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Research Article

Expression of a Specific Mucin Type Recognized by Monoclonal Antibodies in the Rat Gastric Mucosa Regenerating from Acetic Acid-induced Ulcer

Pages 467-473 | Published online: 08 Jul 2009

References

  • Hollander F. The two-component mucus barrier—its activity in protecting the gastro-duodenal mucosa against peptic ulceration. Arch Intern Med 1954;93:107–20.
  • Menguy R. Gastric mucus and the gastric mucosal barrier: a review. Am J Surg 1969;117:806–12.
  • Allen A. Structure of gastrointestinal mucus glycoproteins and the viscous and gel forming properties of mucus. Br Med Bull 1978;34:28–33.
  • Carlstedt I, Sheehan JK, Corfield P, Gallagher JT. Mucus glycoproteins—a gel of a problem. Essays Biochem 1985;20: 40–76.
  • Komuro Y, Ishihara K, Ohara S, Saigenji K, Hotta K. Effects of tetragastrin on mucus glycoprotein in rat gastric mucosal protection. Gastroenterol Jpn 1992;27:597–603.
  • Ichikawa T, Ishihara K, Kusakabe T, Kurihara M, Kawakami T, Takenaka T, Saigenji K, et al. Distinct effect of teragastrin, histamine, and CCh on rat gastric mucin synthesis and contribution of NO. Am J Physiol 1998;274 (Gastrointest Liver Physiol 37):G138–46.
  • Azuumi Y, Ichikawa T, Ishihara K, Hotta K. The validity of the ethanol precipitation method for the measurement of mucin content in human gastric juices and its possible relationship to gastroduodenal diseases. Clin Chim Acta 1993;221:219–25.
  • Spicer SS, Sun DCH. Histochemical and morphologic changes in gastric mucosa of dogs on ulcerogenic regimen. Am J Pathol 1969;56:129–51.
  • Sugiyama A. Histochemical study of mucins on the healing process of experimental gastric ulcers. Shinshu Med J 1990; 38:363–79. In Japanese with English summary.
  • Sugiyama A, Ichikawa H, Kobayashi C, Hashikura Y, Katsuysma T. Physiological significance of mucous neck cell-type mucins in the healing of acetic acid-induced gastric ulcer in rats. Scand J Gastroenterol 1989;24 Suppl 162:142–5.
  • Ishihara K, Kurihara M, Goso Y, Ota H, Katsuyama T, Hotta K. Establishment of monoclonal antibodies against carbohydrate moiety of gastric mucins distributed in the different sites and layers of rat gastric mucosa. Glycoconjugate J 1996;13:857–64.
  • Ishihara K, Kurihara M, Eto H, Kasai K, Shimauchi S, Hotta K. A monoclonal antibody against carbohydrate moiety of rat gastric surface epithelial cell-derived mucin. Hybridoma 1993; 12:609–20.
  • Hayashida H, Ishihara K, Kurihara M, Saigenji K, Hotta K. Alteration of mucins in rat gastric mucosa healing from acetic acid-induced ulcer: an immunohistochemical study using monoclonal antibodies against gastric mucins. Biomed Res 2000;21:95–103.
  • Takagi K, Okabe S, Saziki R. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jap J Pharmacol 1969;19:418–26.
  • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256: 616–26.
  • Groth S, Scheidegger D. Production of monoclonal antibodies: strategy and tactics. J Immunol Methods 1980;35:1–21.
  • Ishihara K, Kurihara M, Goso Y, Urata T, Ota H, Katsuyama T, et al. Peripheral α-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric grand mucous cells: epitope recognized by a newly characterized monoclonal antibody. Biochem J 1996;318:409–16.
  • Hara A, Saegusa M, Mitomi H, Kurihara M, Ishihara K, Hotta K, et al. Colonic mucin-carbohydrate components in colorectal tumors and their possible relationship to MUC2, p53 and DDC immunoreactivities. Pathol Res Pract 2000;196:159–66.
  • Suganuma T, Katsuyama T, Tsukahara M, Tatematsu M, Sakakura Y, Murata F. Comparative histochemical study of alimentary tracts with special reference to the mucous neck cells of the stomach. Am J Anat 1981;161:219–38.
  • Katsuyama T, Spicer SS. Histochemical differentiation of complex carbohydrates with valiants of Concanavalin A-horse-radish peroxidase method. J Histochem Cytochem 1978;26:233–50.
  • Ota H, Katsuyama T, Ishii K, Nakayama J, Shiozawa T, Tsukahara Y. A dual staining method for identifying mucins of different gastric epithelial mucous cell. Histochem J 1991;23: 22–8.
  • Goso Y, Ishihara K, Kurihara M, Sugaya T, Hotta K. Rat gastric mucins recognized by monoclonal antibodies RGM21 and HIK1083: isolatoin of mucin species characteristic of the surface and glandular mucosa. J Biochem 1999;126: 375–81.
  • Ichikawa T, Endoh H, Hotta K, Ishihara K. Hepatocyte growth facter region specifically activates mucin synthesis in rat stomach. Eur J Pharmacol 2000;392:87–91.
  • Ichikawa T, Ishihara K, Kusakabe T, Hiruma H, Kawakami T, Hotta K. CGRP modulates mucin synthesis in surface mucus cells of rat oxyntic mucosa. Am J Physiol 2000;279:G82–9.
  • Nakamura N, Ota H, Katsuyama T, Akamatsu T, Ishihara K, Kurihara M, et al. Histochemical reactivity of normal, metaplastic, and neoplastic tissues to α-linked N-acetyl glucosamine residue specific monoclonal antibody HIK1083. J Histochem Cytochem 1998;46:793–801.
  • Helpap B, Hattori T, Gedigk. Repair of gastric ulcer. A cell kinetic study. Virchows Arch A 1981;392:159–70.
  • Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, et al. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem 1993;268:5879–85.
  • Ho SB, Roberton AM, Shekels LL, Lyftogt CT, Niehans GA, et al. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 1995;109:735–47.
  • de Bolos C, Garrido M, Real FX. MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 1995;109: 723–34.
  • Gum JR Jr, Hicks JW, Toribara NW, Siddiki B, Kim YS. Molecular cloning of human intestinal mucin (MUC2) cDNA. J Biol Chem 1994;269: 2442–6.
  • Gum JR Jr, Ho JJL, Pratt WS, Hicks JW, Hill AS, Vinall LE, et al. MUC3 human intestinal mucin: analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. J Biol Chem 1997;272:26,678–86.
  • Hattori T, Fujita S. Tritiated thymidine autoradiographic study on cellular migration in the gastric gland of the golden hamster. Cell Tissue Res 1976;172:171–84.

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