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Original Article

Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes

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Pages 272-281 | Received 13 Jul 2008, Accepted 18 Sep 2008, Published online: 08 Jul 2009

References

  • Gu K., Cowie C. C., Harris M. I. Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971–1993. Diabetes Care 1998; 21: 1138–45
  • Morrish N. J., Wang S. L., Stevens L. K., Fuller J. H., Keen H. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001; 44 Suppl 2: S14–21
  • Roper N. A., Bilous R. W., Kelly W. F., Unwin N. C., Connolly V. M. Cause‐specific mortality in a population with diabetes: South Tees Diabetes Mortality Study. Diabetes Care 2002; 25: 43–8
  • Logdberg L., Wester L. Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses. Biochim Biophys Acta 2000; 18((1482))284–97
  • Schmid K. Human plasma alpha 1‐acid glycoprotein – biochemical properties, the amino acid sequence and the structure of the carbohydrate moiety, variants and polymorphism. Prog Clin Biol Res 1989; 300: 7–22
  • Poortmans J. R., Haralambie G. Biochemical changes in a 100 km run: proteins in serum and urine. Eur J Appl Physiol Occup Physiol 1979; 40: 245–54
  • Jensen H., Henriksen K. Proteinuria in non‐renal infectious diseases. Acta Med Scand 1974; 196: 75–82
  • Pang J. X., Ginanni N., Dongre A. R., Hefta S. A., Opitek G. J. Biomarker discovery in urine by proteomics. J Proteome Res 2002; 1: 161–9
  • Nielsen S. H., Petersen J. S., Magid E. Albuminuria in ischemic heart disease. Scand J Clin Lab Invest Suppl 1999; 230: 143–52
  • Christiansen M. S., Hommel E., Magid E., Feldt‐Rasmussen B. Orosomucoid in urine predicts cardiovascular and over‐all mortality in patients with Type II diabetes. Diabetologia 2002; 45: 115–20
  • Christiansen M. S., Hommel E., Magid E., Feldt‐Rasmussen B. Orosomucoid in urine is a powerful predictor of cardiovascular mortality in normoalbuminuric patients with type 2 diabetes at five years of follow‐up. Diabetologia 2005; 48: 386–93
  • Duncan B. B., Schmidt M. I., Pankow J. S., Ballantyne C. M., Couper D., Vigo A., Hoogeveen R., Folsom A. R., Heiss G. Low‐grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 2003; 52: 1799–805
  • Pickup J. C., Mattock M. B., Chusney G. D., Burt D. NIDDM as a disease of the innate immune system: association of acute‐phase reactants and interleukin‐6 with metabolic syndrome X. Diabetologia 1997; 40: 1286–92
  • Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med 1999; 14;340: 115–26
  • Stehouwer C. D., Gall M. A., Twisk J. W., Knudsen E., Emeis J. J., Parving H. H. Increased urinary albumin excretion, endothelial dysfunction, and chronic low‐grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death. Diabetes 2002; 51: 1157–65
  • Stehouwer C. D., Lambert J., Donker A. J., van H. V. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 1997; 34: 55–68
  • Levy D., Garrison R. J., Savage D. D., Kannel W. B., Castelli W. P. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561–6
  • Palmieri V., Tracy R. P., Roman M. J., Liu J. E., Best L. G., Bella J. N., Robbins D. C., Howard B. V., Devereux R. B. Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes: the strong heart study. Diabetes Care 2003; 26: 2764–9
  • World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications. World Health Organization, Geneva 1999, Report of a WHO consultation. Part 1: Diagnosis and classification of diabetes mellitus
  • Christiansen M. S., Blirup‐Jensen S., Foged L., Larsen M., Magid E. A particle‐enhanced turbidimetric immunoassay for quantitative determination of orosomucoid in urine: development, validation and reference values. Clin Chem Lab Med 2004; 42: 1168–77
  • Rose G. A., Blackburn H., Gillum R. F., Prineas R. J. Cardiovascular survey methods. 1982; 162–5, WHO Monograph Series
  • Blackburn H., Keys A., Simonson E., Rautaharju P., Punsar S. The electrocardiogram in population studies. A classification system. Circulation 1960; 21: 1160–75
  • Hilsted J., Jensen S. B. A simple test for autonomic neuropathy in juvenile diabetics. Acta Med Scand 1979; 205: 385–7
  • Schiller N. B., Shah P. M., Crawford M., DeMaria A., Devereux R., Feigenbaum H., Gutgesell H., Reichek N., Sahn D., Schnittger I., Silverman N. H., Tajik A. J. Recommendations for quantitation of the left ventricle by two‐dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two‐Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358–67
  • Devereux R. B., Alonso D. R., Lutas E. M., Gottlieb G. J., Campo E., Sachs I., Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450–8
  • Du Bois D., Du Bois E. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 1916; 17: 863–71
  • Garcia M. J., Thomas J. D., Klein A. L. New Doppler echocardiographic applications for the study of diastolic function. J Am Coll Cardiol 1998; 32: 865–75
  • Dujardin K. S., Tei C., Yeo T. C., Hodge D. O., Rossi A., Seward J. B. Prognostic value of a Doppler index combining systolic and diastolic performance in idiopathic‐dilated cardiomyopathy. Am J Cardiol 1998; 82: 1071–6
  • Volk H., Keysser G., Burmester G. Cytokines and cytokine receptors. Clinical laboratory diagnostics, use and assessment of clinical laboratory results, L Thomas. TH‐Books, Frankfurt am Main 1998; 764–73, 1st edn
  • Goetze J. P., Kastrup J., Pedersen F., Rehfeld J. F. Quantification of pro‐B‐type natriuretic peptide and its products in human plasma by use of an analysis independent of precursor processing. Clin Chem 2002; 48: 1035–42
  • Goetze J. P., Mogelvang R., Maage L., Scharling H., Schnohr P., Sogaard P., Rehfeld J. F., Jensen J. S. Plasma pro‐B‐type natriuretic peptide in the general population: screening for left ventricular hypertrophy and systolic dysfunction. Eur Heart J 2006; 27: 3004–10
  • Fournier T., Medjoubi N., Porquet D. Alpha‐1‐acid glycoprotein. Biochim Biophys Acta 2000; 1482: 157–71
  • Libby P., Ridker P. M., Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 1135–43
  • Engstrom G., Stavenow L., Hedblad B., Lind P., Eriksson K. F., Janzon L., Lindgarde F. Inflammation‐sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke: a population‐based study. Diabetes 2003; 52: 442–7
  • Koenig W., Sund M., Frohlich M., Fischer H. G., Lowel H., Doring A., Hutchinson W. L., Pepys M. B. C‐Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle‐aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237–42
  • Harris T. B., Ferrucci L., Tracy R. P., Corti M. C., Wacholder S., Ettinger W. H Jr., Heimovitz H., Cohen H. J., Wallace R. Associations of elevated interleukin‐6 and C‐reactive protein levels with mortality in the elderly. Am J Med 1999; 106: 506–12
  • Pradhan A. D., Manson J. E., Rifai N., Buring J. E., Ridker P. M. C‐reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. J Am Med Assoc 2001; 286: 327–34
  • Lim S. C., Caballero A. E., Smakowski P., LoGerfo F. W., Horton E. S., Veves A. Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes Care 1999; 22: 1865–70
  • Juhan‐Vague I., Alessi M. C., Vague P. Thrombogenic and fibrinolytic factors and cardiovascular risk in non‐insulin‐dependent diabetes mellitus. Ann Med 1996; 28: 371–80
  • Jude E. B., Douglas J. T., Anderson S. G., Young M. J., Boulton A. J. Circulating cellular adhesion molecules ICAM‐1, VCAM‐1, P‐ and E‐selectin in the prediction of cardiovascular disease in diabetes mellitus. Eur J Intern Med 2002; 13: 185–9
  • Garcia Frade L. J., de la C. H., Torrado M. C., Lara J. I., Cuellar L., Garcia A. A. Hypofibrinolysis associated with vasculopathy in non insulin dependent diabetes mellitus. Thromb Res 1990; 59: 51–9
  • Jensen T., Bjerre‐Knudsen J., Feldt‐Rasmussen B., Deckert T. Features of endothelial dysfunction in early diabetic nephropathy. Lancet 1989; 1: 461–3
  • Held C., Hjemdahl P., Rehnqvist N., Wallen N. H., Forslund L., Bjorkander I., Angelin B., Wiman B. Haemostatic markers, inflammatory parameters and lipids in male and female patients in the Angina Prognosis Study in Stockholm (APSIS). A comparison with healthy controls. J Intern Med 1997; 241: 59–69
  • Ihlemann N., Stokholm K. H., Eskildsen P. C. Impaired vascular reactivity is present despite normal levels of von Willebrand factor in patients with uncomplicated Type 2 diabetes. Diabet Med 2002; 19: 476–81
  • Williams S. B., Cusco J. A., Roddy M. A., Johnstone M. T., Creager M. A. Impaired nitric oxide‐mediated vasodilation in patients with non‐insulin‐dependent diabetes mellitus. J Am Coll Cardiol 1996; 27: 567–74
  • Poirier P., Bogaty P., Garneau C., Marois L., Dumesnil J. G. Diastolic dysfunction in normotensive men with well‐controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy. Diabetes Care 2001; 24: 5–10
  • Redfield M. M., Jacobsen S. J., Burnett J. C Jr., Mahoney D. W., Bailey K. R., Rodeheffer R. J. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. J Am Med Assoc 2003; 289: 194–202
  • Zabalgoitia M., Ismaeil M. F., Anderson L., Maklady F. A. Prevalence of diastolic dysfunction in normotensive, asymptomatic patients with well‐controlled type 2 diabetes mellitus. Am J Cardiol 2001; 87: 320–3
  • Magid E., Guldager H., Hesse D., Christiansen M. S. Monitoring urinary orosomucoid in acute inflammation: observations on urinary excretion of orosomucoid, albumin, {alpha}1–microglobulin, and IgG. Clin Chem 2005; 51: 2052–8
  • Sorensson J., Matejka G. L., Ohlson M., Haraldsson B. Human endothelial cells produce orosomucoid, an important component of the capillary barrier. Am J Physiol 1999; 276((2 Pt 2))H530–4
  • Johnsson E., Haraldsson B. Addition of purified orosomucoid preserves the glomerular permeability for albumin in isolated perfused rat kidneys. Acta Physiol Scand 1993; 147: 1–8
  • Bertrand M. E. Provision of cardiovascular protection by ACE inhibitors: a review of recent trials. Curr Med Res Opin 2004; 20: 1559–69
  • Devaraj S., Chan E., Jialal I. Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome. J Clin Endocrinol Metab 2006; 91: 4489–96

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