Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 2
Submit an article Journal homepage
57
Views
70
CrossRef citations to date
0
Altmetric
Research Article

A Polymorphism in the CD14 Gene is Associated with Crohn Disease

W. Klein
,
A. Tromm
,
T. Griga
,
H. Fricke
,
C. Folwaczny
,
M. Hocke
,
K. Eitner
,
M. Marx
,
N. Duerig
&
J. T. Epplen
 show all
Pages 189-191 | Published online: 08 Jul 2009

  • Russel MG, Pastoor CJ, Janssen KM, van Deursen CT, Muris JW, van Wijlick EH, et al. Familial aggregation of inflammatory bowel disease:a population-based study in South Limburg, The Netherlands. The South Limburg IBD Study Group. Scand J Gastroenterol Suppl 1997;223:88-91.
  • Hugot JP, Thomas G. Genome-wide scanning in inflammatory bowel diseases. Dig Dis 1998;16:364-9.
  • Strober W, Ludviksso n BR, Fuss TJ. The pathogènes! s of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease. Ann Intern Med 1998;128:848-56.
  • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993:75:263-74.
  • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000;406:782-7.
  • Antal-Szalmas P. Evaluation of CD 14 in host defence. EurJClin Invest 2000;30:167-79
  • Niessner M, Volk BA. Altered Thl/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995:101:428-35.
  • Kmiec Z. Cytokines in inflammatory bowel disease. Arch Immunol TherExp 1998;46:143-55.
  • Gotteland M, Lopez M, Munoz C, Saez R, Altshiller H, Llorens P, et al. Local and systemic liberation of pro inflammatory cytokines in ulcerative colitis. Dig Dis Sei 1999;44:830-5.
  • Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor kappa B inflammatory bowel disease. Gut 1998;42:477-84.
  • Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism in the 5' flanking region of the CD 14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell MoI Biol 1999 20:976-83.
  • Hubacek JA, Rothe G, Pit'ha J, Skodova Z, Stanek V, Poledne R, et al. C(-260)->T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 1999;99:3218-20.
  • Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989;170:2-6.
  • Epplen C, Jaeckel S, Santos, D'Souza M Poehlau D, Dorzauer B, et al. Genetic predisposition to Multiple sclerosis as revealed by immunoprinting. Ann Neurol 1997;41:341-52.
  • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988:16:1215.
  • Grimm MC, Pavli P, Van de Pol E, Doe WF. Evidence for a CD 14+ population of monocytes in inflammatory bowel disease mucosa-implication s for pathogenesis. Clin Exp Immunol 1995; 100:291-7.
  • Rugtveit J, Haraldsen G, Hogasen AK, Bakka A, Brandtzaeg P, Scott H. Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+Ll+ monocyte derived cells. Gut 1995;37:367-73.
  • Zareie M, Singh PK, Irvine EJ, Sherman PM, McKay DM, Perdue MH. Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease. Am J Pathol 2001 ;158:1101 -9.
  • Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000;68:7010-7.
  • Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK. Lipopolysaccharid e activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J Immunol 2000; 164:966-72.
  • Leiper K, Morris AI, Rhodes JM. Open label trial of oral clarithromycin in active Crohn's disease. Aliment Pharmacol Ther 2000:14:801-6.
  • Greenbloom SL, Steinhart AH, Greenberg GR. Combination ciprofloxacin and metronidazole for active Crohn's disease. Can J Gastroenterol 1998;12:53-6.
  • Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001 ;411 : 599-603.
  • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.