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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 16
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Original Articles

Synthesis of Deoxytabtoxinine-β-Lactam

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Pages 1877-1886 | Published online: 06 Dec 2006

References

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  • Tabtoxinine-β-Lactam at 0.7 mM causes =75% inhibition of sheep brain glutamine synthetase (Sigma) in the presence of ATP using an NADH coupled assay.13 Inhibition of the mammalian enzyme occurs at similar concentrations to that reported for the pea enzyme.2
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  • [(1,2,3-n)-2-butenyl-1,4-diyl][(phyenylmethyl)imino]tricarbonyliron was prepared by the procedure of Ley et al.5 from [(1,2,3-n)-2-butenyl-1,4-diyl]oxycarbonyltricarbonyliron which was prepared from 2-butene-1,4-diol by a modification of the procedure of Murdoch.19 Benzene was used as the solvent instead of low boiling petroleum ether and the reaction was run at 55 rather than 40 °C
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