32
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Antigen Discovery and Tuberculosis Vaccine Development in the Post-genomic Era

Pages 79-83 | Published online: 08 Jul 2009

  • Hart CA, Beeching NJ, Duerden BI. Tuberculosis into the next century. J Med Microbiol 1996; 44: 1–34.
  • Smith DW. Protective effect of BCG in experimental tuberculosis. Adv Tuberc Res 1985; 22: 1–97.
  • McMurray DN, Collins FM, Dannenberg AM, Smith DW. Pathogenesis of experimental tuberculosis in animal models. Curr Top Microbiol Immunol 1996; 215: 157–79.
  • Fine PEM. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 1995; 346: 1339–45
  • Dillon DC, Alderson MR, Day CH, Lewinsohn DM, Coler R, Bement T, et al. Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family. Infect Immun 1999; 67: 2941–50.
  • Barnes PF, Mehra V, Rivoire B, Fong SJ, Brennan PJ, Voegtline MS, et al. Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis. J Immunol 1992; 148: 1835–40.
  • S¢rensen AL, Nagai S, Houen G, Andersen P, Andersen AB. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect Immun 1995; 63: 1710–7.
  • Andersen P, Askgaard D, Ljungqvist L, Bennedsen J, Heron I. Proteins released from Mycobacterium tuberculosis during growth. Infect Immun 1991; 59: 1905–10.
  • Orme IM, Andersen P, Boom WH. T cell response to Mycobacterium tuberculosis. J Infect Dis 1993; 167: 1481–97.
  • Andersen P. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 1994; 62: 2536–44.
  • Hubbard RD, Flory CM, Collins FM. Immunization of mice with mycobacterial culture filtrate proteins. Clin Exp Immunol 1992; 87: 94–8.
  • Pal PG, Horwitz MA. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect Immun 1992; 60: 4781–92.
  • Roberts AD, Sonnenberg MG, Ordway DJ, Furney SK, Brennan PJ, Belisle JT, et al. Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology 1995; 85: 502–8.
  • Brandt L, Oettinger T, Holm A, Andersen P. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J Immunol 1996; 157: 3527–33.
  • Pollock JM, Andersen P. Predominant recognition of the ESAT-6 protein in the first phase of infection with Mycobacterium bovis in cattle. Infect Immun 1997; 65: 2587–92.
  • Boesen H, Jensen BN, Wilcke T, Andersen P. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis. Infect Immun 1995; 63: 1491–7.
  • Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998; 393: 537–44.
  • Berthet FX, Rasmussen PB, Rosenkrands I, Andersen P, Gicquel B. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 1998; 144: 3195–203.
  • Alderson MR, Bement T, Day CH, Zhu L, Molesh D, Skeiky YA, et al. Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4( +) T cells. J Exp Med 2000; 191: 551–60.
  • Andersen P, Andersen ÅB, Soerensen AL, Nagai S. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J Immunol 1995; 154: 3359–72.
  • Ravn P, Demissie A, Eguale T, Wondwosson H, Lein D, Amoudy H, et al. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J Infect Dis 1999; 179: 637–45
  • Elhay MJ, Oettinger T, Andersen P. Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig. Infect Immun 1998; 66: 3454–6.
  • Pollock JM, Andersen P. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J Infect Dis 1997; 175: 1251–4.
  • Skjøt RLV, Oettinger T, Rosenkrands I, Ravn P, Brock I, Jacobsen S, Andersen P. Comparative evaluation of low molecular mass T-cell antigens from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant. Infect Immun 2000; 68: 214–20.
  • Arend SM, Geluk A, van Meijgaarden KE, van Dissel JT, Theisen M, Andersen P, et al. Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1- encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides. Infect Immun 2000; 68: 3314–21.
  • Kamath AT, Feng CG, Macdonald M, Briscoe H, Britton WJ. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect Immun 1999; 67: 1702–7.
  • Li Z, Howard A, Kelley C, Delogu G, Collins F, Morris S. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect Immun 1999; 67: 4780–6.
  • Morris S, Kelley C, Howard A, Li Z, Collins F. The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine 2000; 18: 2155–63.
  • Brandt L, Elhay MJ, Rosenkrands I, Lindblad EB, Andersen P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect Immun 1999; 68: 791–5.
  • Olsen AW, Hansen PR, Holm A, Andersen P. Efficient protection against Mycobacterium tuberculosis by vaccination with a single subdominant epitope from the ESAT-6 antigen. Eur J Immunol 2000; 30: 1724–32.
  • Olsen AW, van Pinxteren LAH, Okkels LM, Rasmussen PB, Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of Ag85B and ESAT-6. Infect Immun 2001; in press (will be published in May).
  • Wards BJ, Lisle GWD, Collins DM. An esat-6 knockout mutant of Mycobacterium bovis produced by allelic exchange will be useful for development of a live tuberculosis vaccine. 100th General Meeting of the American Society for Microbiology. Los Angeles, CA: American Society for Microbiology, 2000: 650.
  • Musser JM, Amin A, Ramaswamy S. Negligible genetic diversity of mycobacterium tuberculosis host immune system protein targets: evidence of limited selective pressure. Genetics 2000; 155: 7–16.
  • Hughes AL. Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions. Genetics 1991; 127: 345–53.
  • Zhu X, Venkataprasad N, Ivanyi J, Vordermeier HM. Vaccination with recombinant vaccinia viruses protects mice against Mycobacterium tuberculosis infection. Immunology 1997; 92: 6–9.
  • Ulmer JB, Liu MA, Montgomery DL, Yawman AM, Deck RR, DeWitt CM, et al. Expression and immunogenecity of Mycobacterium tuberculosis antigen 85 by DNA vaccination. Vaccine 1997; 15: 792–4.
  • Murray PJ, Aldovini A, Young RA. Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines. Proc Natl Acad Sci USA 1996; 93: 934–9.
  • Hess J, Grode L, Hellwig J, Conradt P, Gentschev I, Goebel W, et al. Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG. FEMS Immunol Med Microbiol 2000; 27: 283–9.
  • Harboe M, Malin AS, Dockrell HS, Wiker HG, Ulvund G, Holm A, et al. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infect Immun 1998; 66: 717–23.
  • Rosenkrands I, Weldingh K, Jacobsen S, Hansen CV, Florio W, Gianetri I, et al. Mapping and identification of Mycobacterium tuberculosis proteins by two-dimensional gel electrophoresis, microsequencing and immunodetection. Electrophoresis 1999; 21: 1935–48.
  • Coler RN, Skeiky YA, Vedvick TS, Bement T, Ovendale PJ, Campos-Neto A, et al. Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis. J Immunol 1998; 161: 2356–64.
  • Webb JR, Vedvick TS, Aldersen MR, Guderian JA, Jen SS, Ovendale PJ, et al. Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis. Infect Immun 1998; 66: 4208–14.
  • Bhaskar S, Khanna SP, Mukherjee R. Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis. Vaccine 2000; 18: 2856–66.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.