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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2010 - Issue 2
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Original Articles

Synthesis of Active Metabolites of Carvedilol, an Antihypertensive Drug

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Pages 268-276 | Received 01 Oct 2009, Published online: 15 Dec 2010

REFERENCES

  • Packer , M. ; Fowler , B. M. ; Roecker , B. E. ; Coats , J. S. A. ; Katus , A. H. ; Krum , H. ; Mohacsi , P. ; Rouleau , L. J. ; Tendera , M. ; Staiger , C. ; Holcslaw , L. T. ; Amann-Zalan , I. ; DeMets , L. D. Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study group: Effect of carvedilol on the morbidity of patients with severe chronic heart failure: Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study . Circulation 2002 , 106 ( 22 ), 2194 – 2199 .
  • Ruffolo , R. R. ; Boyle , D. A. ; Brooks , D. P. ; Feuerstein , G. Z. ; Venuti , R. P. ; Lukas , M. A. ; Poste , G. Carvedilol: A novel cardiovascular drug with multiple actions . Cardiovasc. Drug Rev. 1992 , 10 , 127 – 157 .
  • Schaefer , W. H. ; Politowski , J. ; Hwang , B. ; Dixon , F. J. ; Goalwin , A. ; Gutzait , L. ; Anderson , K. ; Debrosse , C. ; Bean , M. ; Rhodes , G. R. Metabolism of carvedilol in dogs, rats, and mice . Drug Metab. Dispos. 1998 , 26 , 958 – 969 .
  • Nakamura , K. ; Kusano , K. ; Nakamura , Y. ; Kakishita , M. ; Ohta , K. ; Nagase , S. ; Yamamoto , M. ; Miyaji , K. ; Saito , H. ; Morita , H. ; Emori , T. ; Matsubara , H. ; Toyokuni , S. ; Ohe , T. Carvedilol decreases elevated oxidative stress in human failing myocardium . Circulation 2002 , 105 , 2867 – 2871 .
  • Kukin , L. M. ; Kalman , J. ; Charney , H. R. ; Levy , K. D. ; Buchholz-Varley , C. ; Ocampo , N. O. Prospective, randomized comparison of effect of long-term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction, and oxidative stress in heart failure . Eng. C Circulation 1999 , 99 , 2645 – 2651 .
  • Poole-Wilson , P. A. ; Swedberg , K. ; Cleland , J. G. ; Di Lenarda , A. ; Hanrath , P. ; Komajda , M. ; Lubsen , J. ; Lutiger , B. ; Metra , M. ; Remme , W. J. ; Torp-Pedersen , C. ; Scherhag , A. ; Skene , A. Rationale and design of the carvedilol or metoprolol tartrate European trial in patients with chronic heart failure: COMET . Eur. J. Heart. Fail. 2002 , 4 , 321 – 329 .
  • Oldham , H. G. ; Clarke , S. E. In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(−)-carvedilol . Drug Metab. Dispos. 1997 , 25 , 970 – 977 .
  • Jhy-Chong , L. ; Jwu-Lai , Y. ; Chia-Sui , W. ; Shwu-Fen , L. ; Chieh-Ho , T. ; Ing-Jun , C. The new generation dihydropyridine-type calcium blockers, bearing 4-phenyl oxypropanolamine, display α,β-adrenoceptor antagonist and long-acting antihypertensive activities . Bioorg. Med. Chem. Lett. 2002 , 10 , 719 – 730 .
  • Dakin , H. D. The oxidation of hydroxyl derivatives of benzaldehyde, acetophenone, and related substances . Am. Chem. J. 1909 , 42 , 477 – 481 .
  • Alker , D. ; Arrowsmith , L. E. ; Campbell , S. F. ; Cross , P. E. Long-acting dihydropyridine calcium antagonists, IX: Structure–activity relationships around amlodipine . Eur. J. Med. Chem. 1991 , 26 , 907 – 913 .
  • Trepat Guixer , E. ; Munoz Alvarex , A. ; Pomares Marco , M. ; Marquillas Olondriz , F. Process for the preparation of carvedilol and its enantiomers . WO patent 2006061364, 2006 ; Chem. Abstr. 2006 , 145 , 62782 .
  • KanKan , R. N. ; Rao , D. R. Process for the preparation of carvedilol with improved yields on an industrial scale. WO Patent 2005113502, 2005; Chem. Abstr. 2006, 143, 266815.
  • Vijay , C. C. ; Rajeev , B. R. ; Rajamannar , T. A process for preparation of 1-[9 h-carbazol-4-yloxy]-3-[{2-(2-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol . US Patent 20060270858, 2006 ; Chem. Abstr. 2004 , 142 , 93675 .

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