Synthesis of 2-ax-Fluoro-2-eq-Hydroxymethyl-2-Deoxymyoinositol

References

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• For convenience, D-myoinositol configuration was used to denote DL-myoinositol throughout Schemes I and II
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• The C-2 axial fluorine splits both C-4 and C-6 hydrogens to a doublet
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• The existence of the bromonium species 8 was further substantiated by the fact that ca. 5% of a 2-fluoromethyl-2-bromo derivative was isolated as a result of nucleophilic attack by fluoride ion at spiro CH2
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