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Research Article

Ethanol-derived Microbial Production of Carcinogenic Acetaldehyde in Achlorhydric Atrophic Gastritis

Pages 648-655 | Published online: 08 Jul 2009

  • Stockbruegger RW. Bacterial overgrowth as a consequence of reduced gastric acidity. Scand J Gastroenterol 198520 Suppl 111:7-15.
  • Drasar BS, Shiner M, McLeod GM. Studies on the intestinal flora I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 1969;56:71-9.
  • Stockbruegger RW, Cotton PB, Menon GG, Beilby JOW, Bartholomew BA, Hill MJ, et al. Pernicious anaemia, intragastric bacterial overgrowth and possible consequences. Scand J Gastroenterol 1984;19:355-64.
  • Verdu E, Viani F, Armstrong D, Fraser R, Siegrist HH, Pignatelli B, et al. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut 1994;35:455-60.
  • Ruddell WSJ, Axon ATR, Findlay JM, Bartholomew BA, Hill MJ. Effect of cimetidine on the gastric bacterial flora. Lancet 1980:29:672-4.
  • Boero M, Pera A, Andriulli A, Canepa G, Palmas F, Duglio A, et al. Candida overgrowth in gastric ulcer subjects on short- and long-term treatment with H2-receptor antagonists. Digestion 1983:28:158-63.
  • Thorens J, Froehlich F, Schwizer W, Saraga E, Bille J, Gyr K, et al. Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 1996;39:54-9.
  • Väkeväinen S, Tillonen J, Salaspuro M, Jousimies-Somer H, Nuutinen H, Färkkflä M. Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol. Aliment Pharmacol Ther 2000;14: 1511-8.
  • Bode JC, Rust S, Bode C. The effect of cimetidine treatment on ethanol formation in the human stomach. Scand J Gastroenterol 1984:19:853-6.
  • Reid MF, Fewson CA. Molecular characterization of microbial alcohol dehydrogenases. Crit Rev Microbiol 1994:20:13-56.
  • Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis 1997:18:101-5.
  • Jokelainen K, Siitonen A, Jousimies-Somer H, Nosova T, Heine R, Salaspuro M. In vitro alcohol dehydrogenas e mediated acetaldehyde production by aerobic bacteria representing normal colonie flora in man. Alcohol Clin Exp Res 1996:20:967-72.
  • Salaspuro V, Nyfors R, Heine R, Siitonen A, Salaspuro M. Ethanol oxidation and acetaldehyde production in vitro by human intestinal strains of Escherichia coli under aerobic, microaerobic, and anaerobic conditions. Scand J Gastroenterol 1999:34:967-73.
  • Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H. Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 1996:5:99-102.
  • Yokoyama A, Muramatsu T, Ohmori T, Makuuchi H, Higuchi S, Matsushita S, et al. Multiple primary esophageal and concurrent upper aerodigestive tract cancer and aldehyde dehydrogenase- 2 genotype of Japanese alcoholics. Cancer 1996:77:1986-90.
  • Yokoyama A, Ohmori T, Muramatsu T, Higuchi S, Yokoyama T, Matsushita S, et al. Cancer screening of upper aerodigestive tract cancers in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase- 2 genotype. Int J Cancer 1996:68:313-6.
  • Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, et al. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 1998; 19:1383-7.
  • Yokoyama A, Ohmori T, Muramatsu T, Yokoyama T, Okuyama K, Makuuchi H, et al. Short-term follow-up after endoscopie mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics. Cancer Epidemiol Biomarkers Prev 1998;7:473-6.
  • Tanabe H, Ohhira M, Ohtsubo T, Watari J, Yokota K, Kongo Y. Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive cancer. Alcohol Clin Exp Res 1999; 23:17S-20S.
  • Murata M, Tagawa M, Watanabe S, Kimura H, Takeshita T, Morimoto K. Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. Jpn J Cancer Res 1999;90: 711-9.
  • Väkeväinen S, Tillonen J, Agarwal DP, Srivastava N, Salaspuro M. High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res 2000:24:873-7.
  • Väkeväinen S, Tillonen J, Salaspuro M. 4-Methylpyrazol e decreases salivary acetaldehyde levels in ALDH2-deficient subjects but in subjects with normal ALDH2. Alcohol Clin Exp Res 2001:25:829-34.
  • Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A. Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 1980:33:711-21.
  • Jokelainen K, Roine RP, Väänänen H, Färkkilä M, Salaspuro M. In vitro acetaldehyde formation by human colonie bacteria. Gut 1994:35:1271-4.
  • Summanen P, Baron EI, Citron DM, Strong CA, Wexler HM, Finegold SM. Wadsworth anaerobic bacteriology manual, 5th ed. Belmont, California: Star Publishing; 1993.
  • Murray PR, Baron EJ, Pfeiler MA, Tenover FC, Yolken RH, editors. Manual of clinical microbiology, 7th ed. Washington DC: ASM Press; 1999.
  • Siurala M, Lehtola J, Ihamäki T. Atrophie gastritis and its sequlae. Results of 19-23 years follow-up examinations. Scand J Gastroenterol 1974;9:441-6.
  • Walker IR, Strickland RG, Ungar B, MacKay IR. Simple atrophie gastritis and gastric carcinoma. Gut 1971:12:906-11.
  • Testoni PA, Masci E, Marchi R, Guslandi M, Ronchi G, Tittobello A. Gastric cancer in chronic atrophie gastritis. J Clin Gastroenterol 1987;9:298-302.
  • Sipponen P, Kekki M, Haapakoski J, Ihamäki T, Siurala M. Gastric cancer risk in chronic atrophie gastritis: statistical calculations of cross sectional data. Int J Cancer 1985;35:173-7.
  • International Agency for Research on Cancer. Alcohol drinking. In: IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol. 44, Lyon: International Agency for Research on Cancer; 1988. p. 1-416.
  • Dinoso VP, Chey WY, Braverman SP, Rosen AP, Ottenberg D, Lorber SR Gastric secretion and gastric mucosal morphology in chronic alcoholics. Arch Intern Med 1972;130:715-9.
  • Pari FF, Lev R, Thomas E, Pitchumoni CS. Histologie and morphometric study of chronic gastritis in alcoholic patients. Hum Pathol 1979;10:45-56.
  • Vaughan TL, Davis S, Kristal A, Thomas DB. Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 1995;4:85-92.
  • Roine RP, Salmela KS, Höök-Nikanne J, Kosunen TU, Salaspuro M. Alcohol dehydrogenase mediated acetaldehyde production by Helicobacter pylori: a possible mechanism behind gastric injury. Life Sci 1992;51:1333-7.
  • Salmela KS, Roine RP, Koivisto T, Höök-Nikanne J, Kosunen TU, Salaspuro M. Characteristics of Helicobacter pylori alcohol dehydrogenase. Gastroenterology 1993;105:325-30.
  • Salmela KS, Roine RP, Höök-Nikanne J, Kosunen TU, Salaspuro M. Acetaldehyde and ethanol production by Helicobacter pylori. Scand J Gastroenterol 1994:29:309-12.
  • Jokelainen K, Matysiak-Budnik T, Makisalo H, Hockerstedt K, Salaspuro M. High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets. Gut 1996:39:100-4.
  • Nosova T, Jousimies-Somer H, Kaihovaara P, Jokelainen K, Salaspuro M. Characteristics of alcohol dehydrogenase s of certain aerobic bacteria representing human colonie flora. Alcohol Clin Exp Res 1997;21:489-94.
  • Nosova T, Jokelainen K, Kaihovaara P, Heine R, JousimiesSomer H, Salaspuro M. Characteristics of aldehyde dehydrogenases of certain aerobic bacteria representing human colonie flora. Alcohol Alcohol 1998;33:273-80.
  • Väkeväinen S, Tillonen J, Blom M, Jousimies-Somer H, Salaspuro M. Acetaldehyde production and other ADH-related characteristic s of aerobic bacteria isolated from hypochlorhydric human stomach. Alcohol Clin Exp Res 2001;25:421-6.
  • Hill MJ. The normal gut flora: flora of the stomach. In: Hill MJ, editor. Role of gut bacteria in human toxicology and pharmacology. Basingstoke: Burgess Science Press; 1995. p. 5-7.
  • Tillonen J, Homann N, Rautio M, Jousimies-Somer H, Salaspuro M. Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associate d oral cavity cancer. Alcohol Clin Exp Res 1999;23:1409-15.
  • Muto M, Hitomi Y, Ohtsu A, Shimada H, Kashiwase Y, Sasaki H, et al. Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: implications for carcinogenesis in upper aerodigestive tract. Int J Cancer 2000;88:342-50.
  • Kosunen TU, Höök J, Rautelin H, Myllyla G. Age-dependent increase of Campylobacter pylori antibodies in blood donors. Scand J Gastroenterol 1989;24:110-4.
  • Tillonen J, Väkeväinen S, Salaspuro V, Zhang Y, Rautio M, Jousimies-Somer H, et al. Metronidazole increases intracolonic but not peripheral blood acetaldehyde in chronic ethanol-treated rats. Alcohol Clin Exp Res 2000;24:570-5.
  • Nosova T, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. Acetaldehyde production and metabolism by human indigenous and probiertic Lactobacillus and Bifidobacterium strains. Alcohol Alcohol 2000;35:561-8.
  • Homann N, Kärkkäinen P, Koivisto T, Nosova T, Jokelainen K, Salaspuro M. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst 1997;89:1692-7.
  • International Agency for Research on Cancer. Acetaldehyde, in IARC monographs on the evaluation of carcinogenic risks to humans: re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. International Agency for Research on Cancer, Vol. 71, part 2, pp. 319-35, Lyon, France, 1999.
  • Salmela KS, Sillanaukee P, Itälä L, Väkeväinen S, Salaspuro M, Roine RP. Binding of acetaldedehyde to rat gastric mucosa during ethanol oxidation. J Lab Clin Med 1997; 129:627-33.
  • Vaca CE, Nilsson JA, Fang J-L, Grafström RC. Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro. Chem Biol Interact 1998:108:197-208.
  • Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blot WJ, et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997; 89:1698-705.
  • Coutelle C, Ward PJ, Fleury B, Quattrocchi P, Chambrin H, Iron A, et al. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase Ml polymorphisms. Hum Genet 1997;99:319-25.

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