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Original Article

Neuroprotection of Vestibular Sensory Cells from Gentamicin Ototoxicity Obtained Using Nitric Oxide Synthase Inhibitors, Reactive Oxygen Species Scavengers, Brain-derived Neurotrophic Factors and Calpain Inhibitors

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Pages 8-13 | Received 01 Jul 2004, Accepted 01 Jul 2004, Published online: 16 Dec 2009

  • Wang J, Ding D, Shulman A, Stracher A, Salvi RJ. Leupeptin protects sensory hair cells from acoustic trauma Neuroreport 1999; 10: 811-816
  • Klöcker N, Cellerino A, Bahr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects on brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo J Neurosci 1998; 18: 1038-1046
  • Agerman K, Canlon B, Duan M, Ernfors P. Neurotrophins, NMDA receptors, and nitric oxide in development and protection of the auditory system Ann N Y Acad Sci 1999; 884: 131-142
  • Takumida M, Anniko M. Brain-derived neurotrophic factor and nitric oxide synthase inhibitor protect the vestibular organ against gentamicin ototoxicity Acta Otolaryngol 2002; 122: 10-15
  • Takumida M, Anniko M. Simultaneous detection of both nitric oxide and reactive oxygen species in guinea pig vestibular sensory cells. ORL J Otorhinolaryngol Relat Spec 2002; 64: 143-147
  • Estevez AG, Spear N, Manuel SM Nitric oxide and superoxide contribute to motor neuron apoptosis induced by tropic factor deprivation J Neurosci 1998; 18: 923-931et al
  • Basile AS, Huang J-M, Xie C, Webster D, Berlin C, Skolnick P. N-methyl-D-aspartate antagonists limit aminoglycoside antibiotics-induced hearing loss Nat Med 1996; 12: 1338-1343
  • Cheng AG, Huang T, Stracher A Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophine-withdrawal induced apoptosis Brain Res 1999; 850: 234-243et al
  • Zheng Y, Ikeda K, Nakamura M, Takasaka T. Endonuclease cleavage of DNA in the aged cochlea of Mongolian gerbil Hear Res 1998; 126: 11-18
  • Watanabe K, Jinnouchi K, Hess A, Michel O, Yagi T. Detection of apoptotic change in the lipopolysaccharide (LPS)-treated cochlea of guinea pig Hear Res 2001; 158: 116-122
  • Watanabe K-I, Hess A, Bloch W, Michel O. Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pig Anticancer Drugs 2000; 11: 401-406
  • Lopez I, Honrubia V, Lee S-C The protective effect of brain-derived neurotrophic factor after gentamicin ototoxicity Am J Otol 1999; 20: 317-324et al
  • Takumida M, Popa R, Anniko M. Free radicals in the guinea pig inner ear following gentamicin exposure ORL J Otorhinolaryngol Relat Spec 1999; 61: 63-70
  • Sha S-H, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potent protectant Hear Res 2000; 142: 34-40
  • Garetz SL, Altschuler RA, Schacht J. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo Hear Res 1994; 77: 81-87
  • Rybak LP, Whitworth C, Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity Laryngoscope 1999; 109: 1740-1744
  • Yamasoba T, Schacht J, Shoji F, Miller JM. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo Brain Res 1999; 815: 317-325
  • Takumida M, Anniko M. Lipopolysaccharide-induced expression of nitric oxide synthase II in the guinea pig vestibular end organs Eur Arch Otorhinolaryngol 1998; 255: 184-188
  • Takumida M, Anniko M, Popa R. Possible involvement of free radicals in lipopolysaccharide-induced labyrinthitis. A morphological and a functional investigation ORL J Otorhinolaryngol Relat Spec 1998; 60: 246-253
  • Gabaizadeh R, Staecker H, Liu W, Van De Water TR. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione Mol Brain Res 1997; 50: 71-78
  • Zheng JL, Stewart RR, Gao WQ. Neurotrophin-4/5, brain derived neurotrophic factor, and neurotrophin-3 promote survival of cultured vestibular ganglion neurons and protect them against neurotoxicity of ototoxicins J Neurobiol 1995; 28: 330-340
  • Neidermeyer HP, Arnold W, Funk A, Neumann Ch, Lamm K. Apoptotic cell death in noise exposed cochlea of guinea pig ARO Abstr 1997; 20: 479
  • Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia Hear Res 2000; 139: 97-115
  • Takumida M, Anniko M, Popa R, Zhang DM. Pharmacological models for inner ear therapy with emphasis on nitric oxide Acta Otolaryngol 2001; 121: 16-20
  • Liu W, Staecker H, Stupak H, Malgrange B, Lefebvre P, Van De Water TR. Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells Neuroreport 1998; 9: 2609-2614

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