References
- Veel T, Villanger O, Holthe MR, Skjørten FS, Ræder MG. Intravenous bilirubin infusion causes vacuolization of the cytoplasm of hepatocytes and canalicular cholestasis. Acta Physiol Scand 1991;143:421–9.
- Villanger O, Bjørnbeth BA, Lyberg T, Ræder MG. Bile acids protect the liver against the cholestatic effect of large bilirubin loads. Scand J Gastroenterol 1995;30:1186–93.
- Crabb DW, Bosron WF, Li TK. Ethanol metabolism. Pharmacol Ther 1987;34:59–73.
- Lieber CS. Metabolism and metabolic effects of alcohol. Med Clin North Am 1984;68:3–31.
- Bjørnbeth BA, Villanger O, Christensen T, Lyberg T, Ræder MG. Large intravenous loads of bilirubin photoconversion products, in contrast to bilirubin, do not cause cholestasis in bile acid-depleted pigs. Scand J Gastroenterol 1997;32:246–53.
- Billington D, Evans CE, Godfrey PP, Coleman R. Effects of bile salts on the plasma membranes of isolated rat hepatocytes. Biochem J 1980;188:321–7.
- Coleman R, Rahman K. Lipid flow in bile formation. Biochim Biophys Acta 1992;1125:113–33.
- Crawford JM, Möckel GM, Crawford AR, Hagen SJ, Hatch VC, Barnes S, et al. Imaging biliary lipid secretion in the rat: Ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane. J Lipid Res 1995;36:2147–63.
- Oude Elferink RPJ, Tytgat GnJ, Groen AK. The role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J 1997;11: 19–28.
- Higgins CF. Flip-flop: the transmembrane translocation of lipids. Cell 1994;79:393–5.
- Ruetz S, Gros P. Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate—implications for hepatic bile formation. J Biol Chem 1995;270:25388–95.
- Jendrassik L, Gróf P. Vereinfachte photometrische Methoden zur Bestimmung des Blutbilirubins. Biochem Z 1938;297:81–9.
- Dawson RMC, Hemington N, Davenport JB. Improvements in the method of determining individual phospholipids in a complex mixture by successive chemical hydrolysis. Biochem J 1962;84:497–501.
- Snedecor GW, Cochran WG. Statistical methods. 6th ed. Ames (IO): The Iowa State University Press; 1971.
- Lowe PJ, Coleman R. Membrane fluidity and bile salt damage. Biochim Biophys Acta 1981;640:55–65.
- Kremmer T, Wisher MH, Evans WH. The lipid composition of plasma membrane subfractions originating from the three major functional domains of the rat hepatocyte cell surface. Biochim Biophys Acta 1976;455:655–4.
- Coleman R, Iqbal S, Godfrey PP, Billington D. Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties. Biochem J 1979;178:201–8.
- Puglielli L, Amigo L, Arrese M, Núñez L, Rigotti A, Garrido J, et al. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage. Gastroenterology 1994;107:244–54.
- Coleman R. Bile salts and biliary lipids. Biochem Soc Trans 1987;15:68S–80S.
- Verkade HJ, Havinga R, Gerding A, Vonk RJ, Kuipers F. Mechanism of bile acid-induced biliary lipid secretion in the rat: effect of conjugated bilirubin. Am J Physiol (Gastrointest Liver Physiol) 1993;264:G462–9.
- Verkade HJ, De Bruijn MAC, Brink MA, Talsma H, Vonk RJ, Kuipers F, et al. Interactions between organic anions, micelles and vesicles in model bile systems. Biochem J 1996;320:917–23.
- Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, van Deemter L, et al. Homozygous distruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993;75: 451–62.
- Ruetz S, Gros P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 1994;77:1071–81.
- Ling V, Bradley G, Veinot LM, Hiruki T, Georges E. Expression of P-glycoprotein isoforms. In: Tsuruo T, Ogawa M, editors. Drug resistance as a biochemical target in cancer chemoherapy. San Diego (CA): Academic Press; 1992. p. 117–28.
- Mauad TH, Van Nieuwkerk CMJ, Dingemans KP, Smit JJM, Schinkel AH, Notenboom RGE, et al. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. Am J Pathol 1994;145:1237–45.
- Van Nieuwkerk CMJ, Groen AK, Ottenhoff R, van Wijland M, van den Bergh Weerman MA, Tytgat GNJ, et al. The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. J Hepatol 1997;26: 138–45.