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Research Articles

LC-MS/MS analysis of 11-nor-9-carboxy-hexahydrocannabinol (HHC-COOH) and 11-hydroxy-hexahydrocannabinol (HHC-OH) for verification of hexahydrocannabinol (HHC) intake

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Pages 109-114 | Received 08 Dec 2023, Accepted 17 Mar 2024, Published online: 26 Mar 2024

References

  • Ladegard K, Bhatia D. Impact of cannabis legalization on adolescent cannabis use. Psychiatr Clin North Am. 2023;46(4):635–646. doi: 10.1016/j.psc.2023.03.008.
  • Helander A, Villen T. [Drug use and drug trends in Sweden 2010-2020 - results from urine drug testing in the workplace]. Lakartidningen. 2021;118:21056
  • Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003;42(4):327–360. doi: 10.2165/00003088-200342040-00003.
  • Ujvary I. Hexahydrocannabinol and closely related semi-synthetic cannabinoids: a comprehensive review. Drug Test Anal. 2024;16(2):127–161.
  • Socialdepartementet. Nio nya substanser blir narkotikaklassade 2023 [2023-11-17]. Available from: https://www.regeringen.se/pressmeddelanden/2023/06/nio-nya-substanser-blir-narkotikaklassade/.
  • Saitman A, Park HD, Fitzgerald RL. False-positive interferences of common urine drug screen immunoassays: a review. J Anal Toxicol. 2014;38(7):387–396. doi: 10.1093/jat/bku075.
  • The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Hexahydrocannabinol (HHC) and related substances. Accessed on 12 dec 2023. Available from: https://www.emcdda.europa.eu/publications/technical-reports/hhc-and-related-substances_en.
  • Schirmer W, Auwärter V, Kaudewitz J, et al. Identification of human hexahydrocannabinol metabolites in urine. Eur J Mass Spectrom (Chichester). 2023;29(5-6):326–337. doi: 10.1177/14690667231200139.
  • Di Trana A, Di Giorgi A, Sprega G, et al. Disposition of hexahydrocannabinol epimers and their metabolites in biological matrices following a single administration of smoked hexahydrocannabinol: a preliminary study. Pharmaceuticals (Basel). 2024;17(2):249. doi: 10.3390/ph17020249.
  • Roth KD, Siegel NA, Johnson RW, Jr., et al. Investigation of the effects of solution composition and container material type on the loss of 11-nor-Delta 9-THC-9-carboxylic acid. J Anal Toxicol. 1996;20(5):291–300. doi: 10.1093/jat/20.5.291.
  • Helander A, Johansson M, Andersson A, et al. Analytical and medico-legal problems linked to the presence of Delta-8-tetrahydrocannabinol (Delta-8-THC): results from urine drug testing in Sweden. Drug Test Anal. 2022;14(2):371–376. doi: 10.1002/dta.3190.
  • Drugs ESSPoAaO. ESPAD report 2019. 2019.
  • Albertson TE, Chenoweth JA, Colby DK, et al. The changing drug culture: emerging drugs of abuse and legal highs. FP Essent. 2016;441:18–24.
  • Manthey J. Cannabis use in Europe: current trends and public health concerns. Int J Drug Policy. 2019;68:93–96. doi: 10.1016/j.drugpo.2019.03.006.
  • Ferretti ML, Gournay LR, Bingaman MG, et al. A survey study of individuals using hexahydrocannabinol cannabis products: use patterns and perceived effects. Cannabis Cannabinoid Res. 2023 [cited 2023-11-17] [
  • Wolf CE, Pokhai AA, Poklis JL, et al. The cross-reactivity of cannabinoid analogs (Delta-8-THC, Delta-10-THC and CBD), their metabolites and chiral carboxy HHC metabolites in urine of six commercially available homogeneous immunoassays. J Anal Toxicol. 2023;47(8):732–736. doi: 10.1093/jat/bkad059.
  • Kemp PM, Abukhalaf IK, Manno JE, et al. Cannabinoids in humans. II. The influence of three methods of hydrolysis on the concentration of THC and two metabolites in urine. J Anal Toxicol. 1995;19(5):292–298. doi: 10.1093/jat/19.5.292.
  • Aizpurua-Olaizola O, Zarandona I, Ortiz L, et al. Simultaneous quantification of major cannabinoids and metabolites in human urine and plasma by HPLC-MS/MS and enzyme-alkaline hydrolysis. Drug Test Anal. 2017;9(4):626–633. doi: 10.1002/dta.1998.
  • Sempio C, Scheidweiler KB, Barnes AJ, et al. Optimization of recombinant beta-glucuronidase hydrolysis and quantification of eight urinary cannabinoids and metabolites by liquid chromatography tandem mass spectrometry. Drug Test Anal. 2018;10(3):518–529. doi: 10.1002/dta.2230.