An Improved Synthesis of la, 3 p-Dihydroxycholesta- 5,7-Diene

References

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• Crystallization of the diacetate 3b afforded material with m. p. 98–9°C. Lit10 : liquid
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• The purified products by column chromatography showed consistant data (TLC, UV, NMR) with pure materials
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• The efficiency of the bromination and dehydrobromination method may be observed in the following experiment: bromination and dehydrobromination of cholesteryl acetate (200 mg) afforded a crude residue which was directly crystallized from 95% ethanol to give pure 1α-hydroxycholesta-5,7-diene acetate (51 mg, 50%)
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