Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 21
822
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis and Characterization of Related Substances of Deferasirox, an Iron (Fe3+) Chelating Agent

, , , &
Pages 3200-3210 | Received 17 Dec 2010, Published online: 17 Aug 2012

REFERENCES

  • Crichton , R. Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, , 2nd edition ; John Wiley and Sons : New York , 2001 , Chem. Abstr. 2005, 143, 73640 q .
  • Nisbet-Brown , E. ; Olivieri , N. F. ; Giardina , P. J. ; Grady , R. W. ; Newfeld , E. J. ; Sechand , R. ; Krebs-Brown , A. J. ; Anderson , J. R. ; Alberti , D. ; Sizer , K. C. ; Nathan , D. G. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomized, double-blind, placebo controlled, dose-escalation trial . Lancet 2003 , 361 ( 9369 ), 1597 – 1602 .
  • Anonymous. Crystalline 4-[3,5-bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid and process for preparation thereof . IP. Com. Journal 2007 , 7 ( 8A ), 25 – 26 ; Chem. Abstr. 2008, 149, 402326 d .
  • International Conference on Harmonization (ICH). Q 3 A (R): Impurities in New Drug Substances; ICH: Geneva, Switzerland, 2002.
  • International Conference on Harmonization (ICH). Q 2 B Validation of Analytical Procedure. Methodology; ICH: Geneva, Switzerland, 1996.
  • Steinhauser , S. ; Heinz , U. ; Bartholomae , M. ; Weyhermueller , T. ; Nick , H. ; Hegetschweiler , K. Complex formation of ICL670 and related ligands with FeIII and FeII . Eur. J. Inorg. Chem. 2004 , 21 , 4177 – 4192 .
  • Brunetti , H. ; Luethi , C. E. Synthesis of asymmetrically substituted o-hydroxyphenyl-s-triazines . Helv. Chim. Acta 1972 , 55 ( 5 ), 1566 – 1595 .
  • Lattmann , R. ; Acklin , P. Preparation of 3,5-bishydroxyphenyl-1,2,4-triazoles as pharmaceutical chelators. US Patent 6,465,504 B1, 2002 .
  • Neela , P. K. ; Charugundla , K. ; Patil , R. S. ; Pradhan , N. S. C. ; Valgeirsson , J. Solid-state forms of deferasirox salts and process for the preparation thereof. PCT Int. Appl. WO 2009 130 604 A2, 2009.
  • Stroh , H. H. ; Westphal , G. Condensation of carbonyl compounds with hydrazines, VI. The basicity constants of nucleus-substituted phenylhydrzines . Ber. 1963 , 96 , 184 – 187 .
  • Yamamoto , S. ; Hashiguchi , S. ; Miki , S. ; Igata , Y. ; Watambe , T. ; Shiraishi , M. Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers . Chem. Pharm. Bull. 1996 , 44 ( 4 ), 734 – 745 .
  • Kaja , R. ; Surendranath , K. V. ; Krishnanand , P. R. ; Satish , J. ; Satyanarayana , P. V. V. A study indicating LC method for deferasirox in bulk drug and pharmacuetical dosage forms . Chromatographia 2010 , 72 ( 5–6 ), 441 – 446 .
  • Palazzo , S. ; Giannola , L. I. Synthesis of some derivative of 4(1H)-quinazolinones . J. Heterocycl. Chem. 1973 , 10 ( 4 ), 675 – 677 .
  • (a) Pfannstiel , K. ; Janecke , J. Preparation of O-hydrazinobenzoic acid and indazolones by the reduction of diazotized anthranilic acids with sulfurous acid . Ber. 1942 , 75B , 1096 – 1107 ; (b) Org. Synthe. collect. 1942, 3, 475–476.
  • Schwarz , R. ; Kuchen , W. The anhydrization of aromatic hydroxy carboxylic acids with silicon tetrachloride . Chem. Ber. 1952 , 85 , 624 – 630 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.