Regional fat mass by DXA: High leg fat mass attenuates the relative risk of insulin resistance and dyslipidaemia in obese but not in overweight postmenopausal women

References

• Rexrode K. M., Carey V. J., Hennekens C. H., Walters E. E., Colditz G. A., Stampfer M. J., et al. Abdominal adiposity and coronary heart disease in women. JAMA 1998; 280: 1843–8
   PubMed Web of Science ®Google Scholar
• Kanaya A. M., Vittinghoff E., Shlipak M. G., Resnick H. E., Visser M., Grady D., et al. Association of total and central obesity with mortality in postmenopausal women with coronary heart disease. Am J Epidemiol 2003; 158: 1161–70
   PubMed Web of Science ®Google Scholar
• Carey V. J., Walters E. E., Colditz G. A., Solomon C. G., Willett W. C., Rosner B. A., et al. Body fat distribution and risk of non‐insulin‐dependent diabetes mellitus in Women. The Nurses' Health Study. Am J Epidemiol 1997; 145: 614–19
   PubMed Web of Science ®Google Scholar
• Lissner L., Bjorkelund C., Heitmann B. L., Seidell J. C., Bengtsson C. Larger hip circumference independently predicts health and longevity in a Swedish female cohort. Obes Res 2001; 9: 644–9
   PubMedGoogle Scholar
• Heitmann B. L., Frederiksen P., Lissner L. Hip circumference and cardiovascular morbidity and mortality in men and women. Obes Res 2004; 12: 482–87
   PubMedGoogle Scholar
• Snijder M. B., Dekker J. M., Visser M., Bouter L. M., Stehouwer C. D., Kostense P. J., et al. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn study. Am J Clin Nutr 2003; 77: 1192–7
   PubMed Web of Science ®Google Scholar
• Seidell J. C., Pérusse L., Deprés J. ‐. P., Bouchard C. Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk: the Quebec family study. Am J Clin Nutr 2001; 74: 315–21
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Zimmet P. Z., Visser M., Dekker J. M., Seidell J. C., Shaw J. E. Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab study. Int J Obes Relat Metab Disord 2004; 28: 402–9
   PubMed Web of Science ®Google Scholar
• Ley C. J., Lees B., Stevenson J. C. Sex‐ and menopause associated changes in body‐fat distribution. Am J Clin Nutr 1992; 55: 950–4
   PubMed Web of Science ®Google Scholar
• Williams M. J., Hunter G. R., Kekes‐Szabo T., Snyder S., Treuth M. S. Regional fat distribution in women and risk of cardiovascular disease. Am J Clin Nutr 1997; 5: 855–60
   Google Scholar
• Van Pelt R. E., Evans E. M., Schechtman K. B., Ehsani A. A., Kohrt W. M. Contribution of total and regional fat mass to risk for cardiovascular disease in older women. Am J Physiol Endocrinol Metab 2002; 282: E1023–8
   PubMed Web of Science ®Google Scholar
• Van Pelt R. E., Jankowski C. M., Gozansky W. S., Schwartz R. S., Kohrt W. M. Lower‐body adiposity and metabolic protection in postmenopausal women. J Clin Endocrinol Metab 2005; 90: 4573–8
   PubMed Web of Science ®Google Scholar
• Tatsukawa M., Kurokawa M., Tamari Y., Yoshimatsu H., Sakata T. Regional fat deposition in the legs is useful as a presumptive marker of antiatherogenicity. In Japanese. Proc Soc Exp Bio Med 2000; 223: 156–62
   PubMed Web of Science ®Google Scholar
• Tankό L. B., Bagger Y. Z., Alexandersen P., Larsen P. J., Christiansen C. Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 2003; 107: 1626–31
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Dekker J. M., Visser M., Bouter L. M., Stehouwer C. D., Yudkin J. S., et al. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels. Diabetes Care 2004; 27: 372–7
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Visser M., Dekker J. M., Gooodpaster B. H., Harris T. B., Kritechevsky S. B., et al. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The health ABC study. Diabetologia 2005; 48: 301–8
   PubMed Web of Science ®Google Scholar
• Gauiller J. ‐. M., Halse J., Høye K., Kristiansen K., Fagertun H., Vik H., et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004; 79: 1118–25
   PubMedGoogle Scholar
• Aasen G., Fagertun H., Halse J. Body composition analysis by dual X‐ray absorptiometry: in vivo and in vitro comparison of three different fan‐beam instruments. Scand J Clin Lab Invest 2006; 66: 659–66
   PubMed Web of Science ®Google Scholar
• Matthews D. R., Hosker J. P., Rudenski A. S., Maylor B. A., Treacher D. F., Turner R. C. Homeostasis model assessment: insulin resistance and beta‐cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–19
   PubMed Web of Science ®Google Scholar
• Bonora E., Targher G., Alberiche M., Bonadonna R. C., Saggianai F., Zenner M. B., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23: 57–63
   PubMed Web of Science ®Google Scholar
• Katz A., Nambi S. S., Mather K., Baron A. D., Follman D. A., Sullivan G., et al. Quantitative insulin sensitivity check index: a simple accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402–10
   PubMed Web of Science ®Google Scholar
• Yokoyama H., Emoto M., Fujiwara S., Motomyama K., Morioka T., Komatsu M., et al. Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment in normal weight range and moderately obese type 2 diabetic patients. Diabetes Care 2003; 26: 2426–32
   PubMed Web of Science ®Google Scholar
• Stumvoll M., Mitrakou A., Pimenta W., Jenssen T., Jarvinen H. Y., Van Haften T., et al. Use of the oral tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23: 295–301
   PubMed Web of Science ®Google Scholar
• Friedewald W. R., Levy R. I., Fredichson D. S. Estimation of the concentration of low‐density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502
   PubMed Web of Science ®Google Scholar
• Goodpaster B. H., Thaete F. L., Kelly D. E. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 2000; 71: 885–92
   PubMed Web of Science ®Google Scholar
• Munoz J., Derstine A., Gower B. A. Fat distribution and insulin sensitivity in postmenopausal women: influence of hormone replacement. Obes Res 2002; 10: 424–31
   PubMedGoogle Scholar
• Shand B. I., Scott R. S., Elder P. A., George P. M. Plasme adiponectin in overweight, nondiabetic individuals with or without insulin resistance. Diabetes Obes Metab 2003; 5: 349–53
   PubMed Web of Science ®Google Scholar
• Abbasi F., Chu J. W., Lamendola C., McLaughlin T., Hayden J., Reaven G. M., et al. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 2004; 53: 585–90
   PubMed Web of Science ®Google Scholar
• Kantartzis K., Fritsche, Tschritter O., Thamer C., Haap M., Schäfer, et al. The association between plasma adiponectin and insulin sensitivity in humans depends on obesity. Obes Res 2005; 13: 1683–91
   PubMedGoogle Scholar
• Tschritter O., Fritsche A., Thamer C., Haap M., Shirkavand F., Rahe S., et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003; 52: 239–43
   PubMed Web of Science ®Google Scholar
• Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R. E., et al. Hypoadiponctinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930–5
   PubMed Web of Science ®Google Scholar
• Behre C. J., Brohall G., Hulthe J., Fagerberg B. Serum adiponectin in a population sample of 64‐year‐old women in relation to glucose tolerance, family history of diabetes, autoimmunity, insulin sensitivity, C‐peptide, and inflammation. Metabolism 2006; 55: 188–94
   PubMed Web of Science ®Google Scholar
• Hanley A. J. G., Bowden D., Wagenknecht L. E., Balasubramanyam A., Langfeld C., Saad M. F., et al. Associations of adiponectin with body fat distribution and insulin sensitivity in non‐diabetic Hispanic and African Americans. J Clin Endocrinol Metab 2007, (DOI: 10.1210/jc.2006‐2614.)
   Google Scholar
• Duclos M., Gatta B., Corcuff J. B., Rashedi M., Pehourcq F., Roger P. Fat distribution in obese women is associated with subtle alterations of the hypothalamic‐pituitary‐adrenal axis activity and sensitivity to glucocorticoids. Clin Endocrinol 2001; 5: 447–54
   Google Scholar
• Landin K., Lönneroth P., Krotkiewski M., Holm G., Smith U. Increased insulin resistance and fat cell lipoplysis in obese but not lean women with high waist/hip ratio. Eur J Clin Invest 1990; 20: 530–5
   PubMed Web of Science ®Google Scholar
• Bos G., Snijder M. B., Nijpels G., Dekker J. M., Coen D. A., Bouter L. M., et al. Opposite contributions of trunk and leg fat mass with plasma lipase activities: the Hoorn study. Obes Res 2005; 3: 817–22
   Google Scholar
• Marette A., Mauriege P., Marcotte B., Atgie C., Bouchard C., Theriault C., et al. Regional variations in adipose tissue insulin action and GLUT4 transporter expression in severely obese premenopausal women. Diabetologia 1997; 40: 590–8
   PubMedGoogle Scholar
• Sites C. K., Brochu M., Tchernof A., Poehlman E. T. Relationship between hormone replacement therapy use with body fat distribution and insulin sensitivity in obese postmenopausal women. Metabolism 2001; 50: 835–40
   PubMed Web of Science ®Google Scholar
• Ryan A., Nicklas B. J., Berman D. M. Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 2002; 25: 127–33
   PubMed Web of Science ®Google Scholar
• Hanley A. J. G., Williams K., Stern M. P., Haffner S. M. Homeostasis model assessment of insulin resistance of cardiovascular disease. The San Antonio Heart Study. Diabetes Care 2002; 25: 1177–84
   PubMed Web of Science ®Google Scholar
• Moan A., Høieggen A., Seljefloth I., Risanger T., Arnesen H., Kjeldsen S. The effect of angiotensin II receptor antagonism with losartan on glucose metabolism and sensitivity. J Hypertens 1996; 14: 1093–7
   PubMed Web of Science ®Google Scholar
• Huptas S., Geiss H. C., Otto C., Parhofer K. G. Effect of atorvastatin (10 mg/day) on glucose metabolism in patients with the metabolic syndrome. Am J Cardiol 2006; 98: 66–9
   PubMed Web of Science ®Google Scholar