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Research Article

Ecological Effects of Linezolid versus Amoxicillin/Clavulanic Acid on the Normal Intestinal Microflora

Pages 899-903 | Published online: 08 Jul 2009

  • Edlund C, Nord CE. Ecological impact of antimicrobial agents on human intestinal microflora. Alpe Adria Microbiol J 1993; 3: 137–64.
  • Swaney SM, Aoki H, Ganoza MC, Shinabarger DL. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria. Antimicrob Agents Chemother 1998; 42: 3251–5.
  • Zurenko GE, Yagi BH, Schaadt RD, Allison JW, Kilburn JO, Glickman SE, et al. In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents. Antimicrob Agents Chemother 1996; 40: 839–45.
  • Edlund C, Oh H, Nord CE. In vitro activity of linezolid and eperezolid against anaerobic bacteria. Clin Microbiol Infection 1999; 5: 51–3.
  • Edlund C, Nord CE. The evaluation and prediction of the ecological impact by antibiotics in human phases I and II trials. Clin Microbiol Infection 2001; in press.
  • Edlund C, Beyer G, Hiemer-Bau M, Ziege S, Lode H, Nord CE. Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora. Scand J Infect Dis 2000; 32: 81–5.
  • Edlund C, Alván G, Barkholt L, Vacheron F, Nord CE. Pharmacokinetics and comparative effects of telithromycin and clarithromycin on the oropharyngeal and intestinal microflora. J Antimicrob Chemother 2000; 46: 741–9.
  • Hamacher J, Luepke J, Reidenberg B, Nord CE, Borner K, Bristol D, et al. Changes in fecal flora and comparative multiple-dose pharmacokinetics of ceftibuten, cefpodoxime proxetil and amoxycillin/clavulanate. Clin Microbiol Infection 1999; 5: 339–54.
  • Norrby SR. Linezolid—a review of the first oxazolidinone. Exp Opin Pharmacother 2001; 2: 293–302.
  • Motohiro T, Tanaka K, Koga T. Effect of BRL 25,000 (Clavulanic-amoxycillin) on bacterial flora in human feces. Jpn J Antibiot 1985; 38 : 441–50.
  • Lambert-Zechovsky N, Bingen E, Proux MC, Aujard Y, Mathieu H. Effect of amoxycillin combined with clavulanic acid on the fecal flora of children. Pathol Biol 1984; 32: 436–42.
  • Mittermayer HW. The effect of amoxycillin and amoxycillin plus clavulanic acid on human bowel flora. In: Croydon EAP, Michel MF, eds. Augmentin: Clavulanate-potentiated amoxycillin. Amsterdam: Elsevier, 1983: 125–33.
  • Brumfitt W, Franklin I, Grady D, Hamilton JMT. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Antimicrob Agents Chemother 1986; 30: 335–7.
  • Edlund C, Stark C, Nord CE. The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances. J Antimicrob Chemother 1994; 34: 127–38.

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