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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 13, 1983 - Issue 8
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Original Articles

Selective Ring Omethylation of Hydroxybenzaldehydes Via Their Mannich Bases

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Pages 677-683 | Published online: 06 Dec 2006

References

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  • Attempts to produce 5 by the direct chloromethylation of 2, under a variety of conditions10 were not successful. Attempts to produce the corresponding iodomethyl derivative using ClCH 2 OCH 3 and HI (ref. 8) were also unsuccessful. These findings are not surprising since, in general, phenols are so highly activated that direct halomethylation reactions are difficult to control and diaryImethanes as well as polymers are formed. 10
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