Synthesis of novel scaffolds based on bis-thiazole or bis-triazolothiadiazine linked to quinoxaline as new hybrid molecules

References

• Parhi, A. K.; Zhang, Y.; Saionz, K. W.; Pradhan, P.; Kaul, M.; Trivedi, K.; Pilch, D. S.; LaVoie, E. J. Antibacterial Activity of Quinoxalines, Quinazolines, and 1, 5-Naphthyridines. Bioorg. Med. Chem. Lett. 2013, 23, 4968–4974. DOI: 10.1016/j.bmcl.2013.06.048.
   PubMed Web of Science ®Google Scholar
• Caleb, A. A.; Ballo, D.; Rachid, B.; Amina, H.; Mostapha, B.; Abdelfettah, Z.; Mokhtar, E. E. Synthesis and Antibacterial Activity of New Spiro [Thiadiazoline-Quinoxaline] Derivatives. Arkivoc 2011, 2, 217–226.
   Google Scholar
• Peraman, R.; Kuppusamy, R.; Killi, S. K.; Reddy, Y. P. New Conjugates of Quinoxaline as Potent Antitubercular and Antibacterial Agents. Int. J. Med. Chem. 2016, 2016, 6471352. DOI: 10.1155/2016/6471352.
   PubMed Web of Science ®Google Scholar
• Shekhar, A. C.; Rao, P. S.; Narsaiah, B.; Allanki, A. D.; Sijwali, P. S. Emergence of Pyrido Quinoxalines as New Family of Antimalarial Agents. Eur. J. Med. Chem. 2014, 77, 280–287.
   PubMed Web of Science ®Google Scholar
• Wilhelmsson, L. M.; Kingi, N.; Bergman, J. Interactions of Antiviral Indolo [2, 3-b] Quinoxaline Derivatives with DNA. J. Med. Chem. 2008, 51, 7744–7750. DOI: 10.1021/jm800787b.
   PubMed Web of Science ®Google Scholar
• Burguete, A.; Pontiki, E.; Hadjipavlou-Litina, D.; Ancizu, S.; Villar, R.; Solano, B.; Moreno, E.; Torres, E.; Pérez, S.; Aldana, I.; Monge, A. Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti‐Inflammatory Agents. Chem. Biol. Drug Des. 2011, 77, 255–267. DOI: 10.1111/j.1747-0285.2011.01076.x.
   PubMed Web of Science ®Google Scholar
• Zhang, M.; Dai, Z.-C.; Qian, S.-S.; Liu, J.-Y.; Xiao, Y.; Lu, A.-M.; Zhu, H.-L.; Wang, J.-X.; Ye, Y.-H. Design, Synthesis, Antifungal, and Antioxidant Activities of (E)-6-((2-Phenylhydrazono) Methyl) Quinoxaline Derivatives. J. Agric. Food Chem. 2014, 62, 9637–9643. DOI: 10.1021/jf504359p.
   PubMed Web of Science ®Google Scholar
• Lee, S.-H.; Kim, N.; Kim, S.-J.; Song, J.; Gong, Y.-D.; Kim, S.-Y. Anti-Cancer Effect of a Quinoxaline Derivative GK13 as a Transglutaminase 2 Inhibitor. J. Cancer Res. Clin. Oncol. 2013, 139, 1279–1294. DOI: 10.1007/s00432-013-1433-1.
   PubMed Web of Science ®Google Scholar
• Suthar, S. K.; Chundawat, N. S.; Singh, G. P.; Padrón, J. M.; Jhala, Y. K. Quinoxaline: A Comprehension of Current Pharmacological Advancement in Medicinal Chemistry. Eur. J. Med. Chem. Rep. 2022, 5, 100040. DOI: 10.1016/j.ejmcr.2022.100040.
   Google Scholar
• Ingle, R.; Marathe, R.; Magar, D.; Patel, H. M.; Surana, S. J. Sulphonamido-Quinoxalines: Search for Anticancer Agent. Eur. J. Med. Chem. 2013, 65, 168–186. DOI: 10.1016/j.ejmech.2013.04.028.
   PubMed Web of Science ®Google Scholar
• Elhelby, A. A.; Ayyad, R. R.; Zayed, M. F. Synthesis and Biological Evaluation of Some Novel Quinoxaline Derivatives as Anticonvulsant Agents. Arzneimittelforschung 2011, 61, 379–381. DOI: 10.1055/s-0031-1296214.
   PubMed Web of Science ®Google Scholar
• Xu, M.; Hu, X.; Zhang, Y.; Bao, X.; Pang, A.; Fang, J.-K. Novel Organic Dyes Featuring Spiro [Dibenzo [3, 4: 6, 7] Cyclohepta [1, 2-b] Quinoxaline-10, 9′-Fluorene](SDBQX) as a Rigid Moiety for Dye-Sensitized Solar Cells. ACS Appl. Energy Mater. 2018, 1, 2200–2207. DOI: 10.1021/acsaem.8b00261.
   Web of Science ®Google Scholar
• Chen, C.-T.; Wei, Y.; Lin, J.-S.; Moturu, M. V. R. K.; Chao, W.-S.; Tao, Y.-T.; Chien, C.-H. Doubly Ortho-Linked Quinoxaline/Diphenylfluorene Hybrids as Bipolar, Fluorescent Chameleons for Optoelectronic Applications. J. Am. Chem. Soc. 2006, 128, 10992–10993.
   PubMed Web of Science ®Google Scholar
• Yang, J.; Uddin, M. A.; Tang, Y.; Wang, Y.; Wang, Y.; Su, H.; Gao, R.; Chen, Z.-K.; Dai, J.; Woo, H. Y.; Guo, X. Quinoxaline-Based Wide Band Gap Polymers for Efficient Nonfullerene Organic Solar Cells with Large Open-Circuit Voltages. ACS Appl. Mater. Interfaces 2018, 10, 23235–23246. DOI: 10.1021/acsami.8b04432.
   PubMed Web of Science ®Google Scholar
• Kim, H.; Reddy, M. R.; Hong, S.-S.; Kim, C.; Seo, S. Synthesis and Characterization of Quinoxaline Derivative as Organic Semiconductors for Organic Thin-Film Transistors. J. Nanosci. Nanotechnol. 2017, 17, 5530–5538. DOI: 10.1166/jnn.2017.13841.
   Web of Science ®Google Scholar
• Pereira, J. D.; dos, S.; Neri, J. M.; Emerenciano, D. P.; Freitas, G. R. S.; De; Felipe, M. B. M. C.; Souza, M. Â. F.; de Menezes, F. G.; Maciel, M. A. M. Experimental and Theoretical Analysis of NA Oxazinoquinoxaline Derivative for Corrosion Inhibition of AISI 1018 Steel. Quim. Nova 2017, 41, 243–250. DOI: 10.21577/0100-4042.20170171.
   Web of Science ®Google Scholar
• Ghonim, A. E.; Ligresti, A.; Rabbito, A.; Mahmoud, A. M.; Di Marzo, V.; Osman, N. A.; Abadi, A. H. Structure–Activity Relationships of Thiazole and Benzothiazole Derivatives as Selective Cannabinoid CB2 Agonists with in Vivo Anti-Inflammatory Properties. Eur. J. Med. Chem. 2019, 180, 154–170. DOI: 10.1016/j.ejmech.2019.07.002.
   PubMed Web of Science ®Google Scholar
• Piechowska, K.; Świtalska, M.; Cytarska, J.; Jaroch, K.; Łuczykowski, K.; Chałupka, J.; Wietrzyk, J.; Misiura, K.; Bojko, B.; Kruszewski, S.; Łączkowski, K. Z. Discovery of Tropinone-Thiazole Derivatives as Potent Caspase 3/7 Activators, and Noncompetitive Tyrosinase Inhibitors with High Antiproliferative Activity: Rational Design, One-Pot Tricomponent Synthesis, and Lipophilicity Determination. Eur. J. Med. Chem. 2019, 175, 162–171. DOI: 10.1016/j.ejmech.2019.05.006.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Wu, C.; Zhang, Q.; Shan, Y.; Gu, W.; Wang, S. Design, Synthesis and Biological Evaluation of Novel β-Pinene-Based Thiazole Derivatives as Potential Anticancer Agents via Mitochondrial-Mediated Apoptosis Pathway. Bioorg. Chem. 2019, 84, 468–477.
   PubMed Web of Science ®Google Scholar
• Prajapati, N. P.; Patel, K. D.; Vekariya, R. H.; Patel, H. D.; Rajani, D. P. Thiazole Fused Thiosemicarbazones: Microwave-Assisted Synthesis, Biological Evaluation and Molecular Docking Study. J. Mol. Struct. 2019, 1179, 401–410. DOI: 10.1016/j.molstruc.2018.11.025.
   Web of Science ®Google Scholar
• Chen, C.; Song, J.; Wang, J.; Xu, C.; Chen, C.; Gu, W.; Sun, H.; Wen, X. Synthesis and Biological Evaluation of Thiazole Derivatives as Novel USP7 Inhibitors. Bioorg. Med. Chem. Lett. 2017, 27, 845–849.
   PubMed Web of Science ®Google Scholar
• Patel, S.; Patle, R.; Parameswaran, P.; Jain, A.; Shard, A. Design, Computational Studies, Synthesis and Biological Evaluation of Thiazole-Based Molecules as Anticancer Agents. Eur. J. Pharm. Sci. 2019, 134, 20–30. DOI: 10.1016/j.ejps.2019.04.005.
   PubMed Web of Science ®Google Scholar
• Metwally, N. H.; Radwan, I. T.; El-Serwy, W. S.; Mohamed, M. A. Design, Synthesis, DNA Assessment and Molecular Docking Study of Novel 2-(Pyridin-2-Ylimino) Thiazolidin-4-One Derivatives as Potent Antifungal Agents. Bioorg. Chem. 2019, 84, 456–467. DOI: 10.1016/j.bioorg.2018.11.050.
   PubMed Web of Science ®Google Scholar
• Qin, Y.-J.; Wang, P.-F.; Makawana, J. A.; Wang, Z.-C.; Wang, Z.-N.; Yan-Gu  , Jiang, A.-Q.; Zhu, H.-L. Design, Synthesis and Biological Evaluation of Metronidazole–Thiazole Derivatives as Antibacterial Inhibitors. Bioorg. Med. Chem. Lett. 2014, 24, 5279–5283.
   PubMed Web of Science ®Google Scholar
• Arshad, M. F.; Alam, A.; Alshammari, A. A.; Alhazza, M. B.; Alzimam, I. M.; Alam, M. A.; Mustafa, G.; Ansari, M. S.; Alotaibi, A. M.; Alotaibi, A. A.; et al. Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents. Molecules 2022, 27, 3994. DOI: 10.3390/molecules27133994.
   PubMed Web of Science ®Google Scholar
• Kamel, M. M.; Abdo, N. Y. M. Synthesis of Novel 1, 2, 4-Triazoles, Triazolothiadiazines and Triazolothiadiazoles as Potential Anticancer Agents. Eur. J. Med. Chem. 2014, 86, 75–80.
   PubMed Web of Science ®Google Scholar
• Aytaç, P. S.; Durmaz, I.; Houston, D. R.; Çetin-Atalay, R.; Tozkoparan, B. Novel Triazolothiadiazines Act as Potent Anticancer Agents in Liver Cancer Cells through Akt and ASK-1 Proteins. Bioorg. Med. Chem. 2016, 24, 858–872. DOI: 10.1016/j.bmc.2016.01.013.
   PubMed Web of Science ®Google Scholar
• Khan, I.; Ibrar, A.; Abbas, N. Triazolothiadiazoles and Triazolothiadiazines–Biologically Attractive Scaffolds. Eur. J. Med. Chem. 2013, 63, 854–868. DOI: 10.1016/j.ejmech.2013.01.060.
   PubMed Web of Science ®Google Scholar
• Kumar, D.; Narayanam, M. K.; Chang, K.; Shah, K. Synthesis of Novel Indolyl‐1, 2, 4‐Triazoles as Potent and Selective Anticancer Agents. Chem. Biol. Drug Des. 2011, 77, 182–188. DOI: 10.1111/j.1747-0285.2010.01051.x.
   PubMed Web of Science ®Google Scholar
• Sever, B.; Altıntop, M. D.; Kuş, G.; Özkurt, M.; Özdemir, A.; Kaplancıklı, Z. A. Indomethacin Based New Triazolothiadiazine Derivatives: Synthesis, Evaluation of Their Anticancer Effects on T98 Human Glioma Cell Line Related to COX-2 Inhibition and Docking Studies. Eur. J. Med. Chem. 2016, 113, 179–186. DOI: 10.1016/j.ejmech.2016.02.036.
   PubMed Web of Science ®Google Scholar
• Šermukšnytė, A.; Kantminienė, K.; Jonuškienė, I.; Tumosienė, I.; Petrikaitė, V. The Effect of 1, 2, 4-Triazole-3-Thiol Derivatives Bearing Hydrazone Moiety on Cancer Cell Migration and Growth of Melanoma, Breast, and Pancreatic Cancer Spheroids. Pharmaceuticals 2022, 15, 1026–1045. DOI: 10.3390/ph15081026.
   Web of Science ®Google Scholar
• Motakatla, V. K. R.; Gokanapalli, A.; Peddiahgari, V. G. R. Cu–N‐Heterocyclic Carbene‐Catalysed Synthesis of 2‐Aryl‐3‐(Arylethynyl) Quinoxalines from One‐Pot Tandem Coupling of O‐Phenylenediamines and Terminal Alkynes. Appl. Organomet. Chem. 2019, 33, e5188-5199.
   Web of Science ®Google Scholar
• Farghaly, T. A.; Alsaedi, A. M. R.; Alenazi, N. A.; Harras, M. F. Anti-Viral Activity of Thiazole Derivatives: An Updated Patent Review. Expert Opin. Ther. Pat. 2022, 32, 791–815.
   PubMed Web of Science ®Google Scholar
• Posso, M. C.; Domingues, F. C.; Ferreira, S.; Silvestre, S. Development of Phenothiazine Hybrids with Potential Medicinal Interest: A Review. Molecules 2022, 27, 276–307. DOI: 10.3390/molecules27010276.
   PubMed Web of Science ®Google Scholar
• Gontijo, V. S.; Viegas, F. P. D.; Ortiz, C. J. C.; de Freitas Silva, M.; Damasio, C. M.; Rosa, M. C.; Campos, T. G.; Couto, D. S.; Tranches Dias, K. S.; Viegas, C. Molecular Hybridization as a Tool in the Design of Multi-Target Directed Drug Candidates for Neurodegenerative Diseases. Curr. Neuropharmacol. 2020, 18, 348–407. DOI: 10.2174/1385272823666191021124443.
   PubMed Web of Science ®Google Scholar
• Alkhzem, A. H.; Woodman, T. J.; Blagbrough, I. S. Design and Synthesis of Hybrid Compounds as Novel Drugs and Medicines. RSC Adv. 2022, 12, 19470–19484. DOI: 10.1039/d2ra03281c.
   PubMed Web of Science ®Google Scholar
• Martins, M. A. P.; Cunico, W.; Siqueira, G. M.; Leidens, V. L.; Zanatta, N.; Bonacorso, H. G.; Flores, A. F. C. Regiospecific Synthesis of 1, 2-Bis (Azolyl) Ethanes. J. Braz. Chem. Soc. 2005, 16, 275–279. DOI: 10.1590/S0103-50532005000200022.
   Web of Science ®Google Scholar
• Padmavathi, V.; Reddy, B. J. M.; Subbaiah, D. R. C. V. Bischalcones – Synthons for a New Class of Bis (Heterocycles). New J. Chem. 2004, 28, 1479–1483. DOI: 10.1039/B409968K.
   Web of Science ®Google Scholar
• Padmavathi, V.; Reddy, B. J. M.; Reddy, B. C. O.; Padmaja, A. Synthesis of a New Class of Keto-Linked Bis Heterocycles. Tetrahedron 2005, 61, 2407–2411. DOI: 10.1016/j.tet.2005.01.018.
   Web of Science ®Google Scholar
• Mohamed, M. F.; Abdelmoniem, A. M.; Elwahy, A. H. M.; Abdelhamid, I. A. DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-Cyclic 2-Oxindole of Pyrimido [4, 5-b] Quinoline-4, 6-Dione Derivatives against Breast Carcinoma. Curr. Cancer Drug Targets 2018, 18, 372–381. DOI: 10.2174/1568009617666170630143311.
   PubMed Web of Science ®Google Scholar
• Antonini, I.; Polucci, P.; Magnano, A.; Sparapani, S.; Martelli, S. Rational Design, Synthesis, and Biological Evaluation of Bis (Pyrimido [5, 6, 1-de] Acridines) and Bis (Pyrazolo [3, 4, 5-Kl] Acridine-5-Carboxamides) as New Anticancer Agents. J. Med. Chem. 2004, 47, 5244–5250. DOI: 10.1021/jm049706k.
   PubMed Web of Science ®Google Scholar
• Salama, S. K.; Mohamed, M. F.; Darweesh, A. F.; Elwahy, A. H. M.; Abdelhamid, I. A. Molecular Docking Simulation and Anticancer Assessment on Human Breast Carcinoma Cell Line Using Novel Bis (1, 4-Dihydropyrano [2, 3-c] Pyrazole-5-Carbonitrile) and Bis (1, 4-Dihydropyrazolo [4′, 3′: 5, 6] Pyrano [2, 3. b] Pyridine-6-Carbonitrile) Derivatives. Bioorg. Chem. 2017, 71, 19–29. DOI: 10.1016/j.bioorg.2017.01.009.
   PubMed Web of Science ®Google Scholar
• Jain, M.; Sakhuja, R.; Khanna, P.; Bhagat, S.; Jain, S. C. A Facile Synthesis of Novel Unsymmetrical Bis-Spiro [Indole-Pyrazolinyl-Thiazolidine]-2, 4’-Diones. Arkivoc 2008, 2008, 54–64. DOI: 10.3998/ark.5550190.0009.f07.
   Web of Science ®Google Scholar
• Di Giacomo, B.; Bedini, A.; Spadoni, G.; Tarzia, G.; Fraschini, F.; Pannacci, M.; Lucini, V. Synthesis and Biological Activity of New Melatonin Dimeric Derivatives. Bioorg. Med. Chem. 2007, 15, 4643–4650. DOI: 10.1016/j.bmc.2007.03.080.
   PubMed Web of Science ®Google Scholar
• Wang, C.; Jung, G.-Y.; Batsanov, A. S.; Bryce, M. R.; Petty, M. C. New Electron-Transporting Materials for Light Emitting Diodes: 1, 3, 4-Oxadiazole–Pyridine and 1, 3, 4-Oxadiazole–Pyrimidine Hybrids. J. Mater. Chem. 2002, 12, 173–180. DOI: 10.1039/b106907c.
   Web of Science ®Google Scholar
• Mohamed, G. G.; Zayed, E. M.; Hindy, A. M. M. Coordination Behavior of New Bis Schiff Base Ligand Derived from 2-Furan Carboxaldehyde and Propane-1, 3-Diamine. Spectroscopic, Thermal, Anticancer and Antibacterial Activity Studies. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2015, 145, 76–84. DOI: 10.1016/j.saa.2015.01.129.
   PubMed Web of Science ®Google Scholar
• Wang, C.; Jung, G.-Y.; Hua, Y.; Pearson, C.; Bryce, M. R.; Petty, M. C.; Batsanov, A. S.; Goeta, A. E.; Howard, J. A. K. An Efficient Pyridine-and Oxadiazole-Containing Hole-Blocking Material for Organic Light-Emitting Diodes: Synthesis, Crystal Structure, and Device Performance. Chem. Mater. 2001, 13, 1167–1173. DOI: 10.1021/cm0010250.
   Web of Science ®Google Scholar
• Shaaban, M. R.; Hm Elwahy, A. Synthesis of Oxazolo-, Thiazolo-, Pyrazolo-, and Imidazo-Fused Heterocycles by Multi-Component Reactions (Part 2). COS. 2014, 11, 471–525. DOI: 10.2174/15701794113106660076.
   Web of Science ®Google Scholar
• Shaaban, M. R.; Hm Elwahy, A. Synthesis of Furo-, Pyrrolo-, and Thieno-Fused Heterocycles by Multi-Component Reactions (Part 1). Curr. Org. Synth. 2013, 10, 425–466.
   Web of Science ®Google Scholar
• Shaaban, M. R.; Elwahy, A. H. M. Bis (Α‐Bromo Ketones): Versatile Precursors for Novel Bis (S‐Triazolo [3, 4‐b][1, 3, 4] Thiadiazines) and Bis (as‐Triazino [3, 4‐b][1, 3, 4] Thiadiazines). J. Heterocyclic Chem. 2012, 49, 640–645. DOI: 10.1002/jhet.861.
   Web of Science ®Google Scholar
• Salem, M. E.; Hosny, M.; Darweesh, A. F.; Elwahy, A. H. M. Synthesis of Novel Bis-and Poly (Aryldiazenylthiazoles). Synth. Commun. 2019, 49, 2319–2329. DOI: 10.1080/00397911.2019.1620283.
   Web of Science ®Google Scholar
• Salem, M. E.; Darweesh, A. F.; Shaaban, M. R.; Elwahy, A. H. M. Synthesis of Novel Bis-and Poly (Hydrazinylthiazole) Linked to Benzofuran or Benzothiazole as New Hybrid Molecules. Arkivoc 2019, 2019, 73–88. DOI: 10.24820/ark.5550190.p010.810.
   Web of Science ®Google Scholar
• Salem, M. E.; Darweesh, A. F.; Elwahy, A. H. M. Synthesis of Novel Scaffolds Based on Thiazole or Triazolothiadiazine Linked to Benzofuran or Benzo [d] Thiazole Moieties as New Hybrid Molecules. Synth. Commun. 2020, 50, 256–270. DOI: 10.1080/00397911.2019.1694689.
   Web of Science ®Google Scholar
• Abdelmoniem, A. M.; Salaheldin, T. A.; Abdelhamid, I. A.; Elwahy, A. H. M. New Bis (Dihydropyridine‐3, 5‐Dicarbonitrile) Derivatives: Green Synthesis and Cytotoxic Activity Evaluation. J. Heterocyclic Chem. 2017, 54, 2670–2677. DOI: 10.1002/jhet.2867.
   Web of Science ®Google Scholar
• Abdella, A. M.; Moatasim, Y.; Ali, M. A.; Elwahy, A. H. M.; Abdelhamid, I. A. Synthesis and Anti‐Influenza Virus Activity of Novel Bis (4H‐Chromene‐3‐Carbonitrile) Derivatives. J. Heterocyclic Chem. 2017, 54, 1854–1862. DOI: 10.1002/jhet.2776.
   Web of Science ®Google Scholar
• Sanad, S. M. H.; Kassab, R. M.; Abdelhamid, I. A.; Elwahy, A. H. M. Microwave Assisted Multi-Component Synthesis of Novel Bis (1, 4-Dihydropyridines) Based Arenes or Heteroarenes. Heterocycles 2016, 92, 910–924.
   Web of Science ®Google Scholar
• Salama, S. K.; Darweesh, A. F.; Abdelhamid, I. A.; Elwahy, A. H. M. Microwave Assisted Green Multicomponent Synthesis of Novel Bis (2‐Amino‐Tetrahydro‐4H‐Chromene‐3‐Carbonitrile) Derivatives Using Chitosan as Eco‐Friendly Basic Catalyst. J. Heterocyclic Chem. 2017, 54, 305–312. DOI: 10.1002/jhet.2584.
   Web of Science ®Google Scholar
• Abdella, A. M.; Hm Elwahy, A.; Abdelhamid, I. A. Multicomponent Synthesis of Novel Bis (2-Amino-Tetrahydro-4H-Chromene-3-Carbonitrile) Derivatives Linked to Arene or Heteroarene Cores. Curr. Org. Synth. 2016, 13, 601–610.
   Web of Science ®Google Scholar
• Hosny, M.; Salem, M. E.; Darweesh, A. F.; Elwahy, A. H. M. Synthesis of Novel Bis (Thiazolylchromen‐2‐One) Derivatives Linked to Alkyl Spacer via Phenoxy Group. J. Heterocyclic Chem. 2018, 55, 2342–2348. DOI: 10.1002/jhet.3296.
   Web of Science ®Google Scholar
• Salem, M. E.; Fares, I. M. Z.; Ghozlan, S. A. S.; Abdel‐Aziz, M. M.; Abdelhamid, I. A.; Elwahy, A. H. M. Facile Synthesis and Antimicrobial Activity of Bis (Fused 4 H‐Pyrans) Incorporating Piperazine as Novel Hybrid Molecules: Michael’s Addition Approach. J. Heterocycl. Chem. 2022, 59, 1907–1926.
   Web of Science ®Google Scholar
• Romer, D. R. Synthesis of 2, 3‐Dichloroquinoxalines via Vilsmeier Reagent Chlorination. J. Heterocyclic Chem. 2009, 46, 317–319. DOI: 10.1002/jhet.56.
   Web of Science ®Google Scholar
• Blau, L.; Menegon, R. F.; Trossini, G. H. G.; Molino, J. V. D.; Vital, D. G.; Cicarelli, R. M. B.; Passerini, G. D.; Bosquesi, P. L.; Chin, C. M. Design, Synthesis and Biological Evaluation of New Aryl Thiosemicarbazone as Antichagasic Candidates. Eur. J. Med. Chem. 2013, 67, 142–151. DOI: 10.1016/j.ejmech.2013.04.022.
   PubMed Web of Science ®Google Scholar