Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations

References

• Bartholomew B, Hill MJ. The pharmacology of dietary nitrate and the origin of urinary nitrate. Food Chem Toxicol 1984; 22: 789–95
   PubMed Web of Science ®Google Scholar
• Tannenbaum SR, Weisman M, Fett D. The effect of nitrate intake on nitrite formation in human saliva. Food Cosmet Toxicol 1976; 14: 549–52
   PubMedGoogle Scholar
• Bos PM, Van den Brandt PA, Wedel M, Ockhuizen T. The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load. Food Chem Toxicol 1988; 26: 93–7
   PubMed Web of Science ®Google Scholar
• Leach S. Mechanisms of endogenous N-nitrosation. Nitrosamines: toxicology and microbiology. Location:Ellis Horwood series in food science and technology, J Hill. United States National Library of Medicine. 1988; 69–87
   Google Scholar
• Moriya A, Grant J, Mowat C, Williams C, Carswell A, Preston T, et al. In vitro studies indicate that acid catalysed generation of N-nitroso compounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia. Scand J Gastroenterology 2002; 37: 253–61
   PubMed Web of Science ®Google Scholar
• Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981; 218: 739–49
   PubMed Web of Science ®Google Scholar
• Hirsch DP, Tiel-Van Buul MM, Tytgat GN, Boeckxstaens GE. Effect of L-NMMA on postprandial transient lower esophageal sphincter relaxations in healthy volunteers. Dig Dis Sci 2000; 45: 2069–75
   PubMedGoogle Scholar
• Eherer AJ, Schwetz I, Hammer HF, Petnehazy T, Scheidl SJ, Weber K, et al. Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders. Gut 2002; 50: 758–64
   PubMed Web of Science ®Google Scholar
• Mittal RK, Holloway RH, Penagini R, Blackshaw LA, Dent J. Transient lower esophageal sphincter relaxation. Gastroenterology 1995; 109601–10.
   Google Scholar
• Campos GM, Oberg S, Gastal O, Theisen J, Nigro JJ, Hagen JA, et al. Manometry of the lower esophageal sphincter: inter- and intraindividual variability of slow motorized pull-through versus station pull-through manometry. Dig Dis Sci 2003; 48: 1057–61
   PubMedGoogle Scholar
• van Maanen JM, van Geel AA, Kleinjans JC. Modulation of nitrate-nitrite conversion in the oral cavity. Cancer Detect Prevent 1996; 6: 590–6
   Google Scholar
• Fletcher J, Wirz A, Young J, Vallance R, McColl KE. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology 2001; 121: 775–83
   PubMed Web of Science ®Google Scholar
• Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995; 268: G128–33
   PubMed Web of Science ®Google Scholar
• Hirsch DP, Holloway RH, Tytgat GN, Boeckxstaens GE. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis. Gastroenterology 1998; 115: 1374–80
   PubMed Web of Science ®Google Scholar
• Percy WH, Miller AJ, Brunz JT. Pharmacologic characteristics of rabbit esophageal muscularis mucosae in vitro. Dig Dis Sci 1997; 42: 2537–46
   PubMedGoogle Scholar
• Iijima K, Henry E, Moriya A, Wirz A, Kelman AW, McColl KE. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology 2002; 122: 1248–57
   PubMed Web of Science ®Google Scholar
• Walker R. Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications. Food Add Contam 1990; 7: 717–68
   PubMedGoogle Scholar
• Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. [Erratum appears in Gastroenterology 1999 Jun;116(6):1507]. Gastroenterology 1999; 116: 813–22
   PubMed Web of Science ®Google Scholar
• Ruddell WS, Blendis LM, Walters CL. Nitrite and thiocyanate in the fasting and secreting stomach and in saliva. Gut 1977; 18: 73–7
   PubMed Web of Science ®Google Scholar
• Rood JC, Ruiz B, Fontham ET, Malcom GT, Hunter FM, Sobhan M, et al. Helicobacter pylori-associated gastritis and the ascorbic acid concentration in gastric juice. Nutr Cancer 1994; 22: 65–72
   PubMed Web of Science ®Google Scholar
• Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KE. Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. Gut 1994; 35: 317–22
   PubMed Web of Science ®Google Scholar
• Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tompkins DS, Godwin P, et al. Ascorbic acid in the human stomach. Gastroenterology 1989; 97: 357–63
   PubMed Web of Science ®Google Scholar
• Ruiz B, Correa P, Fontham ET, Rood JC, Malcom GT, Torrado J, et al. Ascorbic acid, Helicobacter pylori and Lewis phenotype among blacks and whites in New Orleans. Cancer Lett 1994; 83: 323–9
   PubMedGoogle Scholar