Synthesis of Substituted Trans-1,6-Dimethylbicyclo[4.3.0]-non-2-enes Using A Claisen Rearrangement of α-(Thioalkoxy) Esters

References

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• Styrene 8b was prepared from 2′-bromo-3-methoxy-acetophenone using: (1) HSCH2CO2CH3; (2) NaBH4; (3) MsCl, Et3N; (4) DBU; (5) LiOH; (6) Mitsunobu coupling; and (7) Claisen rearrangement.
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• Styrene 8c was prepared from 2′-bromo-3-methoxy-acetophenone using: (1) HSCH2CO2CH3; (2) KH, (CH3)2SO4; (3) LiOH; (4) Mitsunobu coupling; and (5) Claisen rearrangement.
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