Google Scholar