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ORIGINAL ARTICLE

ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases

, , PhD , MD, , , , , , , , , , , , , & show all
Pages 726-733 | Received 20 Jul 2006, Published online: 08 Jul 2009

References

  • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417–29
  • Lakatos L, Pandur T, David G, Balogh Z, Kuronya P, Tollas A, et al. Association of extraintestinal manifestations of inflammatory bowel disease (IBD) in a province of Western Hungary with disease phenotypes: results of a 25-year follow-up study. World J Gastroenterol 2003; 9: 2300–7
  • Lakatos L, Mester G, Erdelyi Z, Balogh M, Szipocs I, Kamaras G, et al. Striking elevation in the incidence and prevalence of inflammatory bowel disease in a province of Western Hungary between 1977–2001. World J Gastroenterology 2004; 10: 404–409
  • Lakatos PL, Lakatos L. Current concepts on the genetics and pharmacogenetics of inflammatory bowel disease: do they help in clinical management?. Curr Genom 2006; 7: 149–62
  • Lakatos PL, Lakatos L, Szalay F, Willheim-Polli C, Osterreicher C, Tulassay Z, et al. Hungarian IBD Study Group. Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn disease: phenotype-genotype correlations. World J Gastroenterol 2005; 11: 1489–95
  • Ho GT, Moodie FM, Satsangi J. Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?. Gut 2003; 52: 759–66
  • Fromm MF. The influence of MDR1 polymorphism on P-glycoprotein expression and function in humans. Adv Drug Deliv Rev 2002; 54: 1295–310
  • Farrell RJ, Murphy A, Long A, Donelly S, Cherikuri A, O'Toole D, et al. High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. Gastroenterology 2000; 118: 279–88
  • Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multi drug resistance gene MDR1a, spontaneously develop colitis. J Immunol 1998; 161: 5733–44
  • Brant SR, Panhuysen CI, Nicolae D, Reddy DM, Bonen DK, Karaliukas R, et al. MDR1 Ala 893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet 2003; 73: 1282–92
  • Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97: 3473–8
  • Schwab M, Schaeffeler E, Marx C, Fromm MF, Kaskas B, Metzler J, et al. Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitits. Gastroenterology 2003; 124: 26–33
  • Ho GT, Nimmo ER, Tenesa A, Fennell J, Drummond H, Mowat C, et al. Allelic variations of the multidrug resistance gene determine susceptibility and disease behaviour in ulcerative colitis. Gastroenterology 2005; 128: 288–96
  • Urcelay E, Mendoza JL, Martin MC, Mas A, Martinez A, Taxonera C, et al. MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients. Inflamm Bowel Dis 2006; 12: 33–7
  • Rocchi E, Khodjakov A, Volk EL, Yang CH, Litman T, Bates SE, et al. The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun 2000; 27: 42–6
  • Maliepaard M, Scheffer GL, Faneyte IF, van Gastelen MA, Pijnenborg AC, Schinkel AH, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001; 61: 3458–64
  • Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, et al. A multidrug resistance transporter from the human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998; 95: 15665–70
  • Krishnamurthy P, Schuetz JD. Role of ABCG2/BCRP in biology and medicine. Annu Rev Pharmacol Toxicol 2006; 46: 381–410
  • Sarkadi B, Ozvegy-Laczka C, Nemet K, Varadi A. ABCG2: a transporter for all seasons. FEBS Lett 2004; 567: 116–20
  • Volk EL, Farley KM, Wu Y, Li F, Robey RW, Schneider E. Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res 2002; 62: 5035–40
  • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y. ABCG2 transports sulfated conjugates of steroids and xenoiotics. J Biol Chem 2003; 278: 22644–9
  • Wang H, Zhou L, Gupta A, Vethanayagam RR, Zhang Y, Unadkat JD, et al. Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Am J Physiol Endocrinol Metab 2006; 290: E798–807
  • Tamura A, Watanabe M, Saito H, Nakagawa H, Kamachi T, Okura I, et al. Functional validation of the genetic polymorphisms of human ABC transporter ABCG2: identification of alleles that are defective in porphyrin transport. Mol Pharmacol 2006; 70: 287–96
  • Polgar O, Ozvegy-Laczka C, Robey RW, Morisaki K, Okada M, Tamaki A, et al. Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization. Biochemistry 2006; 45: 5251–60
  • Sparreboom A, Gelderblom H, Marsh S, Ahluwalia R, Obach R, Principe P, et al. Diflomotecan pharmacokinetics in relation to ABCG2 421C > A genotype. Clin Pharmacol Ther 2004; 76: 38–44
  • Vermeire S, Louis E, Rutgeerts P, De Vos M, Van Gossum A, Belaiche J, et al. NOD2/CARD15 does not influence response to infliximab in Crohn's disease. Gastroenterology 2002; 123: 108–11
  • Urcelay E, Mendoza JL, Martinez A, Fernandez L, Taxonera C, Diaz-Rubio M, et al. IBD5 polymorphisms in inflammatory bowel disease: association with response to infiximab. World J Gastroenterol 2005; 11: 1187–92
  • McGovern D, Ahmad T, Van Heel D, Negora K, Jewell D, et al. Cytochrome p450 and multidrug-resistance gene 1 (MDR1) polymorphisms: prediction of the need for colectomy in ulcerative colitis?. Gastroenterology 2002; 122: W1313
  • Lakatos PL, Fischer S, Claes K, Kovacs A, Molnar T, Altorjay I, et al. Hungarian IBD Study Group. DLG5 R30Q is not associated with inflammatory bowel disease in Hungarian IBD patients, but predicts clinical response to steroids in Crohn's disease. Inflamm Bowel Dis 2006; 12: 362–8
  • Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol ;24 Suppl 1989; 170: 2–6
  • Gasche C, Scholmerich J, Brynskov J, D'Haens G, Hanauer SB, Irvine EJ, et al. A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna. Inflamm Bowel Dis ;6 1998; 2000: 8–15
  • Oselin K, Gerloff T, Mrozikiewicz PM, Pahkla R, Roots I. MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes. Fundam Clin Pharmacol 2003; 17: 463–9
  • Arjomand-Nahad F, Diefenbach K, Landt O, Gaikovitch E, Roots I. Genotyping of the triallelic variant G2677T/A in MDR1 using LightCycler with locked-nucleic-acid-modified hybridization probes. Anal Biochem 2004; 334: 201–3
  • Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. Bioinformatics methods and protocols: methods in molecular biology, S Krawetz, S. Misener. Humana Press, Totowa, N. J 2000; 365–86
  • Szilvasi A, Andrikovics H, Kalmar L, Bors A, Tordai A. Asymmetric PCR increases efficiency of melting peak analysis on the LightCycler. Clin Biochem 2005; 38: 727–30
  • Croucher PJ, Mascheretti S, Foelsch UR, Hampe J, Schreiber S. Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations. Gastroenterology 2003; 125: 1919–20
  • Oostenburg LE, Dijkstra G, Nolte IM, Van Dullemen HM, Oosterom E, Faber KN, et al. Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease. Scand J Gastroenterol 2006; 10: 1174–82
  • Annese V, Valvano MR, Palmieri O, Latiano A, Bossa F, Andriulli A. Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. World J Gastroenterol 2006; 12: 3636–44
  • Ho GT, Soranzo N, Nimmo ER, Tenesa A, Goldstein DG, Satsangi J. ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach. Hum Mol Genet 2006; 15: 797–805
  • Poto(nik U, Ferkolj I, Glavac D, Dean M. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun 2004; 5: 530–9
  • Katsanos KH, Ferrante M, Henckaerts L, Pierik M, Claes K, Van Schuerbeek N, , et al. The single nucleotide polymorphism C3435T in the MDR1 gene predicts steroid tapering in inflammatory bowel disease. Gastroenterology 2006;130 Suppl S:T1994.

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