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Research Article

Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats

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Pages 1119-1127 | Published online: 08 Jul 2009

References

  • Taminiau JA, Gall DG, Hamilton JR. Response of the rat small-intestine epithelium to methotrexate. Gut 1980;21:486–92.
  • Pinkerton CR, Cameron CH, Sloan JM, Glasgow JF, Gwevava NJ. Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukaemia. J Clin Pathol 1982;35:1272–7.
  • Gao F, Ueda S, Horie T. Effect of a synthetic analog of prostaglandin E1 on the intestinal mucosa of methotrexate-treated rats. Anticancer Res 2001;21: 1913–7.
  • Howarth GS, Cool JC, Bourne AJ, Ballard FJ, Read LC. Insulinlike growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors 1998;15:279–92.
  • Kanauchi O, Mitsuyama K, Saiki T, Agata K, Nakamura T, Iwanaga T. Preventive effects of germinated barley foodstuff on methotrexate-induced enteritis in rats. Int J Mol Med 1998; 1: 961–6.
  • Logvinova AV, Foehr MW, Pemberton PA, Khazalpour KM, Funk-Archuleta MA, Bathurst IC, et al. Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat. Nutr Cancer 1999; 33:33–9.
  • Ortega M, de Segura IA, Vazquez I, Lopez JM, De Miguel E. Growth hormone and nutrition as protective agents against methotrexate induced enteritis. Rev Esp Enferm Dig 2001;93: 148–55.
  • Gibson RJ, Keefe DM, Clarke JM, Regester GO, Thompson FM, Goland GJ, et al. The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer. Cancer Chemother Pharmacol 2002; 50:53–8.
  • Tsurui K, Kosakai Y, Horie T, Awazu S. Vitamin A protects the small intestine from methotrexate-induced damage in rats. J Pharmacol Exp Ther 1990;253:1278–84.
  • Horie T, Nakamaru M, Masubuchi Y. Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. Life Sci 1998;62:1333–8.
  • Horie T, Matsumoto H, Kasagi M, Sugiyama A, Kikuchi M, Karasawa C, et al. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med 1999;65:545–8.
  • Gao F, Nakamaru M, Masubuchi Y, Horie T. Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats. J Pharm Sci 2001;90:1040–8.
  • Gao F, Horie T. A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats. Life Sci 2002; 71:1091–9.
  • Gao F, Tomitori H, Igarashi K, Horie T. Correlation between methotrexate-induced intestinal damage and decrease in polyamine content. Life Sci 2002;72:669–76.
  • Iwai A, Iwashita E. Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short-and longterm administration of rebamipide. Dig Dis Sci 1998;43:143S–7S.
  • Tardieu D, Jaeg JP, Deloly A, Corpet DE, Cadet J, Petit CR. The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats. Carcinogenesis 2000;21:973–6.
  • Qu XW, Rozenfeld RA, Huang W, Bulkley GB, Hsueh W. The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. Gut 1999;44:203–11.
  • Nosal’ova V, Cerna S, Bauer V. Effect of N-acetylcysteine on colitis induced by acetic acid in rats. Gen Pharmacol 2000;35:77–81.
  • Canali R, Vignolini F, Nobili F, Mengheri E. Reduction of oxidative stress and cytokine-induced neutrophil chemoattractant (CINC) expression by red wine polyphenols in zinc deficiency induced intestinal damage of rat. Free Radic Biol Med 2000;28: 1661–70.
  • Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 1997;22:269–85.
  • Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000;28:1456–62.
  • Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 2001;280:C719–41.
  • Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47–95.
  • Genestier L, Paillot R, Quemeneur L, Izeradjene K, Revillard JP. Mechanisms of action of methotrexate. Immunopharmacology 2000;47:247–57.
  • Petrone WF, English DK, Wong K, McCord JM. Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma. Proc Natl Acad Sci USA 1980; 77:1159–63.
  • Hotter G, Closa D, Prats N, Pi F, Gelpi E, Rosello-Catafau J. Free radical enhancement promotes leucocyte recruitment through a PAF and LTB4 dependent mechanism. Free Radic Biol Med 1997;22: 947–54.
  • DeForge LE, Preston AM, Takeuchi E, Kenney J, Boxer LA, Remick DG. Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem 1993;268:25568–76.
  • Shi MM, Chong I, Godleski JJ, Paulauskis JD. Regulation of macrophage inflammatory protein-2 gene expression by oxidative stress in rat alveolar macrophages. Immunology 1999; 97: 309–15.
  • Haddad JJ. Glutathione depletion is associated with augmenting a proinflammatory signal: evidence for an antioxidant/pro-oxidant mechanism regulating cytokines in the alveolar epithelium. Cytokines Cell Mol Ther 2000;6:177–87.
  • Haddad JJ, Safieh-Garabedian B, Saade NE, Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J Pharmacol Exp Ther 2001;296:996–1005.
  • Pritsos CA. Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system. Chem Biol Interact 2000;129:195–208.
  • Hassoun PM, Yu FS, Cote CG, Zulueta JJ, Sawhney R, Skinner KA, et al. Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury. Am J Respir Crit Care Med 1998;158:299–305.
  • Brandes RP, Koddenberg G, Gwinner W, Kim D, Kruse HJ, Busse R, et al. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia. Hypertension 1999;33:1243–9.
  • Matsui N, Satsuki I, Morita Y, Inaizumi K, Kasajima K, Kanoh R, et al. Xanthine oxidase-derived reactive oxygen species activate nuclear factor kappa B during hepatic ischemia in rats. Jpn J Pharmacol 2000;84:363–6.
  • Schimpl G, Pesendorfer P, Kuesz AM, Ratschek M, Hollwarth ME. The impact of hepatic xanthine oxidase and xanthine dehydrogenase activities on liver function in chronic cholestasis. Pediatr Surg Int 2000;16:297–301.
  • Vega VL, Mardones L, Maldonado M, Nicovani S, Manriquez V, Roa J, et al. Xanthine oxidase released from reperfused hind limbs mediate kupffer cell activation, neutrophil sequestration, and hepatic oxidative stress in rats subjected to tourniquet shock. Shock 2000;14:565–71.
  • Schimpl G, Pabst MA, Feierl G, Kuesz A, Ozbey H, Takahashi S, et al. A tungsten supplemented diet attenuates bacterial translocation in chronic portal hypertensive and cholestatic rats: role of xanthine dehydrogenase and xanthine oxidase. Gut 1999;45: 904–10.
  • Kono H, Rusyn I, Bradford BU, Connor HD, Mason RP, Thurman RG. Allopurinol prevents early alcohol-induced liver injury in rats. J Pharmacol Exp Ther 2000;293:296–303.
  • Ciz M, Cizova H, Lojek A, Kubala L, Papezikova I. Ischemia/ reperfusion injury of rat small intestine: the effect of allopurinol dosage. Transplant Proc 2001;33:2871–3.
  • Ramachandran A, Balasubramanian KA. Protease activation during surgical stress in the rat small intestine. J Surg Res 2000; 92:283–90.
  • Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302–10.
  • McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244:6049–55.
  • Aebi H. Catalase in vitro. Methods Enzymol 1984;105:121–6.
  • Keller DA, Menzel DB. Picomole analysis of glutathione, glutathione disulfide, glutathione S-sulfonate, and cysteine S-sulfonate by high-performance liquid chromatography. Anal Biochem 1985;151:418–23.
  • de la Lastra CA, Nieto A, Motilva V, Martin MJ, Herrerias JM, Cabre F, et al. Intestinal toxicity of ketoprofen-trometamol vs its enantiomers in rat. Role of oxidative stress. Inflamm Res 2000; 49:627–32.
  • Villegas I, Alarcon de la Lastra C, La Casa C, Motilva V, Martin MJ. Effects of food intake and oxidative stress on intestinal lesions caused by meloxicam and piroxicam in rats. Eur J. Pharmacol 2001;414:79–86.
  • Loguercio C, D’Argenio G, Delle Cave M, Cosenza V, Della Valle N, Mazzacca G, et al. Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats. Dig Dis Sci 1996;41:1204–11.
  • Pui CH, Relling MV, Lascombes F, Harrison PL, Struxiano A, Mondesir JM, et al. Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies. Leukemia 1997;11:1813–6.
  • Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78: 206–9.
  • Johnson JL, Rajagopalan KV, Cohen HJ. Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. J Biol Chem 1974;249:859–66.
  • Rao RK, Li L, Baker RD, Baker SS, Gupta A. Glutathione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol 2000; 279:G332–40.
  • Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK. Reassembly of the tightjunction after oxidative stress depends on tyrosine kinase activity. J Biol Chem 2001;276:22048–55.

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