Increased intragastric pressure gradients are involved in the occurrence of acid reflux in gastroesophageal reflux disease

References

• Dent J, Dodds WJ, Friedman RH, Sekiguchi T, Hogan WJ, Arndorfer RC, et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980; 65: 256–67
   PubMed Web of Science ®Google Scholar
• Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastro-oesophageal reflux. Gut 1988; 29: 1020–8
   PubMed Web of Science ®Google Scholar
• Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 1982; 307: 1547–52
   PubMed Web of Science ®Google Scholar
• Mittal RK, McCallum RW. Characteristics and frequency of transient relaxations of the lower esophageal sphincter in patients with reflux esophagitis. Gastroenterology 1988; 95: 593–9
   PubMed Web of Science ®Google Scholar
• Schoeman MN, Tippett MD, Akkermans LM, Dent J, Holloway RH. Mechanisms of gastroesophageal reflux in ambulant healthy human subjects. Gastroenterology 1995; 108: 83–91
   PubMed Web of Science ®Google Scholar
• Sifrim D, Holloway R. Transient lower esophageal sphincter relaxations: how many or how harmful?. Am J Gastroenterol 2001; 96: 2529–32
   PubMed Web of Science ®Google Scholar
• Scheffer RC, Gooszen HG, Hebbard GS, Samsom M. The role of transsphincteric pressure and proximal gastric volume in acid reflux before and after fundoplication. Gastroenterology 2005; 129: 1900–9
   PubMedGoogle Scholar
• Pandolfino JE, Zhang QG, Ghosh SK, Han A, Boniquit C, Kahrilas PJ. Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry. Gastroenterology 2006; 131: 1725–33
   PubMed Web of Science ®Google Scholar
• Trudgill NJ, Riley SA. Transient lower esophageal sphincter relaxations are no more frequent in patients with gastroesophageal reflux disease than in asymptomatic volunteers. Am J Gastroenterol 2001; 96: 2569–74
   PubMed Web of Science ®Google Scholar
• Sifrim D, Holloway R, Silny J, Tack J, Lerut A, Janssens J. Composition of the postprandial refluxate in patients with gastroesophageal reflux disease. Am J Gastroenterol 2001; 96: 647–55
   PubMed Web of Science ®Google Scholar
• Weusten BL, Roelofs JM, Akkermans LM, Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 1994; 107: 1741–5
   PubMed Web of Science ®Google Scholar
• Clouse RE, Staiano A, Alrakawi A. Development of a topographic analysis system for manometric studies in the gastrointestinal tract. Gastrointest Endosc 1998; 48: 395–401
   PubMedGoogle Scholar
• Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995; 268: G128–33
   PubMed Web of Science ®Google Scholar
• Scheffer RC, Wassenaar EB, Herwaarden MA, Holloway RH, Samsom M, Smout AJ, et al. Relationship between the mechanism of gastro-oesophageal reflux and oesophageal acid exposure in patients with reflux disease. Neurogastroenterol Motil 2005; 17: 654–62
   PubMedGoogle Scholar
• Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 2006; 130: 639–49
   PubMed Web of Science ®Google Scholar
• Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology 2000; 118: 688–95
   PubMedGoogle Scholar
• van Herwaarden MA, Samsom M, Smout AJ. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000; 119: 1439–46
   PubMed Web of Science ®Google Scholar
• Bredenoord AJ, Weusten BL, Timmer R, Smout AJ. Intermittent spatial separation of diaphragm and lower esophageal sphincter favors acidic and weakly acidic reflux. Gastroenterology 2006; 130: 334–40
   PubMed Web of Science ®Google Scholar
• Tefera S, Gilja OH, Olafsdottir E, Hausken T, Hatlebakk JG, Berstad A. Intragastric maldistribution of a liquid meal in patients with reflux oesophagitis assessed by three dimensional ultrasonography. Gut 2002; 50: 153–8
   PubMed Web of Science ®Google Scholar
• Penagini R, Hebbard G, Horowitz M, Dent J, Bermingham H, Jones K, et al. Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease. Gut 1998; 42: 251–7
   PubMed Web of Science ®Google Scholar
• Gonlachanvit S, Maurer AH, Fisher RS, Parkman HP. Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 2006; 18: 894–904
   PubMedGoogle Scholar