Advances in the Chemistry of Aminoisoxazole

REFERENCES

• Carlsen , L. ; Dopp , D. ; Dopp , H. ; Duus , F. ; Hartmann , H. ; Lang-Fugmann , S. ; Schulze , B. ; Smalley , R. K. ; Wakefield , B. J. In Houben-Weyl Methods in Organic Chemistry ; E. Schaumann (Ed.); Georg Thieme Verlag : Stuttgart , Germany , 1992 ; vol. E8a , pp. 45 – 204 .
   Google Scholar
• Frolund , B. ; Jorgensen , A. T. ; Tagmose , L. ; Stensbol , T. B. ; Vestergaad , H. T. ; Engblom , C. ; Kristiansen , U. ; Sanchez , C. ; Krogsgaard-Larsen , P. ; Liljefors , T. Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling . J. Med. Chem. 2002 , 45 , 2454 – 2468 .
   PubMed Web of Science ®Google Scholar
• Daidone , G. ; Raffa , D. ; Maggio , B. ; Plescia , F. ; Cutuli , V. M. C. ; Mangano , N. G. ; Caruso , A. Synthesis and pharmacological activities of novel 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives . Arch. Pharm. 1999 , 332 , 50 – 54 .
   PubMed Web of Science ®Google Scholar
• Rowley , M. ; Broughton , H. B. ; Collins , I. ; Baker , R. ; Emms , F. ; Marwood , R. ; Patel , S. ; Ragan , C. I. 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: A potent, selective antagonist at human cloned dopamine D4 receptors . J. Med. Chem. 1996 , 39 , 1943 – 1945 .
   PubMed Web of Science ®Google Scholar
• Jacobsen , N. ; Pedersen , L.-E. K. ; Wengel , A. Insecticidal activity of 3-isoxazolyl methanesulfonates and related compounds . Pesticide Sci. 1990 , 29 , 95 – 100 .
   Google Scholar
• Talley , J. J. Selective inhibitors of cyclo-oxygenase-2 (COX-2). Prog. Med. Chem. 1999, 36, 201–234.
   PubMed Web of Science ®Google Scholar
• Talley , J. J. ; Brown , D. L. ; Carter , J. S. ; Graneto , M. J. ; Koboldt , C. M. ; Masferrer , J. L. ; Perkins , W. E. ; Rogers , R. S. ; Shaffer , A. F. ; Zhang , Y. Y. ; Zweifel , B. S. ; Seibert , K. 4-[5-Methyl-3-phenylisoxazol-4-yl]benzenesulfonamide, Valdecoxib: A potent and selective inhibitor of COX-2 . J. Med. Chem. 2000 , 43 , 775 – 777 .
   PubMed Web of Science ®Google Scholar
• Giovannoni , M. P. ; Vergelli , C. ; Ghelardini , C. ; Galeotti , N. ; Bartolini , A. ; Piaz , V. D. [(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents . J. Med. Chem. 2003 , 46 , 1055 – 1059 .
   PubMed Web of Science ®Google Scholar
• Li , W. T. ; Hwang , D. R. ; Chen , C. P. ; Shen , C. W. ; Huang , C. L. ; Chen , T. W. ; Lin , C. H. ; Chang , Y. L. ; Chang , Y. Y. ; Lo , Y. K. ; Tseng , H. Y. ; Lin , C. C. ; Song , J. S. ; Chen , H. C. ; Chen , S. J. ; Wu , S. H. ; Chen , C. T. Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents . J. Med. Chem. 2003 , 46 , 1706 – 1715 .
   PubMed Web of Science ®Google Scholar
• Khalafy , J. ; Dilmaghani , K. A. ; Soltani , L. ; Poursattar-Marjani , A. The synthesis of new 5-aminoisoxazoles by reaction of thiocarbamoylcyanoacetates with hydroxylamine . Chem. Heterocycl. Compd. (Engl. Transl.) 2008 , 44 , 729 – 734 .
   Web of Science ®Google Scholar
• Sobenina , L. N. ; Drichkov , V. N. ; Mikhaleva , A. I. ; Petrova , O. V. ; Ushakov , I. A. ; Trofimov , B. A. Synthesis of 3- and 5-amino-5-(3)-(pyrrol-2-yl)isoxazoles . Tetrahedron 2005 , 61 , 4841 – 4849 .
   Web of Science ®Google Scholar
• Kashima , C. Synthetic reactions using isoxazole compounds . Heterocycles 1979 , 12 , 1343 – 1368 .
   Web of Science ®Google Scholar
• Trogu , E. ; De Sarlo , F. ; Cardini , G. ; Machetti , F. Synthesis of isoxazole derivatives by catalytic condensation of primary nitro compounds with dipolarophiles. Ph.D. dissertation, University of Delhi Lodi Di Firenze , 2009 .
   Google Scholar
• Risitano , F. ; Grassi , G. ; Caruso , F. ; Foti , F. Synthesis of meso-tetraarylporphyrins using SeO2 as oxidant . Tetrahedron 1996 , 52 , 1443 – 1450 .
   Web of Science ®Google Scholar
• Ershov , A. Y. ; Dobrodumov , A. V. Ring-ring tautomerism in 1,3-alkanoylhydrazonoximes of acetylacetone . Chem. Heterocycl. Compd. (Engl. Transl.) 2000 , 36 , 722 – 727 .
   Google Scholar
• Shaw , G. ; Sugowdz , G. Isooxazolones, part VI: The hydrogenation of 5-aminoisooxazoles: A new synthesis of pyrimidines . J. Chem. Soc. 1954 , 665 – 668 .
   Web of Science ®Google Scholar
• Frydenvang , K. ; Matzen , L. ; Norrby , P.-O. ; Sløk , F. A. ; Liljefors , T. ; Krogsgaard-Larsen , P. ; Jaroszewski , J. Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by x-ray crystallography and ab initio calculations . J. Chem. Soc., Perkin Trans. 2 1997 , 1783 – 1792 .
   Google Scholar
• Ori , L. ; Joshua , H. Preparation of 3-amino-5-methylisoxazole . DE Patent 3731850 1988 .
   Google Scholar
• Tatee , T. ; Kurashige , S. ; Ito , S. ; Miyazaki , H. ; Shiozawa , A. ; Yamanaka , H. 5-Aminoisoxazole derivatives and pharmaceutical preparations containing them . German Offen. 1983 , DE Patent 3237149 .
   Google Scholar
• Abushanab , E. ; Lee , D. Y. ; Goodman , L. Synthetic studies in the lsoxazoko[4,5-b]pyrazine system . J. Heterocycl. Chem. 1973 , 10 , 181 – 185 .
   Web of Science ®Google Scholar
• Hansen , T. V. ; Wu , P. ; Fokin , V. V. One-pot copper(I)-catalyzed synthesis of 3,5-disubstituted isoxazoles . J. Org. Chem. 2005 , 70 , 7761 – 7764 .
   PubMed Web of Science ®Google Scholar
• Bourbeau , M. P. ; Rider , J. T. A convenient synthesis of 4-alkyl-5-aminoisoxazoles . Org. Lett. 2006 , 8 , 3679 – 3680 .
   PubMed Web of Science ®Google Scholar
• Al-Mousawi , S. M. ; Moustafa , M. S. ; Elnagdi , M. H. Studies with malononitrile derivatives: Synthesis and reactivity of 4-benzylpyrazole-3,5-diamine, 4-benzylisoxazole-3,5-diamine, and thiazolidin-3-phenylpropanenitrile . Heterocycles 2008 , 75 , 1371 – 1383 .
   Web of Science ®Google Scholar
• Dilman , A. D. ; Tishkov , A. A. ; Lyapkalo , I. M. ; Ioffe , S. L. ; Strelenko , Y. A. ; Tartakovsky , V. A. Novel convenient method for the synthesis of N,N-bis(trimethylsilyloxy) enamines . Synthesis 1998 , 181 – 185 .
   Web of Science ®Google Scholar
• Dilman , A. D. ; Tishkov , A. A. ; Lyapkalo , I. M. ; Ioffe , S. L. ; Kachala , V. V. ; Strelenko , Y. A. ; Tartakovsky , V. A. Synthesis of N,N-bis(silyloxy)enamines with a functionalized double bond. J. Chem. Soc., Perkin Trans. 1 2000, 2926–2929.
   Google Scholar
• Tartakovsky , V. A. ; Loffe , S. L. ; Dilman , A. D. ; Tishkov , A. A. Silylation as a new strategy of the use of aliphatic nitro compounds in organic synthesis . Izv. Akad. Nauk. Ser. Khim. 2001 , 1850 ; Russ. Chem. Bull., Int. Ed. 2001 , 50 , 1936 – 1948 .
   Google Scholar
• Lesiv , A. V. ; Ioffe , S. L. ; Strelenko , Y. A. ; Bliznets , I. V. ; Tartakovsky , V. A. Reactions of N,N-bis(siloxy)enamines with trimethylsilyl cyanide: Aliphatic nitro compounds as convenient precursors of 5-aminoisoxazoles . Mendeleev Commun. 2002 , 12 , 99 – 102 .
   Web of Science ®Google Scholar
• Fomum , Z. T. ; Greaves , P. M. ; Landor , P. D. ; Landor , S. R. Allenes, part XXVI: The synthesis of enaminic nitriles by the nucleophilic addition of amines to allenic nitriles . J. Chem. Soc., Perkin Trans. 1 1973 , 1108 – 1110 .
   Google Scholar
• Fomum , Z. T. ; Landor , P. D. ; Landor , S. R. ; Mpango , G. B. Oxazolines, thiazolines, oxazoles, thiazoles, and pyrazoles from allenic and acetylenic nitriles . Tetrahedron Lett. 1975 , 13 , 1101 – 1104 .
   Google Scholar
• Fomum , Z. T. ; Asobo , P. F. Allenes, part 42: Nucleophilic addition of hydroxylamine to allenic and acetylenic nitriles: Synthesis of 3-alkyl-5-amino, 5-amino-3-phenyl-, and 3-amino-5-phenyl-isoxazoles . J. Chem. Soc., Perkin Trans. 1 1984 , 1079 – 1084 .
   Google Scholar
• Fomum , Z. T. ; Asobo , P. F. ; Landor , S. R. ; Landor , P. D. Allenes, part 42: Nucleophilic addition of hydroxylamine to allenic and acetylenic nitriles: Synthesis of 3-alkyl-5-amino, 5-amino-3-phenyl-, and 3-amino-5-phenyl-isoxazoles . J. Chem. Soc., Perkin Trans. 1 1984 , 1 , 1079 – 1083 .
   Google Scholar
• Elnagdi , M. H. ; Elmoghayar , M. R. H. ; Hafez , E. A. A. ; Alnima , H. H. Reaction of 2-arylhydrazono-3-oxonitriles with hydroxylamine: Synthesis of 3-amino-4-arylazoisoxazoles . J. Org. Chem. 1975 , 40 , 2604 – 2607 .
   Web of Science ®Google Scholar
• Sobenina , L. N. ; Drichkov , V. N. ; Mikhalcva , A. I. ; Petrova , O. V. ; Ushakov , I. A. ; Trofimov , B. A. Synthesis of 3- and 5-amino-5-(3)-(pyrrol-2-yl)isoxazoles . Tetrahedron 2005 , 61 , 4841 – 4849 .
   Web of Science ®Google Scholar
• Shriner , R. L. ; Neuman , F. W. The chemistry of the amidines . Chem. Rev. 1944 , 35 , 351 – 425 .
   Google Scholar
• Smith , P. A. S. The Chemistry of Open Chain Nitrogen Compounds ; W. A. Benjamin : New York , 1966 ; vol. 1 , p. 177 .
   Google Scholar
• Tanimoto , S. Syntheses of heterocyclic compounds using amidines . Yddki Gdsei Kagaku Kydkai-shi (J. Soc. Org. Synth. Chem., Japan) 1969 , 27 , 551 ; Chem. Abstr. 1969 , 71 , 101740n .
   Google Scholar
• Lopez , L. ; Barrans , J. Enamines as synthons for fused heterocycles . C. R. Acad. Sci., Paris, Ser. C. 1966 , 263 , 1088 – 1091 ; Chem. Abstr. 1967 , 66 , 37846u .
   Google Scholar
• Fujita , H. ; Endo , R. ; Aoyama , A. ; Ichii , T. Propiolamidines I: Syntheses of N,N′-disubstituted phenylpropiolamidines and new routes to 5-N-substituted amino-3-phenylisoxazoles and 5-N-substituted amino-1,3-diphenylpyrazoles . Bull. Chem. Soc. Jap. 1972 , 45 , 1846 – 1852 ; Chem. Abstr. 1972 , 77 , 75162c .
   Web of Science ®Google Scholar
• Wakefield , B. J. ; Wright , D. J. Isoxazole chemistry since 1963 . Adv. Heterocycl. Chem. 1979 , 25 , 147 – 204 .
   Google Scholar
• Barbero , A. ; Pulido , F. Isoxazoles as latent siloxybutadienes: An easy entry to polyfunctionalized benzene systems via Diels–Alder reaction with acetylenes . Synthesis 2004 , 3 , 401 – 404 .
   Google Scholar
• Alberola , A. ; Gonzalez , A. M. ; Gonzalez , B. ; Laguna , M. A. ; Pulido , F. J. Synthesis of Z-β-siloxyacrylonitriles and study of their dienophilic properties . Tetrahedron Lett. 1986 , 27 , 2027 – 2030 .
   Web of Science ®Google Scholar
• Golic , L. ; Stropnik , C. ; Stanovnik , B. ; Tisler , M. Functionalized enamines in the synthesis of some heterocyclic compounds . Heterocycles 1987 , 25 , 347 – 358 .
   Web of Science ®Google Scholar
• Pattabiraman , K. ; El-Khouri , R. ; Modi , K. ; McGee , L. R. ; Chow , D. Synthesis of novel biaryl 2-benzimidazoles and 2-benzothiazoles. Tetrahedron Lett. 2009, 50, 1571–1574.
   Web of Science ®Google Scholar
• Moureu , C. ; Lazennec , I. Bull. Soc. Chim. Fr. 1907 , 1 , 1084 ; Chem. Abstr. 1908 , 2 , 807a .
   Google Scholar
• Moureu , C. ; Lazennec , I. Compt. Rend. 1907 , 144 , 1281 – 1283 ; Chem. Abstr. 1907 , 1 , 2597 .
   Google Scholar
• Buron , C. ; El Kaïm , L. ; Uslu , A. A new straightforward formation of aminoisoxazoles from isocyanides . Tetrahedron Lett. 1997 , 38 , 8027 – 8030 .
   Web of Science ®Google Scholar
• Mohareb , R. M. ; Habashi , A. ; Hafez , E. A. A. ; Sherif , S. M. α-Halo ketoximes in heterocyclic synthesis: Polyfunctional azoles and azines from α-bromo ketoximes . Arch. Pharm. 1987 , 320 , 776 – 780 .
   Web of Science ®Google Scholar
• Wang , K. ; Xiang , D. ; Liu , J. ; Pan , W. ; Dong , D. Efficient and divergent synthesis of fully substituted 1H-pyrazoles and isoxazoles from cyclopropyl oximes . Org. Lett. 2008 , 10 , 1691 – 1694 .
   PubMed Web of Science ®Google Scholar
• Tatee , T. ; Narita , K. ; Kurashige , S. ; Ito , S. ; Miyazaki , H. ; Yamanaka , H. ; Mizugaki , M. ; Sakamoto , T. ; Fukuda , H. Isoxazole derivatives as centrally acting muscle relaxants, III: Synthesis and activity of conformationally restricted analogs (medicinal chemistry, chemical) . Chem. Pharm. Bull. 1987 , 35 , 3676 – 3690 .
   PubMed Web of Science ®Google Scholar
• Khalafy , J. ; Ebrahimlo , A. R. M. ; Eisavi , R. ; Dilmaghani , K. Synthesis of imidazo[1,2-a] pyridines by rearrangement of 2-pyridyl-3-arylaminoisoxazol-5-(2H)-ones . Arkivoc 2005 , 14 , 59 – 70 .
   Web of Science ®Google Scholar
• Olesen , P. H. ; Swedberg , M. D. B. ; Rimvall , K. 3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: A novel class of central nicotinic receptor ligands . Bioorg. Med. Chem. 1998 , 6 , 1623 – 1629 .
   PubMed Web of Science ®Google Scholar
• (a) Minami , N. ; Sato , M. ; Hasumi , K. ; Yamamoto , N. ; Keino , K. ; Matsui , T. ; Kaneda , A. ; Ota , S. ; Saito , N. ; Sato , S. ; Asadori , A. ; Doi , S. ; Kobayashi , M. ; Sato , J. ; Asano , S. Isoxazole compounds as cyclooxygenase inhibitors . U.S. Patent 5859257 , 1999 , Chem. Abstr. 1999 , 130 , 110269 ; (b) Sastraruji , K. ; Sastraruji , T. ; Ung , A. T. ; Griffith , R. ; Jatisatienr , A. ; Pyne , S. G. Synthesis of stemofoline analogues as acetylcholinesterase inhibitors . Tetrahedron 2012 , 68 , 7103 – 7115 .
   Google Scholar
• De Luca , L. ; Giacomelli , G. ; Riu , A. Solid-phase synthesis of isoxazole-based amino acids: A new scaffold for molecular diversity . J. Org. Chem. 2001 , 66 , 6823 – 6825 .
   PubMed Web of Science ®Google Scholar
• Sandanayaka , V. P. ; Yang , Y. Dipolar cycloaddition of novel 6-(nitrileoxidomethyl) penam sulfone: An efficient route to a new class of β-lactamase inhibitors . Org. Lett. 2000 , 2 , 3087 – 3090 .
   PubMed Web of Science ®Google Scholar
• Alguacil , R. ; Farina , F. ; Martin , M. V. 1,3-Dipolar cycloaddition of nitrile oxides to 2(5H)-furanones substituted at the 5-position by sulphur-bearing groups . Tetrahedron 1996 , 52 , 3457 – 3472 .
   Web of Science ®Google Scholar
• Pevarello , P. ; Amici , R. ; Colombo , M. ; Varasi , M. Nitrile oxide cycloaddition of non-activated alkynes: A novel approach to the synthesis of neuroactive isoxazoles . J. Chem. Soc. Perkin Trans. 1993 , 1 , 2151 – 2152 .
   Google Scholar
• Lasri , J. ; Mukhopadhyay , S. ; Charmier , M. A. J. Efficient regioselective synthesis of 4- and 5-substituted isoxazoles under thermal and microwave conditions . J. Heterocycl. Chem. 2008 , 45 , 1385 – 1389 .
   Web of Science ®Google Scholar
• Li , H. ; You , L. ; Zhang , X. ; Johnson , W. L. ; Figueroa , R. ; Hsung , R. P. Synthesis of amide-substituted isoxazoles and pyrazoles via regioselective [3+2] cycloadditions of terminally unsubstituted ynamides . Heterocycles 2007 , 74 , 553 – 568 .
   Web of Science ®Google Scholar
• Navarr-Ocana , A. ; Jimenez-Estrada , M. ; Gonzalez-Paredes , M. B. ; Barzana , E. Synthesis of substituted isoxazoles from (Z)-3-alkyl-3-nitro-2-phenylpropenenitriles using baker's yeast . Synlett 1996 , 7 , 695 – 696 .
   Google Scholar
• Casini , G. ; Gualtieri , F. ; Stein , M. L. On 1,2-benzisoxazole-3-acetic acid and 3-methyl-1,2-benzisoxazole: A restatement . J. Heterocycl. Chem. 1969 , 6 , 279 – 283 .
   Web of Science ®Google Scholar
• Uno , H. ; Kurokawa , M. ; Nishimura , H. Studies on 3-substituted 1,2-benzisoxazole derivatives, II: The catalytic reductions of 1,2-benzisoxazole-3-acetamide oxime and related compounds. Chem. Pharm. Bull. 1976, 24, 644–647.
   Web of Science ®Google Scholar
• Moore , J. E. ; Spink , D. ; Harrity , J. P. A. Microwave-promoted amination of 3-bromoisoxazoles . Tetrahedron Lett. 2004 , 45 , 3189 – 3191 .
   Web of Science ®Google Scholar
• Konoike , T. ; Kanda , Y. Directed lithiation of N-(tert-butoxycarbonyl)aminoisoxazole: Synthesis of 4-substituted aminoisoxazoles . Tetrahedron Lett. 1996 , 37 , 3339 – 3342 .
   Web of Science ®Google Scholar
• Auricchio , S. ; Bini , A. ; Pastormerlo , E. ; Truscello , A. M. Iron dichloride–induced isomerization or reductive cleavage of isoxazoles: A facile synthesis of 2-carboxy-azirines . Tetrahedron 1997 , 53 , 10911 – 10920 .
   Web of Science ®Google Scholar
• Lipshutz , B. H. ; Reuter , D. C. Cyclopeptide alkaloid model studies: A two-step conversion of 5-aminoisoxazoles to amino acid bis-amides . Tetrahedron Lett. 1988 , 29 , 6067 – 6070 .
   Web of Science ®Google Scholar
• Yamanaka , H. ; Sakamoto , T. ; Shiozawa , A. Synthesis of Isoxazolo[5,4-b]pyridines and isoxazolo[5,4-d]pyrimidines from 5-aminoisoxazoles . Heterocycles 1977 , 7 , 51 – 55 ; Chem. Abstr. 1978 , 88 , 37745q .
   Web of Science ®Google Scholar
• Yamanaka , H. ; Egawa , H. ; Sakamoto , T. Studies on quinoline and isoquinoline derivatives, I: Condensation of quinoline and isoquinoline N-oxides with isoxazoles . Chem. Pharm. Bull. 1978 , 26 , 2759 – 2764 .
   Web of Science ®Google Scholar
• Rajanarwdar , E. ; Mohan , G. ; Ramesh , P. ; Kaerunakar , D. A one-pot synthesis of 3-methyl-5-aryl-4H-pyrrolo[2,3-d]isoxazoles . Tetrahedron Lett. 2006 , 47 , 4957 – 4959 .
   Web of Science ®Google Scholar
• Lynch , B. M. ; Khan , M. A. ; Teo , H. C. ; Pedrotti , F. Pyrazolo[3,4-b]pyridines: Syntheses, reactions, and nuclear magnetic resonance spectra . Can. J. Chem. 1988 , 66 , 420 – 428 .
   Web of Science ®Google Scholar
• Emerson , W. S. ; Holly , F. W. ; Klemm , L. H. 4,6-Dimethylthieno[2,3-b]pyridine, an isoster of 2,4-dimethylquinoline . J. Am. Chem. Soc. 1941 , 63 , 2569 – 2570 .
   Google Scholar
• Balicki , R. Studies in the field of nitrogen heterocyclic compounds, part XI: Abnormal cyclocondensation of ethyl 4,4,4-trifluoroacetoacetate with aminopyrazoles . Pol. J. Chem. 1983 , 57 , 789 – 797 .
   Google Scholar
• Volochnyuk , D. M. ; Pushechikov , A. O. ; Krotko , D. G. ; Sibgatulin , D. A. ; Kovalyova , S. A. ; Tolmachev , A. A. Electron-rich amino heterocycles for regiospecific synthesis of trifluoromethyl-containing fused pyridines . Synthesis 2003 , 10 , 1531 – 1540 .
   Web of Science ®Google Scholar
• Yamamori , T. ; Hiramatu , Y. ; Sakai , K. ; Adachi , I. Studies on dihydropyridine derivatives I: 4,7-Dihydroisoxazolo[5,4-b]pyridines . Tetrahedron 1985 , 41 , 913 – 917 .
   Web of Science ®Google Scholar
• Taylor , M. D. ; Himmelsbach , R. J. ; Kornberg , B. E. ; Quin , J. ; Lunney , E. ; Michel , A. 1,3-Dipolar cycloaddition of nitrile oxides with 1,4-dihydropyridines and conformational analysis of isoxazolo[5,4-b]pyridines . J. Org. Chem. 1989 , 54 , 5585 – 5590 .
   Web of Science ®Google Scholar
• Adhikari , V. A. ; Badiger , V. V. Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and antimicrobial activities of isoxazolo[4,5-e]imidazo/pyrimido[1,2-c]pyrimidines . Indian J. Chem. Sect. B: Org. Chem. Incl. Med. Chem. 1991 , 30 , 946 – 949 .
   Google Scholar
• Price , C. C. ; Roberts , R. M. The synthesis of 4-hydroxyquinolines, I: Through ethoxymethylenemalonic ester . J. Am. Chem. Soc. 1946 , 68 , 1204 – 1208 .
   PubMed Web of Science ®Google Scholar
• Zask , A. ; Gu , Y. ; Albright , J. D. ; Du , X. ; Hogan , M. ; Levin , J. I. ; Chen , J. M. ; Killar , L. M. ; Sung , A. ; DiJoseph , J. F. ; Sharr , M. A. ; Roth , C. E. ; Skala , S. ; Jin , G. ; Cowling , R. ; Mohler , K. M. ; Barone , D. ; Black , R. ; March , C. ; Skotnicki , J. S. Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors . Bioorg. Med. Chem. Lett. 2003 , 13 , 1487 – 1490 .
   PubMed Web of Science ®Google Scholar
• Chiarino , D. ; Napoletano , M. ; Sala , A. Synthesis of 4,7-dihydro-4-oxoisoxazolo[5,4-b]pyridine-5-carboxylic acid derivatives as potential antimicrobial agents . J. Heterocycl. Chem. 1988 , 25 , 231 – 233 .
   Web of Science ®Google Scholar
• Rubio , M. R. ; Seoane , C. ; Soto , J. L. Synthesis of heterocyclic compounds, XXXV: Thiopyridones from α-benzoylcinnamonitriles . Heterocycles 1983 , 20 , 783 – 786 .
   Web of Science ®Google Scholar
• Elbannany , A. A. A. ; Ibrahiem , L. I. ; Chozlan , S. A. S. Synthesis of new isoxazolo [4,3-b]pyridine derivatives. Pharmazie 1988, 43, 128–129; Chem. Abstr. 1989, 110, 57554c.
   Web of Science ®Google Scholar
• Belenkii , L. I. Nitrile Oxides, Nitrones, and Nitronates in Organic Synthesis: Novel Strategies in Synthesis, 2nd ed. ; John Wiley & Sons : New York , 2008 .
   Google Scholar
• Abramov , M. A. ; Ceulemans , E. ; Jackers , C. ; der Auweraer , M. V. ; Dehaen , W. Reactions of 5-amino-1,2-azoles with aromatic and heterocyclico-chloroaldehydes: [1+1] versus [2+1] cyclocondensation . Tetrahedron 2001 , 57 , 9123 – 9129 .
   Web of Science ®Google Scholar
• Hamama , W. S. ; Ibrahim , M. E. ; Zoorob , H. H. Efficient regioselective synthesis and potential antitumor evaluation of isoxazolo[5,4-b]pyridines and related annulated compounds . Arch. Pharm. 2012 , 345 , 468 – 475 .
   PubMed Web of Science ®Google Scholar
• Quiroga , J. ; Hormaza , A. ; Insuasty , B. ; Nogueras , M. ; Sanchez , A. ; Hanold , N. ; Meier , H. Synthesis of pyrido[2,3-d]pyrimidinones by the reaction of aminopyrimidin-4-ones with benzylidene Meldrum's acid derivatives . J. Heterocycl. Chem. 1997 , 34 , 521 – 524 .
   Web of Science ®Google Scholar
• Quiroga , J. ; Hormaza , A. ; Insuasty , B. ; Saitz , C. ; Cañete , A. ; Jullian , C. Reaction of 5-amino-1-aryl-3-methylpyrazoles with benzylidene derivatives of Meldrum's acid: Synthesis and characterization of pyrazolo[3,4-b]pyridinones . J. Heterocycl. Chem. 1998 , 35 , 409 – 412 .
   Web of Science ®Google Scholar
• Claudio , S. ; Carolina , J. ; Alvaro , C. Synthesis of pyrazolo[1,5-a]pyrimidines in the reaction of 5-amino-3-arylpyrazoles with methoxymethylene Meldrum's acid derivatives and thermolysis of their pyrazolylaminomethylene derivatives . J. Heterocycl. Chem. 1998 , 35 , 61 – 64 .
   Web of Science ®Google Scholar
• Quiroga , J. ; Hormaza , A. ; Insuasty , B. ; Ortiz , A. J. ; Sanchez , A. ; Nogueras , M. Synthesis of pyrimido[4,5-b]quinolines in the reaction of 6-aminopyrimidines with dimedone and benzaldehydes . J. Heterocycl. Chem. 1998 , 35 , 231 – 233 .
   Web of Science ®Google Scholar
• Mason , H. J. ; Wu , X. ; Schmitt , R. ; Macor , J. E. ; Yu , G. Synthesis of fused pyridopyrrolidine dione derivatives using hetero-Diels–Alder reactions . Tetrahedron Lett. 2001 , 42 , 8931 – 8934 .
   Web of Science ®Google Scholar
• Sakamoto , T. ; Yamanaka , H. ; Shiozawa , A. ; Tanaka , W. ; Miyazaki , H. Studies on pyrimidine derivatives, XIX: Synthesis of isoxazolo [5,4-d]pyrimidines . Chem. Pharm. Bull. 1980 , 28 , 1832 – 1835 .
   Web of Science ®Google Scholar
• Vovk , M. V. ; Bolbut , A. V. ; Dorokhov , V. I. Cyclizations of N-(1-chloro-2,2,2-trihaloethylidene)-O-methylurethanes with 5-amino-3-methylisoxazole and 3-amino-5-methylisoxazole . Chem. Heterocycl. Compd. (Engl. Transl.) 2004 , 40 , 496 – 499 .
   Google Scholar
• Davoodnia , A. ; Roshani , M. ; Malaeke , S. H. ; Bakavoli , M. A rapid synthesis of isoxazolo[5,4-d]pyrimidin-4(5H)-ones under microwave irradiation with solid acid catalysis in solvent-free conditions . Chin. Chem. Lett. 2008 , 19 , 525 – 528 .
   Web of Science ®Google Scholar
• Alyabiev , S. B. ; Kravchchenko , D. V. ; Ivachtchenko , A. V. Regioselective synthesis of substituted isoxazolo[5,4-d]pyrimidines . Mendeleev Commun. 2008 , 18 , 144 – 146 .
   Web of Science ®Google Scholar
• Plescia , S. ; Ajello , E. ; Sprio , V. ; Marino , M. L. Synthesis of some pyrimido[1,2-c]quinazolin-4-one derivatives . J. Heterocycl. Chem. 1974 , 11 , 603 – 606 ; Chem. Abstr. 1974 , 81 , 152158t .
   Web of Science ®Google Scholar
• Raffa , D. ; Daidone , G. ; Maggio , B. ; Cascioferro , S. ; Plescia , F. ; Schillaci , D. Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones . Farmaco 2004 , 59 , 451 – 455 .
   PubMedGoogle Scholar
• Plescia , S. ; Bajardi , M. L. ; Daidone , G. Boll. Chim. Farm. 1982 , 121 , 563 – 566 .
   Google Scholar
• Raffa , D. ; Daidone , G. ; Plescia , S. ; Schillaci , D. Synthesis and antifungal evaluation of some 3-(3-methyl-5-isoxazolyl)-2-styrylquinazolin-4(3H)-ones . Pharmazie 1991 , 46 , 667 – 668 .
   PubMed Web of Science ®Google Scholar
• Ryng , S. ; Machon , Z. ; Glowiak , T. Synthesis and x-ray structure of new 5-amino-methyl-4-isoxazolecarboxylic acid azides . J. Chem. Crystal. 1994 , 24 , 483 – 488 .
   Web of Science ®Google Scholar
• Maczynski , M. ; Zimecki , M. ; Drozdszczygiel , E. ; Ryng , S. The synthesis, physicochemical properties, and immunological activity of 5-amino-3-methylisoxazolo[5,4-d]4-pyrimidinone derivatives . Cell. Mol. Biol. Lett. 2005 , 10 , 613 – 623 .
   PubMed Web of Science ®Google Scholar
• Tietze , L. F. ; Utecht , J. Inter- and intramolecular hetero-Diels–Alder reactions, 41: Unusual stereocontrol in intramolecular hetero-Diels–Alder reactions of 2-aza-1,3-butadienes: A stereoselective sequential synthesis of annulated tetrahydropyridines. Chem. Ber. 1992, 125, 2259–2263; Chem. Abstr. 1992, 117, 212367j.
   Google Scholar
• Raffa , D. ; Daidone , G. ; Maggio , B. ; Cascioferro , S. ; Plescia , F. ; Schillaci , D. Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones . Farmaco 2004 , 59 , 215 – 221 .
   PubMedGoogle Scholar
• Shen , T.-Y. ; Clark , R. L. ; Pessolano , A. A. ; Witzel , B. E. ; Lanza , T. J. Anti-inflammatory oxazolo[5,4-b]pyridines. US Patent 4,131,677 , 1978 .
   Google Scholar
• Boulton , A. J. ; Katritzky , A. R. The tautomerism of heteroaromatic compounds with five-membered rings, II: 3-, 4-, and 5-amino- and acetamido-isoxazoles . Tetrahedron 1961 , 12 , 51 – 55 .
   Web of Science ®Google Scholar
• Graner , G. ; Hirota , E. ; Iijima , T. ; Kuchitsu , K. ; Ramsay , D. A. ; Vogt , J. ; Vogt , N. Molecules containing three or four carbon atoms ; In Landolt–Börnstein Group II Molecules and Radicals ; K. Kuchitsu (Ed.); Springer.
   Google Scholar
• Dannhardt , G. ; Dominiak , P. ; Laufer , S. Hypertensiv wirksame 5-(β-Aminoethyl)aminoisoxazole: Synthese und Prüfung von Isoxazolopyrazinen und Isoxazolodiazepinen . Arch. Pharm. 1991 , 324 , 141 – 148 .
   PubMed Web of Science ®Google Scholar
• Raffa , D. ; Daidone , G. ; Maggio , B. ; Schillaci , D. ; Plescia , F. ; Torta , L. Synthesis and antifungal activity of new N-isoxazolyl-2-iodobenzamides . Farmaco 1999 , 54 , 90 – 94 ; and references there in .
   PubMedGoogle Scholar
• Langer , P. ; Wuckelt , J. ; Doring , M. ; Schreinger , P. R. ; Gorls , H. Regioselective anionic [3+2] cyclizations of isoxazole, pyrazole, and 1,2,4-triazole dinucleophiles: Efficient synthesis of 2,4-dihydroimidazo[4,5-b]quinoxalines, 3H-imidazo[1,2-b]pyrazoles, and 5H-imidazo[2,1-c][1,2,4]triazoles . Eur. J. Org. Chem. 2001 , 2257 – 2263 .
   Web of Science ®Google Scholar
• Zayed , E. M. ; Khalifa , M. A. E. ; Ibraheim , L. I. ; Elnagdi , M. H. Reactions with heterocyclic enamines synthesis of new isoxazole derivatives . Arch. Pharm. 1983 , 316 , 105 – 110 .
   Web of Science ®Google Scholar
• Pushechnikov , A. O. ; Volochnyuk , D. M. ; Tolmachev , A. A. Interaction of izatins with some five-membered aminoheterocycles . Synlett 2002 , 7 , 1140 – 1142 .
   Google Scholar
• Volochnyuk , D. M. ; Kostyuk , A. N. ; Pinchuk , A. M. ; Tonachev , A. A. Addition of some aminoheterocycles to N-benzyl-3-cyanopyridinium chloride . Tetrahedron Lett. 2003 , 44 , 391 – 394 .
   Web of Science ®Google Scholar
• Winters , G. ; Sala , A. ; De Paoli , A. ; Conti , M. Reaction of cyclic ketones with 5-aminopyrazoles and 5-aminoisoxazoles . Synthesis 1984 , 12 , 1050 – 1051 ; Chem. Abstr. 1985 , 103 , 37406h .
   Google Scholar
• Yamanaka , H. ; Sakamoto , T. ; Bannai , Y. ; Ogawa , S. Studies on pyrimidine derivatives, VIII: Ring-cleavage reaction of 4,6-dimethylpyrimidine 1-oxide . Chem. Pharm. Bull. 1978 , 26 , 3404 – 3409 .
   Web of Science ®Google Scholar
• Albrecht , H. A. ; Blount , J. F. ; Konzelmann , F. M. ; Plati , T. Synthesis of 1,2,6-thiadiazine 1,1-dioxides via isoxazolylsulfamides . J. Org. Chem. 1979 , 44 , 4191 – 4193 .
   Web of Science ®Google Scholar
• Rajanarender , E. ; Ramu , K. ; Reddy , A. S. R. Synthesis and in vitro study of novel isoxazolyl benzoimidazolyl benzamides, acrylamides, and propionamides as antimicrobial agents . Indian J. Chem. Sect. B: Org. Chem. Incl. Med. Chem. 2008 , 47 , 1284 – 1290 .
   Google Scholar
• Elfahham , H. A. ; Elsakka , I. ; Mohamed , N. R. ; Elnagdi , M. H. Reactions with heterocyclic arylazo compounds: Synthesis of new 1-azoloylimidazolones . Arch. Pharm. 1983 , 316 , 792 – 795 .
   Web of Science ®Google Scholar
• Garmaise , D. L. ; Paris , G. Y. ; Quebec , D. Chelocardin derivatives . U.S. Patent 1975, 3,907,889 ; Chem. Abstr. 1975 , 83 , 20610n .
   Google Scholar
• Ortiz , C. S. ; Longhi , M. R. ; De Bertorello , M. M. ; Brinon , M. C. Synthesis of bis-isoxazolylnaphthoquinones . Org. Prep. Proced. Int. 1991 , 23 , 181 – 185 ; Chem. Abstr. 1991 , 114 , 185348h .
   Web of Science ®Google Scholar
• Longhi , M. R. ; De Bertorello , M. M. ; Brinon , M. C. Isoxazoles, VII: Hydrolysis of 4-methyl-5-isoxazolylnaphthoquinone derivatives in aqueous solutions. J. Pharm. Sci. 1991, 80, 573–577; Chem. Abstr. 1991, 115, 99092j.
   PubMed Web of Science ®Google Scholar
• Jakopcic , K. ; Mintas , M. ; Isufi , I. Preparation of 3-hydroxy- and 3-methoxy-N-heteroaryl-2-methyl-4-pyridones . J. Heterocycl. Chem. 1993 , 30 , 429 – 433 ; Chem. Abstr. 1994 , 120 , 163917q .
   Web of Science ®Google Scholar
• Lautens , M. ; Han , W. ; Liu , J. H. C. MgI2-mediated ring expansions of secondary methylenecyclopropyl amides . J. Am. Chem. Soc. 2003 , 125 , 4028 – 4029 .
   PubMed Web of Science ®Google Scholar
• Maczynski , M. ; Zimecki , M. ; Ryng , S. Acta Poloniae Pharm. Drug Res. 2008 , 65 , 241 – 244 .
   PubMed Web of Science ®Google Scholar
• Tatee , T. ; Narita , K. ; Kurashige , S. ; Ito , S. ; Miyazaki , H. ; Yamanaka , H. ; Mizugaki , M. ; Sakamoto , T. ; Fukuda , H. Isoxazole derivatives as centrally acting muscle relaxants, II: Synthesis and structure–activity relationship of 3-amino-N-(3-phenyl-5-isoxazolyl)propanamides . Chem. Pharm. Bull. 1986 , 34 , 1643 – 1655 .
   PubMed Web of Science ®Google Scholar
• Sircar , J. C. ; Capiris , T. ; Bobovski , T. P. ; Schwender , C. F. Synthesis of 4-hydroxy-N-[5-(hydroxymethyl)-3-isoxazolyl]-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and [(5-methyl-3-isoxazolyl)amino]oxoacetic acid: Major metabolites of isoxicam . J. Org. Chem. 1985 , 50 , 5723 – 5727 .
   Web of Science ®Google Scholar
• Grol , C. J. ; Dijkstra , D. ; Schunselaar , W. ; Westerink , B. H. C. ; Martin , A. R. Synthesis and pharmacological evaluation of conformationally restricted phenothiazine analogues . J. Med. Chem. 1982 , 25 , 5 – 9 .
   PubMed Web of Science ®Google Scholar
• Zinnes , H. ; Sircar , J. C. ; Lindo , N. ; Schwartz , M. L. ; Fabian , A. C. ; Shavel , J. ; Kasulanis Jr. , C. F. ; Genzer , J. D. ; Lutomski , C. ; Dipasquale , G. Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides: Potent nonsteroidal antiinflammatory agents . J. Med. Chem. 1982 , 25 , 12 – 18 .
   PubMed Web of Science ®Google Scholar
• Shawali , A. S. ; Edrees , M. M. Reactions of nitrilimines with heterocyclic amines and enamines: Convenient methodology for synthesis and annulation of heterocycles . Arkivoc 2006 , 9 , 292 – 365 .
   Google Scholar
• Elfahham , H. A. ; Sadek , K. U. ; Elgemeie , G. E. H. ; Elnagdi , M. H. Novel synthesis of pyrazolo[5,1-c]-1,2,4-triazoles, imidazo[1,2-b]pyrazoles, and [1,2,4]-triazolo[4,3-a]benzimidazoles: Reaction of nitrite imines with amino- and oxo-substituted diazoles . J. Chem. Soc., Perkin Trans. 1 1982 , 2663 – 2666 .
   Google Scholar
• Lipshutz , B. H. ; Reuter , D. C. Cyclopeptide alkaloid model studies: A two-step conversion of 5-aminoisoxazoles to amino acid bis-amides . Tetrahedron Lett. 1988 , 29 , 6067 – 6070 .
   Web of Science ®Google Scholar
• Tatee , T. ; Kurashige , S. ; Ito , S. ; Miyazaki , H. ; Shiozawa , A. ; Yamanaka , H. 5-Aminoisoxazole derivatives and pharmaceutical preparations containing them. Ger. Offen. 1983 , 3237149 .
   Google Scholar
• Honma , Y. ; Sekine , Y. ; Hashiyama , T. ; Takeda , M. ; Ono , Y. ; Tsuzurahara , K. Studies on antiallergic agents, I: Phenyl-substituted heterocycles with a 5-tetrazolyl or N-(5-tetrazolyl) carbamoyl group . Chem. Pharm. Bull. 1982 , 30 , 4314 – 4324 .
   PubMed Web of Science ®Google Scholar
• Rajanarendar , E. ; Ramu , K. ; Karunakar , D. Indian J. Chem. 2004 , 43B , 2488 – 2490 .
   Google Scholar
• Robert , J.-M. H. ; Sabourin , C. ; Alvarez , N. ; Robert-Piessard , S. ; Le Baut , G. ; Le Pape , P. Synthesis and antileishmanial activity of new imidazolidin-2-one derivatives . Eur. J. Med. Chem. 2003 , 38 , 711 – 718 .
   PubMed Web of Science ®Google Scholar
• Li , W.-T. ; Hwang , D.-R. ; Chen , C.-P. ; Shen , C.-W. ; Huang , C.-L. ; Chen , T.-W. ; Lin , C.-H. ; Chang , Y.-L. ; Chang , Y.-Y. ; Lo , Y.-K. ; Tseng , H.-Y. ; Lin , C.-C. ; Song , J.-S. ; Chen , H.-C. ; Chen , S.-J. ; Wu , S.-H. ; Chen , C.-T. Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents . J. Med. Chem. 2003 , 46 , 1706 – 1715 .
   PubMed Web of Science ®Google Scholar
• Eddington , N. D. ; Cox , D. S. ; Roberts , R. R. ; Butcher , R. J. ; Edafiogho , I. O. ; Stables , J. P. ; Cooke , N. ; Goodwin , A. M. ; Smith , C. A. ; Scott , K. R. Synthesis and anticonvulsant activity of enaminones, 4: Investigations on isoxazole derivatives. Eur. J. Med. Chem. 2002, 37, 635–648.
   PubMed Web of Science ®Google Scholar
• Rajanarendar , E. ; Ramu , K. ; Karunakar , D. Microwave-induced acetoacetylation of isoxazolyl amines with β-keto esters . Indian J. Chem. Sect. B: Org. Chem. Incl. Med. Chem. 2004 , 43 , 2488 – 2490 .
   Google Scholar
• DeVita , R. J. ; Hollings , D. D. ; Goulet , M. T. ; Wyvratt Jr. , M. G. Identification and initial structure–activity relationships of a novel non-peptide quinolone GnRH receptor antagonist . Bioorg. Med. Chem. Lett. 1999 , 9 , 2615 – 2620 .
   PubMed Web of Science ®Google Scholar
• Walsh , T. F. ; Toupence , R. B. ; Young , J. R. ; Huang , S. X. ; Ujjainwalla , F. ; DeVita , R. J. ; Goulet , M. T. ; Wyvratt Jr. , M. J. ; Fisher , M. H. ; Lo , J.-L. ; Ren , N. ; Yudkovitz , J. B. ; Yang , Y. T. ; Cheng , K. ; Smith , R. G. Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides . Bioorg. Med. Chem. Lett. 2000 , 10 , 443 – 447 .
   PubMed Web of Science ®Google Scholar
• Chan , M. F. ; Kois , A. ; Verner , E. J. ; Raju , B. G. ; Castillo , R. S. ; Wu , C. ; Okun , L. ; Stavros , F. D. ; Balaji , V. N. The discovery and structure–activity relationships of nonpeptide, low-molecular-weight antagonists selective for the endothelin ETB receptor . Bioorg. Med. Chem. 1998 , 6 , 2301 – 2316 .
   PubMed Web of Science ®Google Scholar
• Wu , C. ; Chan , M. F. ; Stavros , F. ; Raju , B. ; Okun , I. ; Castillo , R. S. Structure–activity relationships of N 2-aryl-3-(isoxazolylsulfamoyl)-2-thiophene-carboxamides as selective endothelin receptor-A antagonists . J. Med. Chem. 1997 , 40 , 1682 – 1689 .
   PubMed Web of Science ®Google Scholar
• Hirpara , K. V. ; Patel , S. P. ; Parikh , K. A. ; Bhimani , A. S. ; Parekh , H. H. J. Sci. Islam. Rep. Iran 2004 , 15 , 135 – 138 .
   Google Scholar
• Daidone , G. ; Raffa , D. ; Bajardi , M. L. ; Plescia , S. ; Milici , M. Farmaco, Ed. Sci. 1988 , 43 , 753 – 761 .
   PubMedGoogle Scholar
• Rajender , P. S. ; Sridevi , G. ; Reddy , K. K. Synthesis of novel isoxazole fused heterocycles . Synth. Commun. 2012 , 42 , 2191 – 2200 .
   Web of Science ®Google Scholar
• Stagno , G. ; Alcontres , D. Advances in the chemistry of aminoisoxazole . Gazz. Chim. Ital. 1950 , 80 , 441 – 455 ; Chem. Abstr. 1950 , 45 , 3837a .
   Google Scholar
• Liu , J.-K. N-Containing compounds of macromycetes . Chem. Rev. 2005 , 105 , 2723 – 2744 .
   PubMed Web of Science ®Google Scholar
• Filer , C. N. ; Lacy , J. M. ; Peng , C. T. Ibotenic acid decarboxylation to muscimol: Dramatic solvent and radiolytic rate acceleration . Synth. Commun. 2005 , 35 , 967 – 970 .
   Web of Science ®Google Scholar
• Lin , N.-H. ; He , Y. ; Kopecka , H. A short, efficient chiral synthesis of a novel cholinergic channel activator, ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole], from (S)-pyroglutamic acid . Tetrahedron Lett. 1995 , 36 , 2563 – 2566 .
   Web of Science ®Google Scholar
• Wittenberger , S. J. An efficient synthesis of the cholinergic channel activator ABT-418 . J. Org. Chem. 1996 , 61 , 356 – 358 .
   Web of Science ®Google Scholar
• Shet , J. ; Desai , V. ; Tilve , S. Domino primary alcohol oxidation–wittig reaction: Total synthesis of ABT-418 and (E)-4-oxonon-2-enoic acid . Synthesis 2004 , 1859 – 1863 .
   Web of Science ®Google Scholar
• Thamizharasi , S. ; Vasantha , J. ; Reddy , B. S. R. Synthesis, characterization, and pharmacologically active sulfamethoxazole polymers . Eur. Polym. J. 2002 , 38 , 551 – 559 .
   Web of Science ®Google Scholar
• El-Gaby , M. S. A. ; Taha , N. M. ; Micky , J. A. ; El-Sharief , M. A. M. Sh. Preparation of some novel 3,5-diaminopyrazole, pyrazolo[1,5-a][1,3,5]triazine, and pyrazolo[1,5-a]pyrimidine derivatives containing sulfonamido moieties as antimicrobial agents . Acta Chim. Slov. 2002 , 49 , 159 – 171 .
   Web of Science ®Google Scholar