Advanced search
Publication Cover
Scandinavian Journal of Infectious Diseases Volume 32, 2000 - Issue 2
Submit an article Journal homepage
212
Views
68
CrossRef citations to date
0
Altmetric
Research Article

Clinical Aspects of Nephropathia Epidemica (Puumala Virus Infection) in Europe: A Review

Bo Settergren Department of Infectious Diseases, Karolinska Hospital, S-17176 Stockholm, Sweden
Pages 125-132 | Published online: 08 Jul 2009

  • Myhrman G. En njursjukdom med egenartad symptombild (in Swedish). Nord Med 1934; 7: 793–4.
  • Zetterholm SG. Akuta nefriter simulerande akuta bukfall (in Swedish). J Swed Med Assoc 1934; 31: 425–9.
  • Myhrman G. En ny infektionsjukdom i Nordsverige och Nordfinland (in Swedish). Nord Med 1945; 28: 2571–2.
  • Brummer-Korvenkontio M, Vaheri A, Hovi T, von Bonsdorff CH, Vuorimies J, Manni T, et al. Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 1980; 141: 131–4.
  • Schmaljohn CS, Hasty SE, Dalrymple JM, LeDuc JW, Lee HW, von Bonsdorff CH, et al. Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science 1985; 227: 1041–4.
  • Nicol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, et al. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 1993; 262: 914–7.
  • Hughes JM, Peters CJ, Cohen ML, Mahy BWJ. Hantavirus pulmonary syndrome: an emerging infectious disease. Science 1993; 262: 850–1.
  • World Health Organisation. Haemorrhagic fever with renal syndrome: memorandum from a WHO meeting. Bull WHO 1983; 61: 269–75.
  • Saha H, Mustonen J, Pietila K, Pasternack A. Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis: a study of 41 patients with nephropathia epidemica. Nephron 1993; 63: 159–63.
  • Lähdevirta J. Nephropathia epidemica in Finland. A clinical, histological and epidemiological study. Ann Clin Res 1971; 3 Suppl 8: 1–154.
  • Settergren B. Nephropathia epidemica (hemorrhagic fever with renal syndrome) in Scandinavia., Rev. Infect Dis 1991; 13: 736–44.
  • Settergren B, Juto P, Trollfors B, Wadell G, Norrby SR. Clinical characteristics of nephropathia epidemica in Sweden: prospective study of 74 cases. Rev Infect Dis 1989; 11: 921–7.
  • Niklasson B, LeDuc JW. Epidemiology of nephropathia epidemica in Sweden. J Infect Dis 1987; 155: 269–76.
  • Niklasson B, Hörnfeldt B, Mullaart M, Settergren B, Tkahenko E, Myasnikov YA, et al. An epidemiologic study of hemorrhagic fever with renal syndrome in Bashkirtostan (Russia) and Sweden. Am J Trop Med Hyg 1993; 48: 670–5.
  • Settergren B, Juto P, Wadell G, Trollfors B, Norrby SR. Incidence and geographical distribution of serologically verified cases of nephropathia epidemica in Sweden. Am J Epidemiol 1988; 127: 801–7.
  • Settergren B, Leschinskaya E, Zagidullin I, Fazlyeva R, Khunafina D, Niklasson B. Hemorrhagic fever with renal syndrome: comparison of clinical course in Sweden and in the Western Soviet Union. Scand J Infect Dis 1991; 23: 549–52.
  • Ahlm C, Linderholm M, Juto P, Stegmayr B, Settergren B. Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in Northern Sweden. Epidemiol Infect 1994; 113: 129–36.
  • Foged N, Spencer ES, Andersen HK. Nephropathia epidemica-hantavirus og akut nyreinsufficiens (in Danish). Ugeskr Laeger 1990; 152: 89–92.
  • Traavik T, Mehl R, Berdal BP, Lund S, Dalrymple JM. Nephropathia epidemica in Norway: description of serological response in human disease and implication of rodent reservoirs. Scand J Infect Dis 1983; 15: 11–6.
  • Osterhaus ADME, Groen G, Uytdehaag FG, van Steenis G, van Groen G, Clement J, et al. Hantavirus nephropathy in The Netherlands. Lancet 1989; ii: 338.
  • Leschinskaya EV, Tkachenko EA, Dzagurova TK, Drozdov SG. Acute haemorrhagic fever with renal syndrome in Austria. Acta Virol 1991; 35: 1991.
  • World Health Organisation. Haemorrhagic fever with renal syndrome . Weekly Epidemiological Record 1993; 68: 189–91.
  • Gajdusek DC. Virus hemorrhagic fevers-special reference to hemorrhagic fever with renal syndrome. J Ped 1962; 60: 841–57.
  • Casals J, Henderson BE, Hoogstraal H, Johnson KM, Shelokov A. A review of Soviet viral hemorrhagic fevers. J Infect Dis 1970; 122: 437–53.
  • Alexeyev OA, Settergren B, Billheden J, Ahlm C, Suzdaltsev A, Tsaig M. Laboratory findings in patients with hemorrhagic fever with renal syndrome in Western Russia. Infection 1993; 64: 412.
  • Lähdevirta J, Savola J, Brummer-Korvenkontio M, Berndt R, Illikainen R, Vaheri A. Clinical and serological diagnosis of nephropathia epidemica, the mild type of haemorrhagic fever with renal syndrome. J Infect 1984; 9: 230–8.
  • Mustonen J, Brummer-Korvenkontio M, Hedman K, Pasternack A, Pietila K, Vaheri A. Nephropathia epidemica in Finland: a retrospective study of 126 cases. Scand J Infect Dis 1994; 26: 7–13.
  • Nyström K. Incidence and prevalence of endemic benign (epidemic) nephropathy in AC county, Sweden, in relation to population density and prevalence of small rodents. Acta Med Scand 1977; Suppl 609: 1–92.
  • Settergren B, Juto P, Trollfors B, Wadell G, Norrby SR. Hemorrhagic complications and other clinical findings in nephropathia epidemica in Sweden: a study of 355 seriologically verified cases. J Infect Dis 1988; 157: 380–2.
  • Rollin PE, Coudrier D, Sureau P. Hantavirus epidemic in Europe. Lancet 1994; 343: 115–6.
  • van Ypersele de Strihou C, Mery JP. Hantavirus-related acute interstitial nephritis in Western Europe. Expansion of a worldwide zoonosis. Q J Med 1989; 73: 941–50.
  • Kulzer P, Schaefer RM, Heidbreder E, Heidland A. Hantavirus infektion mit akutem nierenversagen (in German). Dtsch Med Wochenschrift 1992; 117: 1429–33.
  • Kulzer P, Schaefer RM, Heidbreder E, Heidland A. Haemorrhagic fever with renal syndrome, : endemic or unrecognised pandemic? Lancet 1993; 342: 313.
  • Diglisic G, Xiao SY, Gligic A, Obradovic M, Stojanovic R, Velimirivic D, et al. Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome. J Infect Dis 1994; 169: 204–7.
  • Pether JVS, Lloyd G. The clinical spectrum of human hantavirus infection in Somerset, UK. Epidemiol Infect 1993; 111: 171–5.
  • Settergren B, Boman J, Linderholm M, Wiström J, Hägg E, Arvidsson PA. A case of nephropathia epidemica with panhypopituitarism and nephrotic syndrome. Nephron 1992; 61: 234–5.
  • Settergren B, Trollfors B, Fasth A, Hultberg B, Norrby SR. Glomerular filtration rate and tubular involvement during acute disease and convalescence in patients with nephropathia epidemica. J Infect Dis 1990; 161: 716–20.
  • Fievet P, Boudjelal M, Demontis R, Veyssier P, Lallement PY, Bove N, et al. Hemorrhagic fever with renal syndrome and Tamm-Horsfall protein. Ann Int Med 1989; 110: 325.
  • Collan Y, Mihatsch MJ, Lähdevirta J, Jokinen EJ, Romppanen T, Jantunen E. Nephropathia epidemica: mild variant of hemorrhagic fever with renal syndrome. Kidney Int 1991; 40 Suppl 35: 62–71.
  • Lähdevirta J, Collan Y, Jokinen EJ, Hiltunen R. Renal sequele to nephropathia epidemica. Acta Path Microbiol Scand 1978; 86: 265–71.
  • Jokinen EJ, Lähdevirta J, Collan Y. Nephropathia: immunohistochemical study of pathogenesis. Clin Nephrol 1978; 9: 1–5.
  • Linderholm M, Billström Å, Settergren B, Tärnvik A. Pulmonary involvement in nephropathia epidemica as demonstrated by computed tomography. Infection 1882; 265: 27–30.
  • Linderholm M, Bjermer L, Juto P, Roos G, Sandstrom T, Settergren B, et al. Local host response in the lower respiratory tract in nephropathia epidemica. Scand J Infect Dis 1993; 25: 639–46.
  • Clement J, Colson P, McKenna P. Hantavirus pulmonary syndrome in New England and Europe. N Engl J Med 1994; 331: 545–6.
  • Kontkanen K, Puustjärvi T, Lähdevirta J. Myopic shift and its mechanism in nephropathia epidemica or Puumala virus infection. J Ophthalmol 1994; 78: 903–6.
  • Launes J, Hautanen A. Nephropathia epidemica encephalitis. Acta Neurol Scand 1988; 78: 234–5.
  • Forslund T, Saltevo J, Anttinen J, Auvinen S, Brummer-Korvenkontio M, Korhonen A, et al. Complications of nepropathia epidemica: three cases. J Int Med 1992; 232: 87–90.
  • Esselink RAJ, Gerding MN, Brouwers PJAM, Solleveld H, Jordans JGM, Groen G, et al. Guillain-Barre syndrome associated with hantavirus infection. Lancet 1994; 343: 180–1.
  • Zeier M, Zöller L, Weinreich T, Padberg-Wolf E, Andrassy K, Ritz E. Severe hemorrhagic complications from infection with nephropathia epidemica strain of hantavirus. Clin Nephrol 1992; 38: 190–2.
  • Alexeyev OA, Morozov VG. Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: review of 811 cases. Clin Infect Dis 1995; 20: 25–8.
  • Nuutinen H, Vuoristo M, Färkilä M, Kahri A, Seppälä K, Valtonen V, et al. Hemorrhagic gastropathy in epidemic nephropathy. Gastrointest Endosc 1992; 38: 476–80.
  • Alexeyev OA, Morozov VG, Efremov AG, Settergren B. A case of haemorrhagic fever with renal syndrome complicated by spleen haemorrhage. Scand J Infect Dis 1994; 26: 491–2.
  • Cosgriff TM. Mechanisms of disease in hantavirus infection: pathophysiology of hemorrhagic fever with renal syndrome. Rev Infect Dis 1991; 13: 97–107.
  • Hory B, Estavoyer JM, Cardot N, Couetdic G. Serum lipids in muroid virus nephropathy. Nephron 1988; 48: 66.
  • Forslund T, Liisanantti R, Saijonmaa O, Fyhrquist F. Raised plasma endothelin-1 concentration in patients with nephropathia epidemica. Clin Nephrol 1993; 40: 69–73.
  • Penttinen K, Lähdevirta J, Kekomäki R, Ziola B, Salmi A, Hautanen A, et al. Circulating immune complexes, immunoconglutinins and rheumatoid factors in nephropathia epidemica. J Infect Dis 1981; 143: 15–21.
  • Billheden J, Boman J, Stegmayr B, Wieslander J, Settergren B. Glomerular basement membrane antibodies in hantavirus disease (haemorrhagic fever with renal syndrome). Clin Nephrol 1997; 48: 137–40.
  • Wangel AG, Temonen M, Brummer-Korvenkontio M, Vaheri A. Anti-endothelial cell antibodies in nephropathia epidemica and other viral diseases. Clin Exp Immunol 1992; 90: 13–7.
  • Lautala P, Uhari M. Epidemic nephropathy in children. AJDC 1991; 145: 1181–3.
  • Ahlm C, Settergren B, Gothefors L, Juto P. Nephropathia epidemica (hemorrhagic fever with renal syndrome) in children: clinical characteristics. Pediatr Infect Dis 1994; 13: 45–9.
  • Partanen S, Kahanpää K, Lähdevirta J. Infection with the Puumala virus in pregnancy. Br J Obstet Gynecol 1990; 97: 274–5.
  • Silberberg L, Rollin PE, Kerouani G, Courdrier D. Haemorrhagic fever with renal syndrome and pregnancy: a case report. Trans Royal Soc Trop Med Hyg 1993; 87: 65.
  • Partanen S, Sariola A, Lähdevirta J. Lack of evidence of Puumala virus infection in patients with spontaneous abortion. Eur J Clin Microbiol Inf Dis 1993; 12: 142–3.
  • Elgh F, Lundkvist Å, Alexeyev OA, Stenlund H, Avsic-Zupanc T, Hjelle B, et al. Serological diagnosis of hantavirus infections by an enzyme-linked immunosorbent assay based on detection of immunoglobulin G and M responses to recombinant nucleocapsid proteins of five viral serotypes. J Clin Microbiol 1997; 35: 1122–30.
  • Settergren B, Juto P, Wadell G. Detection of specific serum immunoglobulin M in nephropathia epidemica (Scandinavian epidemic nephropathy) by a biotin-avidin amplified immunofluorescence method. J Clin Microbiol 1987; 25: 1134–6.
  • Hedman K, Vaheri A, Brummer-Korvenkontio M. Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet 1991; 338: 1353–6.
  • Juto P, Elgh F, Ahlm C, Alexeyev OA, Edlund K, Lundkvist Å, et al. The first human isolate of Puumala virus in Scandinavia as cultured from phytohemagglutinin stimulated leucocytes. J Med Virol 1997; 53: 150–6.
  • Grankvist O, Juto P, Settergren B, Ahlm C, Bjermer L, Linderholm M, et al. Detection of nephropathia epidemica virus RNA in patient samples using a nested primer-based polymerase chain reaction. J Infect Dis 1992; 165: 934–7.
  • Huggins JW, Hsiang CM, Cosgriff TM, Guang MY, Smith JI, Wu ZO, et al. Prospective, double-blind, concurrent, placebocontrolled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis 1991; 164: 1119–27.
  • Gui XE, Ho M, Cohen M, Wang QL, Huang HP, Xie QX. Hemorrhagic fever with renal syndrome: treatment with recombinant alfa-interferon. J Infect Dis 1987; 155: 1047–51.
  • Qian DY, Ding YS, Chen GF, Ding JJ, Chen YX, Lu TF, et al. A placebo-controlled clinical trial of prednisone in the treatment of early hemorrhagic fever. J Infect Dis 1990; 162: 1213–4.
  • Settergren B, Ahlm C, Juto P, Niklasson B. Specific Puumala virus IgG half a century after haemorrhagic fever with renal syndrome. Lancet 1991; 338: 66.
  • Becker C, Goubeaud G, Willems WR. Hanta-virus infektion (in German). Deutsch Med Wochenschr 1991; 116: 598.
  • Kleinknecht D, Rollin PE. Hypertension after hemorrhagic fever with renal syndrome. Nephron 1992; 61: 121.
  • Niklasson B, Hellsten G, LeDuc J. Hemorrhagic fever with renal syndrome: a study of sequele following nephropathia epidemica. Arch Virol 1994; 137: 241–7.
  • Linderholm M, Settergren B, Ahlm C, Burman LA, Traff S, Bäcklund U, et al. A Swedish fatal case of nephropathia epidemica. Scand J Infect Dis 1991; 23: 501–2.
  • Lee HW, Ahn CN, Song JW, Baek LJ, Seo TJ, Park SC. Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome. Arch Virol 1990; Suppl 1: 34–47.
  • Song G, Hand CS, Huang YC, Hou FY. Preliminary trials of inactivated vaccine against haemorrhagic fever with renal syndrome. Lancet 1991; 337: 801.
  • Temonen M, Vapalahti O, Holthöfer H, Brummer-Korvenkontio M, Vaheri A, Lankinen H. Susceptibility of human cells to Puumala virus infection. J Gen Virol 1993; 74: 515–8.
  • Niklasson B, Jonsson M, Lundkvist Å, Hörling J, Tkachenko E. Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. Am J Trop Med Hyg 1991; 45: 660–5.
  • Saari M, Alanko H, Järvi J, Vetoniemi-Korhonen SL, Räsänen O. Nephropathia epidemica-the Scandinavian form of hemorrhagic fever with renal syndrome. JAMA 1977; 238: 874–7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.