Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 8
481
Views
6
CrossRef citations to date
0
Altmetric
Articles

Synthesis and anticancer assessment of some new 2-amino-3-cyanopyridine derivatives

, , &
Pages 1160-1170 | Received 20 Oct 2020, Published online: 20 Jan 2021

References

  • Prakash, L.; Shaihla , Malik, S.; Mital, R. Synthesis of Some 2-Amino-3- Cyano-4, 6-Disubstituted Pyridine Derivatives and Their Antibacterial Activity. Curr. Sci. 1989, 58, 967–970. 2020,
  • Altalbawy, F. M. Synthesis and Antimicrobial Evaluation of Some Novel bis-α,β-unsaturated ketones, nicotinonitrile, 1,2-dihydropyridine-3-carbonitrile, fused thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives. Int. J. Mol. Sci. 2013, 14, 2967–2979. DOI: 10.3390/ijms14022967.
  • Faycel, J.; Bel Haj Kether, F.; Amri, I.; Bassem, J.; Khiari, J. e. Synthesis and Biological Activity of Novel Benzothiazole Pyridine Derivatives. IOSR J. Appl. Chem. 2014, 7, 62–66.
  • Azza, M. A.-F.; Attaby, F. A.; Elneairy, M. A. A.; Gouda, M. N. M. Synthesis, Characterization and Antimicrobial Activity of Pyridine-3- Carbonitrile Derivatives. Curr. Bioact. Compd. 2012, 8, 176–187.
  • Ahmed, M. H.; El-Hashash, M. A.; Marzouk, M. I.; El-Naggar, A. M. Design, Synthesis, and Biological Evaluation of Novel Pyrazole, Oxazole, and Pyridine Derivatives as Potential Anticancer Agents Using Mixed Chalcone. J. Heterocyc. Chem. 2019, 56, 114–123. DOI: 10.1002/jhet.3380.
  • Ataf, A. A.; Shahzad, A.; Gul, Z.; Rasool, N.; Badshah, A.; Lal, B.; Khan, E. A Review on the Medicinal Importance of Pyridine Derivatives. J. Drug Design Med. Chem. 2015, 1, 1–11.
  • Asif, M. Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus. AJCPS. 2016, 1, 29–35. DOI: 10.18311/ajcps/2016/7693.
  • Krause, M.; Foks, H.; Gobis, K.; Foks, H.; Gobis, K. Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]Pyridine and Imidazo[4,5-c]Pyridine Derivatives. Molecules 2017, 22, 399. DOI: 10.3390/molecules22030399.
  • Cocco, M. T.; Congiu, C.; Onnis, V. Synthesis and Antitumor Activity of 4-Hydroxy-2-Pyridone Derivatives. Eur. J. Med. Chem. 2000, 35, 545–552. DOI: 10.1016/S0223-5234(00)00149-5.
  • Dey, S.; Bajaj, S. O. Promising Anticancer Drug Thapsigargin:A Perspective toward the Total Synthesis. Synth. Commun. 2018, 48, 1–13. DOI: 10.1080/00397911.2017.1386789.
  • Chaban, T. I.; Klenina, O. V.; Zimenkovsky, B. S.; Chaban, I. G.; Ogurtsov, V. V.; Shelepeten, L. S. Synthesis of Novel Thiazolo[4,5-b]Pyridines as Potential Biologically Active Substances. Der. Pharma. Chemic. 2016, 8, 534–542.
  • Rizk, S. A.; Shaban, S.; Sallam, H. A. A Facile Synthesis and Antioxidant Evaluation of Conjugated 8-Azacoumarins Based on. DFT Parameters. J. Heterocyclic Chem. 2020, 57, 867–879. DOI: 10.1002/jhet.3833.
  • Bamford, M. 3 H+/K+ ATPase Inhibitors in the Treatment of Acid-Related Disorders. Prog. Med. Chem. 2009, 47, 75–162. DOI: 10.1016/S0079-6468(08)00203-8.
  • Adachi, I.; Hiramatsu, Y.; Ueda, M.; Kawakami, M. 4,7-Dihydrothieno[2,3-b] Pyridine Derivatives Useful in the Treatment of Cardiovascular Diseases. U.S. Patent 4703-051 A, 1987.
  • Sayed, G. H.; Azab, M. E.; Anwer, K. E. Conventional and Microwave-Assisted Synthesis and Biological Activity Study of Novel Heterocycles Containing Pyran Moiety. J. Heterocyclic Chem. 2019, 56, 2121–2133. DOI: 10.1002/jhet.3606.
  • Sayed, G. H.; Azab, M. E.; Negm, N. A.; Anwer, K. E. Antimicrobial and Cytotoxic Activities of Some Novel Heterocycles Bearing Pyrazole Moiety. J. Heterocyclic Chem. 2018, 55, 1615–1625. DOI: 10.1002/jhet.3196.
  • Anwer, K. E.; Sayed, G. H.; Hassan, H. H.; Azab, M. E. Conventional Microwave Synthesis of Some New Pyridine Derivatives and Evaluation Their Antimicrobial and Cytotoxic Activities. Egypt. J. Chem. 2019, 62, 1107–1126.
  • Dey, S.; Lo, H.-J.; Wong, C.-H. An Efficient Modular One-Pot Synthesis of Heparin-Based Anticoagulant Idraparinux. J. Am. Chem. Soc. 2019, 141, 10309–10314. DOI: 10.1021/jacs.9b03266.
  • Dey, S.; Lo, H.-J.; Wong, C.-H. Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux. Org. Lett. 2020, 22, 4638–4642. DOI: 10.1021/acs.orglett.0c01386.
  • Balaswamy, P.; Aravind, S.; Satyanarayana, B. Polyethylene Glycol-400 Used as Phase Transfer Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives under Aqueous Conditions. Rasayan J. Chem. 2017, 10, 1334–1339.
  • Magda, I. M.; Shaker, S. A.; Hafiz, A. A. A.; El-Baghdady, K. Z. Design and Synthesis of New Phthalazinone Derivatives Containing Benzyl Moiety with Anticipated Antitumor Activity. Biol. Pharma. Bull. 2016, 39, 239–251.
  • Marzouk, M. I.; Shaker, S. A.; Farghaly, T. A.; El-Hashash, M. A.; Hussein, S. M. Synthesis of Some Novel Quinazolinone Derivatives with Anticipated. J. Heterocyclic Chem. 2017, 54, 3331–3341. DOI: 10.1002/jhet.2953.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.