Synthesis, characterization, antimicrobial activities, anticancer of some new pyridines from 2, 3-dihydro-2-oxo-4-phenyl-6-(thien-2-yl) pyridine-3-carbonitrile

References

• Weigelt, B.; Reis-Filho, J. S. Nat. Rev. Clin. Oncol. 2009, 6, 718–730. DOI: 10.1038/nrclinonc.2009.166.
   PubMed Web of Science ®Google Scholar
• Forouzanfar, M. H.; Foreman, K. J.; Delossantos, A. M.; Lozano, R.; Lopez, A. D.; Murray, C. J.; Naghavi, M. Lancet 2011, 378, 1461–1484. DOI: 10.1016/S0140-6736(11)61351-2.
   PubMed Web of Science ®Google Scholar
• O’Shaughnessy, J. Supplement 3 2005, 10, 20–29.
   Google Scholar
• Tinoco, G.; Warsch, S.; Glück, S.; Avancha, K.; Montero, A. J. J. Cancer 2013, 4, 117–132. DOI: 10.7150/jca.4925.
   PubMed Web of Science ®Google Scholar
• Supriya, D.; Sumit, O. B. Synth. Commun. 2018, 48, 1–13.
   Web of Science ®Google Scholar
• Akgul, C.; Yildirim, M. J. Serb. Chem. Soc. 2010, 75, 1203–1208. DOI: 10.2298/JSC100201104A.
   Web of Science ®Google Scholar
• Narayan Acharya, B.; Thavaselvam, D.; Parshad Kaushik, M. Med. Chem. Res. 2008, 17, 487–494. DOI: 10.1007/s00044-008-9092-5.
   Web of Science ®Google Scholar
• Jachak, M. N.; Bagul, S. M.; Birari, D. R.; Ghagare, M. G.; Kazi, M. A.; Toche, R. B.; Mathad, V. T. J. Fluoresc. 2010, 20, 787–796. DOI: 10.1007/s10895-010-0622-4.
   PubMed Web of Science ®Google Scholar
• Toche, R. B.; Kazi, M. A.; Ghotekar, B. K.; Bagul, S. M.; Tantak, C. D.; Jachak, M. N. J. Fluoresc. 2009, 19, 1119–1124. DOI: 10.1007/s10895-009-0511-x.
   PubMed Web of Science ®Google Scholar
• Drabina, P.; Funk, P.; Růžička, A.; Hanusek, J.; Sedlak, M. Transition Met. Chem. 2010, 35, 363–371. DOI: 10.1007/s11243-010-9336-3.
   Web of Science ®Google Scholar
• El-Sherbeny, D. Chem. Heterocycl. Compd. 2010, 46, 325–333.
   Web of Science ®Google Scholar
• Nigade, G.; Chavan, P.; Deodhar, M. Med. Chem. Res. 2010, 2010, 1–11.
   Google Scholar
• Al-Salahi, R. A.; Al-Omar, M. A.; Amr, A. E. G. E. Molecules 2010, 15, 6588–6597. DOI: 10.3390/molecules15096588.
   PubMed Web of Science ®Google Scholar
• Uenishi, J.; Hamada, M.; Aburatani, S.; Matsui, K.; Yonemitsu, O.; Tsukube, H. J. Org. Chem. 2004, 69, 6781–6789. DOI: 10.1021/jo0491758.
   PubMed Web of Science ®Google Scholar
• Abele, E.; Abele, R.; Lukevics, E. Chem. Heterocycl. Compd. 2003, 39, 825–865. DOI: 10.1023/A:1026181918567.
   Google Scholar
• Vrabel, M.; Hocek, M.; Havran, L.; Fojta, M.; Votruba, I.; Klepetařova, B.; Pohl, R.; Rulišek, L.; Zendlova, L.; Hobza, P.; et al. Eur. J. Inorg. Chem. 2007, 2007, 1752–1769. DOI: 10.1002/ejic.200700030.
   Web of Science ®Google Scholar
• Worachartcheewan, A.; Prachayasittikul, S.; Pingaew, R.; Nantasenamat, C.; Tantimongcolwat, T.; Ruchirawat, S.; Prachayasittikul, V. Med. Chem. Res. 2011, 2011, 1–9.
   Google Scholar
• Yang, X. T.; Wu, H.; Ma, S. J.; Hu, J. J.; Wang, Y. Transition Met. Chem. 2011, 2011, 1–5.
   Google Scholar
• Nassar, E. J. Am. Sci. 2010, 6, 338–347.
   Google Scholar
• Kowol, C. R.; Berger, R.; Eichinger, R.; Roller, A.; Jakupec, M. A.; Schmidt, P. P.; Arion, V. B.; Keppler, B. K. J. Med. Chem. 2007, 50, 1254–1265. DOI: 10.1021/jm0612618.
   PubMed Web of Science ®Google Scholar
• Kowol, C. R.; Trondl, R.; Heffeter, P.; Arion, V. B.; Jakupec, M. A.; Roller, A.; Galanski, M.; Berger, W.; Keppler, B. K. J. Med. Chem. 2009, 52, 5032–5043. DOI: 10.1021/jm900528d.
   PubMed Web of Science ®Google Scholar
• Li, R.-Y.; Wang, B.-W.; Wang, X.-Y.; Wang, X.-T.; Wang, Z.-M.; Gao, S. Inorg. Chem. 2009, 48, 7174–7180. DOI: 10.1021/ic9003092.
   PubMed Web of Science ®Google Scholar
• Jansson, P. J.; Sharpe, P. C.; Bernhardt, P. V.; Richardson, D. R. J. Med. Chem. 2010, 53, 5759–5769. DOI: 10.1021/jm100561b.
   PubMed Web of Science ®Google Scholar
• Stanojkovic, T. P.; Kovala-Demertzi, D.; Primikyri, A.; Garcia-Santos, I.; Castineiras, A.; Juranic, Z.; Demertzis, M. A. J. Inorg. Biochem. 2010, 104, 467–476. DOI: 10.1016/j.jinorgbio.2009.12.021.
   PubMed Web of Science ®Google Scholar
• Pingaew, R.; Prachayasittikul, S.; Ruchirawat, S. Molecules 2010, 15, 988–996. DOI: 10.3390/molecules15020988.
   PubMed Web of Science ®Google Scholar
• Bharti, N.; Maurya, M. R.; Naqvi, F.; Azam, A. Bioorg. Med. Chem. Lett. 2000, 10, 2243–2245. DOI: 10.1016/s0960-894x(00)00446-7.
   PubMed Web of Science ®Google Scholar
• Abdelhamid, A. O.; El Sayed, I. E.; Zaki, Y. H.; Hussein, A. M.; Mangoud, M. M.; Hosny, M. A. BMC Chem. 2019, 13, 48 DOI: 10.1186/s13065-019-0566-y.
   PubMed Web of Science ®Google Scholar
• Abdelhamid, A. O.; Gomha, S. M.; El-Enany, W. A. M. A. J. Heterocyclic Chem. 2019, 56, 426–433. DOI: 10.1002/jhet.3415.
   Web of Science ®Google Scholar
• Hosny1, M. A.; Zaki, Y. H.; Mokbel1, W. A.; and A. O. Abdelhamid, BMC Chem. 2019, 13, 37. DOI: 10.1186/s13065-019-0559-x.
   PubMed Web of Science ®Google Scholar
• Abdelhamid, A. O.; Gomha, S. M.; Abdelrehem, N. A.; Shalaby, A. M.; Kandeel, S. M. Synth. Commun. 2018, 48, 677–684. DOI: 10.1080/00397911.2017.1416637.
   Web of Science ®Google Scholar
• Gomha, S. M.; Abdelhamid, A. O.; Kandil, O. M.; Kandeel, S. M.; Abdelrehem, N. A. Mini Rev. Med. Chem. 2018, 18, 1670–1682. DOI: 10.2174/1389557518666180424113819.
   PubMed Web of Science ®Google Scholar
• Gomha, S. M.; Abdelhamid, A. O.; Abdelrehem, N. A.; Kandeel, S. M. J. Heterocycl. Chem. 2018, 55, 995–1001. DOI: 10.1002/jhet.3131.
   Web of Science ®Google Scholar
• Mohamed, M. S.; Abdelhamid, A. O.; Almutairi, F. M.; Ali, A. G.; Bishr, M. K. Bioorg. Med. Chem. 2018, 26, 623–629. DOI: 10.1016/j.bmc.2017.12.026.
   PubMed Web of Science ®Google Scholar
• Yasser, H.; Zaki  , Marwa, S.; Al-Gendey A. O.; Abdelhamid  , Chem. Cent. J. 2018, 12, 70.
   PubMedGoogle Scholar
• Hamed, A. A.; Abdel-Aziz, M. S.; Abd El Hady, F. K. Bull. Natl. Res. Cent. 2018, 42, 29. DOI: 10.1186/s42269-018-0027-0.
   Google Scholar
• Rabin, N.; Zheng, Y.; Opoku-Temeng, C.; Du, Y.; Bonsu, E.; Sintim, H. O. Future Med. Chem. 2015, 7, 493–512. DOI: 10.4155/fmc.15.6.
   PubMed Web of Science ®Google Scholar
• Hamed, A. A.; Khedr, M.; Abdelraof, M. Egypt. Pharm. J. 2019, 18, 419–433. DOI: 10.4103/epj.epj_47_19.
   Web of Science ®Google Scholar
• Omar, A.; Wright, J.; Schultz, B.; Burrell, G. R.; Nadworny, P. Microorganisms 2017, 5, 9. DOI: 10.3390/microorganisms5010009.
   PubMed Web of Science ®Google Scholar
• Donlan, R. M.; Costerton, J. W. Clin. Microbiol. Rev. 2002, 15, 167–193. DOI: 10.1128/cmr.15.2.167-193.2002.
   PubMed Web of Science ®Google Scholar
• Thangamani, S.; Mohammad, H.; Abushahba, M. F. N.; Sobreira, T. J. P.; Hedrick, V. E.; Paul, L. N.; Seleem, M. N. Sci. Rep. 2016, 6, 22571. DOI: 10.1038/srep22571.
   PubMed Web of Science ®Google Scholar
• Ingebrigtsen, R. A.; Hansen, E.; Andersen, J. H.; Eilertsen, H. C. J. Appl. Phycol. 2016, 28, 939–950. DOI: 10.1007/s10811-015-0631-4.
   PubMed Web of Science ®Google Scholar
• Christensen, G. D.; Simpson, W. A.; Younger, J. J.; Baddour, L. M.; Barrett, F. F.; Melton, D. M.; Beachey, E. H. J. Clin. Microbiol. 1985, 22, 996–1006. DOI: 10.1128/JCM.22.6.996-1006.1985.
   PubMed Web of Science ®Google Scholar
• Hamed, A. A.; Kabary, H.; Khedr, M.; Emam, A. N. RSC Adv. 2020, 10, 10361–10367. DOI: 10.1039/C9RA11021F.
   PubMed Web of Science ®Google Scholar
• Mosmann, T.; Immunol, J. J. Immunol. Methods 1983, 65, 55–63. DOI: 10.1016/0022-1759(83)90303-4.
   PubMed Web of Science ®Google Scholar
• Denizot, F.; Lang, R. J. Immunol. Methods 1986, 89, 271–277. DOI: 10.1016/0022-1759(86)90368-6.
   PubMed Web of Science ®Google Scholar