Patients with Functional Dyspepsia Responding to Omeprazole Have a Characteristic Gastro-oesophageal Reflux Pattern

References

• Farup PG, Larsen S, Ulshagen K, Osnes M. Ranitidine for nonulcer dyspepsia. A clinical study of the symptomatic effect of ranitidine and a classification and characterization of the responders to treatment. Scand J Gastroenterol 1991;26:1209–16.
   Google Scholar
• Gotthard R, Bodemar G, Brodin U, Jönsson KA. Treatment with cimetidine, antacid, or placebo in patients with dyspepsia of unknown origin. Scand J Gastroenterol 1988;23:7–18.
   Google Scholar
• Johannessen T, Fjøsne U, Kleveland PM, Halvorsen T, Kristensen P, Løge I, et al. Cimetidine responders in non-ulcer dyspepsia. Scand J Gastroenterol 1988;23:327–36.
   Google Scholar
• Johannessen T, Kristensen P, Petersen H, Fosstvedt D, Løge I, Kleveland PM, et al. The symptomatic effect of 1-day treatment periods with cimetidine in dyspepsia. Combined results from randomized, controlled single-subject trials. Scand J Gastroenterol 1991;26:974–80.
   Google Scholar
• Johannessen T, Petersen H, Kristensen P, Fosstvedt D, Kleveland PM, Dybdahl J, et al. Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials. Scand J Gastroenterol 1992;27:189–95.
   Google Scholar
• Saunders JHB, Oliver RJ, Higson DL. Dyspepsia: incidence of non-ulcer disease in a controlled trial of ranitidine in general practice. Br Med J 1986;292:665–8.
   Google Scholar
• Nyrén O, Adami HO, Bates S, Bergström R, Gustavsson S, Lööf L, et al. Absence of therapeutic benefit from antacids or cimetidine in non-ulcer dyspepsia. N Engl J Med 1986;314:339–43.
   PubMed Web of Science ®Google Scholar
• Hansen JM, Bytzer P, Schaffalitzky de Muckadell OB. Placebocontrolled trial of cisapride and nizatidine in unselected patients with functional dyspepsia. Am J Gastroenterol 1998;93: 368–74.
   Google Scholar
• Knuhtsen S, Hansen JM, Pedersen FM, Havelund T, Schaffalitzky de Muckadell OB. No effect of omeprazole in treatment of non-ulcer dyspepsia. Gut 1994;35 Suppl 4:A8–9.
   Google Scholar
• Lauritsen K, Aalykke C, Havelund T, Knudsen T, Glise H, Unge P, et al. Effect of omeprazole in functional dyspepsia; a doubleblind randomized, placebo-controlled study. Gastroenterology 1996;110:A702.
   Web of Science ®Google Scholar
• Farup PG, Wetterhus S, Osnes M, Ulshagen K. Ranitidine effectively relieves symptoms in a subset of patients with functional dyspepsia. Scand J Gastroenterol 1997;32:755–9.
   Google Scholar
• Blum AL, Arnold R, Koelz HR, Stolte M, the FROSCH Study Group. Treatment of functional dyspepsia (FD) with omeprazole and ranitidine. Gastroenterology 1997;112 Suppl:A73.
   Google Scholar
• Talley NJ, Meineche-Schmidt V, Paré P, Duckworth M, Räisänen P, Pap A, et al. Is acid supression efficacious in nonulcer dyspepsia? A doubleblind, randomised, controlled trial with omeprazole. Gastroenterology 1998;114 Suppl:A305.
   Google Scholar
• Farup PG, Hovde Ø, Breder O. Are frequent short gastro- oesophageal reflux episodes the cause of symptoms in patients with non-ulcer dyspepsia responding to treatment with ranitidine? Scand J Gastroenterol 1995;30:829–32.
   Google Scholar
• Thors H, Sigurdsson H, Oddsson E, Thjodleifsson B. Survey of prescriptions for peptic ulcer drugs (ACT Class AOB2) in Iceland. Scand J Gastroenterol 1994;29:988–94.
   Google Scholar
• Goudie BM, McKenzie PE, Cipriano J, Griffin EM, Murray FE. Repeat prescribing of ulcer healing drugs in general practice—prevalence and underlying diagnosis. Aliment Pharmacol Ther 1996;10:147–50.
   Google Scholar
• Bodger K, Daly MJ, Healey RV. Prescribing patterns for dyspepsia in primary care. Gut 1996;39 Suppl 3:A226–7.
   Google Scholar
• Johnsson F, Weywadt L, Solhaug JH, Hernqvist H, Bengtsson L. One-week omeprazole treatment in the diagnosis of gastrooesophageal reflux disease. Scand J Gastroenterol 1998;33:15–20.
   Google Scholar
• Carlsson R, Bolling E, Jerndal P, Junghard O, Lauritsen K, Glise H. Factors predicting response to omeprazole treatment in patients with functional dyspepsia. Gastroenterology 1996;110: A76.
   Web of Science ®Google Scholar
• Jebbink HJA, Smout AJPM, van Berge-Henegouwen GP. Pathophysiology and treatment of functional dyspepsia. Scand J Gastroenterol 1993;28 Suppl 200:8–14.
   Google Scholar
• Robinson MG, Orr WC, McCallum R, Nardi R. Do endoscopic findings influence response to H2 antagonist therapy for gastroesophageal reflux disease? Am J Gastroenterol 1987;82: 519–22.
   Google Scholar
• Carlsson R, Dent J, Watts R, Riley S, Sheikh R, Hatlebakk J, et al. Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol 1998;10:119–24.
   Google Scholar
• Klauser AG, Schindlbeck NE, Müller-Lissner SA. Symptoms in gastro-oesophageal reflux disease. Lancet 1990;335:205–8.
   Google Scholar
• Shi G, des Varannes SB, Scarpignato C, Rhun ML, Galmiche JP. Reflux related symptoms in patients with normal oesophageal exposure to acid. Gut 1995;37:457–64.
   Google Scholar
• George AA, Tsuchiyose M, Dooley CP. Sensitivity of the gastric mucosa to acid and duodenal contents in patients with nonulcer dyspepsia. Gastroenterology 1991;101:3–6.
   Google Scholar
• Karnad DR, Abraham P, Rathod NM, Nazareth HM. Test for H2-antagonist response in non-ulcer dyspepsia. Lancet 1990; 335:657–8.
   PubMed Web of Science ®Google Scholar
• Misra SP, Broor SL. Is gastric acid responsible for the pain in patients with essential dyspepsia? J Clin Gastroenterol 1990; 12:624–7.
   Google Scholar