Long-term Omeprazole Treatment Suppresses Body Weight Gain and Bone Mineralization in Young Male Rats

References

• Solcia E, Rindi G, Buffa R, Fiocca R, Capella C. Gastric endocrine cells: types, function and growth. Regul Pept 2000;25:31–5.
   Google Scholar
• Waldum HL, Sandvik AK, Syversen U, Brenna E. The enterochromaffi n-like (ECL) cell: physiological and pathological role. Acta Oncol 1993;32:141–7.
   PubMed Web of Science ®Google Scholar
• Håkanson R, Chen D, Sundler F. The ECL cells. In: Johnson LR, editor. Physiology of the gastrointestinal tract, vol. 2. New York: Raven Press; 1994. p. 1171–84.
   Google Scholar
• Walsh JH. Gastrointestinal hormones. In: Johnson LR, editor. Physiology of the gastrointestinal tract. New York: Raven Press; 1994. p. 1–128.
   Google Scholar
• Persson P, Håkanson R, Axelson J, Sundler F. Gastrin releases a blood-calcium lowering peptide from the acid-producing part of the rat stomach. Proc Natl Acad Sci USA 1989;86:2834–8.
   PubMed Web of Science ®Google Scholar
• Persson P, Gagnemo-Persson R, Orberg J, Chen D, Hakanson R. Effect of gastrin on calcium homeostasis in chicken. Endocrinology 1991;129:1162–6.
   PubMed Web of Science ®Google Scholar
• Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656–7.
   PubMed Web of Science ®Google Scholar
• Dornonvill de la Cour C, Mjorkqvisk M, Sandvik AK, Bakke I, Zhao C-M, Chen D, et al. A-like cells in the rat stomach contacin ghrelin and do not operate under gastrin control. Regul Pept 2001;99:141–50.
   Google Scholar
• Langtry HD, Wilde MI. Omeprazole: a review of its use in Helicobacter pylori infection, gastro-oesphageal reflux diseases and peptic ulcers induced by nonsteroidal anti-inflammatory drugs. Drugs 1998;6:47–86.
   Google Scholar
• Larsson H, Carlsson E, Mattsson H, Lundell L, Sundler F, Sundell G, et al. Plasma gastrin and gastric enterchromaffi n-like cell activation and proliferation. Gastroenterology 1986;90:391–9.
   PubMed Web of Science ®Google Scholar
• Eissele R, Rosskopf B, Koop H, Adler G, Arnold R. Proliferation of endocrine cells in the rat stomach caused by drug- induced achlorhydria. Gastroenterology 1991;101:70–6.
   Google Scholar
• Chen D, Zhao C-M, Norlen P, Bjorkqvist M, Ding X-Q, Kitano M, et al. Effect of cholecystokinin-2 receptor blockade on rat stomach ECL cells: a histochemical, electron-microscopic and chemical study. Cell Tissue Res 2000;299: 81–95.
   Google Scholar
• Thirumazhisai SG, Hassall EG. Efficacy and safety of omeprazole for severe gastroesophageal reflux in children. J Paediatr 1993;123:148–54.
   PubMed Web of Science ®Google Scholar
• Israel D, Hassall E. Omeprazole and other proton pump inhibi- tiors: pharmacology, efficacy, and safety, with special reference to use in children. J Pediatr Gastroenterol Nutr 1998;27:568–79.
   PubMed Web of Science ®Google Scholar
• Stadil F, Rehfeld JF. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol 1973;8:101–12.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Sandvik AK, Brenna E, Søgnen B. Radioimmunoassay of histamine. Scand J Gastroenterol 1991;26 Suppl 180:32–9.
   Web of Science ®Google Scholar
• Persson P, Gagnemo-Persson R, Chen D, Axelson J, Nylander AG, Johnell O, et al. Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible? Scand J Gastroenterol 1993;28:301–6.
   PubMed Web of Science ®Google Scholar
• Klinge B, Lehto-Axtelius D, Akerman M, Håkanson R. Structure of calvaria after gastrectomy. An experimental study in the rat. Scand J Gastroenterol 1995;30:952–7.
   PubMed Web of Science ®Google Scholar
• Muhlbauer RC, Schenk RK, Chen D, Lehto-Axtelius D, Håkanson R. Morphometric analysis of gastrectomy-evoked osteopenia. Calcif Tissue Int 1998;62:323–6.
   PubMed Web of Science ®Google Scholar
• Håkanson R, Chen D, Lindstrom E, Norlén P, Björkqvist M, Lehto-Axtelius D. Physiology of the ECL cells. Yale J Biol Med 1998;71:163–71.
   PubMed Web of Science ®Google Scholar
• Håkanson R, Persson P, Axelson J, Johnell O, Sundler F. Evidence that gastrin enhences 45Ca uptake into bone through release of a gastric hormone. Regul Pept 1990;28: 107–18.
   Google Scholar
• Campbell BJ, Dimaline R, Dockray GJ, Hughes J. Inhibition of food intake by omeprazole in the chicken. Eur J Pharmacol 1991;209:231–5.
   PubMed Web of Science ®Google Scholar
• Gagnemo-Persson R, Hakanson R, Sundler F, Persson P. Growth of the parathyroid gland in omeprazole-treated chicken. Scand J Gastroenterol 1994;29:493–7.
   PubMed Web of Science ®Google Scholar
• Grimelius L, Johanssen H, Lundgvist G, Olazabal A, Polak JH, Pearse GE. The parathyroid gland in experimentally induced hypergastrinemia in the rats. Scand J Gastroenterol 1977;12:739–44.
   PubMed Web of Science ®Google Scholar
• Mizunashi K, Furukawa Y, Abe K, Yoshinaga K. The relationship between serum intact parathyroid hormone and calcium in idiopathic hypoparathyroidism. Calcif Tissue Int 1993;53:378–83.
   PubMed Web of Science ®Google Scholar
• Gagnemo-Persson R, Samuelsson, Håkanson R, Persson P. Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol and restricted food intake. Calcif Tissue Int 1997;61:210–5.
   Google Scholar
• Waltman MD, Diamond TH, Botha JR, Myburgh JA, Wing A. Serum gastrin response to parathyroidectomy for primary hyperparathyroidism. S Afr J Surg 1988,26:63–5.
   Google Scholar
• Larsson H, Carlsson E, Håkanson R, Mattsson H, Nilsson G, Seengalu R, et al. Time-course of development and reversal of gastric endocrine cell hyperplasia after inhibition of acid secretion. Gastroenterology 1988;95:1477–86.
   Google Scholar
• Brenna E, Waldum HL, Sandvik AK, Søgnen BS, Kristensen A. Effect on the rat oxyntic mucosa of the histamine2-antagonist loxtidine and the H+,K+-ATPase inhibitor omeprazole. Aliment Pharmacol Ther 1992;6: 335–49.
   Google Scholar
• Havu N, Mattson H, Ekman L, Carlsson E. Enterochromaffi n- like cell carcinoids in the rat gastric mucosa following long-term administration of ranitidine. Digestion 1990;45:189–95.
   PubMed Web of Science ®Google Scholar
• Larsson L-I, St-Onge L, Hougaard DM, Sosa-Pineda, Cruss P. Pax 4 and pax 6 regulate gastrointestinal endocrine cell development. Mech Dev 1998;79:153–9.
   PubMed Web of Science ®Google Scholar
• Larsson L-I. Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach. Micro Res Tech 2000;48:272–81.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Lehy T, Brenna E, Sandvik AK, Petersen H, S0gnen BS, et al. Effect of the histamine-1 antagonist astemizole alone or with omeprazole on rat gastric mucosa. Scand J Gastroenterol 1991;26: 23–35.
   Google Scholar
• Rasmussen L, Qvist N, Øster-Jørgensen E, Rehfeld JF, Holst JJ, Pedersen SA. A double-blind placebo-controlled study on the effect of omeprazole on gut hormone secretion and gastric emptying rate. Scand J Gastroenterol 1997;32:900–5.
   Google Scholar
• Benini L, Castellani G, Bardelli E, Sembenini C, Brentegani MT, Caliari S, et al. Omeprazole causes delay in gastric emptying of digestible meals. Dig Dis Sci 1996;41:469–74.
   PubMed Web of Science ®Google Scholar