503
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure

, , , , , , , & show all
Pages 577-583 | Received 01 Aug 2023, Accepted 20 Jan 2024, Published online: 02 Feb 2024

References

  • European Association for the Study of the Liver. EASL clinical practice guidelines: management of alcohol-related liver disease. J Hepatol. 2018;69(1):154–181. doi: 10.1016/j.jhep.2018.03.018.
  • Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med. 2009;360(26):2758–2769. doi: 10.1056/NEJMra0805786.
  • Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426–1437.e9., 37 e1-9. doi: 10.1053/j.gastro.2013.02.042.
  • Trebicka J, Fernandez J, Papp M, et al. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis. J Hepatol. 2021;74(5):1097–1108. doi: 10.1016/j.jhep.2020.11.019.
  • Korf H, Du Plessis J, van Pelt J, et al. Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity. Gut. 2019;68(10):1872–1883. doi: 10.1136/gutjnl-2018-316888.
  • Bernsmeier C, van der Merwe S, Périanin A. Innate immune cells in cirrhosis. J Hepatol. 2020;73(1):186–201. doi: 10.1016/j.jhep.2020.03.027.
  • Van der Merwe S, Chokshi S, Bernsmeier C, et al. The multifactorial mechanisms of bacterial infection in decompensated cirrhosis. J Hepatol. 2021;75 Suppl 1(Suppl 1):S82–S100. doi: 10.1016/j.jhep.2020.11.029.
  • Albillos A, Martin-Mateos R, Van der Merwe S, et al. Cirrhosis-associated immune dysfunction. Nat Rev Gastroenterol Hepatol. 2022;19(2):112–134. doi: 10.1038/s41575-021-00520-7.
  • Arroyo V, Moreau R, Kamath PS, et al. Acute-on-chronic liver failure in cirrhosis. Nat Rev Dis Primers. 2016;2(1):16041. doi: 10.1038/nrdp.2016.41.
  • Katoonizadeh A, Laleman W, Verslype C, et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut. 2010;59(11):1561–1569. doi: 10.1136/gut.2009.189639.
  • Sersté T, Cornillie A, Njimi H, et al. The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis. J Hepatol. 2018;69(2):318–324. doi: 10.1016/j.jhep.2018.02.022.
  • Jalan R, Pavesi M, Saliba F, et al. The CLIF consortium acute decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure. J Hepatol. 2015;62(4):831–840. doi: 10.1016/j.jhep.2014.11.012.
  • Maleux G, Willems E, Fieuws S, et al. Prospective study comparing different indirect methods to measure portal pressure. J Vasc Interv Radiol. 2011;22(11):1553–1558. doi: 10.1016/j.jvir.2011.08.003.
  • Lackner C, Stauber RE, Davies S, et al. Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease. J Hepatol. 2021;75(4):810–819. doi: 10.1016/j.jhep.2021.05.029.
  • European Association for the Study of the Liver. Electronic address eee, European Association for the Study of the L. EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406–460. doi: 10.1016/j.jhep.2018.03.024.
  • Thursz MR, Richardson P, Allison M, et al. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med. 2015;372(17):1619–1628. doi: 10.1056/NEJMoa1412278.
  • Mookerjee RP, Lackner C, Stauber R, et al. The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis. J Hepatol. 2011;55(5):1103–1111. doi: 10.1016/j.jhep.2011.02.021.
  • Altamirano J, Miquel R, Katoonizadeh A, et al. A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology. 2014;146(5):1231–1239. e1-6. doi: 10.1053/j.gastro.2014.01.018.
  • Lackner C, Spindelboeck W, Haybaeck J, et al. Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease. J Hepatol. 2017;66(3):610–618. doi: 10.1016/j.jhep.2016.11.011.
  • Spahr L, Rubbia-Brandt L, Genevay M, et al. Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients with alcoholic steatohepatitis. BMC Gastroenterol. 2011;11(1):115. doi: 10.1186/1471-230X-11-115.
  • O’Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology. 2010;51(1):307–328. doi: 10.1002/hep.23258.
  • Filingeri V, Francioso S, Sforza D, et al. A retrospective analysis of 1.011 percutaneous liver biopsies performed in patients with liver transplantation or liver disease: ultrasonography can reduce complications? Eur Rev Med Pharmacol Sci. 2016;20(17):3609–3617.
  • Forrest EH, Gleeson D. Is a liver biopsy necessary in alcoholic hepatitis? J Hepatol. 2012;56(6):1427–1428; author reply 8-9. doi: 10.1016/j.jhep.2011.12.028.
  • Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038–1047. doi: 10.1016/j.jhep.2014.06.012.
  • Lefkowitch JH. Bile ductular cholestasis: an ominous histopathologic sign related to sepsis and "cholangitis lenta. Hum Pathol. 1982;13(1):19–24. doi: 10.1016/s0046-8177(82)80134-2.
  • Crawford JM, Boyer JL. Clinicopathology conferences: inflammation-induced cholestasis. Hepatology. 1998;28(1):253–260. doi: 10.1002/hep.510280133.
  • Arroyo V, Angeli P, Moreau R, et al. The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis. J Hepatol. 2021;74(3):670–685. doi: 10.1016/j.jhep.2020.11.048.
  • Hernaez R, Kramer JR, Liu Y, et al. Prevalence and short-term mortality of acute-on-chronic liver failure: a national cohort study from the USA. J Hepatol. 2019;70(4):639–647. doi: 10.1016/j.jhep.2018.12.018.
  • Trebicka J, Fernandez J, Papp M, et al. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology. J Hepatol. 2020;73(4):842–854. doi: 10.1016/j.jhep.2020.06.013.