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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 16, 1986 - Issue 3
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Original Articles

Chemoselective Methylation of Carboxylic Acids using DBU and Iodomethane

Pages 331-335 | Published online: 19 Dec 2006

References

  • Ballini , R. and Carotti , A. 1983 . Synth. Commun. , 13 : 1197
  • Ziegler , F. E. and Berger , G. D. 1979 . Synth. Commun. , 9 : 539
  • Acid-catalysed esterifications that are commonly used can cause extensive dehydration or lactonization of hydroxy acids. Use of diazomethane, on the other hand, is not suitable for such preparations, because of its toxicity and hazard. Alternatively, the carboxyl groups are converted into monosilver salts which are then reacted with appropiate alkyl halides
  • Yamada , N. , Saito , T. , Tanaka , T. , Kaji , K and Bull. , A. 1978 . Chem. Soc-(Japan). , 51 : 2401 Ono
  • Rao , C. G. and Org. ∗∗∗rep. Proc. Int. 1980 . 12 : 225
  • 1965 . Dictionary of Organic Compounds , Spottiswoode Publishers Ltd . Eyre
  • Kato , M. , Kageyama , M. , Tanaxa , R. , Ku∗∗∗ara , K. and Yoshikoshi , A. 1975 . J.Org.Chem. , 40 : 1932
  • McCoy , L. 1967 . J. Amer. Chem. Soc. , 89 : 1673

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