The beta-adrenergic system in man: Physiological and pathophysiological response: Regulation of receptor density and functioning

References

• Endert E. Determination of noradrenaline and adrenaline in plasma by a radioenzymatic assay using high pressure liquid chromatography for the separation of the radiochemical products. Clin Chim Acta 1979; 96: 233–9
   PubMed Web of Science ®Google Scholar
• Nyyssönen K., Parviainen M. Plasma catecholamines: laboratory aspects. Critical Reviews in Clinical Laboratory Sciences 1989; 27: 211–36, Ed. Batsakis J, Savory J. CRC Press, Inc. Boca Raton, Florida, USA
   PubMed Web of Science ®Google Scholar
• Helin P., Kuoppasalmi K., Laakso J., Härkönen M. Human urinary biogenic amines and some physiological responses during situation stress. J int Psychophysical 1988; 6: 125–32
   PubMed Web of Science ®Google Scholar
• Lefkowitz R. J., Mukherjee C., Coverstone M., Caron M. C. Stereospecific [3H] (-)-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase. Biochem Biophys Res Commun 1974; 60: 703–9
   PubMed Web of Science ®Google Scholar
• Lefkowitz R. J., Caron M. G., Stiles G. L. Mechanisms of membrane-receptor regulation: biochemical, physiological and clinical insights derived from studies of the adrenergic receptors. N Engl J Med 1984; 310: 1570–9
   PubMed Web of Science ®Google Scholar
• Mäki T. Modulation of β-adrenoceptor density in human lymphocytes: effects of physical exercise, β-adrenergic antagonists and congestive heart failure. thesis, University of Helsinki, HelsinkiFinland 1990
   Google Scholar
• Brodde O-E, Engel G., Hoyer D., Bock K. D., Weber F. The β-adrenergic receptor in human lymphocytes: subclassification by the use of a new radio-ligand, (±)-125iodocyanopindolol. Life Sci 1981; 29: 2189–98
   PubMed Web of Science ®Google Scholar
• Motulsky H. J., Cunningham E. MS, DeBlasi A., Insel P. A. Desensitization and redistribution of β-adrenergic receptors on human mononuclear leukocytes. Am J Physiol 1986; 250: E583–90
   PubMed Web of Science ®Google Scholar
• Williams L. T., Snyderman R., Lefkowitz R. J. Identification of β-adrenergic receptors in human lymphocytes by (-)[3H]alprenolol binding. J Clin Invest 1976; 57: 149–55
   PubMed Web of Science ®Google Scholar
• Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660–72
   Web of Science ®Google Scholar
• Mäki T., Kontula K., Myllynen P., Härkönen M. β-adrenergic receptors of human lymphocytes in physically active and immobilized subjects: characterization by a polyethylene glycol precipitation assay. Scand J Clin Lab Invest 1987; 47: 261–67
   PubMed Web of Science ®Google Scholar
• Ahlquist R. P. A study of the adrenotropic receptors. Am J Physiol 1948; 153: 586–600
   PubMed Web of Science ®Google Scholar
• Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G., Jr. Differentiation of receptor systems activated by sympathomimetic amines. Nature 1967; 214: 597–8
   PubMed Web of Science ®Google Scholar
• Langer S. Z. Presynaptic regulation of catecholamine release. Biochem Pharmacol 1974; 23: 1793–800
   PubMed Web of Science ®Google Scholar
• Dunlop D., Shanks R. G. Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmac Chemother 1968; 32: 201–18
   PubMed Web of Science ®Google Scholar
• Doxey J. C., Smith C. FC, Walker J. M. Selectivity of blocking agents for pre-and postsynaptic α-adrenoceptors. Br J Pharmacol 1977; 60: 91–6
   PubMed Web of Science ®Google Scholar
• Kobilka B. K., Dixon R. AF, Frielle T., et al. cDNA for the human β2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 1987a; 84: 46–50
   PubMed Web of Science ®Google Scholar
• Chung F-Z, Lentes K-U, Gocayne J., et al. Cloning and sequence analysis of the human brain β-adrenergic receptor. FEBS Lett 1987; 211: 200–6
   PubMed Web of Science ®Google Scholar
• Frielle T., Collins S., Daniel K. W., Caron M. G. ym Cloning of the cDNA for the human β1-adrenergic receptor. Proc Natl Acad Sci 1987; 84: 7920–4
   PubMed Web of Science ®Google Scholar
• Kobilka B. K., Matsui H., Kobilka T. S., et al. Cloning, sequencing, and expression of the gene coding for the human platelet α2-adrenergic receptor. Science 1987b; 238: 650–6
   PubMed Web of Science ®Google Scholar
• Regan J. W., Kobilka T. S., Yang-Feng T. L., Caron M. G., Lefkowitz R. J., Kobilka B. K. Cloning and expression of a human kidney cDNA for an α2-adrenergic receptor subtype. Proc Natl Acad Sci USA 1988; 85: 6301–5
   PubMed Web of Science ®Google Scholar
• Emorine L. J., Marullo S., Briend-Sutren M-M, et al. Molecular characterization of the human β3-adrenergic receptor. Science 1989; 245: 1118–21
   PubMed Web of Science ®Google Scholar
• Sigal I. S., Dixon R. AF, Strader C. D. Molecular biology of adrenergic receptors. ISI Atlas Sci: Pharmacol 1988; 2: 387–91
   Google Scholar
• Dixon R. AF, Sigal I. S., Candelore M. R., et al. Structural features required for ligand binding to the β-adrenergic receptor. EMBO J 1987a; 6: 3269–75
   PubMed Web of Science ®Google Scholar
• Strader C. D., Sigal I. S., Register R. B., Candelore M. R., Rands E., Dixon R. AF. Identification of residues required for ligand binding to the β-adrenergic receptor. Proc Natl Acad Sci USA 1987a; 84: 4384–8
   PubMed Web of Science ®Google Scholar
• Dohlman H. G., Caron M. G., Strader C. D., Amlaiky N., Lefkowitz R. J. Identification and sequence of a binding site peptide of the β2-adrenergic receptor. Biochemistry 1988; 27: 1813–7
   PubMed Web of Science ®Google Scholar
• Kobilka B. K., Kobilka T. S., Daniel K., Regan J. W., Caron M. G., Lefkowitz R. J. Chimeric α2-, β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science 1988; 240: 1310–6
   PubMed Web of Science ®Google Scholar
• Strader C. D., Sigal I. S., Blake A. D., et al. The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration. Cell 1987b; 49: 855–63
   PubMed Web of Science ®Google Scholar
• Levitzki A. From epinephrine to cyclic AMP. Science 1988; 241: 800–6
   PubMed Web of Science ®Google Scholar
• Lefkowitz R. J., Caron M. G. Molecular and regulatory properties of adrenergic receptors. Recent Prog Horm Res 1987; 43: 469–97
   PubMedGoogle Scholar
• Brodde O-E, Wang X. L., O'Hara N., Daul A., Schiess W. Effect of propranolol, alprenolol, pindolol, and bopindolol on β2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol 1986a; 8(suppl 6)S70–3
   PubMed Web of Science ®Google Scholar
• Liggett S. B., Marker J. C., Shah S. D., Roper C. L., Cryer P. E. Direct relationship between mononuclear leukocyte and lung β-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, α-and β-adrenergic receptors by the sympathochromaffin system in humans. J Clin Invest 1988; 82: 48–56
   PubMed Web of Science ®Google Scholar
• Michel M. C., Pingsmann A., Nohlen M., Siekmann U., Brodde O-E. Decreased myometrial β-adrenoceptors in women receiving β2-adrenergic tocolytic therapy: correlation with lymphocyte β-adrenoceptors. Clin Pharmacol Ther 1989; 45: 1–8
   PubMed Web of Science ®Google Scholar
• Michel M. C., Beckeringh J. J., Ikezono K., Kretsch R., Brodde O-E. Lymphocyte beta2-adrenoceptors mirror precisely beta2-adrenoceptor, but poorly betapadrenoceptor changes in the human heart. J Hypertens 1986; 4(suppl 6)S215–8
   PubMed Web of Science ®Google Scholar
• Aarons R. D., Nies A. S., Gerber J. G., Molinoff P. B. Decreased beta adrenergic receptor density on human lymphocytes after chronic treatment with agonists. J Pharmacol Exp Ther 1983; 224: 1–6
   PubMed Web of Science ®Google Scholar
• Galant S. P., Duriseti L., Underwood S., Allred S. Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma. J Clin Invest 1980; 65: 577–85
   PubMed Web of Science ®Google Scholar
• Colucci W. S., Alexander R. W., Williams G. H., et al. Decreased lymphocyte beta-adrenergic-receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. N Engl J Med 1981; 305: 185–90
   PubMed Web of Science ®Google Scholar
• Valet P., Damase-Michel C., Chamontin B., et al. Adrenoceptors in the diagnosis of pheochromocytoma. Lancet 1987; II: 337
   Google Scholar
• Valet P., Damase-Michel C., Chamontin B., Durand D., Chollet F., Montastruc J. L. Platelet α2-and leucocyte β2-adrenoceptors in pheochromocytoma: effect of tumour removal. Eur J Clin Invest 1988; 18: 481–5
   PubMed Web of Science ®Google Scholar
• Benovic J. L., Kühn H., Weyand I., Codina J., Caron M. G., Lefkowitz R. J. Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc Natl Acad Sci USA 1987; 84: 8879–82
   PubMed Web of Science ®Google Scholar
• Sibley D. R., Benovic J. L., Caron M. G., Lefkowitz R. J. Regulation of transmembrane signaling by receptor phosphorylation. Cell 1987; 48: 913–22
   PubMed Web of Science ®Google Scholar
• Strulovici B., Stadel J. M., Lefkowitz R. J. Functional integrity of desensitized β-adrenergic receptors. J Biol Chem 1983; 258: 6410–4
   PubMed Web of Science ®Google Scholar
• Hadcock J. R., Malbon C. C. Down-regulation of β-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc Natl Acad Sci USA 1988; 85: 5021–5
   PubMed Web of Science ®Google Scholar
• Collins S., Bouvier M., Bolanowski M. A., Caron M. G., Lefkowitz R. J. cAMP stimulates transcription of the β2-adrenergic receptor gene in response to shortterm agonist exposure. Proc Natl Acad Sci USA 1989; 86: 4853–7
   PubMed Web of Science ®Google Scholar
• Burman K. D., Ferguson E. W., Djuh Y-Y, Wartofsky L., Latham K. Beta receptors in peripheral mononuclear cells increase acutely during exercise. Acta Endocrinol (Copenh) 1985; 109: 563–8
   PubMedGoogle Scholar
• Brodde O-E, Daul A. E., Wang X. L., Michel M. C., Galal O. Dynamic exercise-induced increase in lymphocyte β2-adrenoceptors: Abnormality in essential hypertension and its correction by antihypertensives. Clin Pharmacol Ther 1987; 41: 371–9
   PubMed Web of Science ®Google Scholar
• Mäki T., Näveri H., Härkönen M., Kontula K. Propranolol attenuates exercise-induced increment in human lymphocytic β-adrenergic receptors. Scand J Clin Lab Invest 1988; 48: 357–63
   PubMed Web of Science ®Google Scholar
• Mäki T., Leinonen H., Näveri H., Sovijärvi A., Kontula K., Härkönen M. Response of the β-adrenergic system to maximal dynamic exercise in congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 1989; 63: 1348–53
   PubMed Web of Science ®Google Scholar
• Mäki T., Näveri H., Leinonen H., Sovijärvi A., Lewko B., Härkönen M., Kontula K. Effect of propranolol and pindolol on the up-regulation of lymphocytic β-adrenoceptors during acute submaximal physical exercise. J Cardiovasc Pharmacol, (in press)
   Web of Science ®Google Scholar
• Middeke M., Lohmöller O., Remien J., Kirzinger S., Holzgreve H. Acute regulation of lymphocyte β-adrenoceptor activity in pheochromocytoma. Klin Wochenschr 1988; 66: 187–9
   PubMedGoogle Scholar
• Tohmeh J. F., Cryer P. E. Biphasic adrenergic modulation of β-adrenergic receptors in man: agonist-induced early increment and late decrement in β-adrenergic receptor number. J Clin Invest 1980; 65: 836–40
   PubMed Web of Science ®Google Scholar
• Izawa T., Komabayashi T., Suda K., Kunisada Y., Shinoda S., Tsuboi M. An acute exercise-induced translocation of β-adrenergic receptors in rat myocardium. J Biochem 1989; 105: 110–3
   PubMed Web of Science ®Google Scholar
• Scheuer J., Tipton C. M. Cardiovascular adaptations to physical training. Annu Rev Physiol 1977; 39: 221–51
   PubMed Web of Science ®Google Scholar
• Lehmann M., Keul J., Huber G., Da Prada M. Plasma catecholamines in trained and untrained volunteers during graduated exercise. Int J Sports Med 1981; 2: 143–7
   PubMed Web of Science ®Google Scholar
• Lehmann M., Dickhuth H. H., Schmid P., Porzig H., Keul J. Plasma catecholamines, β-adrenergic receptors, and isoproterenol sensitivity in endurance trained and non-endurance trained volunteers. Eur J Appl Physiol 1984; 52: 362–9
   Web of Science ®Google Scholar
• Ohman E. M., Butler J., Kelly J., Horgan J., O'Malley K. Beta-adrenoceptor adaptation to endurance training. J Cardiovasc Pharmacol 1987; 10: 728–31
   PubMed Web of Science ®Google Scholar
• Butler J., O'Brien M., O'Malley K., Kelly J. G. Relationship of β-adrenoceptor density to fitness in athletes. Nature 1982; 298: 60–2
   PubMed Web of Science ®Google Scholar
• Williams R. S. Physical conditioning and membrane receptors for cardioregulatory hormones. Cardiovasc Res 1980; 14: 178–183
   Web of Science ®Google Scholar
• Williams R. S., Eden R. S., Moll M. E., Lester R. M., Wallace A. G. Autonomic mechanisms of training bradycardia: β-adrenergic receptors in humans. J Appl Physiol 1981; 51: 1232–7
   PubMed Web of Science ®Google Scholar
• Galbo H., Hoist J. J., Christensen N. J. Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J Appl Physiol 1975; 38: 70–6
   PubMed Web of Science ®Google Scholar
• Galbo H., Hoist J. J., Christensen N. J., Hilsted J. Glucagon and plasma catecholamines during β-receptor blockade in exercising man. J Appl Physiol 1976; 40: 855–63
   PubMed Web of Science ®Google Scholar
• Näveri H. Blood hormone and metabolite levels during graded cycle ergometer exercise. Scand J Clin Lab Invest 1985; 45: 599–603
   PubMed Web of Science ®Google Scholar
• Butler J., Kelly J. G., O'Malley K., Pidgeon F. β-adrenoceptor adaptation to acute exercise. J Physiol 1983; 344: 113–7
   PubMed Web of Science ®Google Scholar
• Mäki T. Density and functioning of human lymphocytic β-adrenergic receptors during prolonged physical exercise. Acta Physical Scand 1989; 136: 5569–74
   Google Scholar
• Brodde O-E, Brinkmann M., Schemuth R., O'Hara N., Daul A. Terbutaline-induced desensitization of human lymphocyte β2-adrenoceptors: accelerated restoration of β-adrenoceptor responsiveness by prednisone and ketotifen. J Clin Invest 1985; 76: 1096–101
   PubMed Web of Science ®Google Scholar
• Landmann R., Portenier M., Staehelin M., Wesp M., Box R. Changes in β-adrenoceptors and leucocyte subpopulations after physical exercise in normal subjects. Naunyn Schmiedeberg's Arch Pharmacol 1988; 337: 261–6
   Google Scholar
• Oshida Y., Yamanouchi K., Hayamizu S., Sato Y. Effect of acute physical exercise on lymphocyte subpopulations in trained and untrained subjects. Int J Sports Med 1988; 9: 137–40
   PubMed Web of Science ®Google Scholar
• Krawietz W., Werdan K., Schober M., Erdmann E., Rindfleisch G. E., Hannig K. Different numbers of β-receptors in human lymphocyte subpopulations. Biochem Pharmacol 1982; 31: 133–6
   PubMed Web of Science ®Google Scholar
• Griese M., Körholz U., Körholz D., Seeger K., Wahn V., Reinhardt D. Density and agonist-promoted high and low affinity states of the β-adrenoceptor on human B-and T-cells. Eur J Clin Invest 1988; 18: 213–7
   PubMed Web of Science ®Google Scholar
• Brodde O-E, Wang X-L. Beta-adrenoceptor changes in blood lymphocytes and altered drug responsiveness. Ann Clin Res 1988b; 20: 311–23
   PubMedGoogle Scholar
• Michel M. C., Johnston T., Nohlen M. Acute regulation of human lymphocyte β2-adrenoceptor density by β-agonists. Naunyn-Schmiedeberg's arch Pharmacol 1987; 335(suppl)R87
   Google Scholar
• Werle E. O., Koglin J., Weicker H. Exercise-induced increase in beta2-adrenoceptor density in human lymphocyte subsets. Paavo Nurmi Congress Book: Advanced European Course on Sports Medicine, M. Kvist, TurkuFinland 1989; 345
   Google Scholar
• Aarons R. D., Molinoff P. B. Changes in the density of beta adrenergic receptors in rat lymphocytes, heart and lung after chronic treatment with propranolol. J Pharmacol Exp Ther 1982; 221: 439–43
   PubMed Web of Science ®Google Scholar
• Hedberg A., Gerber J. G., Nies A. S., Wolfe B. B., Molinoff P. B. Effects of pindolol and propranolol on beta-adrenergic receptors on human lymphocytes. J Pharmacol Exp Ther 1986; 239: 117–23
   PubMed Web of Science ®Google Scholar
• Miller R. R., Olson H. G., Amsterdam E. A., Mason D. T. N Engl J Med 1975; 293: 416–8
   PubMed Web of Science ®Google Scholar
• Nattel S., Rangno R. E., Van Loon G. Mechanism of propranolol withdrawal phenomena. Circulation 1979; 59: 1158–64
   PubMed Web of Science ®Google Scholar
• Bolli P., Amann F. W., Müller F. B., Meyer B., Burckhardt D., Bühler F. R. Withdrawal of the long-acting β-blocker bopindolol is not associated with β-adrenoceptor supersensitivity. J Cardiovasc Pharmacol 1986; 8(suppl 6)S64–9
   PubMed Web of Science ®Google Scholar
• Michel M. C., Pingsmann A., Beckeringh J. J., Zerkowski H-R, Doetsch N., Brodde O-E. Selective regulation of βp and β2-adrenoceptors in the human heart by chronic β-adrenoceptor antagonist treatment. Br J Pharmacol 1988; 94: 685–92
   PubMed Web of Science ®Google Scholar
• Aellig W. H., Clark B. J. Is the ISA of pindolol β2-adrenoceptor selective?. Br J Clin Pharmacol 1987; 24: 21S–8
   PubMed Web of Science ®Google Scholar
• Brodde O-E, Daul A., Wellstein A., Palm D., Michel M. C., Beckeringh J. J. Differentiation of β1-and β2-adrenoceptor-mediated effects in humans. Am J Physiol 1988; 254: H199–206
   PubMed Web of Science ®Google Scholar
• Lundborg P., Åström H., Bengtsson C., et al. Effect of β-adrenoceptor blockade on exercise performance and metabolism. Clin Sci 1981; 61: 299–305
   PubMed Web of Science ®Google Scholar
• Ades P. A. Cardiac effects of β-adrenoceptor blockade with intrinsic sympathomimetic activity during submaximal exercise. Br J Clin Pharmacol 1987; 24: 29S–33S
   PubMed Web of Science ®Google Scholar
• Ohyanagi M., Matsumori Y., Iwasaki T. Beta-adrenergic receptors in ischemic and nonischemic canine myocardium: relation to ventricular fibrillation and effects of pretreatment with propranolol and hexamethonium. J Cardiovasc Pharmacol 1988; 11: 107–14
   PubMed Web of Science ®Google Scholar
• Vatner D. E., Knight D. R., Shen Y-T, Thomas J. X., Homey C. J., Vatner S. F. One hour of myocardial ischaemia in conscious dogs increases β-adrenergic receptors, but decreases adenylate cyclase activity. J Mol Cell Cardiol 1988; 20: 75–82
   PubMed Web of Science ®Google Scholar
• Cohn J. N., Levine T. B., Olivari M. T., et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984; 311: 819–23
   PubMed Web of Science ®Google Scholar
• Masking G. J., Esler M. D. Jennings GL, Burton D, Johns JA, Korner PI, Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986; 73: 615–21
   PubMed Web of Science ®Google Scholar
• Rona G., Chappel C. I., Balazs T., Gaudry R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 1959; 67: 443–55
   PubMedGoogle Scholar
• Fowler M. B., Laser J. A., Hopkins G. L., Minobe W., Bristow M. R. Assessment of the β-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. Circulation 1986; 74: 1290–302
   PubMed Web of Science ®Google Scholar
• Bristow M. R., Hershberger R. E., Port J. D., Minobe W., Rasmussen R. βp and β2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 1989; 35: 295–303
   PubMed Web of Science ®Google Scholar
• Bristow M. R., Ginsburg R., Umans V., et al. β1-and β2-adrenergic-receptor subpopulations in non-failing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective β1-preceptor down-regulation in heart failure. Circ Res 1986; 59: 297–309
   PubMed Web of Science ®Google Scholar
• Horn E. M., Corwin S. J., Steinberg S. F., Chow Y. K., Neuberg G. W., Cannon P. J., Powers E. R., Bilezikian J. P. Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and β-adrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy. Circulation 1988; 78: 1373–9
   PubMed Web of Science ®Google Scholar
• Mancini D. M., Frey M. J., Fischberg D., Molinoff P. B., Wilson J. R. Characterization of lymphocyte beta-adrenergic receptors at rest and during exercise in ambulatory patients with chronic congestive heart failure. Am J Cardiol 1989; 63: 307–12
   PubMed Web of Science ®Google Scholar
• Limas C. J., Goldenberg I. F., Limas C. Autoantibodies against β-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 1989a; 64: 97–103
   PubMed Web of Science ®Google Scholar
• Limas C. J., Goldenberg I. F., Limas C. Effect of cardiac transplantation on anti-beta-receptor antibodies in idiopathic dilated cardiomyopathy. Am J Cardiol 1989b; 63: 1134–7
   PubMed Web of Science ®Google Scholar
• Feldman A. M., Cates A. E., Veazey W. B., et al. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest 1988; 82: 189–97
   PubMed Web of Science ®Google Scholar
• Neumann J., Schmitz W., Scholz H., von Meyerinck L., Döring V., Kalmar P. Increase in myocardial Gi-proteins in heart failure. Lancet 1988; 2: 936–7
   PubMed Web of Science ®Google Scholar
• Bilezikian J. P., Steinberg S. F., Horn E. M., Robinson R. B., Rosen M. R. G protein-adrenergic interactions in the heart. Mol Cell Biochem 1988; 82: 5–11
   PubMed Web of Science ®Google Scholar
• Waagstein F., Hjalmarson A., Swedeberg K., Wallentin I. Beta-blockers in dilated cardiomyopathies: they work. Eur Heart J 1983; 4(suppl A)173–8
   PubMed Web of Science ®Google Scholar
• Engelmeier R. S., O'Connell J. B., Walsh R., Rad N., Scanlon P. J., Gunnar R. M. Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial. Circulation 1985; 72: 536–46
   PubMed Web of Science ®Google Scholar
• Fowler M. B., Bristow M. R. Rationale for beta-adrenergic blocking drugs in cardiomyopathy. Am J Cardiol 1985; 55: 120D–4
   PubMed Web of Science ®Google Scholar
• Heilbrunn S. M., Shah P., Bristow M. R., Valantine H. A., Ginsburg R., Fowler M. B. Increased β-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation 1989; 79: 483–90
   PubMed Web of Science ®Google Scholar
• Hynie S., Lanefelt F., Fredholm B. B. Effects of ethanol on human lymphocyte levels of cyclic AMP in vitro: Potentiation of the response to isoproterenol, prostaglandin E2 or adenosine stimulation. Acta Pharmacol Toxicol 1980; 47: 58–65
   PubMedGoogle Scholar
• Heikkonen E., Mäki T., Kontula K., Ylikahri R., Härkönen M. Effect of acute ethanol intake and hangover on the levels of plasma and urinary catecholamines and lymphocytic β-adrenergic receptors. Alcohol Clin Exp Res 1989; 13: 20–4
   PubMed Web of Science ®Google Scholar
• Brohult J., Levi L., Reichard H. Urinary excretion of adrenal hormones in man. Effects of ethanol ingestion, and their modification by chlomethiazole. Acta Med Scand 1979; 188: 5–13
   Google Scholar
• Eisenhofer G., Lambie D. G., Johnson R. H. Effects of ethanol on plasma catecholamines and norepinephrine clearance. Clin Pharmacol Ther 1983; 34: 143–7
   PubMed Web of Science ®Google Scholar
• Heikkonen E. Endocrine and metabolic changes induced by alcohol and physical exercise in healthy males. thesis, The Rehabilitation Research Centre of the Social Insurance Institution, TurkuFinland 1989; 50–1
   Google Scholar
• Mochly-Rosen D., Chang F-H, Cheever L., Kim M., Diamond I., Gordon A. S. Chronic ethanol causes heterologous desensitization of receptors by reducing αs messenger RNA. Nature 1988; 333: 848–50
   PubMed Web of Science ®Google Scholar
• Banerjee S. P., Sharma V. K., Khanna J. M. Alterations in β-adrenergic receptor binding during ethanol withdrawal. Nature 1978; 276: 407–9
   PubMed Web of Science ®Google Scholar
• Hoffman P. L., Valverius P., Kwast M., Tabakoff B. Comparison of the effects of ethanol on beta-adrenergic receptors in heart and brain. Alcohol Alcohol 1987; 749–54, (suppl 1)
   Web of Science ®Google Scholar
• Diamond I., Wrubel B., Estrin W., Gordon A. Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. Proc Natl Acad Sci USA 1987; 84: 1413–6
   PubMed Web of Science ®Google Scholar
• Lykouras L., Markianos M., Moussas G. Plasma cyclic AMP in non-abstinent chronic alcoholics. Relation to clinical parameters. Drug Alcohol Depend 1988; 21: 7–9
   PubMed Web of Science ®Google Scholar
• Bylund D. B., Solomon N., Ray-Prenger C., Jones S. B., Harris R. A. Comparison of adrenergic receptor binding in blood cells from alcoholics and controls. Alcohol 1984; 1: 369–72
   PubMedGoogle Scholar
• Mäki T., Heikkonen E., Härkönen T., Kontula K., Härkönen M., Ylikahri R. Reduction of lymphocytic β-adrenoceptor level in chronic alcoholics and rapid reversal after ethanol withdrawal. Eur J Clin Invest, (in press)
   Web of Science ®Google Scholar
• Brooks S. M., McGowan K., Altenau P. Relationship between β-adrenergic binding in lymphocyte and severity of disease in asthma. Chest 1979; 75: 232–34
   PubMed Web of Science ®Google Scholar
• Motojima S., Fukuda T., Makino S. Measurements of β-adrenergic receptors of lymphocytes in normal subjects and asthmatics in relation to β-edrenergic hyperglycaemic response and bronchial responsivness. Allergy 1983; 38: 331–7
   PubMed Web of Science ®Google Scholar
• Galant S. P., Duriseti L., Underwood S., Allred S. Beta-adrenergic receptors of polymorphonuclear particulates in bronchial asthma. J Clin Invest 1980; 65: 577–85
   PubMed Web of Science ®Google Scholar
• Reinhardt D., Zehmisch T., Becker B., Nagel-Hiemke M. Age-dependency of alpha-and beta-adrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children. Eur J Pediatr 1984; 142: 111–6
   PubMed Web of Science ®Google Scholar
• Scarpace P. J., Littner M. R., Tashkin D. P., Abrass I. B. Lymphocyte β-adrenergic refractoriness induced by theophylline or metaproterenol in healthy and asthmatic subjects. Life Sci 1982; 31: 1567–3
   PubMed Web of Science ®Google Scholar
• Barnes P. J., Dollery C. T., MacDermot J. Increased pulmonary α-adrenergic and reduced β-adrenergic receptors in experimental asthma. Nature 1980; 285: 569–71
   PubMed Web of Science ®Google Scholar
• Ginsberg A. M., Clutter W. E., Shah S. D., Cryer P. E. Triiodothyronine-induced thyrotoxicosis increases mononuclear leukocyte β-adrenergic receptor density in man. J Clin Invest 1981; 67: 1785–91
   PubMed Web of Science ®Google Scholar
• Andersson R. G G, Nilsson O. R., Kuo J. F. β-adrenoceptor-adenosine 3′,5′-monophosphate system in human leucocytes before and after treatment for hyperthyroidism. J Clin Ednocrinol Met b 1983; 56: 42–5
   PubMed Web of Science ®Google Scholar
• Gognini G., Piantanelli L., Paolinelli E. Decreased β-adrenergic receptor density in mononuclear leucocytes from thyroidectomized patients. Acta Endocrinol 1983; 103: 40–5
   PubMedGoogle Scholar
• Limas C., Limas C. J. Influence of thyroid status on the intracellular distribution of cardiac adrenoceptor. Circ Res 1987; 61: 827–8
   Web of Science ®Google Scholar
• Shamoon H., Hendler R., Sherwin R. S. Altered responsiveness to cortisol, epinephrine and glucagon in insulin-infused juvenile-onset diabetics. Diabetes 1980; 29: 284–91
   PubMed Web of Science ®Google Scholar
• Gœtzsche O. The adrenergic β-receptor adenylate cyclase system in heart and lymphocytes from streptozotocin-diabetic rats. In vivo and in vitro evidence for a desensitized myocardial β-receptor. Diabetes 1983; 32: 1110–6
   PubMed Web of Science ®Google Scholar
• Sérusclat P., Rosen S. G., Smith E. B. Mononuclear leukocyte β-adrenergic receptors and adenylate cyclase sensitivity in insulin-dependent diabetes mellitus. Diabetes 1983; 32: 825–9
   PubMed Web of Science ®Google Scholar
• Stiles G. L., Caron M. G., Lefkowitz R. J. β-Adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol Rev 1984; 64: 661–743
   PubMed Web of Science ®Google Scholar
• Rosendorf C., Susanni E., Hurwitz M. L., Ross F. P. Adrenergic receptors in hypertension: Radioligand binding studies. J Hypertension 1985; 3: 571–81
   PubMed Web of Science ®Google Scholar
• Hoffman E. P., Brown R. H., Kunkel L. M. Dystrophin: the protein of the Duchenne muscular dystrophy locus. Cell 1987; 5: 919–28
   Web of Science ®Google Scholar
• Rowland L. P. Biochemistry of muscle membranes in Duchenne muscular dystrophy. Muscle Nerve 1980; 3: 3–20
   PubMed Web of Science ®Google Scholar
• Cerri C., Willner J. H., Rowland L. P. Assay of adenylate cyclase in homogenates of control and Duchenne human skeletal muscle. Clin Chim Acta 1981; 111: 133–46
   PubMed Web of Science ®Google Scholar
• Bøyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21(suppl 97)77–89
   PubMed Web of Science ®Google Scholar