Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 6
302
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Improved Syntheses of N‐Desmethylcitalopram and N,N‐Didesmethylcitalopram

, , &
Pages 901-908 | Received 27 Jul 2006, Published online: 24 Feb 2007

References

  • Spinks , D. and Spinks , G. 2002 . Serotonin reuptake inhibition: An update on current research strategies . Curr. Med. Chem. , 9 : 799 – 810 .
  • Brøsen , K. and Naranjo , C. 2001 . A Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram . Eur. Neuropsychopharmacol. , 11 : 275 – 283 .
  • Bigler , A. J. , Bøgesø , K. P. and Toft , A. 1977 . Quantitative structure–activity relationships in a series of selective 5‐HT uptake inhibitors . Eur. J. Med. Chem. , 12 : 289 – 295 .
  • von Braun , J. 1909 . Mitteilungen Die Aufspaltung cyclischer Basen durch Bromcyan . Chem Ber. , 42 : 2035 – 2057 .
  • Cooley , J. H. and Evain , E. J. 1989 . Amine dealkylations with acyl chlorides . Synthesis , : 1 – 17 .
  • Brine , G. A. , Boldt , K. G. , Hart , C. K. and Carroll , F. I. 1976 . The N‐demethylation of morphine and codeine using methyl chloroformate . Org. Prep. Proced. Int. , 8 : 103 – 106 .
  • Rice , K. C. and May , E. L. 1977 . Procedural refinements in the N‐demethylation of morphine and codeine using phenyl chloroformate and hydrazine . J. Heterocycl. Chem. , 14 : 665 – 666 .
  • Olofson , R. A. and Martz , J. T. 1984 . A new reagent for the selective, high‐yield N‐dealkylation of tertiary amines: Improved syntheses of naltrexone and nalbuphine . J. Org. Chem. , 49 : 2081 – 2082 .
  • Greene , T. W. and Wuts , P. G. M. “ Protection for the amino group ” . In Protective Groups in Organic Synthesis , 3rd Ed. 494 – 653 . New York : John Wiley & Sons .
  • de Kimpe , N. , Yao , Z. , de Buyck , L. , Verhe , R. and Schamp , N. 1986 . Synthesis of functionalized 2,3‐dihydro‐[9bH]oxazole[2,3‐a]‐isoindoline‐5‐ones . Bull Soc. Chim. Belg. , 95 : 197 – 202 .
  • Reetz , M. T. , Drewes , M. W. and Schmitz , A. 1987 . Stereoselective synthesis of β‐amino alcohols from optically active α‐amino acids . Angew. Chem., Int. Ed. Engl. , 26 : 1441 – 1443 .
  • Laguzza , B. C. and Ganem , B. 1981 . A new protecting group for amines: Synthesis of anticapsin from L‐tyrosine . Tetrahedron Lett. , 22 : 1483 – 1486 .
  • Djuric , S. , Venit , J. and Magnus , P. 1981 . Silicon in synthesis: Stabase adducts—A new primary amine protecting group: Alkylation of ethyl glycinate . Tetrahedron Lett. , 22 : 1787 – 1790 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.