Alkylation of 3-Ethoxy-2-Lithioacrylonitrile: Synthesis of 5-Alkylcytosines

References

• De Clercq , E. 1983 . Pure & Appl. Chem. , 55 : 623
   Web of Science ®Google Scholar
• Robins , R. K. 1986 . Chem. & Eng. News , : 28
   Google Scholar
• Bergstrom , D. E. and Ruth , J. L. 1977 . J. Carbohydr. Nucleosides Nucleotides , 4 : 257
   Google Scholar
• Ruth , J. L. and Bergstrom , D. E. 1978 . J. Org. Chem. , 43 : 2870
   Web of Science ®Google Scholar
• Bergstrom , D. E. and Ruth , J. L. 1976 . J. Am. Chem. Soc. , 98 : 1587
   PubMedGoogle Scholar
• Robins , M. J. and Barr , P. J. 1983 . J. Org. Chem. , 48 : 1854 – 1862 .
   Web of Science ®Google Scholar
• Tarsio , P. J. and Nicholl , L. 1957 . J. Org. Chem. , 22 : 192
   Web of Science ®Google Scholar
• Budesinsky , Z. and Perina , Z. 1960 . Chem. Abs. , 54 : 2378
   Google Scholar
• Peeters , H. , Theis , C. and Vogt , W. 1983 . Chem Abs. , 99 : 175480c
   Google Scholar
• Peeters , H. and Vogt , W. 1982 . Chem. Abs. , 97 : 6318j
   Google Scholar
• Baker , B. R. and Kelley , J. L. 1969 . J. Med. Chem. , 12 : 1039
   PubMedGoogle Scholar
• Baker , B. R. and Kelley , J. L. 1968 . J. Med. Chem. , 11 : 686
   PubMedGoogle Scholar
• Schmidt , R. R. and Speer , H. 1981 . Tetrahedron Lett. , 22 : 4259
   Google Scholar
• Schmidt , R. R. and Hirsenkorn , R. 1983 . Tetrahedron , 39 : 2043
   Google Scholar
• All of the new compounds described herein were characterized by H NMR (80 or 500 MHz). and IR; cytosine derivatives were characterized by UV. Selected compounds were further characterized by high resolution MS
   Google Scholar
• We have experienced difficulty in the separation of urea from the 5-alkylcytosines. For this reason, we recommend that a large excess of urea be avoided in the cyclization reactions
   Google Scholar