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Esophagus

Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats

, , MD, , , , , , , & show all
Pages 527-537 | Received 17 Nov 2008, Published online: 08 Jul 2009

References

  • Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999; 45: 172–80
  • Okamoto K, Iwakiri R, Mori M, Hara M, Oda K, Danjo A, et al. Clinical symptom in endoscopic reflux esophagitis: evaluation in 8031 adult subjects. Dig Dis Sci 2003; 48: 2237–41
  • Labenz J, Nocon M, Lind T, Leodolter A, Jaspersen D, Meyer-Sabellek W, et al. Prospective follow-up study data from ProGERD study suggest that GERD is not a categorical disease. Am J Gastroenterol 2006; 101: 2457–62
  • Eisen GM, Sandler RS, Murray S, Gottfried M. The relationship between gastroesophageal reflux disease and its complications with Barrett's esophagus. Am J Gastroenterol 1997; 92: 27–31
  • Fink S, McCallum RW. The role of prolonged esophageal pH monitoring in the diagnosis of gastroesophageal reflux. JAMA 1984; 84: 362–6
  • Shapiro M, Green C, Faybush EM, Esquivel RF, Fass R. The extent of oesophageal acid overlap among the different gastro-oesophageal reflux disease groups. Aliment Pharmacol Ther 2006; 23: 321–9
  • Vantrappen G, Tack J, Huyberechts G, Sifrim D, Geboes K, Janmsens J, et al. Studies on the relationship between esophageal acid exposure, mucosal lesions and heartburn using an acid exposure sensor. Scand J Gastroenterol 2002; 37: 1253–8
  • Naya MJ, Pereboom D, Ortego J, Alda JO, Lanas A. Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. Gut 1997; 40: 175–81
  • Wetscher GJ, Hinder PR, Bagchi D, Perdikis G, Redmond EJ, Glaser K, et al. Free radical scavengers prevent reflux esophagitis in rats. Dig Dis Sci 1995; 40: 1292–6
  • Wetscher GJ, Hinder RA, Bagchi D, Hinder PR, Bagchi M, Perdikis G, et al. Reflux esophagitis in human is mediated by oxygen-derived free radicals. Am J Surg 1995; 170: 552–7
  • Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim YB, et al. Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut 2001; 49: 364–71
  • Olyaee M, Sontag S, Salman W, Schnell T, Mobarhan S, Eiznhamer D, et al. Mucosal reactive oxygen species production in oesophagitis and Barrett's oesophagus. Gut 1995; 37: 168–73
  • Lanas A, Soteras F, Jimenez P, Fiteni I, Piazuelo E, Royo Y,O, et al. Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits. Dig Dis Sci 2001; 46: 2733–43
  • Wagner DA, Schultz DS, Deen WM, Young VR, Tannenbaum SR. Metabolic fate of an oral dose of 15N-labeled nitrate in humans: effect of diet supplementation with ascorbic acid. Cancer Res 1983; 43: 1921–5
  • Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, et al. Chemical generation of nitric oxide in the mouth the enterosalivary circulation of dietary nitrate. Nat Med 1995; 1: 546–51
  • Iijima K, Henry E, Moriya A, Wirz A, Kelman AW, McColl KE. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastro-esophageal junction. Gastroenterology 2002; 122: 1248–57
  • McColl KEL. When saliva meets acid: chemical warfare at the oesophagogastric junction. Gut 2005; 54: 1–3
  • Iijima K, Fyfe V, McColl KEL. Studies of nitric oxide generation from salivary nitrite in human gastric juice. Scand J Gastroenterol 2003; 38: 246–52
  • Iijima K, Grant J, McElroy K, Fyfe V, Preston T, McColl KEL. Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-esophageal junction cancers. Carcinogenesis 2003; 24: 1951–60
  • Suzuki H, Iijima K, Moriya A, McElroy K, Scobie G, Fyfe V, et al. Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia. Gut 2003; 52: 1095–101
  • Asanuma K, Iijima K, Sugata H, Ohara S, Shimosegawa T, Yoshimura T. Diffusion of cytotoxic concentrations of nitric oxide generated luminally at the gatro-esophageal junction of rats. Gut 2005; 54: 1072–7
  • Asanuma K, Iijima K, Ara N, Koike T, Yoshitake J, Ohara S, et al. Fe-S cluster proteins are intracellular targets for nitric oxide generated luminally at the gastro-oesophageal junction. Nitric Oxide 2007; 16: 395–402
  • Ara N, Iijima K, Asanuma K, Yoshitake J, Ohara S, Shimosegawa T, et al. Disruption of gastric barrier function by luminal nitrosative stress: a potential chemical insult to human gastro-oesophageal junction. Gut 2008; 57: 306–13
  • Suzuki H, Iijima K, Scobie G, Fyfe V, McColl KE. Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut 2005; 54: 1527–235
  • Wink DA, Feelisch M, Vodovotz Y. The chemical biology of nitric oxide. Reactive oxygen species in biological systems, CA Colton, DL Gilbert. Kluwer Academic/Plenum Publishing, New York 1999; 245–91
  • Reiter CD, Teng RJ, Beckman JS. Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite. J Biol Chem 2000; 275: 32460–6
  • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620–4
  • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996; 271: C1424–37
  • Moriya A, Grant J, Mowat C, Williams C, Carswell A, Preston T, et al. In vitro studies indicate that acid catalyzed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia. Scand J Gastroenterol 2002; 37: 253–61
  • Omura N, Kashiwagi H, Chen G, Suzuki Y, Yano F, Aoki T. Establishment of surgically induced chronic acid reflux esophagitis in rats. Scand J Gastroenterol 1999; 34: 948–53
  • Yoshida Y, Hirose M, Takaba K, Kimura J, Ito N. Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N’-nitro-N-nitrosoguanidine pre-treatment. Int J Cancer 1994; 56: 124–8
  • Okazaki K, Ishii Y, Maruyama S, Maruyama S, Umemura T, Miyauchi M, et al. Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N’-nitro-nitroguanidine: possible contribution of nitric-oxide-associated oxdative DNA damage. Cancer Sci 2006; 97: 175–82
  • Zavros Y, Rieder G, Ferguson A, Samuelson LC, Merchant JL. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell population in mice. Gastroenterology 2002; 122: 119–33
  • Chen T, Nines RG, Peschke SM, Kresty LA, Stoner GD. Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumoriogenesis. Cancer Res 2004; 64: 3714–7
  • Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 1983; 132: 345–52
  • Goldstein SR, Yang GY, Chen X, Curtis SK, Yang CS. Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma. Carcinogenesis 1998; 19: 1445–9
  • Ismail-Beigi F, Horton PF, Pope CE II. Histological consequences of gastroesophageal reflux in man. Gastroenterology 1970; 58: 163–74
  • Liu X, Miller MJS, Joshi MS, Thomas DD, Lancaster JR, Jr. Accelerated reaction of NO with O2 within the hydrophobic interior of biological membranes. Proc Natl Acad Sci 1998; 95: 2175–9
  • Akaike T, Ando M, Doi T, Doi T, Ijiri S, Araki S, et al. Dependence on O2( generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest 1990; 85: 739–45
  • Sawa T, Akaike T, Maeda H. Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase. J Biol Chem 2000; 42: 32467–74
  • Moriwaki Y, Yamamoto T, Yamaguchi K, Takahashi S, Higashino K. Immunohistochemical localization of aldehyde and xanthine oxidase in rat tissue using polyclonal antibodies. Histochem Cell Biol 1996; 105: 71–9
  • Van Den Munckhof RJ, Vreeling-Sindelarova H, Schellens JP, Van Noorden CJ, Frederiks WM. Ultrastructural localization of xanthine oxidase activity in digestive tract of the rat. Histochem J 1995; 27: 897–905
  • Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, et al. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease Gastroenterology 1996; 111: 871–85
  • McKnight GM, Smith LM, Drummond RS, Duncan CW, Golden M, Benjamin N. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut 1997; 40: 211–4
  • Pannala A, Mani AR, Spencer JP, Skinner V, Bruckdorfer KR, Moore KP, et al. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 2003; 34: 576–84
  • Mowat C, Carswell A, Wirz A, Hossack M, Gilmour D, Carswell A, et al. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999; 116: 813–22
  • Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, et al. Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr 2005; 81: 736–45
  • Schwarzpaul S, Stassburg A, Luhrmann PM, Neuhauser-Berthold M. Intake of vitamin and mineral supplements in an elderly German population. Ann Nutr Metab 2006; 1: 155–62
  • Yamamoto T, Yuyama K, Nakamura K, Kato T, Yamamoto H. Kinetics characterization of nitric oxide toxicity for PC12 cells: effect of half life time of NO release. Eur J Pharmocol 2000; 26: 25–33
  • Nouraie M, Radmard AR, Zaer-Rezaii H, Razjouyan H, Nasseri-Moghaddam S, Malekzadeh R. Hygiene could affect GERD prevalence independently: a population-based study in Teheran. Am J Gastroenterol 2007; 102: 1–8
  • Schroeder PL, Filler SJ, Ramirez B, Lazarchik DA, Vaezi MF, Richter JE. Dental erosion and acid reflux disease. Ann Intern Med 1995; 122: 809–15
  • Doel JJ, Benjamin N, Hector MP, Rogers M, Allaker RP. Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci 2005; 113: 14–9

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